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T. Seya · SciRah

Researcher profile · Semantic Scholar

T. Seya

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T. Seya — researcher profile on SciRah

h-index: 84
Works: 426
Citations: 23K

Most-cited papers

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
K. Kataoka, Y. Shiraishi, Yohei Takeda, S. Sakata +40 more
2016Nature606 citations
Semantic Scholar
Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection
T. Kouwaki, Yoshimi Fukushima, T. Daito, Takahiro Sanada +8 more
2016Frontiers in Immunology177 citations Open access
Semantic Scholar
DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
H. Oshiumi, Moeko Miyashita, Masaaki Okamoto, Yuka Morioka +3 more
2015Cell Reports167 citations Open access
Semantic Scholar
Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo
M. Matsumoto, Megumi Tatematsu, F. Nishikawa, M. Azuma +4 more
2015Nature Communications123 citations Open access
Semantic Scholar
A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.
Yohei Takeda, K. Kataoka, Junya Yamagishi, S. Ogawa +2 more
2017Cell Reports115 citations Open access
Semantic Scholar
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.
Ken Takashima, Yohei Takeda, H. Oshiumi, H. Shime +4 more
2016Biochemical and Biophysical Research Communications - BBRC97 citations
Semantic Scholar
PolyI:C–Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector–Mediated Tumor Elimination In Vivo
R. Takemura, Hiromi Takaki, S. Okada, H. Shime +5 more
2015Cancer immunology research92 citations Open access
Semantic Scholar
Extracellular RNA Sensing by Pattern Recognition Receptors
Megumi Tatematsu, Kenji Funami, T. Seya, M. Matsumoto
2018Journal of Innate Immunity78 citations Open access
Semantic Scholar
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses.
Megumi Tatematsu, T. Seya, M. Matsumoto
2014Biochemical Journal72 citations
Semantic Scholar
Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy
M. Matsumoto, Yohei Takeda, Megumi Tatematsu, T. Seya
2017Frontiers in Immunology68 citations Open access
Semantic Scholar
RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
Ken Takashima, H. Oshiumi, Hiromi Takaki, M. Matsumoto +1 more
2015Cell Reports68 citations Open access
Semantic Scholar
Mucosal Immune Response in Nasal-Associated Lymphoid Tissue upon Intranasal Administration by Adjuvants
Hiromi Takaki, S. Ichimiya, M. Matsumoto, T. Seya
2018Journal of Innate Immunity67 citations Open access
Semantic Scholar
Adjuvant for vaccine immunotherapy of cancer – focusing on Toll‐like receptor 2 and 3 agonists for safely enhancing antitumor immunity
T. Seya, H. Shime, Yohei Takeda, Megumi Tatematsu +2 more
2015Cancer Science63 citations Open access
Semantic Scholar
Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type–Specific Manner
Megumi Tatematsu, Ryuji Yoshida, Yuka Morioka, N. Ishii +5 more
2016Journal of Immunology60 citations Open access
Semantic Scholar
Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response
H. Oshiumi, T. Kouwaki, T. Seya
2016Frontiers in Immunology59 citations Open access
Semantic Scholar
Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections
Masaaki Okamoto, Hirotake Tsukamoto, T. Kouwaki, T. Seya +1 more
2017Viral immunology53 citations
Semantic Scholar
Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells
H. Shime, Akira Maruyama, Sumito Yoshida, Yohei Takeda +2 more
2017Oncoimmunology49 citations Open access
Semantic Scholar
Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo
C. Leong, Kenji Funami, H. Oshiumi, Deng Mengao +6 more
2016OncoTarget44 citations Open access
Semantic Scholar
A toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy.
T. Seya, Yohei Takeda, M. Matsumoto
2019Advanced Drug Delivery Reviews42 citations
Semantic Scholar
Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy
M. Azuma, Yohei Takeda, H. Nakajima, H. Sugiyama +4 more
2016Oncoimmunology41 citations Open access
Semantic Scholar
Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Kenji Funami, M. Matsumoto, H. Oshiumi, F. Inagaki +1 more
2017Biochemical Society Transactions39 citations Open access
Semantic Scholar
Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production
Hiromi Takaki, S. Kure, H. Oshiumi, Y. Sakoda +5 more
2017Mucosal Immunology39 citations Open access
Semantic Scholar
Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.
Akira Maruyama, H. Shime, Yohei Takeda, M. Azuma +2 more
2015Biochemical and Biophysical Research Communications - BBRC38 citations
Semantic Scholar
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains
Yuri Shibata, F. Tokunaga, Eiji Goto, Ginga Komatsu +12 more
2017PLoS Pathogens37 citations Open access
Semantic Scholar
LRRC59 Regulates Trafficking of Nucleic Acid–Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1
Megumi Tatematsu, Kenji Funami, N. Ishii, T. Seya +2 more
2015Journal of Immunology35 citations Open access
Semantic Scholar
Adjuvant immunotherapy for cancer: both dendritic cell-priming and check-point inhibitor blockade are required for immunotherapy
T. Seya, Yohei Takeda, Ken Takashima, Sumito Yoshida +2 more
2018Proceedings of the Japan Academy. Series B, Physical and biological sciences34 citations Open access
Semantic Scholar
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway
H. Shime, M. Matsumoto, T. Seya
2017Cell Death and Differentiation34 citations Open access
Semantic Scholar
Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy
Sumito Yoshida, H. Shime, M. Matsumoto, M. Kasahara +1 more
2019Frontiers in Immunology28 citations Open access
Semantic Scholar
DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70
Ken Takashima, H. Oshiumi, M. Matsumoto, T. Seya
2017Journal of Innate Immunity28 citations Open access
Semantic Scholar
Targeting Toll-like receptor 3 in dendritic cells for cancer immunotherapy
M. Matsumoto, Yohei Takeda, T. Seya
2020Expert Opinion on Biological Therapy27 citations
Semantic Scholar
Toll‐like receptor 3 signal augments radiation‐induced tumor growth retardation in a murine model
Sumito Yoshida, H. Shime, Yohei Takeda, Jin-Min Nam +5 more
2018Cancer Science27 citations Open access
Semantic Scholar
The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages
Sumito Yoshida, H. Shime, Kenji Funami, Hiromi Takaki +3 more
2017PLoS ONE27 citations Open access
Semantic Scholar
Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
Yohei Takeda, M. Azuma, M. Matsumoto, T. Seya
2016Journal of experimental & clinical cancer research : CR27 citations Open access
Semantic Scholar
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response
T. Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima +3 more
2017Scientific Reports26 citations Open access
Semantic Scholar
Vaccine immunotherapy with ARNAX induces tumor‐specific memory T cells and durable anti‐tumor immunity in mouse models
Yohei Takeda, Sumito Yoshida, Ken Takashima, Noriko Ishii-Mugikura +3 more
2018Cancer Science24 citations Open access
Semantic Scholar
14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation.
Kenji Funami, M. Matsumoto, C. Obuse, T. Seya
2016Molecular Immunology22 citations
Semantic Scholar
IPS-1 Is Essential for Type III IFN Production by Hepatocytes and Dendritic Cells in Response to Hepatitis C Virus Infection
Masaaki Okamoto, H. Oshiumi, M. Azuma, N. Kato +2 more
2014Journal of Immunology22 citations Open access
Semantic Scholar
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog
Haruko Sato, H. Oshiumi, Hiromi Takaki, H. Hikono +1 more
2015Microbiology and immunology19 citations Open access
Semantic Scholar
Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response
Olga Romanets-Korbut, L. Kovalevska, T. Seya, S. P. Sidorenko +1 more
2015Cellular & Molecular Immunology19 citations Open access
Semantic Scholar
Development of mouse models for analysis of human virus infections
Hiromi Takaki, H. Oshiumi, M. Shingai, M. Matsumoto +1 more
2017Microbiology and immunology18 citations Open access
Semantic Scholar
cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue
Hiromi Takaki, Ken Takashima, H. Oshiumi, A. Ainai +4 more
2017Medical Science17 citations Open access
Semantic Scholar
Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide
Yohei Takeda, M. Azuma, Kenji Funami, H. Shime +2 more
2018Frontiers in Immunology16 citations Open access
Semantic Scholar
Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV)
M. Nakai, H. Oshiumi, Kenji Funami, Masaaki Okamoto +3 more
2015Italian National Conference on Sensors15 citations Open access
Semantic Scholar
Tumor vaccines with dsRNA adjuvant ARNAX induces antigen-specific tumor shrinkage without cytokinemia
T. Seya, Yohei Takeda, M. Matsumoto
2016Oncoimmunology13 citations Open access
Semantic Scholar
Toward Establishing an Ideal Adjuvant for Non-Inflammatory Immune Enhancement
T. Seya, Megumi Tatematsu, M. Matsumoto
2022Cells12 citations Open access
Semantic Scholar
Vaccine adjuvant ARNAX promotes mucosal IgA production in influenza HA vaccination.
Yohei Takeda, Hiromi Takaki, Aya Fukui‐Miyazaki, Sumito Yoshida +2 more
2018Biochemical and Biophysical Research Communications - BBRC12 citations Open access
Semantic Scholar
Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
J. Kasamatsu, Meng Deng, M. Azuma, Kenji Funami +5 more
2016BMC Immunology12 citations Open access
Semantic Scholar
Alternative pathway activation due to low level of complement factor H in primary antiphospholipid syndrome.
Hiroyuki Nakamura, K. Oku, Yusuke Ogata, K. Ohmura +10 more
2018Thrombosis Research11 citations
Semantic Scholar
Nucleic Acid Sensors Involved in the Recognition of HBV in the Liver–Specific in vivo Transfection Mouse Models—Pattern Recognition Receptors and Sensors for HBV
C. Leong, H. Oshiumi, Takayuki Suzuki, M. Matsumoto +1 more
2015Medical Science11 citations Open access
Semantic Scholar
Functional Alteration of Tumor-infiltrating Myeloid Cells in RNA Adjuvant Therapy.
T. Seya, H. Shime, M. Matsumoto
2015Anticancer Research10 citations
Semantic Scholar

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Megumi Tatematsu×8

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