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Hirotake Tsukamoto · SciRah

Researcher profile · Semantic Scholar

Hirotake Tsukamoto

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Hirotake Tsukamoto — researcher profile on SciRah

h-index: 26
Works: 68
Citations: 2,291

Most-cited papers

Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment.
Hirotake Tsukamoto, Koji Fujieda, A. Miyashita, S. Fukushima +6 more
2018Cancer Research274 citations Open access
Semantic Scholar
Age-associated increase in lifespan of naïve CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
Hirotake Tsukamoto, K. Clise-Dwyer, G. Huston, D. Duso +4 more
2009Proceedings of the National Academy of Sciences of the United States of America178 citations Open access
Semantic Scholar
Immune‐suppressive effects of interleukin‐6 on T‐cell‐mediated anti‐tumor immunity
Hirotake Tsukamoto, Koji Fujieda, S. Senju, T. Ikeda +2 more
2017Cancer Science156 citations Open access
Semantic Scholar
Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response
T. Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima +1 more
2017International Journal of Molecular Sciences104 citations Open access
Semantic Scholar
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
Hirotake Tsukamoto, S. Senju, Keiko Matsumura, S. Swain +1 more
2015Nature Communications103 citations Open access
Semantic Scholar
Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.
T. Akiyama, Tadahito Yasuda, T. Uchihara, Noriko Yasuda-Yoshihara +22 more
2022Cancer Research85 citations Open access
Semantic Scholar
Myeloid-Derived Suppressor Cells Attenuate TH1 Development through IL-6 Production to Promote Tumor Progression
Hirotake Tsukamoto, Ryutaro Nishikata, S. Senju, Y. Nishimura
2013Cancer immunology research82 citations Open access
Semantic Scholar
Proliferation Potential-Related Protein, an Ideal Esophageal Cancer Antigen for Immunotherapy, Identified Using Complementary DNA Microarray Analysis
Y. Yoshitake, T. Nakatsura, M. Monji, S. Senju +12 more
2004Clinical Cancer Research77 citations Open access
Semantic Scholar
Aging-associated and CD4 T-cell–dependent ectopic CXCL13 activation predisposes to anti–PD-1 therapy-induced adverse events
Hirotake Tsukamoto, Yoshihiro Komohara, Yusuke Tomita, Y. Miura +9 more
2022Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Wnt Signaling Regulates Hemopoiesis Through Stromal Cells1
T. Yamane, T. Kunisada, Hirotake Tsukamoto, H. Yamazaki +3 more
2001Journal of Immunology68 citations Open access
Semantic Scholar
This information is current as Functional Defects the Development of Age-Associated Bim Dictates Naive CD 4 T Cell Lifespan and Duso
Hirotake Tsukamoto, G. Huston, John Dibble, D. Duso +1 more
201067 citations
Semantic Scholar
Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo
Seiji Hosaka, T. Nakatsura, Hirotake Tsukamoto, T. Hatayama +2 more
2006Cancer Science67 citations Open access
Semantic Scholar
Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells.
Hasita Horlad, Y. Fujiwara, Kenichi Takemura, Koji Ohnishi +6 more
2013Molecular Nutrition & Food Research62 citations
Semantic Scholar
Identification of Promiscuous KIF20A Long Peptides Bearing Both CD4+ and CD8+ T-cell Epitopes: KIF20A-Specific CD4+ T-cell Immunity in Patients with Malignant Tumor
Yusuke Tomita, Akira Yuno, Hirotake Tsukamoto, S. Senju +14 more
2013Clinical Cancer Research61 citations Open access
Semantic Scholar
Soluble IL6R Expressed by Myeloid Cells Reduces Tumor-Specific Th1 Differentiation and Drives Tumor Progression.
Hirotake Tsukamoto, Koji Fujieda, M. Hirayama, T. Ikeda +8 more
2017Cancer Research55 citations Open access
Semantic Scholar
Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
Yoshihiro Komohara, D. Kurotaki, Hirotake Tsukamoto, Yuko Miyasato +4 more
2023Cancer Science53 citations Open access
Semantic Scholar
Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections
Masaaki Okamoto, Hirotake Tsukamoto, T. Kouwaki, T. Seya +1 more
2017Viral immunology53 citations
Semantic Scholar
HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling
Y. Higuchi, Jun-ichirou Yasunaga, Yu Mitagami, Hirotake Tsukamoto +3 more
2020Proceedings of the National Academy of Sciences of the United States of America49 citations Open access
Semantic Scholar
Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly
Hirotake Tsukamoto, T. Kouwaki, H. Oshiumi
2020iScience45 citations Open access
Semantic Scholar
Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations
Y. Tomita, Shinya Sakata, K. Imamura, S. Iyama +15 more
2023Cancers42 citations Open access
Semantic Scholar
Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination
Yusuke Miyashita, T. Yoshida, Y. Takagi, Hirotake Tsukamoto +6 more
2022npj Vaccines42 citations Open access
Semantic Scholar
B-Raf Contributes to Sustained Extracellular Signal-regulated Kinase Activation Associated with Interleukin-2 Production Stimulated through the T Cell Receptor*
Hirotake Tsukamoto, A. Irie, Y. Nishimura
2004Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Identification of glypican-3-derived long peptides activating both CD8+ and CD4+ T cells; prolonged overall survival in cancer patients with Th cell response
M. Sayem, Yusuke Tomita, Akira Yuno, M. Hirayama +8 more
2015Oncoimmunology35 citations Open access
Semantic Scholar
Systematic Analysis of the Combinatorial Nature of Epitopes Recognized by TCR Leads to Identification of Mimicry Epitopes for Glutamic Acid Decarboxylase 65-Specific TCRs1
Y. Uemura, S. Senju, K. Maenaka, L. K. Iwai +6 more
2003Journal of Immunology35 citations
Semantic Scholar
Wnt Signaling Regulates Hemopoiesis Through Stromal Cells
T. Yamane, T. Kunisada, Hirotake Tsukamoto, H. Yamazaki +3 more
200131 citations
Semantic Scholar
Identification of CDCA1‐derived long peptides bearing both CD4+ and CD8+ T‐cell epitopes: CDCA1‐specific CD4+ T‐cell immunity in cancer patients
Yusuke Tomita, Akira Yuno, Hirotake Tsukamoto, S. Senju +14 more
2014International Journal of Cancer30 citations Open access
Semantic Scholar
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response
T. Kouwaki, Masaaki Okamoto, Hirotake Tsukamoto, Yoshimi Fukushima +3 more
2017Scientific Reports26 citations Open access
Semantic Scholar
Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Yuichiro Hagiya +15 more
2020Oncoimmunology25 citations Open access
Semantic Scholar
Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells.
A. Irie, K. Harada, Hirotake Tsukamoto, Jeong-Ran Kim +2 more
2006International Immunology24 citations
Semantic Scholar
TCR ligand avidity determines the modeof B‐Raf/Raf‐1/ERK activation leading to the activationof human CD4+ T cell clone
Hirotake Tsukamoto, A. Irie, Yu-Zhen Chen, K. Takeshita +2 more
2006European Journal of Immunology22 citations
Semantic Scholar
The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets
Hirotake Tsukamoto, Yoshihiro Komohara, H. Oshiumi
2021Human Cell19 citations
Semantic Scholar
B‐Raf‐mediated signaling pathway regulates T cell development
Hirotake Tsukamoto, A. Irie, S. Senju, A. Hatzopoulos +2 more
2008European Journal of Immunology19 citations Open access
Semantic Scholar
Improved safety of induced pluripotent stem cell-derived antigen-presenting cell-based cancer immunotherapy
Hiroaki Mashima, Rong Zhang, Tsuyoshi Kobayashi, Hirotake Tsukamoto +11 more
2021Molecular Therapy: Methods & Clinical Development18 citations Open access
Semantic Scholar
β-glucan from Aureobasidium pullulans augments the anti-tumor immune responses through activated tumor-associated dendritic cells.
Yi-Fang I. Shui, Xin Hu, H. Hirano, Kisato Kusano +5 more
2021International Immunopharmacology16 citations
Semantic Scholar
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responses
Yusuke Miyashita, T. Kouwaki, Hirotake Tsukamoto, Masaaki Okamoto +2 more
2021Life Science Alliance16 citations Open access
Semantic Scholar
An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs
M. Hirayama, Yusuke Tomita, Akira Yuno, Hirotake Tsukamoto +15 more
2016Oncoimmunology15 citations Open access
Semantic Scholar
Identification of immunogenic LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes and eliciting CD4+ T-cell immunity in patients with malignant disease
Yusuke Tomita, Akira Yuno, Hirotake Tsukamoto, S. Senju +16 more
2014Oncoimmunology15 citations Open access
Semantic Scholar
Unique T cell proliferation associated with PKCμ activation and impaired ZAP‐70 phosphorylation in recognition of overexpressed HLA/partially agonistic peptide complexes
A. Irie, Yu-Zhen Chen, Hirotake Tsukamoto, T. Jotsuka +2 more
2003European Journal of Immunology13 citations
Semantic Scholar
Degenerate recognition and response of human CD4+ Th cell clones: implications for basic and applied immunology.
Y. Nishimura, Yu-Zhen Chen, Y. Uemura, Yoshihiko Tanaka +7 more
2004Molecular Immunology12 citations
Semantic Scholar
Suppression of Th1-Mediated Autoimmunity by Embryonic Stem Cell-Derived Dendritic Cells
T. Ikeda, S. Hirata, Koutaro Takamatsu, Miwa Haruta +7 more
2014PLoS ONE11 citations Open access
Semantic Scholar
Predictive value of CXCL10 for the occurrence of immune‐related adverse events in patient with renal cell carcinoma
Y. Miura, T. Motoshima, T. Anami, H. Yano +11 more
2023Microbiology and immunology10 citations
Semantic Scholar
Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells.
Yoshimi Fukushima, Masaaki Okamoto, Kana Ishikawa, T. Kouwaki +2 more
2018Biochemical and Biophysical Research Communications - BBRC10 citations Open access
Semantic Scholar
Establishment of HLA-DR4 Transgenic Mice for the Identification of CD4+ T Cell Epitopes of Tumor-Associated Antigens
Junji Yatsuda, A. Irie, K. Harada, Yayoi Michibata +13 more
2013PLoS ONE10 citations Open access
Semantic Scholar
Induced pluripotent stem cell-derived myeloid cells expressing OX40 ligand amplify antigen-specific T cells in advanced melanoma.
T. Kimura, S. Fukushima, E. Okada, H. Kuriyama +17 more
2020Pigment Cell & Melanoma Research8 citations Open access
Semantic Scholar
CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.
T. Motoshima, Yoshihiro Komohara, Hasita Horlad, Hirotake Tsukamoto +9 more
2016Oncology Letters8 citations Open access
Semantic Scholar
Combined phospholipids adjuvant augments anti-tumor immune responses through activated tumor-associated dendritic cells
Yi-Fang I. Shui, Xin Hu, H. Hirano, Hirotake Tsukamoto +5 more
2023Neoplasia6 citations Open access
Semantic Scholar
miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis
Momoka Nakashima, Kana Ishikawa, A. Fugiwara, K. Shu +5 more
2021Scientific Reports6 citations Open access
Semantic Scholar
Cancer therapy with major histocompatibility complex‐deficient and interferon β‐producing myeloid cells derived from allogeneic embryonic stem cells
Satoshi Umemoto, Miwa Haruta, Masataka Sakisaka, T. Ikeda +5 more
2019Cancer Science6 citations Open access
Semantic Scholar
E3 Ubiquitin Ligase Riplet Is Expressed in T Cells and Suppresses T Cell–Mediated Antitumor Immune Responses
A. Iwamoto, Hirotake Tsukamoto, H. Nakayama, H. Oshiumi
2022Journal of Immunology5 citations Open access
Semantic Scholar
Immunotherapy with 4-1BBL-Expressing iPS Cell‐Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma
H. Kuriyama, S. Fukushima, T. Kimura, H. Kanemaru +17 more
2021International Journal of Molecular Sciences5 citations Open access
Semantic Scholar

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Y. Nishimura — researcher profile on SciRah
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