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T. Hoey · SciRah

Researcher profile · Semantic Scholar

T. Hoey

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T. Hoey — researcher profile on SciRah

h-index: 47
Works: 148
Citations: 16K

Most-cited papers

Phenotypic characterization of human colorectal cancer stem cells
P. Dalerba, S. Dylla, In-kyung Park, Rui Liu +10 more
2007Proceedings of the National Academy of Sciences of the United States of America2,270 citations Open access
Semantic Scholar
The prognostic role of a gene signature from tumorigenic breast-cancer cells.
Rui Liu, Xinhao Wang, Grace Y. Chen, P. Dalerba +6 more
2007New England Journal of Medicine1,060 citations Open access
Semantic Scholar
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy
S. Dylla, L. Beviglia, In-kyung Park, C. Chartier +10 more
2008PLoS ONE610 citations Open access
Semantic Scholar
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
A. Gurney, F. Axelrod, Chris Bond, Jennifer A. Cain +19 more
2012Proceedings of the National Academy of Sciences of the United States of America599 citations Open access
Semantic Scholar
DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency.
T. Hoey, W. Yen, F. Axelrod, Jesspreet Basi +11 more
2009Cell Stem Cell443 citations Open access
Semantic Scholar
Intratumoral heterogeneity generated by Notch signaling promotes small cell lung cancer
Jing S. Lim, Alvaro Ibaseta, Marcus M. Fischer, B. Cancilla +16 more
2017Nature347 citations Open access
Semantic Scholar
Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency
W. Yen, M. Fischer, F. Axelrod, Chris Bond +14 more
2015Clinical Cancer Research239 citations Open access
Semantic Scholar
Canonical Wnt signaling Is required for pancreatic carcinogenesis
Ya-Qing Zhang, John P. Morris, Wei Yan, Heather K. Schofield +6 more
2013Cancer Research197 citations Open access
Semantic Scholar
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
M. Fischer, B. Cancilla, V. P. Yeung, F. Cattaruzza +13 more
2017Science Advances133 citations Open access
Semantic Scholar
Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations.
M. Fischer, W. Yen, A. Kapoun, Min Wang +4 more
2011Cancer Research128 citations
Semantic Scholar
Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts
V. Agnusdei, S. Minuzzo, C. Frasson, Angela Grassi +10 more
2014Leukemia127 citations
Semantic Scholar
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.
C. Chartier, J. Raval, F. Axelrod, Chris Bond +18 more
2016Cancer Research101 citations
Semantic Scholar
Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells
W. Yen, M. Fischer, Mark J. Hynes, Jing-Jiang Wu +9 more
2012Clinical Cancer Research66 citations Open access
Semantic Scholar
Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo.
E. H. van der Horst, L. Chinn, Min Wang, T. Velilla +6 more
2009Neoplasia65 citations Open access
Semantic Scholar
Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
Francis Grafton, Jaclyn J. Ho, Sara Ranjbarvaziri, F. Farshidfar +8 more
2021eLife58 citations Open access
Semantic Scholar
NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells.
Anna Pastò, V. Serafin, G. Pilotto, C. Lago +11 more
2014Cancer Research57 citations Open access
Semantic Scholar
RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations
Marcus M. Fischer, V. P. Yeung, F. Cattaruzza, Rajaa A. Hussein +10 more
2017Scientific Reports51 citations Open access
Semantic Scholar
Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs
Ming-Jun Zhang, Michael Haughey, Nai-Yu Wang, K. Blease +20 more
2020PLoS ONE41 citations Open access
Semantic Scholar
DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice.
S. Minuzzo, V. Agnusdei, I. Pusceddu, M. Pinazza +8 more
2015Carcinogenesis39 citations Open access
Semantic Scholar
Anti-DLL4, a cancer therapeutic with multiple mechanisms of action
A. Gurney, T. Hoey
2011Vascular Cell34 citations Open access
Semantic Scholar
Drug Resistance, Epigenetics, and Tumor Cell Heterogeneity
T. Hoey
2010Science Translational Medicine33 citations
Semantic Scholar
COP1, a negative regulator of photomorphogenesis, positively regulates plant disease resistance via double-stranded RNA binding proteins
G. Lim, T. Hoey, Shi-Feng Zhu, Marion Clavel +5 more
2018PLoS Pathogens30 citations Open access
Semantic Scholar
Therapeutic targeting of tumor-derived R-spondin attenuates β-catenin signaling and tumorigenesis in multiple cancer types
Cecile Chartier, J. Raval, F. Axelrod, Chris Bond +19 more
201524 citations
Semantic Scholar
Abstract 1907: Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models
P. Yeung, L. Beviglia, B. Cancilla, C. Dee-Hoskins +7 more
201416 citations
Semantic Scholar
From Research to the Clinic
A. Gurney, T. Hoey
201611 citations
Semantic Scholar
Abstract 2003: Antibody against TIGIT (T cell immunoreceptor with Ig and ITIM domains) induces anti-tumor immune response and generates long-term immune memory
A. I. Park, M. Srivastava, E. Mayes, Hyun-bae Jie +10 more
20178 citations
Semantic Scholar
Abstract 3728: Anti-Notch1 antibody (OMP-52M51) impedes tumor growth and cancer stem cell frequency (CSC) in a chemo-refractory breast cancer xenograft model with an activating Notch1 mutation and screening for activated Notch1 across multiple solid tumor types.
B. Cancilla, Jennifer A. Cain, Min Wang, L. Beviglia +6 more
20138 citations
Semantic Scholar
The analogous and opposing roles of double-stranded RNA-binding proteins in bacterial resistance
G. Lim, Shi-Feng Zhu, Kai Zhang, T. Hoey +3 more
2019Journal of Experimental Botany7 citations
Semantic Scholar
Abstract 973: Targeting cancer stem cells by a novel anti-frizzled antibody inhibits pancreatic tumor growth and induces differentiation
W. Yen, M. Fischer, J. Lewicki, A. Gurney +1 more
20117 citations
Semantic Scholar
Abstract 4233: Wnt pathway antagonist ipafricept (FZD8-Fc, OMP-54F28) inhibits tumor growth and reduces tumor-initiating cell frequency in ovarian patient-derived xenograft models
M. Fischer, W. Yen, Chunhua Zheng, Randall Henner +8 more
20156 citations
Semantic Scholar
Abstract C164: Dual targeting of the DLL4 and VEGF pathways with a bispecific monoclonal antibody inhibits tumor growth and reduces cancer stem cell frequency
W. Yen, M. Fischer, G. Argast, B. Wallace +6 more
20156 citations
Semantic Scholar
Abstract 2612: Anti-Tigit induces T cell mediated anti-tumor immune response and combines with immune checkpoint inhibitors to enhance strong and long term anti-tumor immunity
M. Srivastava, Rui Yun, E. Mayes, Janice Yu +11 more
20174 citations
Semantic Scholar
Paracrine wnt-β-catenin signaling inhibition as a strategy to enhance the efficacy of anti-PD-1 antibody (Ab) therapy in a transgenic model of melanoma.
N. DeVito, C. Xiao, F. Zhao, Kathy S. Evans +6 more
20174 citations
Semantic Scholar
Deep Learning Predicts Patterns of Cardiotoxicity in a High-Content Screen Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes
Francis Grafton, Jaclyn J. Ho, Sara Ranjbarvaziri, F. Farshidfar +8 more
2021bioRxiv3 citations Open access
Semantic Scholar
Abstract 599: Pharmacodynamic biomarkers for anti-TIGIT treatment and prevalence of TIGIT expression in multiple solid tumor types
F. Cattaruzza, P. Yeung, Min Wang, A. Brunner +10 more
20173 citations
Semantic Scholar
Abstract 4652: Effects of anti-DLL4 treatment on non-small cell lung cancer (NSCLC) human xenograft tumors
A. Brunner, F. Cattaruzza, W. Yen, P. Yeung +10 more
20163 citations
Semantic Scholar
Abstract 3129: Predictive biomarker identification for response to vantictumab (OMP-18R5; anti-Frizzled) using primary patient-derived human pancreatic tumor xenografts
Chun Zhang, F. Cattaruzza, P. Yeung, W. Yen +10 more
20163 citations
Semantic Scholar
Abstract 207: Dual targeting of DLL4 and VEGF signaling by a novel bispecific antibody inhibits tumor growth and reduces cancer stem cell frequency
W. Yen, F. Axelrod, Chris Bond, Jennifer A. Cain +9 more
20143 citations
Semantic Scholar
Abstract 3725: Anti-DLL4 (demcizumab) inhibits tumor growth and reduces cancer stem cell frequency in patient-derived ovarian cancer xenografts.
W. Yen, M. Fischer, Jalpa Shah, Jie Wei +8 more
20133 citations
Semantic Scholar
Abstract 3357: Targeting cancer stem cells by an anti-DLL4 antibody inhibits epithelial-to-mesenchymal transition, delays tumor recurrence and overcomes drug resistance in breast and pancreatic cancer
W. Yen, M. Fischer, J. Lewicki, A. Gurney +1 more
20123 citations
Semantic Scholar
Abstract 3356: Development of a novel Wnt pathway antagonist antibody, OMP-18R5, that reduces tumor initiating cell frequency in breast cancer
J. Lewicki, F. Axelrod, L. Beviglia, Chris Bond +9 more
20123 citations
Semantic Scholar
Abstract 2834: Anti-DLL4 treatment inhibits melanoma tumor growth, recurrence, metastases, and reduces frequency of cancer stem cells in a clinically relevant tumor model in NOD/SCID mice
L. Beviglia, P. Yeung, M. Fischer, W. Yen +4 more
20113 citations
Semantic Scholar
Targeting Cancer Stem Cells and Vasculature by a Novel Anti-Delta-Like 4 Ligand (DLL4) Antibody for Treatment of Triple Negative Breast Cancer.
W. Yen, M. Fischer, J. Lewicki, A. Gurney +1 more
20093 citations
Semantic Scholar
Abstract 404: Development of a RSPO3 CLIA-validated assay as a predictive biomarker for response to anti-RSPO3 antibody treatment in patients with solid tumors
Chun Zhang, Yu-Wang Liu, Min Wang, G. O'young +15 more
20162 citations
Semantic Scholar
Abstract 4367: Discovery and evaluation of pharmacodynamic and predictive biomarkers for anti-RSPO3, a treatment that reduces tumor growth and cancer stem cell frequency in patient derived xenograft tumor models
F. Cattaruzza, P. Yeung, W. Yen, A. Brunner +9 more
20152 citations
Semantic Scholar
Abstract A30: Predictive and pharmacodynamic biomarkers of vantictumab (OMP-18R5; anti-Frizzled) in non-small cell lung cancer
Chun Zhang, F. Cattaruzza, P. Yeung, W. Yen +8 more
20152 citations
Semantic Scholar
Co-targeting of delta-like ligand 4 (DLL4) and vascular endothelial growth factor a (VEGF) with programmed death 1 (PD1) blockade inhibits tumor growth and facilitates anti-tumor immune responses
M. Srivastava, Christopher L. Murriel, Rui Yun, E. Mayes +12 more
2015Journal of Immunotherapy for Cancer2 citations Open access
Semantic Scholar
Abstract 2576: Enhanced antitumor efficacy by sequential application of Wnt pathway antagonists in combination with taxanes
W. Yen, M. Fischer, B. Cancilla, F. Cattaruzza +5 more
20152 citations
Semantic Scholar
Abstract 255: Dual targeting of Delta-like ligand 4 (DLL4) and programmed death 1(PD1) inhibits tumor growth and generates enhanced long-term immunological memory
M. Srivastava, Christopher L. Murriel, J. Roda, Hyun-bae Jie +13 more
20152 citations
Semantic Scholar
Abstract LB-196: Anti-DLL4 reduces tumor growth and tumorigenicity in B-RAF V600E melanomas including those with acquired resistance to B-RAF inhibitors
L. Beviglia, P. Yeung, M. Fischer, W. Yen +4 more
20122 citations
Semantic Scholar

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J. Lewicki×34
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Min Wang — researcher profile on SciRah

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F. Axelrod — researcher profile on SciRah

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