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Aaron M. Hosios · SciRah

Researcher profile · Semantic Scholar

Aaron M. Hosios

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Aaron M. Hosios — researcher profile on SciRah

h-index: 21
Works: 40
Citations: 4,829

Most-cited papers

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
Lucas B. Sullivan, Dan Y. Gui, Aaron M. Hosios, Lauren N. Bush +2 more
2015Cell1,098 citations Open access
Semantic Scholar
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
Aaron M. Hosios, Vivian C. Hecht, Laura V. Danai, Marc O. Johnson +4 more
2016Developmental Cell597 citations Open access
Semantic Scholar
Tissue-of-origin Dictates Branched-Chain Amino Acid Metabolism in Mutant Kras-driven Cancers
Jared R. Mayers, M. Torrence, Laura V. Danai, T. Papagiannakopoulos +13 more
2016Science549 citations Open access
Semantic Scholar
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
William J. Israelsen, T. Dayton, Shawn M. Davidson, Brian P. Fiske +18 more
2013Cell536 citations Open access
Semantic Scholar
Aspartate is an endogenous metabolic limitation for tumour growth
Lucas B. Sullivan, Alba Luengo, Laura V. Danai, Lauren N. Bush +7 more
2018Nature Cell Biology317 citations Open access
Semantic Scholar
Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin
Dan Y. Gui, Lucas B. Sullivan, Alba Luengo, Aaron M. Hosios +6 more
2016Cell Metabolism307 citations Open access
Semantic Scholar
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
Sophia Y. Lunt, V. Muralidhar, Aaron M. Hosios, William J. Israelsen +18 more
2014Molecules and Cells254 citations Open access
Semantic Scholar
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
M. Torrence, Michael R. MacArthur, Aaron M. Hosios, A. Valvezan +3 more
2020bioRxiv202 citations Open access
Semantic Scholar
The redox requirements of proliferating mammalian cells
Aaron M. Hosios, M. V. Vander Heiden
2018Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Pyrimidine homeostasis is accomplished by directed overflow metabolism
Marshall Reaves, Brian D. Young, Aaron M. Hosios, Yi-Fan Xu +1 more
2013Nature122 citations Open access
Semantic Scholar
Lack of evidence for PKM2 protein kinase activity
Aaron M. Hosios, Brian P. Fiske, Dan Y. Gui, M. V. Vander Heiden
2015Molecules and Cells109 citations Open access
Semantic Scholar
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
A. G. Cox, Allison Tsomides, Dean Yimlamai, K. L. Hwang +19 more
2018bioRxiv103 citations Open access
Semantic Scholar
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Zhao-Qi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine +9 more
2022Nature Metabolism71 citations Open access
Semantic Scholar
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios +9 more
2019Nature Communications67 citations Open access
Semantic Scholar
Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect
Aaron M. Hosios, B. Manning
2021Cancer Research66 citations Open access
Semantic Scholar
mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species
Aaron M. Hosios, M. Wilkinson, Molly C. McNamara, Krystle C. Kalafut +3 more
2022Nature Metabolism61 citations Open access
Semantic Scholar
An RNA damage response network mediates the lethality of 5-FU in colorectal cancer
Jung-Kuei Chen, Karl A. Merrick, Yi W. Kong, A. Izrael-Tomasevic +16 more
2024Cell Reports Medicine45 citations Open access
Semantic Scholar
Acetate metabolism in cancer cells
Aaron M. Hosios, M. V. Vander Heiden
2014Cancer & Metabolism39 citations Open access
Semantic Scholar
Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes
Vivian C. Hecht, Lucas B. Sullivan, Robert J. Kimmerling, Dong-hwee Kim +7 more
2016Journal of Cell Biology29 citations Open access
Semantic Scholar
Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity
Vivian M. Liu, Andrea J. Howell, Aaron M. Hosios, Zhao-Qi Li +2 more
2019FEBS Letters26 citations Open access
Semantic Scholar
Preparation of Lipid-Stripped Serum for the Study of Lipid Metabolism in Cell Culture.
Aaron M. Hosios, Zhao-Qi Li, Evan C. Lien, M. V. Vander Heiden
2018Bio-protocol25 citations
Semantic Scholar
The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell +7 more
2022Cell Reports19 citations Open access
Semantic Scholar
Cooperative nutrient accumulation sustains growth of mammalian cells
Sung-Min Son, Mark M. Stevens, Hui-Xiao Chao, C. Thoreen +7 more
2015Scientific Reports19 citations Open access
Semantic Scholar
Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate
J. P. Dexter, P. Ward, T. Dasgupta, Aaron M. Hosios +2 more
2018Journal of Biological Chemistry13 citations Open access
Semantic Scholar
Lysosomal catch-and-release controls mTORC1
Aaron M. Hosios, B. Manning
2018Nature Cell Biology8 citations
Semantic Scholar
An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor Types
Jung-Kuei Chen, Karl A. Merrick, Yi W. Kong, A. Izrael-Tomasevic +16 more
2023bioRxiv6 citations Open access
Semantic Scholar
Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
Molly C. McNamara, Aaron M. Hosios, M. Torrence, Ting Zhao +8 more
2022iScience6 citations Open access
Semantic Scholar
Differential Substrate Use in EGF- and Oncogenic KRAS-Stimulated Human Mammary Epithelial Cells
Mark A. Keibler, Wentao Dong, Keegan D. Korthauer, Aaron M. Hosios +13 more
2021The FEBS Journal5 citations Open access
Semantic Scholar
Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis.
Aaron M. Hosios, M. V. Vander Heiden
2017Developmental Cell5 citations Open access
Semantic Scholar
Abstract A36: Amino acids rather than glucose accounts for the majority of cell mass in rapidly proliferating mammalian cells
Aaron M. Hosios, Vivian C. Hecht, Marc T. J. Johnson, J. Rathmell +2 more
20162 citations
Semantic Scholar
Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells
Sung-Min Son, Mark M. Stevens, Hui-Xiao Chao, C. Thoreen +7 more
2020Scientific Reports1 citations Open access
Semantic Scholar
Author response: The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
M. Torrence, Michael R. MacArthur, Aaron M. Hosios, A. Valvezan +3 more
20210 citations Open access
Semantic Scholar
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Zhao-Qi Li, Brian W. Ji, Purushottam D. Dixit, Evan C. Lien +8 more
2020bioRxiv0 citations Open access
Semantic Scholar
Defining the contributors to mammalian cell mass
Aaron M. Hosios
20170 citations
Semantic Scholar
Abstract PR10: Serine biosynthesis from glucose regulates folate availability
Caroline A. Lewis, Brian P. Fiske, M. Pacold, Aaron M. Hosios +3 more
20160 citations
Semantic Scholar
Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes
Vivian C. Hecht, Lucas B. Sullivan, Robert J. Kimmerling, Dong-hwee Kim +7 more
2016Journal of Experimental Medicine0 citations Open access
Semantic Scholar
2-Hydroxyglutarate Production by Mutant Isocitrate Dehydrogenase is Independent of Substrate Channeling but Sensitive to Compartment-Specific Metabolite Levels
J. P. Dexter, P. Ward, T. Dasgupta, Aaron M. Hosios +2 more
20160 citations Open access
Semantic Scholar
Acetate metabolism in cancer cells
Aaron M. Hosios, M. V. Vander Heiden
2014Cancer & Metabolism0 citations Open access
Semantic Scholar
MIT Open Access Articles Cooperative nutrient accumulation sustains growth of mammalian cells
Sungmin Son, Mark M. Stevens, Hui-Xiao Chao, C. Thoreen +7 more
0 citations
Semantic Scholar
Developmental Cell Previews Endothelial Cells Get box-ed In to Support Lymphangiogenesis
Aaron M. Hosios, M. V. Vander Heiden
0 citations
Semantic Scholar

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