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Chun Zhang · SciRah

Researcher profile · Semantic Scholar

Chun Zhang

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Chun Zhang — researcher profile on SciRah

h-index: 6
Works: 23
Citations: 490

Most-cited papers

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency
W. Yen, M. Fischer, F. Axelrod, Chris Bond +14 more
2015Clinical Cancer Research239 citations Open access
Semantic Scholar
Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer
J. Diamond, C. Becerra, D. Richards, A. Mita +11 more
2020Breast Cancer Research and Treatment136 citations Open access
Semantic Scholar
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC)
Qingnan Zhao, Xiajing Gu, Chun Zhang, Qin Lu +2 more
2015Cancer Biology & Therapy42 citations Open access
Semantic Scholar
Phase 1b study of WNT inhibitor vantictumab (VAN, human monoclonal antibody) with nab-paclitaxel (Nab-P) and gemcitabine (G) in patients (pts) with previously untreated stage IV pancreatic cancer (PC)
W. Messersmith, S. J. Cohen, S. Shahda, H. Lenz +14 more
201620 citations Open access
Semantic Scholar
Phase 1b study of WNT inhibitor vantictumab (VAN, human monoclonal antibody) with paclitaxel (P) in patients (pts) with 1st- to 3rd-line metastatic HER2-negative breast cancer (BC).
M. Mita, C. Becerra, D. Richards, A. Mita +11 more
201619 citations
Semantic Scholar
Association of Baseline and Pharmacodynamic Biomarkers With Outcomes in Patients Treated With the PD-1 Inhibitor Budigalimab
S. Lambert, Chun Zhang, Claire J. Guo, Tolga Turan +8 more
2022Journal of immunotherapy14 citations Open access
Semantic Scholar
[Serum her-2/neu level and related factors in patients with breast cancer].
P. Yuan, Bing-He Xu, Chun Zhang, J. Qi
2003Zhonghua zhong liu za zhi [Chinese journal of oncology]5 citations
Semantic Scholar
Abstract 3129: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts
Chun Zhang, F. Cattaruzza, P. Yeung, W. Yen +10 more
20163 citations
Semantic Scholar
Abstract B24: Biomarker analysis in the first-in-human phase 1a study for vantictumab (OMP-18R5; anti-Frizzled) demonstrates pharmacodynamic (PD) modulation of the Wnt pathway in patients with advanced solid tumors.
David C. Smith, L. Rosen, Min Wang, Chun Zhang +8 more
20133 citations
Semantic Scholar
Abstract A030: Biomarker study of vantictumab plus paclitaxel in HER2- breast cancer patients
Chun Zhang, W. Henner, Min Wang, F. Cattaruzza +8 more
20182 citations
Semantic Scholar
Abstract 404: Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors
Chun Zhang, Yu-Wang Liu, Min Wang, G. O'young +15 more
20162 citations
Semantic Scholar
Abstract A30: Predictive and pharmacodynamic biomarkers of vantictumab (OMP-18R5; anti-Frizzled) in non-small cell lung cancer
Chun Zhang, F. Cattaruzza, P. Yeung, W. Yen +8 more
20152 citations
Semantic Scholar
Application of Serum Thymidine Kinase-1 in Cancer Risk Detection in Healthy Population
Ji-Hong Xiao, Yu-Fei Zhao, Chun Zhang
20191 citations
Semantic Scholar
Abstract P3-07-57: Development of a 6-gene qPCR RUO-validated assay as a predictive biomarker for response of vantictumab (OMP-18R5; anti-frizzled) in HER2- breast cancer patients
Chun Zhang, G. O'young, K. Wikstrom, T. Davison +12 more
20161 citations
Semantic Scholar
Abstract 1549: Development and validation of a biomarker for prospective selection of Notch1 activation in patients with certain advanced solid tumors in a first-in-human phase1 study of the cancer stem cell targeting antibody OMP-52M51 (anti-Notch1)
B. Cancilla, R. Tam, Chun Zhang, S. Anderson +6 more
20151 citations
Semantic Scholar
Abstract 2830: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) by mining gene expression data of human breast cancer xenografts
Chun Zhang, P. Yeung, L. Beviglia, B. Cancilla +6 more
20141 citations
Semantic Scholar
Abstract 4464: Pharmacodynamic and predictive biomarkers of clinical responses to PD-1 inhibitor budigalimab from the first-in-human clinical trial
S. Lambert, Chun Zhang, S. Englert, Claire J. Guo +6 more
2020Immunology0 citations
Semantic Scholar
Abstract 1727: Circulating Tumor Cells (CTCs) in patients with extensive stage small cell lung cancer and their association with clinical outcome
Chun Zhang, R. Graf, A. Jendrisak, A. Anderson +12 more
20170 citations
Semantic Scholar
Abstract A42: Using a PDX tumor bank to screen for cancer stem cell therapies
James W. Evans, Chun Zhang, A. I. Park, A. Brunner +16 more
20160 citations
Semantic Scholar
Abstract A41: Use of patient-derived tumor xenografts (PDX) for discovery and development of an anti-Notch2/3 monoclonal antibody targeting cancer stem cells
M. Fischer, W. Yen, F. Axelrod, Chris Bond +16 more
20160 citations
Semantic Scholar
Abstract 3048: OMP-59R5 (Anti-Notch2/3) inhibits tumor growth and reduces cancer stem cell frequency in patient derived SCLC xenografts
M. Fischer, Jalpa Shah, Jennifer A. Cain, B. Cancilla +10 more
20140 citations
Semantic Scholar
Abstract 910: NOTCH3 expression is predictive of efficacy in pancreas tumor models treated with OMP-59R5, a monoclonal antibody targeting the NOTCH2 and NOTCH3 receptors
B. Cancilla, W. Yen, Chun Zhang, M. Fischer +9 more
20140 citations
Semantic Scholar
314 Biomarker Analysis in the First-in-human OMP-59R5 (anti-Notch2/3) Phase I Study Demonstrates Pharmacodynamic (PD) Modulation of the Notch Pathway in Patients with Advanced Solid Tumors
A. Tolcher, A. Kapoun, Min Wang, Chun Zhang +6 more
20120 citations
Semantic Scholar

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