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A. Pearson · SciRah

Researcher profile · Semantic Scholar

A. Pearson

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A. Pearson — researcher profile on SciRah

h-index: 64
Works: 301
Citations: 16K

Most-cited papers

Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
N. Pinto, M. Applebaum, S. Volchenboum, K. Matthay +9 more
2015Journal of Clinical Oncology799 citations Open access
Semantic Scholar
Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial.
R. Ladenstein, U. Pötschger, D. Valteau-Couanet, R. Luksch +20 more
2018The Lancet Oncology341 citations
Semantic Scholar
The ALKF1174L mutation potentiates the oncogenic activity of MYCN in neuroblastoma
Teeara Berry, W. Luther, Namrata Bhatnagar, Y. Jamin +23 more
2012Cancer Cell320 citations Open access
Semantic Scholar
Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.
R. Ladenstein, U. Pötschger, A. Pearson, P. Brock +24 more
2017The Lancet Oncology295 citations Open access
Semantic Scholar
Clinical, biologic, and prognostic differences on the basis of primary tumor site in neuroblastoma: a report from the international neuroblastoma risk group project.
Kieuhoa T. Vo, K. Matthay, J. Neuhaus, W. London +8 more
2014Journal of Clinical Oncology185 citations Open access
Semantic Scholar
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
A. Moore, A. Faisal, D. D. de Castro, V. Bavetsias +14 more
2012Leukemia178 citations Open access
Semantic Scholar
A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
B. Geoerger, F. Bourdeaut, S. DuBois, M. Fischer +13 more
2017Clinical Cancer Research162 citations Open access
Semantic Scholar
Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1)
R. Ladenstein, U. Pötschger, D. Valteau-Couanet, R. Luksch +20 more
2020Cancers153 citations Open access
Semantic Scholar
Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo
J. Renshaw, Kathryn R. Taylor, Ryan Bishop, M. Valenti +11 more
2013Clinical Cancer Research145 citations Open access
Semantic Scholar
New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK
G. Barone, John Anderson, A. Pearson, K. Petrie +1 more
2013Clinical Cancer Research127 citations Open access
Semantic Scholar
Neuroblastoma mRNAs predict outcome in children with stage 4 neuroblastoma: a European HR-NBL1/SIOPEN study.
V. Viprey, W. Gregory, M. Corrias, A. Tchirkov +11 more
2014Journal of Clinical Oncology118 citations Open access
Semantic Scholar
How can attrition rates be reduced in cancer drug discovery?
L. Moreno, A. Pearson
2013Expert Opinion on Drug Discovery113 citations Open access
Semantic Scholar
Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.
K. Holmes, U. Pötschger, A. Pearson, S. Sarnacki +35 more
2020Journal of Clinical Oncology102 citations Open access
Semantic Scholar
Factors associated with recurrence and survival length following relapse in patients with neuroblastoma
N. Basta, G. Halliday, G. Makin, J. Birch +9 more
2016British Journal of Cancer95 citations Open access
Semantic Scholar
Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database.
D. Morgenstern, W. London, D. Stephens, S. Volchenboum +8 more
2016European Journal of Cancer86 citations
Semantic Scholar
A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors
M. Kieran, B. Geoerger, I. Dunkel, A. Broniscer +15 more
2019Clinical Cancer Research76 citations
Semantic Scholar
Neuroblastoma Survivors are at Increased Risk for Second Malignancies: A Report from the International Neuroblastoma Risk Group Project
M. Applebaum, Z. Vaksman, Sang-Mee Lee, E. Hungate +11 more
2016European Journal of Cancer76 citations Open access
Semantic Scholar
Implementation of mechanism of action biology-driven early drug development for children with cancer.
A. Pearson, R. Herold, R. Rousseau, Chris Copland +23 more
2016European Journal of Cancer69 citations Open access
Semantic Scholar
A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations
Sally L. George, E. Izquierdo, James J. Campbell, Eleni Koutroumanidou +33 more
2019European Journal of Cancer66 citations Open access
Semantic Scholar
Age, Diagnostic Category, Tumor Grade, and Mitosis-Karyorrhexis Index Are Independently Prognostic in Neuroblastoma: An INRG Project.
Elizabeth A. Sokol, A. Desai, M. Applebaum, D. Valteau-Couanet +9 more
2020Journal of Clinical Oncology65 citations Open access
Semantic Scholar
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.
L. Moreno, G. Barone, S. DuBois, J. Molenaar +34 more
2020European Journal of Cancer64 citations Open access
Semantic Scholar
ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.
A. Pearson, C. Rossig, G. Lesa, S. Diede +41 more
2020European Journal of Cancer60 citations Open access
Semantic Scholar
Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors
L. Vaughan, P. Clarke, K. Barker, Yvan H. Chanthery +13 more
2016OncoTarget60 citations Open access
Semantic Scholar
The prognostic strength of serum LDH and serum ferritin in children with neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project
Veronica Moroz, D. Machin, B. Hero, R. Ladenstein +6 more
2020Pediatric Blood & Cancer59 citations
Semantic Scholar
The challenge of defining “ultra‐high‐risk” neuroblastoma
D. Morgenstern, R. Bagatell, S. Cohn, M. Hogarty +8 more
2018Pediatric Blood & Cancer58 citations
Semantic Scholar
Adaptive dosing approaches to the individualization of 13-cis-retinoic acid (isotretinoin) treatment for children with high-risk neuroblastoma
G. Veal, J. Errington, Sophie E Rowbotham, Nicola A. Illingworth +5 more
2012Clinical Cancer Research56 citations Open access
Semantic Scholar
A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study
L. Moreno, L. Marshall, A. Pearson, B. Morland +14 more
2014Clinical Cancer Research52 citations Open access
Semantic Scholar
From class waivers to precision medicine in paediatric oncology.
A. Pearson, S. Pfister, A. Baruchel, J. Bourquin +15 more
2017The Lancet Oncology50 citations Open access
Semantic Scholar
MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance.
G. Barone, D. Tweddle, J. Shohet, L. Chesler +3 more
2014Current Drug Targets47 citations Open access
Semantic Scholar
Repeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort
N. Jerome, K. Miyazaki, D. Collins, M. Orton +9 more
2016European Radiology45 citations Open access
Semantic Scholar
ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children.
A. Pearson, Nicole Scobie, K. Norga, Franca Ligas +35 more
2019European Journal of Cancer43 citations Open access
Semantic Scholar
Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project
L. Moreno, H. Caron, B. Geoerger, A. Eggert +25 more
2017Expert Opinion on Drug Discovery39 citations Open access
Semantic Scholar
Metastatic neuroblastoma confined to distant lymph nodes (stage 4N) predicts outcome in patients with stage 4 disease: A study from the International Neuroblastoma Risk Group Database.
D. Morgenstern, W. London, D. Stephens, S. Volchenboum +9 more
2014Journal of Clinical Oncology39 citations Open access
Semantic Scholar
Phase 1 study of dabrafenib in pediatric patients (pts) with relapsed or refractory BRAF V600E high- and low-grade gliomas (HGG, LGG), Langerhans cell histiocytosis (LCH), and other solid tumors (OST).
M. Kieran, D. Hargrave, K. Cohen, I. Aerts +16 more
201538 citations
Semantic Scholar
Phase I study of ceritinib in pediatric patients (Pts) with malignancies harboring a genetic alteration in ALK (ALK+): Safety, pharmacokinetic (PK), and efficacy results.
B. Geoerger, J. Schulte, C. Zwaan, M. Casanova +13 more
201537 citations
Semantic Scholar
Evaluation of Clinically Translatable Magnetic Resonance Imaging Biomarkers of Therapeutic Response in the TH-MYCN Transgenic Mouse Model of Neuroblastoma
Y. Jamin, E. Tucker, E. Poon, S. Popov +10 more
2012Radiology37 citations Open access
Semantic Scholar
Paediatric Strategy Forum for medicinal product development for acute myeloid leukaemia in children and adolescents
A. Pearson, C. Zwaan, E. Kolb, Dominik Karres +36 more
2020European Journal of Cancer36 citations Open access
Semantic Scholar
A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high‐risk neuroblastoma: An International Neuroblastoma Risk Group project
L. Moreno, D. Guo, M. Irwin, F. Berthold +11 more
2020Pediatric Blood & Cancer35 citations
Semantic Scholar
Pseudoprogression in children, adolescents and young adults with non-brainstem high grade glioma and diffuse intrinsic pontine glioma
F. Carceller, Lucy A. Fowkes, K. Khabra, L. Moreno +18 more
2016Journal of Neuro-Oncology34 citations
Semantic Scholar
Toxicity and Outcome of Children and Adolescents Participating in Phase I/II Trials of Novel Anticancer Drugs: The Royal Marsden Experience
D. Morgenstern, D. Hargrave, L. Marshall, S. Gatz +9 more
2014Journal of pediatric hematology/oncology31 citations
Semantic Scholar
A phase 1 study of oral ridaforolimus in pediatric patients with advanced solid tumors
A. Pearson, Sara M. Federico, I. Aerts, D. Hargrave +7 more
2016OncoTarget30 citations Open access
Semantic Scholar
Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma
Konstantinos Zormpas-Petridis, E. Poon, M. Clarke, N. Jerome +15 more
2020Cancer Research27 citations
Semantic Scholar
Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study
K. Miyazaki, N. Jerome, D. Collins, M. Orton +9 more
2015European Radiology26 citations Open access
Semantic Scholar
Lactate and Choline Metabolites Detected In Vitro by Nuclear Magnetic Resonance Spectroscopy Are Potential Metabolic Biomarkers for PI3K Inhibition in Pediatric Glioblastoma
N. Al-Saffar, L. Marshall, L. Jackson, G. Balarajah +7 more
2014PLoS ONE26 citations Open access
Semantic Scholar
Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group
I. Ambros, G. Tonini, U. Pötschger, N. Gross +39 more
2020Journal of Clinical Oncology25 citations Open access
Semantic Scholar
Quizartinib-resistant FLT3-ITD acute myeloid leukemia cells are sensitive to the FLT3-Aurora kinase inhibitor CCT241736.
A. Moore, A. Faisal, Grace W. Y. Mak, F. Miraki-Moud +14 more
2020Blood Advances24 citations Open access
Semantic Scholar
Bromodomain and extra-terminal inhibitors-A consensus prioritisation after the Paediatric Strategy Forum for medicinal product development of epigenetic modifiers in children-ACCELERATE.
A. Pearson, S. DuBois, Vickie Buenger, M. Kieran +25 more
2021European Journal of Cancer23 citations Open access
Semantic Scholar
Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
A. Pearson, K. Stegmaier, F. Bourdeaut, G. Reaman +34 more
2020European Journal of Cancer22 citations Open access
Semantic Scholar
Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours.
D. Frappaz, Sara M. Federico, A. Pearson, L. Gore +8 more
2016European Journal of Cancer22 citations
Semantic Scholar
Prognostic factors of overall survival in children and adolescents enrolled in dose-finding trials in Europe: An Innovative Therapies for Children with Cancer study.
F. Carceller, F. Bautista, I. Jimenez, Raquel Hladun-Álvaro +14 more
2016European Journal of Cancer21 citations
Semantic Scholar

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