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Sébastien S. Hébert · SciRah

Researcher profile · Semantic Scholar

Sébastien S. Hébert

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Sébastien S. Hébert — researcher profile on SciRah

h-index: 43
Works: 90
Citations: 8,050

Most-cited papers

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, A. Papadopoulou +5 more
2008Proceedings of the National Academy of Sciences of the United States of America1,203 citations Open access
Semantic Scholar
Alterations of the microRNA network cause neurodegenerative disease.
Sébastien S. Hébert, B. de Strooper
2009Trends in Neurosciences455 citations
Semantic Scholar
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.
Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, B. Bergmans +3 more
2009Neurobiology of Disease437 citations Open access
Semantic Scholar
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor, Katherine R. Sadleir, E. Maus, R. A. Velliquette +12 more
2008Neuron409 citations Open access
Semantic Scholar
The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases
John R. Finnerty, Wang-Xia Wang, Sébastien S. Hébert, Bernard R. Wilfred +2 more
2010Journal of Molecular Biology370 citations Open access
Semantic Scholar
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.
Sébastien S. Hébert, A. Papadopoulou, Pascal Y. Smith, M. Galas +5 more
2010Human Molecular Genetics322 citations Open access
Semantic Scholar
The amyloid‐β precursor protein: integrating structure with biological function
Constanze Reinhard, Sébastien S. Hébert, B. de Strooper
2005257 citations Open access
Semantic Scholar
MicroRNAs in Alzheimer's disease.
C. Delay, W. Mandemakers, Sébastien S. Hébert
2012Neurobiology of Disease239 citations Open access
Semantic Scholar
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo.
Pascal Y. Smith, Julia Hernandez-Rapp, Francis Jolivette, C. Lecours +13 more
2015Human Molecular Genetics224 citations Open access
Semantic Scholar
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
Pascal Y. Smith, Amelle Al Hashimi, Johanne Girard, C. Delay +1 more
2011Journal of Neurochemistry217 citations Open access
Semantic Scholar
Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain
M. Leyssen, Derya Ayaz, Sébastien S. Hébert, Simon Reeve +2 more
2005EMBO Journal216 citations Open access
Semantic Scholar
Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes
Sébastien S. Hébert, L. Serneels, A. Tolia, K. Craessaerts +4 more
2006EMBO Reports197 citations Open access
Semantic Scholar
A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease.
Xiong Wang, Dan Liu, He-Zhou Huang, Zhi-Hao Wang +14 more
2017Biological Psychiatry189 citations
Semantic Scholar
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
L. Serneels, T. Dejaegere, K. Craessaerts, Katrien Horré +9 more
2005170 citations
Semantic Scholar
Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity.
Sébastien S. Hébert, L. Serneels, T. Dejaegere, Katrien Horré +5 more
2004Neurobiology of Disease168 citations Open access
Semantic Scholar
The amyloid-beta precursor protein: integrating structure with biological function.
Constanze Reinhard, Sébastien S. Hébert, B. de Strooper
2005EMBO Journal144 citations
Semantic Scholar
Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia
Chin W. Hui, Abygaël St-Pierre, H. el-Hajj, Yvan Remy +4 more
2018Frontiers in Molecular Neuroscience143 citations Open access
Semantic Scholar
Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein affect microRNA function
C. Delay, F. Calon, P. Mathews, Sébastien S. Hébert
2011Molecular Neurodegeneration137 citations Open access
Semantic Scholar
Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions
Franck R. Petry, J. Pelletier, A. Bretteville, F. Morin +4 more
2014PLoS ONE128 citations Open access
Semantic Scholar
A Study of Small RNAs from Cerebral Neocortex of Pathology-Verified Alzheimer’s Disease, Dementia with Lewy Bodies, Hippocampal Sclerosis, Frontotemporal Lobar Dementia, and Non-Demented Human Controls
Sébastien S. Hébert, Wang-Xia Wang, Qi Zhu, P. Nelson
2013Journal of Alzheimer's Disease122 citations Open access
Semantic Scholar
microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice
Julia Hernandez-Rapp, S. Rainone, Claudia Goupil, Véronique G. Dorval +8 more
2016Scientific Reports120 citations Open access
Semantic Scholar
miRNAs in Neurodegeneration
Sébastien S. Hébert, B. de Strooper
2007Science113 citations
Semantic Scholar
Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.
Dan Liu, Hui Tang, Xinyan Li, Man-Fei Deng +10 more
2017Molecular Therapy111 citations Open access
Semantic Scholar
Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.
N. N. Kasri, S. Kocks, Leen Verbert, Sébastien S. Hébert +4 more
2006Cell Calcium94 citations
Semantic Scholar
Memory formation and retention are affected in adult miR-132/212 knockout mice.
Julia Hernandez-Rapp, Pascal Y. Smith, M. Filali, Claudia Goupil +4 more
2015Behavioural Brain Research89 citations
Semantic Scholar
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo.
L. Serneels, T. Dejaegere, K. Craessaerts, Katrien Horré +9 more
2005Proceedings of the National Academy of Sciences of the United States of America87 citations
Semantic Scholar
Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease
S. Parsi, Pascal Y. Smith, Claudia Goupil, Véronique G. Dorval +1 more
2015Molecular Therapy: Nucleic Acids86 citations Open access
Semantic Scholar
Co-occurrence of mixed proteinopathies in late-stage Huntington’s disease
I. St-Amour, A. Turgeon, Claudia Goupil, E. Planel +1 more
2018Acta Neuropathologica85 citations
Semantic Scholar
Huntingtin Aggregation Impairs Autophagy, Leading to Argonaute-2 Accumulation and Global MicroRNA Dysregulation.
Karolina Pircs, Rebecca Petri, Sofia Madsen, P. Brattås +12 more
2018Cell Reports84 citations Open access
Semantic Scholar
Circulating microRNAs in Alzheimer’s disease: the search for novel biomarkers
Véronique G. Dorval, P. Nelson, Sébastien S. Hébert
2013Frontiers in Molecular Neuroscience81 citations Open access
Semantic Scholar
MicroRNAs underlying memory deficits in neurodegenerative disorders
Julia Hernandez-Rapp, S. Rainone, Sébastien S. Hébert
2017Progress in Neuro-psychopharmacology and Biological Psychiatry72 citations
Semantic Scholar
MicroRNAs and the Regulation of Tau Metabolism
Sébastien S. Hébert, N. Sergeant, L. Buée
2012International Journal of Alzheimer's Disease72 citations Open access
Semantic Scholar
Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.
Maud Gratuze, Anastasia Noël, Carl Julien, G. Cisbani +13 more
2015Human Molecular Genetics66 citations Open access
Semantic Scholar
Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
M. Papon, Noura B. El Khoury, François Marcouiller, Carl Julien +8 more
2013Diabetes65 citations Open access
Semantic Scholar
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.
A. Papadopoulou, L. Serneels, T. Achsel, W. Mandemakers +13 more
2015Neurobiology of Disease60 citations Open access
Semantic Scholar
MicroRNAs and Alzheimer's Disease Mouse Models: Current Insights and Future Research Avenues
C. Delay, Sébastien S. Hébert
2011International Journal of Alzheimer's Disease60 citations Open access
Semantic Scholar
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein
Sandra Huysseune, P. Kienlen-Campard, Sébastien S. Hébert, B. Tasiaux +5 more
2009The FASEB Journal49 citations
Semantic Scholar
Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
I. St-Amour, Cristina R. Bosoi, Isabelle Paré, Prenitha Mercy Ignatius Arokia Doss +4 more
2019Journal of Neuroinflammation47 citations Open access
Semantic Scholar
Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anaїs-Camille Vreulx +22 more
2019Molecular Psychiatry47 citations Open access
Semantic Scholar
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Elaine Waldron, Simone Isbert, Andreas Kern, S. Jaeger +6 more
2008Experimental Cell Research47 citations
Semantic Scholar
Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain
W. Mandemakers, Liron Abuhatzira, Huan-Yu Xu, L. Caromile +7 more
2013Diabetologia46 citations Open access
Semantic Scholar
Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).
Sébastien S. Hébert, Valérie Bourdages, C. Godin, Mélissa Ferland +2 more
2003Neurobiology of Disease46 citations Open access
Semantic Scholar
Gene and MicroRNA Transcriptome Analysis of Parkinson's Related LRRK2 Mouse Models
Véronique G. Dorval, W. Mandemakers, Francis Jolivette, L. Coudert +3 more
2014PLoS ONE43 citations Open access
Semantic Scholar
Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature.
Isabelle Guisle, Maud Gratuze, Séréna Pétry, F. Morin +5 more
2019Sleep41 citations
Semantic Scholar
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
Noura B. El Khoury, Maud Gratuze, Franck R. Petry, M. Papon +8 more
2016Neurobiology of Disease39 citations Open access
Semantic Scholar
Repeated cold exposures protect a mouse model of Alzheimer's disease against cold-induced tau phosphorylation
M. Tournissac, P. Bourassa, Ruben D. Martinez-Cano, Tra-My Vu +3 more
2019Molecular Metabolism36 citations Open access
Semantic Scholar
Mutation in the 3’untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy
G. Nicolas, D. Wallon, Claudia Goupil, A. Richard +18 more
2015European Journal of Human Genetics35 citations Open access
Semantic Scholar
Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes.
Sébastien S. Hébert, C. Godin, T. Tomiyama, H. Mori +1 more
2003Biochemical and Biophysical Research Communications - BBRC34 citations
Semantic Scholar
MicroRNAs targeting Nicastrin regulate Aβ production and are affected by target site polymorphisms
C. Delay, Véronique G. Dorval, Alice C. Fok, B. Grenier-Boley +3 more
2014Frontiers in Molecular Neuroscience31 citations Open access
Semantic Scholar
Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation
Carl Julien, François Marcouiller, A. Bretteville, Noura B. El Khoury +3 more
2012PLoS ONE30 citations Open access
Semantic Scholar

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