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S. Kakuda · SciRah

Researcher profile · Semantic Scholar

S. Kakuda

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S. Kakuda — researcher profile on SciRah

h-index: 18
Works: 45
Citations: 1,327

Most-cited papers

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity
Vincent C. Luca, Byoung Choul Kim, Chenghao Ge, S. Kakuda +6 more
2017Science275 citations Open access
Semantic Scholar
Deciphering the Fringe-mediated Notch Code: Identification of activating and inhibiting sites allowing discrimination between ligands
S. Kakuda, R. Haltiwanger
2017Developmental Cell167 citations Open access
Semantic Scholar
A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands
Shinya Yamamoto, W. Charng, N. Rana, S. Kakuda +9 more
2012Science104 citations Open access
Semantic Scholar
O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1*
N. Rana, Aleksandra Nita-lazar, H. Takeuchi, S. Kakuda +2 more
2011Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi)
S. Thakurdas, Mario F. Lopez, S. Kakuda, Rodrigo Fernandez‐Valdivia +3 more
2015Hepatology93 citations Open access
Semantic Scholar
Structural Basis for Acceptor Substrate Recognition of a Human Glucuronyltransferase, GlcAT-P, an Enzyme Critical in the Biosynthesis of the Carbohydrate Epitope HNK-1*
S. Kakuda, T. Shiba, M. Ishiguro, H. Tagawa +5 more
2004Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2
S. Kakuda, R. Lopilato, Atsuko Ito, R. Haltiwanger
2020Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Expression and function of the HNK-1 carbohydrate.
Ippei Morita, Yasuhiko Kizuka, S. Kakuda, S. Oka
2007Journal of Biochemistry (Tokyo)58 citations
Semantic Scholar
HNK-1 Glyco-epitope Regulates the Stability of the Glutamate Receptor Subunit GluR2 on the Neuronal Cell Surface*
Ippei Morita, S. Kakuda, Y. Takeuchi, S. Itoh +4 more
2009Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion
Brian Benz, Sumeda Nandadasa, Megumi Takeuchi, R. C. Grady +7 more
2016Developmental Biology43 citations Open access
Semantic Scholar
HNK-1 (human natural killer-1) glyco-epitope is essential for normal spine morphogenesis in developing hippocampal neurons.
Ippei Morita, S. Kakuda, Y. Takeuchi, Toshisuke Kawasaki +1 more
2009Neuroscience43 citations Open access
Semantic Scholar
O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function
Julia Müller, N. Rana, Katrin Serth, S. Kakuda +2 more
2014PLoS ONE42 citations Open access
Semantic Scholar
Nanodomains can persist at physiologic temperature in plasma membrane vesicles and be modulated by altering cell lipids[S]
Guang-Tao Li, Qing Wang, S. Kakuda, E. London
2020Journal of Lipid Research38 citations Open access
Semantic Scholar
Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate.
S. Kakuda, Yuki Sato, Y. Tonoyama, S. Oka +1 more
2004Glycobiology29 citations Open access
Semantic Scholar
Induction of Ordered Lipid Raft Domain Formation by Loss of Lipid Asymmetry.
Johnna Wellman St Clair, S. Kakuda, E. London
2020Biophysical Journal24 citations Open access
Semantic Scholar
Crystal structure of GlcAT‐S, a human glucuronyltransferase, involved in the biosynthesis of the HNK‐1 carbohydrate epitope
T. Shiba, S. Kakuda, M. Ishiguro, Ippei Morita +4 more
2006Proteins: Structure, Function, and Bioinformatics20 citations
Semantic Scholar
Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in Escherichia coli.
S. Kakuda, S. Oka, T. Kawasaki
2004Protein Expression and Purification19 citations
Semantic Scholar
Loss of plasma membrane lipid asymmetry can induce ordered domain (raft) formation
S. Kakuda, Pavana Suresh, Guang-Tao Li, E. London
2021bioRxiv18 citations Open access
Semantic Scholar
Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity
Guang-Tao Li, S. Kakuda, Pavana Suresh, D. Canals +2 more
2019PLoS ONE18 citations Open access
Semantic Scholar
Laminin-1 is a novel carrier glycoprotein for the nonsulfated HNK-1 epitope in mouse kidney.
Yasuhiko Kizuka, Kyoko Kobayashi, S. Kakuda, Yukari Nakajima +3 more
2008Glycobiology17 citations Open access
Semantic Scholar
Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock
M. Bochter, Dustin Servello, S. Kakuda, R. D'Amico +3 more
2022Developmental Biology13 citations Open access
Semantic Scholar
Analyzing the posttranslational modification status of Notch using mass spectrometry.
S. Kakuda, R. Haltiwanger
2014Methods in molecular biology13 citations
Semantic Scholar
Essential role of beta-1,4-galactosyltransferase 2 during medaka (Oryzias latipes) gastrulation.
Y. Tonoyama, Daisuke Anzai, Atsushi Ikeda, S. Kakuda +3 more
2009Mechanisms of Development9 citations Open access
Semantic Scholar
Preparation and Utility of Asymmetric Lipid Vesicles for Studies of Perfringolysin O-Lipid Interactions.
S. Kakuda, Bing-Chen Li, E. London
2021Methods in Enzymology3 citations Open access
Semantic Scholar
Fucosyltransferases 12, 13: Protein O-Fucosyltransferases 1 and 2 (POFUT1, POFUT2) 56
S. Kakuda, R. Haltiwanger
20142 citations
Semantic Scholar
Plasma membrane asymmetry and lipid homeostasis: general discussion.
Francisco Barerra, Manuel Bibrowski, John C. Conboy, Niclas P. Decker +26 more
2025Faraday discussions1 citations
Semantic Scholar
Effect of a scramblase activator upon scrambling and membrane domain formation in HEK293T cells
S. Kakuda, Erwin London
2025Faraday discussions0 citations Open access
Semantic Scholar
Cyclodextrin phospholipid exchange alters viral membrane properties and infectivity
S. Kakuda, Guang-Tao Li, D. Tortorella, Erwin London
2024Biophysical Journal0 citations Open access
Semantic Scholar
Nanodomains Persist to much Higher Temperatures than Large Scale Phase Separation in Giant Plasma Membrane Vesicles and Can Respond Differently to Alterations of Plasma Membrane Lipid Composition
Guang-Tao Li, S. Kakuda, Bing-Chen Li, Qing Wang +1 more
20200 citations Open access
Semantic Scholar
What Determines Fringe Specificity for a Notch EGF?
K. B. Luther, S. Kakuda, Atsuko Ito, Robert S. Haltiwanger
2020The FASEB Journal0 citations Open access
Semantic Scholar
Efficient Replacement of Outer Leaflet Lipids of Plasma Membrane using Exogenous Lipids with Minimal Cell Damage
Guang-Tao Li, S. Kakuda, Pavana Suresh, E. London
2019Biophysical Journal0 citations Open access
Semantic Scholar
P1-b21 Cloning and characterization of Aplysia 5HT GPCRs involved in the translocation of PKC Apl II
I. Nagakura, Carole Abi-Farah, A. Heppner, S. Wayne +22 more
20180 citations
Semantic Scholar
1 HNK-1 glyco-epitope is essential for normal spine morphogenesis in developing hippocampal neurons
Ippei Morita, S. Kakuda, Y. Takeuchi, T. Kawasaki +2 more
20160 citations
Semantic Scholar
Development of a new syringe/needle accessible cryovial for storage of human injectable vaccines and immunotherapeutics compatible with storage below −150°C and use in all clinical environments
E. James, S. Kakuda, R. Grimwood, R. Moore +7 more
20150 citations
Semantic Scholar
Site‐Specific Analysis of O‐Fucose and O‐Glucose Glycans on Notch
R. Haltiwanger, N. Rana, S. Kakuda, Ga-Ram Hwang +2 more
20130 citations
Semantic Scholar
Aviezer Positive and Negative Emotions Body Cues , Not Facial Expressions , Discriminate Between Intense
N. Rana, S. Kakuda, Manish Jaiswal, Vafa Bayat +5 more
20120 citations
Semantic Scholar
Involvement of HNK-1 glyco-epitope in the spine morphogenesis
Ippei Morita, S. Kakuda, Y. Takeuchi, S. Oka
20090 citations
Semantic Scholar
Glucuronyltransferases Involved in the HNK-1 Biosynthesis
S. Kakuda, T. Kawasaki, S. Oka
20080 citations
Semantic Scholar
[Involvement of carbohydrate modification in learning and memory].
S. Oka, S. Kakuda, T. Kawasaki
2005Seikagaku. The Journal of Japanese Biochemical Society0 citations
Semantic Scholar
[Molecular mechanisms in acceptor substrate recognition of a human glucuronyltransferase, GlcAT-P, an enzyme critical in the biosynthesis of the carbohydrate epitope HNK-1].
T. Shiba, S. Kakuda, S. Oka, M. Ishiguro +3 more
2005Seikagaku. The Journal of Japanese Biochemical Society0 citations
Semantic Scholar
[Mice deficient in the HNK-1 carbohydrate exhibit impaired learning and memory].
S. Kakuda, S. Oka, T. Kawasaki
2004Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme0 citations
Semantic Scholar
Crystal structure of human GlcAT-P in complex with N-acetyllactosamine, Udp, and Mn2+
S. Kakuda, T. Shiba, M. Ishiguro, H. Tagawa +5 more
20040 citations
Semantic Scholar
Crystal structure of human GlcAT-P in complex with Udp and Mn2+
S. Kakuda, T. Shiba, M. Ishiguro, H. Tagawa +5 more
20040 citations
Semantic Scholar
Crystal structure of human GlcAT-P apo form
S. Kakuda, T. Shiba, M. Ishiguro, H. Tagawa +5 more
20040 citations
Semantic Scholar
SUBSTRATE SPECIFICITY AND STRUCTURE-FUNCTION RELATIONSHIP OF THE HNK-1 ASSOCIATED GLUCURONYL TRANSFERASES, GlcAT-P and GlcAT-S
S. Kakuda, Yuki Sato, K. Ohtsubo, S. Imajo +3 more
20020 citations
Semantic Scholar

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T. Kawasaki×15
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R. Haltiwanger×12
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E. London×7
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S. Wakatsuki×6

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Ippei Morita×6

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Ippei Morita — researcher profile on SciRah

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