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C. Tikellis · SciRah

Researcher profile · Semantic Scholar

C. Tikellis

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C. Tikellis — researcher profile on SciRah

h-index: 46
Works: 93
Citations: 8,329

Most-cited papers

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail
D. Brasacchio, J. Okabe, C. Tikellis, Aneta Balcerczyk +6 more
2008Diabetes542 citations Open access
Semantic Scholar
Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease
C. Tikellis, M. Thomas
2012International Journal of Peptides541 citations Open access
Semantic Scholar
A Breaker of Advanced Glycation End Products Attenuates Diabetes‐Induced Myocardial Structural Changes
R. Candido, J. Forbes, M. Thomas, V. Thallas +7 more
2003Circulation Research457 citations Open access
Semantic Scholar
Myocardial infarction increases ACE2 expression in rat and humans.
Louise M. Burrell, J. Risvanis, E. Kubota, R. Dean +8 more
2005European Heart Journal409 citations Open access
Semantic Scholar
Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy
C. Tikellis, C. Johnston, J. Forbes, W. C. Burns +3 more
2003HYPERTENSION356 citations Open access
Semantic Scholar
Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2
G. Paizis, C. Tikellis, M. Cooper, Josefa M. Schembri +7 more
2005Gut344 citations Open access
Semantic Scholar
ACE2, a new regulator of the renin–angiotensin system
L. Burrell, C. Johnston, C. Tikellis, M. Cooper
2004Trends in endocrinology and metabolism342 citations Open access
Semantic Scholar
Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes.
K. Jandeleit-Dahm, C. Tikellis, C. Reid, C. Johnston +1 more
2005Journal of Hypertension293 citations
Semantic Scholar
Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat.
C. Tikellis, P. Wookey, R. Candido, S. Andrikopoulos +2 more
2004Diabetes281 citations Open access
Semantic Scholar
Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.
W. C. Burns, S. Twigg, J. Forbes, J. Pete +5 more
2006Journal of the American Society of Nephrology246 citations
Semantic Scholar
Genetic Ace2 Deficiency Accentuates Vascular Inflammation and Atherosclerosis in the ApoE Knockout Mouse
M. Thomas, R. Pickering, Despina Tsorotes, A. Koitka +9 more
2010Circulation Research223 citations
Semantic Scholar
Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver.
G. Paizis, M. Cooper, Josefa M. Schembri, C. Tikellis +2 more
2002Gastroenterology205 citations
Semantic Scholar
Imbalance of the renin–angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?
M. Garg, S. Royce, C. Tikellis, C. Shallue +19 more
2019Gut198 citations
Semantic Scholar
ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes
C. Tikellis, K. Bialkowski, J. Pete, K. Sheehy +4 more
2008Diabetes185 citations Open access
Semantic Scholar
Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis.
G. Paizis, Richard E. Gilbert, Mark E. Cooper, P. Murthi +8 more
2001Journal of Hepatology161 citations
Semantic Scholar
Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
J. Okabe, Christian Orlowski, Aneta Balcerczyk, C. Tikellis +3 more
2012Circulation Research159 citations Open access
Semantic Scholar
Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis
E. Brennan, Bo Wang, A. McClelland, Muthukumar Mohan +15 more
2017Diabetes156 citations Open access
Semantic Scholar
Angiotensin-converting enzyme 2 is a key modulator of the renin–angiotensin system in cardiovascular and renal disease
C. Tikellis, S. Bernardi, W. C. Burns
2011Current opinion in nephrology and hypertension151 citations
Semantic Scholar
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms
S. Tonna, A. El-Osta, M. Cooper, C. Tikellis
2010Nature Reviews Nephrology138 citations
Semantic Scholar
Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.
C. Tikellis, M. Thomas, Brooke E. Harcourt, M. Coughlan +6 more
2008American Journal of Physiology. Endocrinology and Metabolism133 citations Open access
Semantic Scholar
Interactions between renin angiotensin system and advanced glycation in the kidney.
M. Thomas, C. Tikellis, W. M. Burns, K. Bialkowski +5 more
2005Journal of the American Society of Nephrology132 citations
Semantic Scholar
Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis
Michelle C. Flynn, M. Kraakman, C. Tikellis, ManKS. Lee +22 more
2020Circulation Research117 citations Open access
Semantic Scholar
Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure.
R. Komers, T. Oyama, D. R. Beard, C. Tikellis +3 more
2011Kidney International98 citations Open access
Semantic Scholar
Developmental expression of ACE2 in the SHR kidney: a role in hypertension?
C. Tikellis, M. Cooper, K. Bialkowski, C. Johnston +4 more
2006Kidney International97 citations Open access
Semantic Scholar
Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis.
V. Levidiotis, C. Freeman, C. Tikellis, M. Cooper +1 more
2004Journal of the American Society of Nephrology94 citations
Semantic Scholar
Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes
C. Tikellis, R. Pickering, Despina Tsorotes, O. Huet +3 more
2014Diabetes90 citations Open access
Semantic Scholar
Identification of angiotensin converting enzyme 2 in the rodent retina
C. Tikellis, C. Johnston, J. Forbes, W. C. Burns +5 more
2004Current Eye Research83 citations
Semantic Scholar
Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis
E. Brennan, Muthukumar Mohan, A. McClelland, M. de Gaetano +20 more
2018Diabetes81 citations Open access
Semantic Scholar
The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent.
Amanda K. Sampson, Lucinda M. Hilliard, K. Moritz, M. Thomas +3 more
2012American Journal of Physiology. Regulatory Integrative and Comparative Physiology75 citations
Semantic Scholar
High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage.
S. Bernardi, Barbara Toffoli, C. Zennaro, C. Tikellis +8 more
2012Nephrology, Dialysis and Transplantation74 citations Open access
Semantic Scholar
Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition.
C. Tikellis, M. Cooper, S. Twigg, W. C. Burns +1 more
2004Endocrinology72 citations
Semantic Scholar
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis
R. Pickering, C. Tikellis, Carlos J. Rosado, Despina Tsorotes +12 more
2018Journal of Clinical Investigation69 citations Open access
Semantic Scholar
Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2
C. Moran, E. Biros, S. Krishna, Yu-Tang Wang +8 more
2017Arteriosclerosis, Thrombosis and Vascular Biology69 citations Open access
Semantic Scholar
Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice
A. Watson, S. Gray, Jia-Ze Li, A. Soro-Paavonen +8 more
2012Diabetes67 citations Open access
Semantic Scholar
Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.
E. Brennan, Muthukumar Mohan, A. McClelland, C. Tikellis +12 more
2018Journal of the American Society of Nephrology64 citations Open access
Semantic Scholar
Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes.
S. Bernardi, B. Fabris, M. Thomas, Barbara Toffoli +8 more
2014Molecular and Cellular Endocrinology64 citations
Semantic Scholar
Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin.
Peter J. Wookey, C. Tikellis, H.-C. Du, H.-F. Qin +2 more
1996American Journal of Physiology64 citations
Semantic Scholar
Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes.
C. Tikellis, M. Cooper, M. Thomas
2006International Journal of Biochemistry and Cell Biology61 citations
Semantic Scholar
Reduced tubular cation transport in diabetes: prevented by ACE inhibition.
M. Thomas, C. Tikellis, W. C. Burns, V. Thallas +8 more
2003Kidney International60 citations Open access
Semantic Scholar
Angiotensin converting enzyme 2 and atherosclerosis.
Yu-Tang Wang, C. Tikellis, M. Thomas, J. Golledge
2013Atherosclerosis55 citations
Semantic Scholar
The Role of Advanced Glycation in Reduced Organic Cation Transport Associated with Experimental Diabetes
M. Thomas, C. Tikellis, P. Kantharidis, W. C. Burns +2 more
2004Journal of Pharmacology and Experimental Therapeutics54 citations
Semantic Scholar
Activation of the Renin-Angiotensin System Mediates the Effects of Dietary Salt Intake on Atherogenesis in the Apolipoprotein E Knockout Mouse
C. Tikellis, R. Pickering, Despina Tsorotes, O. Huet +3 more
2012HYPERTENSION53 citations Open access
Semantic Scholar
Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes.
C. Tikellis, R. Pickering, Despina Tsorotes, Xiao-Jun Du +5 more
2012Clinical science48 citations
Semantic Scholar
Heparanase inhibition reduces proteinuria in a model of accelerated anti‐glomerular basement membrane antibody disease
V. Levidiotis, C. Freeman, C. Tikellis, M. Cooper +1 more
2005Nephrology48 citations
Semantic Scholar
TNF-related apoptosis-inducing ligand significantly attenuates metabolic abnormalities in high-fat-fed mice reducing adiposity and systemic inflammation.
S. Bernardi, G. Zauli, C. Tikellis, R. Candido +4 more
2012Clinical science47 citations
Semantic Scholar
ANGIOTENSIN CONVERTING ENZYME 2 IN THE KIDNEY
A. Koitka, M. E. Cooper, Merlin C. Thomas, C. Tikellis
2008Clinical and Experimental Pharmacology and Physiology47 citations Open access
Semantic Scholar
Preventing diabetes in patients with hypertension: one more reason to block the renin–angiotensin system
M. Cooper, C. Tikellis, M. Thomas
2006Journal of Hypertension - Supplement46 citations
Semantic Scholar
Amylin as a growth factor during fetal and postnatal development of the rat kidney.
Peter J. Wookey, C. Tikellis, M. Nobes, D. Casley +2 more
1998Kidney International45 citations Open access
Semantic Scholar
High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction.
S. Kooptiwut, M. Kebede, S. Zraika, Sherley Visinoni +9 more
2005Journal of Molecular Endocrinology44 citations Open access
Semantic Scholar
Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat
M. Tolcos, C. Tikellis, S. Rees, M. Cooper +1 more
2003The Journal of comparative neurology44 citations
Semantic Scholar

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M. Thomas×29
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J. Forbes×10
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R. Pickering×10
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W. C. Burns — researcher profile on SciRah

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L. Burrell — researcher profile on SciRah

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K. Jandeleit-Dahm×7

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Despina Tsorotes×6

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A. El-Osta — researcher profile on SciRah

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S. Bernardi — researcher profile on SciRah