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R. Widdop · SciRah

Researcher profile · Semantic Scholar

R. Widdop

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R. Widdop — researcher profile on SciRah

h-index: 49
Works: 289
Citations: 8,186

Most-cited papers

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
Irène R. Chassagnon, Claudia A. McCarthy, Yan-Ni K. Y. Chin, S. Pineda +8 more
2017Proceedings of the National Academy of Sciences of the United States of America214 citations Open access
Semantic Scholar
Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis
T. Gaspari, Iressa Spizzo, Hong-Bin Liu, Yun-Shan Hu +3 more
2018Diabetes & vascular disease research124 citations Open access
Semantic Scholar
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.
Bryna S. Man Chow, M. Kočan, S. Bosnyak, M. Sarwar +7 more
2014Kidney International117 citations Open access
Semantic Scholar
Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease
C. Samuel, Hasangika Bodaragama, Jacqueline Y Chew, R. Widdop +2 more
2014HYPERTENSION96 citations Open access
Semantic Scholar
Transition from Acute Kidney Injury to Chronic Kidney Disease: Mechanisms, Models, and Biomarkers.
Tingfang Zhang, R. Widdop, Sharon D. Ricardo
2024AJP - Renal Physiology89 citations
Semantic Scholar
Direct Angiotensin AT2 Receptor Stimulation Using a Novel AT2 Receptor Agonist, Compound 21, Evokes Neuroprotection in Conscious Hypertensive Rats
Claudia A. McCarthy, A. Vinh, Alyson A. Miller, A. Hallberg +3 more
2014PLoS ONE81 citations Open access
Semantic Scholar
The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target
U. Steckelings, R. Widdop, E. Sturrock, L. Lubbe +6 more
2022Pharmacological Reviews72 citations Open access
Semantic Scholar
Anti-fibrotic Potential of AT2 Receptor Agonists
Yan Wang, M. Del Borgo, Huey W. Lee, Dhaniel Baraldi +6 more
2017Frontiers in Pharmacology68 citations Open access
Semantic Scholar
PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.
Claudia A. McCarthy, L. Rash, Irène R. Chassagnon, G. King +1 more
2015Neuropharmacology66 citations Open access
Semantic Scholar
Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor.
Katrina M. Mirabito, Lucinda M. Hilliard, M. Kett, Russell D. Brown +5 more
2014AJP - Renal Physiology61 citations
Semantic Scholar
Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo
Amanda K. Sampson, J. Irvine, W. Shihata, D. Dragoljevic +8 more
2016British Journal of Pharmacology52 citations Open access
Semantic Scholar
Differential Phenotypes of Tissue-Infiltrating T Cells during Angiotensin II-Induced Hypertension in Mice
Zi-Hui Wei, Iresha Spizzo, H. Diep, G. Drummond +2 more
2014PLoS ONE50 citations Open access
Semantic Scholar
Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice
K. Schwengel, P. Namsolleck, K. Lucht, B. Clausen +13 more
2016Journal of molecular medicine49 citations
Semantic Scholar
Angiotensin Type 2 Receptor Stimulation Increases Renal Function in Female, but Not Male, Spontaneously Hypertensive Rats
Lucinda M. Hilliard, Charis L E Chow, Katrina M. Mirabito, U. Steckelings +3 more
2014HYPERTENSION49 citations Open access
Semantic Scholar
Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis
T. Gaspari, Melita Brdar, Huey W. Lee, Iresha Spizzo +4 more
2016Diabetes & vascular disease research48 citations Open access
Semantic Scholar
AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.
B. Chow, M. Kočan, Matthew Shen, Yan Wang +16 more
2019Journal of the American Society of Nephrology44 citations Open access
Semantic Scholar
The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin.
Deidree V N Somanader, Pei-Shen Zhao, R. Widdop, C. Samuel
2024Biochemical Pharmacology42 citations Open access
Semantic Scholar
Preclinical rodent models of cardiac fibrosis
Yan Wang, Miao Wang, C. Samuel, R. Widdop
2021British Journal of Pharmacology37 citations
Semantic Scholar
Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor
Katrina M. Mirabito, Lucinda M. Hilliard, G. Head, R. Widdop +1 more
2014Biology of Sex Differences33 citations Open access
Semantic Scholar
Electronic Sculpting of Ligand-GPCR Subtype Selectivity: The Case of Angiotensin II
F. Magnani, C. Pappas, T. Crook, V. Magafa +10 more
2014ACS Chemical Biology31 citations Open access
Semantic Scholar
Optimising the photothrombotic model of stroke in the C57BI/6 and FVB/N strains of mouse
Adriana Knezic, B. Broughton, R. Widdop, Claudia A. McCarthy
2021Scientific Reports30 citations Open access
Semantic Scholar
β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
M. Del Borgo, Yan Wang, S. Bosnyak, M. Khan +8 more
2015Clinical science30 citations
Semantic Scholar
Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo
Seyoung Lee, Megan A. Evans, Hannah X. Chu, Hyun Ah Kim +3 more
2015PLoS ONE28 citations Open access
Semantic Scholar
Serelaxin and the AT2 Receptor Agonist CGP42112 Evoked a Similar, Nonadditive, Cardiac Antifibrotic Effect in High Salt-Fed Mice That Were Refractory to Candesartan Cilexetil.
Yan Wang, Lei Han, Matthew Shen, E. Jones +6 more
2020ACS Pharmacology & Translational Science24 citations Open access
Semantic Scholar
In Aged Females, the Enhanced Pressor Response to Angiotensin II Is Attenuated By Estrogen Replacement via an Angiotensin Type 2 Receptor-Mediated Mechanism
Giannie Barsha, K. M. Mirabito Colafella, S. L. Walton, T. Gaspari +6 more
2021HYPERTENSION23 citations Open access
Semantic Scholar
Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid.
Antonis D. Tsiailanis, Alexander Renziehausen, S. Kiriakidi, Eirinaios I Vrettos +11 more
2020Free Radical Biology & Medicine23 citations
Semantic Scholar
Decorated self-assembling β(3)-tripeptide foldamers form cell adhesive scaffolds.
Kerstin Luder, Ketav Kulkarni, Huey W. Lee, R. Widdop +2 more
2016Chemical Communications22 citations
Semantic Scholar
Role of Inflammation and the Angiotensin Type 2 Receptor in the Regulation of Arterial Pressure During Pregnancy in Mice
Katrina M. Mirabito, Lucinda M. Hilliard, Zi-Hui Wei, C. Tikellis +3 more
2014HYPERTENSION22 citations
Semantic Scholar
The anti‐fibrotic actions of relaxin are mediated through AT2R‐associated protein phosphatases via RXFP1‐AT2R functional crosstalk in human cardiac myofibroblasts
Chao Wang, A. Pinar, R. Widdop, M. Hossain +4 more
2020The FASEB Journal20 citations
Semantic Scholar
Assessment of renal fibrosis and anti‐fibrotic agents using a novel diagnostic and stain‐free second‐harmonic generation platform
Sadman Bhuiyan, Matthew Shen, Sharenya Chelvaretnam, Andre Tan +4 more
2021The FASEB Journal19 citations
Semantic Scholar
Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice.
Yifang Li, A. Chakraborty, Bradley R. S. Broughton, D. Ferens +3 more
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie19 citations Open access
Semantic Scholar
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt‐induced hypertension
Yifang Li, Matthew Shen, D. Ferens, Bradley R. S. Broughton +6 more
2021British Journal of Pharmacology18 citations Open access
Semantic Scholar
Esterase-Mediated Sustained Release of Peptide-Based Therapeutics from a Self-Assembled Injectable Hydrogel.
Ketav Kulkarni, Rachel L. Minehan, Tanesh D Gamot, H. Coleman +9 more
2021ACS Applied Materials and Interfaces18 citations
Semantic Scholar
Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2
Daniel J. Clayton, Iresha Hanchapola, W. Thomas, R. Widdop +3 more
2015Frontiers in Pharmacology17 citations Open access
Semantic Scholar
The Protective Arms of the Renin-Angiontensin System in Stroke
Claudia A. McCarthy, Lachlan J Facey, R. Widdop
2014Current Hypertension Reports17 citations
Semantic Scholar
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.
Fariha Alam, T. Gaspari, B. Kemp-Harper, Edward Low +9 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie15 citations Open access
Semantic Scholar
Catch your breath: The protective role of the angiotensin AT2 receptor for the treatment of idiopathic pulmonary fibrosis.
O. Young, J. E. Bourke, R. Widdop
2023Biochemical Pharmacology13 citations Open access
Semantic Scholar
The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein‐E deficient mice
R. Libinaki, A. Vinh, Sonja Tesanovic‐Klajic, R. Widdop +1 more
2017Clinical and Experimental Pharmacology and Physiology12 citations Open access
Semantic Scholar
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke
Jonathon Telianidis, A. Hunter, R. Widdop, B. Kemp-Harper +3 more
2023Scientific Reports11 citations Open access
Semantic Scholar
A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
Rebecka Isaksson, Jens Lindman, J. Wannberg, Jessica Sallander +8 more
2019ChemistryOpen11 citations Open access
Semantic Scholar
Novel approaches for treating hypertension
Andrew J. Freeman, A. Vinh, R. Widdop
2017F1000Research11 citations Open access
Semantic Scholar
Vasoactive Role for Angiotensin II Type 2 Receptors in Human Radial Artery
A. Zulli, David L. Hare, Brian F. Buxton, R. Widdop
2014International Journal of Immunopathology and Pharmacology11 citations Open access
Semantic Scholar
Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD.
Hong Chen, Qing Wan, Jianfeng Yang, Haojie Rao +17 more
2025Circulation Research10 citations
Semantic Scholar
Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats.
Mandy Li, Levi Nguyen, D. Ferens, Iresha Spizzo +9 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie10 citations Open access
Semantic Scholar
Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis
C. Samuel, Yifang Li, Yan Wang, R. Widdop
2022British Journal of Pharmacology10 citations Open access
Semantic Scholar
The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
Yan Wang, Jonathan Yodgee, M. Del Borgo, Iresha Spizzo +5 more
2022International Journal of Molecular Sciences10 citations Open access
Semantic Scholar
Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2 Receptor Mechanism in Aged Hypertensive Female Rats
Giannie Barsha, S. L. Walton, E. Kwok, K. M. Mirabito Colafella +6 more
2021Kidney36010 citations Open access
Semantic Scholar
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands.
J. Wannberg, J. Gising, Jens Lindman, Jessica Salander +12 more
2020Bioorganic & Medicinal Chemistry10 citations Open access
Semantic Scholar
The protective effects of a novel AT2 receptor agonist, β-Pro7Ang III in ischemia-reperfusion kidney injury.
Tingfang Zhang, Yifang Li, Andrea F. Wise, Ketav Kulkarni +5 more
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie9 citations Open access
Semantic Scholar
Morphology and Function of the Lamb Ileum following Preterm Birth
Tracey J. Flores, V. Nguyen, R. Widdop, Megan R. Sutherland +3 more
2018Frontiers in Pediatrics9 citations Open access
Semantic Scholar

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K. Denton×14
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Iresha Spizzo — researcher profile on SciRah

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M. Del Borgo×8

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Claudia A. McCarthy×6

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Claudia A. McCarthy — researcher profile on SciRah

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