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Silvia N. Kariuki · SciRah

Researcher profile · Semantic Scholar

Silvia N. Kariuki

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Silvia N. Kariuki — researcher profile on SciRah

h-index: 23
Works: 50
Citations: 2,118

Most-cited papers

Cutting Edge: Autoimmune Disease Risk Variant of STAT4 Confers Increased Sensitivity to IFN-α in Lupus Patients In Vivo1
Silvia N. Kariuki, K. Kirou, E. MacDermott, L. Barillas-arias +2 more
2009Journal of Immunology222 citations Open access
Semantic Scholar
Genetic Variation at the IRF7/PHRF1 Locus Is Associated With Autoantibody Profile and Serum Interferon-α Activity in Lupus Patients
R. Salloum, B. Franek, Silvia N. Kariuki, L. Rhee +4 more
2010Arthritis & Rheumatism165 citations Open access
Semantic Scholar
Autoimmune Disease Risk Variant of IFIH1 Is Associated with Increased Sensitivity to IFN-α and Serologic Autoimmunity in Lupus Patients
T. Robinson, Silvia N. Kariuki, B. Franek, Marissa Kumabe +13 more
2011Journal of Immunology157 citations Open access
Semantic Scholar
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus
T. Niewold, J. Kelly, Silvia N. Kariuki, B. Franek +24 more
2011Annals of the Rheumatic Diseases143 citations Open access
Semantic Scholar
Human genetics and malaria resistance
Silvia N. Kariuki, T. Williams
2020Human Genetics137 citations Open access
Semantic Scholar
Elevated Serum Interferon Alpha Activity in Juvenile Dermatomyositis: Associations with Disease Activity at Diagnosis and After 36 Months of Therapy
T. Niewold, Silvia N. Kariuki, Gabrielle A. Morgan, S. Shrestha +1 more
2009Arthritis & Rheumatism120 citations Open access
Semantic Scholar
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
Silvia N. Kariuki, B. Franek, Akaash A. Kumar, Jasmine Arrington +6 more
2010Arthritis Research & Therapy106 citations Open access
Semantic Scholar
African-Derived Genetic Polymorphisms in TNFAIP3 Mediate Risk for Autoimmunity
James P. Lodolce, Lauren E. Kolodziej, L. Rhee, Silvia N. Kariuki +11 more
2010Journal of Immunology105 citations Open access
Semantic Scholar
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Carolyne M. Ndila, S. Uyoga, A. Macharia, G. Nyutu +20 more
2018The Lancet Haematology101 citations Open access
Semantic Scholar
Age- and gender-specific modulation of serum osteopontin and interferon-α by osteopontin genotype in systemic lupus erythematosus
Silvia N. Kariuki, Julian Moore, Kyriakos A. Kirou, M. Crow +2 more
2009Genes and Immunity96 citations Open access
Semantic Scholar
PTPN22 C1858T Polymorphism is Associated with Skewing of Cytokine Profiles Toward High IFN-α Activity and Low TNF-α in Lupus Patients
Silvia N. Kariuki, M. Crow, T. Niewold
2008Arthritis & Rheumatism95 citations Open access
Semantic Scholar
Red blood cell tension protects against severe malaria in the Dantu blood group
Silvia N. Kariuki, A. Marín-Menéndez, Viola Introini, Benjamin J. Ravenhill +14 more
2020Nature91 citations Open access
Semantic Scholar
Genetic Regulation of Serum Cytokines in Systemic Lupus Erythematosus
Silvia N. Kariuki, T. Niewold
2009Translational Research: The Journal of Laboratory and Clinical Medicine72 citations Open access
Semantic Scholar
Genetic Analysis of the Pathogenic Molecular Sub-phenotype Interferon Alpha Identifies Multiple Novel Loci Involved in Systemic Lupus Erythematosus
Silvia N. Kariuki, Y. Ghodke-Puranik, Jessica M. Dorschner, B. Chrabot +11 more
2014Genes and Immunity67 citations Open access
Semantic Scholar
Genetic Variation near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis
B. Chrabot, Silvia N. Kariuki, M. Zervou, Xuan Feng +6 more
2013Genes and Immunity47 citations Open access
Semantic Scholar
IRF5 SLE-Risk Haplotype is Associated with Asymptomatic Serologic Autoimmunity and Progression to Clinical Autoimmunity in Neonatal Lupus Mothers
T. Cherian, Silvia N. Kariuki, B. Franek, J. Buyon +2 more
2012Arthritis & Rheumatism42 citations Open access
Semantic Scholar
Gene-Gene-Sex Interaction between Cytokine Gene Polymorphisms Revealed by Serum Interferon Alpha Phenotype in Juvenile Dermatomyositis
T. Niewold, Silvia N. Kariuki, Gabrielle A. Morgan, S. Shrestha +1 more
2010Jornal de Pediatria38 citations Open access
Semantic Scholar
Osteopontin Alleles Are Associated with Clinical Characteristics in Systemic Lupus Erythematosus
Tarak K. Trivedi, B. Franek, S. L. Green, Silvia N. Kariuki +5 more
2011Journal of Biomedicine and Biotechnology37 citations Open access
Semantic Scholar
Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria
D. Odera, J. Tuju, K. Mwai, I. Nkumama +66 more
2023Science Translational Medicine30 citations
Semantic Scholar
Linkage of Type I Interferon Activity and TNF-Alpha Levels in Serum with Sarcoidosis Manifestations and Ancestry
N. Sweiss, Wei Zhang, B. Franek, Silvia N. Kariuki +8 more
2011PLoS ONE29 citations Open access
Semantic Scholar
Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African-American Lupus Patients
Silvia N. Kariuki, B. Franek, R. Mikolaitis, T. Utset +3 more
2010Journal of Biomedicine and Biotechnology29 citations Open access
Semantic Scholar
Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
M. Kapulu, D. Kimani, P. Njuguna, M. Hamaluba +38 more
2022BMC Infectious Diseases25 citations Open access
Semantic Scholar
Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
F. Musasia, I. Nkumama, R. Frank, Victor Kipkemboi +45 more
2022Nature Communications23 citations Open access
Semantic Scholar
Mapping Variation in Cellular and Transcriptional Response to 1,25-Dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells
Silvia N. Kariuki, J. Maranville, Shaneen S Baxter, Choongwon Jeong +5 more
2016PLoS ONE18 citations Open access
Semantic Scholar
The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study
Silvia N. Kariuki, A. Macharia, J. Makale, W. Nyamu +5 more
2023eLife16 citations Open access
Semantic Scholar
Familial Aggregation of High Tumor Necrosis Factor Alpha Levels in Systemic Lupus Erythematosus
Dorothy Mangale, Silvia N. Kariuki, B. Chrabot, Marissa Kumabe +5 more
2013Clinical and Developmental Immunology16 citations Open access
Semantic Scholar
Gene-Expression-Guided Selection of Candidate Loci and Molecular Phenotype Analyses Enhance Genetic Discovery in Systemic Lupus Erythematosus
Y. Koldobskaya, Kichul Ko, Akaash A. Kumar, Sandra Agik +8 more
2012Clinical and Developmental Immunology16 citations Open access
Semantic Scholar
Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study volunteers and other stakeholders
P. Chi, E. Owino, I. Jao, Fredrick O. Olewe +57 more
2021Trials15 citations Open access
Semantic Scholar
Elevated Serum Interferon Alpha Activity in Juvenile Dermatomyositis: Associations with Disease Activity at Diagnosis and After 36 Months of Therapy
T. Niewold, Silvia N. Kariuki, Gabrielle A. Morgan, S. Shrestha +1 more
201113 citations
Semantic Scholar
The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion
Viola Introini, A. Marín-Menéndez, Guilherme Nettesheim, Yen-Chun Lin +8 more
2022Scientific Reports12 citations Open access
Semantic Scholar
Red blood cell tension controls Plasmodium falciparum invasion and protects against severe malaria in the Dantu blood group
Silvia N. Kariuki, A. Marín-Menéndez, Viola Introini, Benjamin J. Ravenhill +14 more
2018bioRxiv9 citations Open access
Semantic Scholar
BIRC6 modifies risk of invasive bacterial infection in Kenyan children
J. Gilchrist, Silvia N. Kariuki, J. Watson, G. Band +14 more
2022medRxiv6 citations Open access
Semantic Scholar
Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes
Silvia N. Kariuki, J. Blischak, Shigeki Nakagome, D. Witonsky +1 more
2015G3: Genes, Genomes, Genetics6 citations Open access
Semantic Scholar
T.16. Genetic Variation at the IRF7/KIAA1542 Locus is Associated with Autoantibody Profile and Serum Interferon Alpha Levels in Lupus Patients
R. Salloum, B. Franek, Silvia N. Kariuki, T. Utset +1 more
20095 citations
Semantic Scholar
Dantu Blood Group Erythrocytes Form Large Plasmodium falciparum Rosettes Less Commonly
M. Carlier, W. Nyamu, J. Makale, Thomas N. Williams +2 more
2024American Journal of Tropical Medicine and Hygiene2 citations Open access
Semantic Scholar
Racial discrimination and disease damage among African American women with systemic lupus erythematosus
David H. Chae, C. Drenkard, J. Esdaile, P. Fortin +76 more
2 citations
Semantic Scholar
Relation Between the Dantu Blood Group Variant and Bacteremia in Kenyan Children: A Population-Based Case-Control Study
Silvia N. Kariuki, James J. Gilchrist, S. Uyoga, A. Macharia +3 more
2024Journal of Infectious Diseases1 citations Open access
Semantic Scholar
MAPPING THE GENETIC DETERMINANTS OF IMMUNE DISEASE SUSCEPTIBILITY
Silvia N. Kariuki
20161 citations
Semantic Scholar
IRF8 allele associated with susceptibility to multiple sclerosis is associated with serum interferon α and serologic profile in systemic lupus erythematosus
B. Franek, Silvia N. Kariuki, Jasmine Arrington, R. Mikolaitis +6 more
20111 citations Open access
Semantic Scholar
Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon α activity in patients with systemic lupus erythematosus
R. Salloum, B. Franek, Silvia N. Kariuki, L. Rhee +4 more
20101 citations Open access
Semantic Scholar
OR.105. PTPN22 C1858T Polymorphism is Associated with Skewing of Cytokine Profiles Toward High IFN- α Activity and Low TNF- α in Lupus Patients
Silvia N. Kariuki, M. Crow, T. Niewold
20081 citations
Semantic Scholar
The effect of heterozygous β-thalassaemia on childhood health and survival in Kilifi, Kenya
A. Macharia, S. Uyoga, Silvia N. Kariuki, G. Mochamah +9 more
2026Wellcome Open Research0 citations Open access
Semantic Scholar
BIRC6 modiﬁes risk of invasive 1 bacterial infection in Kenyan 2 children. 3
J. Gilchrist, Silvia N. Kariuki, J. Watson, G. Band +17 more
20220 citations
Semantic Scholar
Human genetics and malaria resistance
Silvia N. Kariuki, T. Williams
2020Human Genetics0 citations Open access
Semantic Scholar
THU0026 Genetic Variation Near IRF8 is Associated with Serologic and Cytokine Profiles in Systemic Lupus Erythematosus and Multiple Sclerosis
Beverly S. Chrabot, Silvia N. Kariuki, M. Zervou, Xuan Feng +6 more
20130 citations
Semantic Scholar
Lupus and Serologic Autoimmunity in a IFN-Is Associated with Increased Sensitivity to Autoimmune Disease Risk Variant of IFIH1
T. Robinson, Silvia N. Kariuki, B. Franek, Marissa Kumabe +13 more
20110 citations
Semantic Scholar
Serum IFN-α and TNF-α Levels in Sarcoidosis Patients are Associated with Disease Manifestations and Differ Significantly by Ancestry
N. Sweiss, B. Franek, Silvia N. Kariuki, Linda L Hushaw +2 more
20100 citations
Semantic Scholar
Serum IFN-± And TNF-± Levels In Sarcoidosis Patients Correlate With Disease Manifestations And Differ Significantly By Ancestry
N. Sweiss, B. Franek, Silvia N. Kariuki, Linda L Hushaw +4 more
2010Asian Test Symposium0 citations
Semantic Scholar
A Genetic Model for IRF5, Autoantibodies, and Interferon Alpha in Human Lupus Pathogenesis
T. Niewold, J. Kelly, Silvia N. Kariuki, Kenaz Thomas +15 more
20090 citations
Semantic Scholar
A serine/threonine phosphatase, PP2A, controls autoimmunity
J. Esdaile, P. R. Fortin, Matthew Liang, P. Lipsky +75 more
0 citations
Semantic Scholar

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