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R. Novak · SciRah

Researcher profile · Semantic Scholar

R. Novak

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R. Novak — researcher profile on SciRah

h-index: 28
Works: 79
Citations: 2,342

Most-cited papers

Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review
Kyla W. Taylor, R. Novak, H. Anderson, L. Birnbaum +12 more
2013Environmental Health Perspectives333 citations Open access
Semantic Scholar
DNA damage is an early event in doxorubicin-induced cardiac myocyte death.
T. L'ecuyer, S. Sanjeev, Ronald L. Thomas, R. Novak +3 more
2006American Journal of Physiology. Heart and Circulatory Physiology219 citations
Semantic Scholar
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.
S. K. Kim, R. Novak
2007Pharmacology and Therapeutics166 citations Open access
Semantic Scholar
The alcohol-inducible form of cytochrome P450 (CYP2E1): Role in toxicology and regulation of expression
R. Novak, K. Woodcroft
2000Archives of pharmacal research150 citations
Semantic Scholar
miRNAs: effectors of environmental influences on gene expression and disease.
A. Hudder, R. Novak
2008Toxicological Sciences116 citations Open access
Semantic Scholar
Pyridine induction of cytochrome P-450 in the rat: role of P-450j (alcohol-inducible form) in pyridine N-oxidation.
S. G. Kim, David E. Williams, E. Schuetz, P. Guzelian +1 more
1988Journal of Pharmacology and Experimental Therapeutics93 citations
Semantic Scholar
Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants.
M. Philbert, C. Beiswanger, M. Manson, J. A. Green +4 more
1995Neurotoxicology65 citations
Semantic Scholar
Insulin Signaling Regulates γ-Glutamylcysteine Ligase Catalytic Subunit Expression in Primary Cultured Rat Hepatocytes
S. K. Kim, K. Woodcroft, S. Khodadadeh, R. Novak
2004Journal of Pharmacology and Experimental Therapeutics60 citations
Semantic Scholar
Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system.
C. Beiswanger, M. Diegmann, R. Novak, M. Philbert +3 more
1995Neurotoxicology60 citations
Semantic Scholar
Gene‐specific dye bias in microarray reference designs
Alan A. Dombkowski, Bryan J. Thibodeau, Susan L. Starcevic, R. Novak
2004FEBS Letters57 citations Open access
Semantic Scholar
Acetoacetate Activation of Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase in Primary Cultured Rat Hepatocytes: Role of Oxidative Stress
M. Abdelmegeed, S. K. Kim, K. Woodcroft, R. Novak
2004Journal of Pharmacology and Experimental Therapeutics52 citations
Semantic Scholar
Mechanism of inhibition of microsomal drug metabolism by imidazole.
K. Hájek, N. Cook, R. Novak
1982Journal of Pharmacology and Experimental Therapeutics50 citations
Semantic Scholar
DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells.
K. Shen, R. Novak
1997Biochemical and Biophysical Research Communications - BBRC49 citations
Semantic Scholar
Cellular distribution of cytochromes P-450 in the rat kidney.
B. Cummings, R. Zangar, R. Novak, L. Lash
1999Drug Metabolism And Disposition47 citations
Semantic Scholar
Inhibition of adriamycin-stimulated microsomal lipid peroxidation by mitoxantrone and ametantrone, two new anthracenedione antineoplastic agents.
E. Kharasch, R. Novak
1982Biochemical and Biophysical Research Communications - BBRC43 citations
Semantic Scholar
Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon alpha/beta.
A. Cribb, E. Delaporte, S. G. Kim, R. Novak +1 more
1994Journal of Pharmacology and Experimental Therapeutics41 citations
Semantic Scholar
Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).
S. L. Starcevic, Nicole M Diotte, K. Zukowski, M. Cameron +1 more
2003Toxicological Sciences38 citations Open access
Semantic Scholar
Inhibitory effects of anthracenedione antineoplastic agents on hepatic and cardiac lipid peroxidation.
E. Kharasch, R. Novak
1983Journal of Pharmacology and Experimental Therapeutics36 citations
Semantic Scholar
Acetoacetate Induces CYP2E1 Protein and Suppresses CYP2E1 mRNA in Primary Cultured Rat Hepatocytes
M. Abdelmegeed, N. Carruthers, K. Woodcroft, S. K. Kim +1 more
2005Journal of Pharmacology and Experimental Therapeutics35 citations
Semantic Scholar
Mitoxantrone: Propensity for free radical formation and lipid peroxidation — implications for cardiotoxicity
R. Novak, E. Kharasch
2004Investigational new drugs33 citations
Semantic Scholar
Piperine effects on the expression of P4502E1, P4502B and P4501A in rat.
Min-hee Kang, S. Won, S. S. Park, Sang Geon Kim +2 more
1994Xenobiotica; the fate of foreign compounds in biological systems33 citations
Semantic Scholar
Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease.
S. L. Starcevic, C. Elferink, R. Novak
2001Journal of the National Cancer Institute31 citations
Semantic Scholar
Insulin and glucagon signaling in regulation of microsomal epoxide hydrolase expression in primary cultured rat hepatocytes.
S. K. Kim, K. Woodcroft, S. G. Kim, R. Novak
2003Drug Metabolism And Disposition30 citations
Semantic Scholar
N6-Trimethyl-lysine metabolism. 3-Hydroxy-N6-trimethyl-lysine and carnitine biosynthesis.
Charles L. Hoppel, R. A. Cox, R. Novak
1980Biochemical Journal30 citations Open access
Semantic Scholar
Insulin and Glucagon Regulation of GlutathioneS-Transferase Expression in Primary Cultured Rat Hepatocytes
S. K. Kim, K. Woodcroft, R. Novak
2003Journal of Pharmacology and Experimental Therapeutics29 citations
Semantic Scholar
Differential expression of glutathione S-transferase isoforms in compartments of the testis and segments of the epididymis of the rat.
Jay Gandy, T. Primiano, R. Novak, W. Kelce +1 more
1996Drug Metabolism And Disposition29 citations
Semantic Scholar
Pyridine effects on P450IIE1, IIB and IVB expression in rabbit liver: characterization of high- and low-affinity pyridine N-oxygenases.
S. G. Kim, R. Philpot, R. Novak
1991Journal of Pharmacology and Experimental Therapeutics29 citations
Semantic Scholar
Pyridine effects on expression and molecular regulation of the cytochrome P450IA gene subfamily.
S. G. Kim, S. Reddy, J. States, R. Novak
1991Molecular Pharmacology28 citations
Semantic Scholar
Identification of the Insulin Signaling Cascade in the Regulation of Alpha-Class Glutathione S-Transferase Expression in Primary Cultured Rat Hepatocytes
S. K. Kim, M. Abdelmegeed, R. Novak
2006Journal of Pharmacology and Experimental Therapeutics26 citations
Semantic Scholar
Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke: redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine.
Sang Geon Kim, R. Novak
1990Cancer Research26 citations
Semantic Scholar
Oxidation of 1,1,1,2-tetrafluoroethane in rat liver microsomes is catalyzed primarily by cytochrome P-450IIE1.
M. J. Olson, S. G. Kim, C. Reidy, J. T. Johnson +1 more
1991Drug Metabolism And Disposition25 citations
Semantic Scholar
Rapamycin Effects on mTOR Signaling in Benign, Premalignant and Malignant Human Breast Epithelial Cells
S. Kim, K. Zukowski, R. Novak
2009Anticancer Research24 citations
Semantic Scholar
THE MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) INHIBITOR PD98059 ELEVATES PRIMARY CULTURED RAT HEPATOCYTE GLUTATHIONE LEVELS INDEPENDENT OF INHIBITING MEK
S. K. Kim, M. Abdelmegeed, R. Novak
2006Drug Metabolism And Disposition23 citations
Semantic Scholar
Role of mechanical and redox stress in activation of mitogen-activated protein kinases in primary cultured rat hepatocytes.
S. K. Kim, K. Woodcroft, S. Oh, M. Abdelmegeed +1 more
2005Biochemical Pharmacology22 citations
Semantic Scholar
Insulin and Glucagon Regulation of Glutathione S-Transferase Expression in Primary Cultured Rat Hepatocytes
S. K. Kim, K. Woodcroft, R. Novak
200322 citations
Semantic Scholar
Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation.
E. Kharasch, R. Novak
1985Journal of Biological Chemistry19 citations
Semantic Scholar
Induction of microsomal epoxide hydrolase by sulfur amino acid deprivation via the pathway of C-Jun N-terminal kinase and its extracellular exposure during cell death.
K. Kang, R. Novak, C. Lee, S. G. Kim
2002Free Radical Biology & Medicine16 citations
Semantic Scholar
Malotilate, a hepatoprotectant, suppresses CYP2E1 expression in rats.
Sang Geon Kim, J. Kwak, J. W. Lee, R. Novak +2 more
1994Biochemical and Biophysical Research Communications - BBRC16 citations
Semantic Scholar
Secretome analysis of microarray data reveals extracellular events associated with proliferative potential in a cell line model of breast disease.
Alan A. Dombkowski, D. Cukovic, R. Novak
2006Cancer Letters15 citations
Semantic Scholar
Further structural analysis of rat liver microsomal metabolites of 2-methylnaphthalene.
R. Breger, R. Novak, R. Franklin, D. Rickert +1 more
1983Drug Metabolism And Disposition14 citations
Semantic Scholar
Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes.
J. C. Rowlands, R. Budinsky, B. Gollapudi, R. Novak +3 more
2011Chemosphere13 citations
Semantic Scholar
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells
Jie Zheng, A. Hudder, K. Zukowski, R. Novak
2010Cancer Letters12 citations Open access
Semantic Scholar
Differential effects of aroclors and DDT on growth factor gene expression and receptor tyrosine kinase activity in human breast epithelial cells.
Katherine A. Shen, R. Novak
1997Advances in Experimental Medicine and Biology12 citations
Semantic Scholar
Inhibition of microsomal oxidative drug metabolism by 1,4-bis (2-[(2-hydroxyethyl)amino]-ethylamino)-9,10-anthracenedione diacetate, a new antineoplastic agent.
E. Kharasch, R. Novak
1982Molecular Pharmacology11 citations
Semantic Scholar
1H Fourier transform nuclear magnetic resonance relaxation rate studies on the interaction of acetanilide with purified isozymes of rabbit liver microsomal cytochrome P-450 and with cytochrome b5.
R. Novak, K. P. Vatsis
1982Molecular Pharmacology10 citations
Semantic Scholar
Acetoacetate Induces CYP 2 E 1 Protein and Suppresses CYP 2 E 1 mRNA in Primary Cultured Rat Hepatocytes
M. Abdelmegeed, N. Carruthers, K. Woodcroft, S. K. Kim +1 more
20057 citations
Semantic Scholar
Effects of mitoxantrone and bisantrene on platelet aggregation and prostaglandin/thromboxane biosynthesis in vitro.
P. Frank, R. Novak
1986Anticancer Research7 citations
Semantic Scholar
DIFFERENTIAL INDUCTION OF RAT HEPATIC CYTOCHROMES P 450 3 A 1 , 3 A 2 , 2 B 1 , 2 B 2 , AND 2 E 1 IN RESPONSE TO PYRIDINE TREATMENT
Hyesook Kim, D. Putt, R. Zangar, C. Wolf +4 more
20016 citations
Semantic Scholar
Kepone (chlordecone) disrupts adherens junctions in human breast epithelial cells cultured on matrigel.
S. L. Starcevic, S. Bortolin, K. Woodcroft, R. Novak
2001In Vivo5 citations
Semantic Scholar
Enhanced glutathione S-transferase 7-7 expression in rat hepatic cytosol following treatment with pyrrole.
T. Primiano, Jay Gandy, J. York, R. Novak
1993Biochemical and Biophysical Research Communications - BBRC5 citations
Semantic Scholar

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