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The amyloid‐β precursor protein: integrating structure with biological function

Constanze Reinhard^{a b c}, Sébastien S. Hébert^{b c d}, Bart De Strooper^{b c d}✉

^aLaboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB, Leuven, Belgium
^bLaboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB
^cLeuven Belgium
^dLaboratory for Neuronal Cell Biology and Gene Transfer, Department of Human Genetics, Center for Human Genetics, KU Leuven and VIB Leuven Belgium
✉Corresponding author

The EMBO Journal Springer Nature2005-10-27 278 citations120 references

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Abstract

Proteolytic processing of the amyloid-beta precursor protein (APP) generates the Abeta amyloid peptide of Alzheimer's disease. The biological function of APP itself remains, however, unclear. In the current review, we study in detail the different subdomains of APP and try to assign functional significance to particular structures identified in the protein.

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The amyloid‐β precursor protein: integrating structure with biological function

Abstract

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