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Khalil H. Bdeir · SciRah

Researcher profile · Semantic Scholar

Khalil H. Bdeir

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Khalil H. Bdeir — researcher profile on SciRah

h-index: 40
Works: 120
Citations: 3,952

Most-cited papers

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis
H. Langer, E. Choi, Hong Zhou, Rebecca Schleicher +23 more
2012Circulation Research207 citations Open access
Semantic Scholar
Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac‐1 integrin
S. Sotiriou, V. Orlova, N. Al-Fakhri, Eveliina Ihanus +8 more
2006The FASEB Journal180 citations
Semantic Scholar
Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner.
Guangyao Yu, A. Rux, Peihong Ma, Khalil H. Bdeir +1 more
2005Blood135 citations Open access
Semantic Scholar
Regulation of neovascularization by human neutrophil peptides (α‐defensins): a link between inflammation and angiogenesis
T. Chavakis, D. Cines, Joong-Sup Rhee, Olin D. Liang +6 more
2004The FASEB Journal131 citations
Semantic Scholar
In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone.
T. Nassar, S. Akkawi, A. Shina, A. Haj-Yehia +4 more
2004Blood116 citations Open access
Semantic Scholar
Structural basis of interaction between urokinase-type plasminogen activator and its receptor.
C. Bařinka, G. Parry, J. Callahan, D. E. Shaw +5 more
2006Journal of Molecular Biology109 citations Open access
Semantic Scholar
Developmental endothelial locus-1 (Del-1) is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination
E. Choi, Jong-Hyung Lim, A. Neuwirth, M. Economopoulou +18 more
2014Molecular Psychiatry84 citations Open access
Semantic Scholar
Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.
Khalil H. Bdeir, A. Higazi, I. Kulikovskaya, M. Christofidou-Solomidou +6 more
2010American Journal of Respiratory and Critical Care Medicine84 citations Open access
Semantic Scholar
Blood Clearance and Activity of Erythrocyte-Coupled Fibrinolytics
K. Ganguly, Tatiana Krasik, Sandra P Medinilla, Khalil H. Bdeir +3 more
2005Journal of Pharmacology and Experimental Therapeutics80 citations
Semantic Scholar
Nuclear translocation of urokinase-type plasminogen activator.
V. Stepanova, T. Lebedeva, A. Kuo, S. Yarovoi +9 more
2008Blood75 citations Open access
Semantic Scholar
Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.
V. Pillai, J. Bao, C. Zander, Jenny K. McDaniel +5 more
2016Blood71 citations Open access
Semantic Scholar
Inhibition of pathologic retinal neovascularization by α-defensins
M. Economopoulou, Khalil H. Bdeir, D. Cines, F. Fogt +6 more
200564 citations
Semantic Scholar
Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability.
Rami Abu-Fanne, V. Stepanova, R. Litvinov, Suhair Abdeen +8 more
2019Blood63 citations Open access
Semantic Scholar
Platelet‐Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury
Khalil H. Bdeir, K. Gollomp, M. Stasiak, Mei Junjie +6 more
2016American Journal of Respiratory Cell and Molecular Biology63 citations Open access
Semantic Scholar
Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression*
V. Stepanova, Padma-Sheela Jayaraman, S. Zaitsev, T. Lebedeva +8 more
2016Journal of Biological Chemistry63 citations Open access
Semantic Scholar
The kringle stabilizes urokinase binding to the urokinase receptor.
Khalil H. Bdeir, A. Kuo, B. Sachais, A. Rux +4 more
2003Blood59 citations
Semantic Scholar
Targeting of a Mutant Plasminogen Activator to Circulating Red Blood Cells for Prophylactic Fibrinolysis
S. Zaitsev, D. Spitzer, J. Murciano, B. Ding +9 more
2010Journal of Pharmacology and Experimental Therapeutics58 citations Open access
Semantic Scholar
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes.
Michele P. Lambert, Yuhuan Wang, Khalil H. Bdeir, Y. Nguyen +2 more
2009Blood58 citations Open access
Semantic Scholar
Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin αvβ3 induces signal transduction and enhances plasminogen activation
T. Tarui, N. Akakura, M. Majumdar, N. Andronicos +7 more
2006Thrombosis and Haemostasis54 citations Open access
Semantic Scholar
Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK–mediated pathway
S. Kwak, Xue-qing Wang, Qianbin He, Wen-Feng Fang +7 more
2006Thrombosis and Haemostasis53 citations
Semantic Scholar
The kringle domain of urokinase‐type plasminogen activator potentiates LPS‐induced neutrophil activation through interaction with αVβ3 integrins
S. Kwak, Sanchayita Mitra, Khalil H. Bdeir, D. Strassheim +5 more
200548 citations
Semantic Scholar
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
D. Yuh, T. Maekawa, Xiaofei Li, T. Kajikawa +3 more
2020Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by Surface Plasmon Resonance (BiaCore)
R. Pixley, R. Espinola, B. Ghebrehiwet, K. Joseph +4 more
2011Thrombosis and Haemostasis46 citations Open access
Semantic Scholar
Signaling, Delivery and Age as Emerging Issues in the Benefit/Risk Ratio Outcome of tPA For Treatment of CNS Ischemic Disorders
W. Armstead, K. Ganguly, J. Kiessling, John Riley +8 more
2010Journal of Neurochemistry46 citations Open access
Semantic Scholar
Adrenomedullin Prevents Sex-Dependent Impairment of Autoregulation during Hypotension after Piglet Brain Injury through Inhibition of ERK MAPK Upregulation
W. Armstead, J. Kiessling, Khalil H. Bdeir, W. Kofke +1 more
2010Journal of Neurotrauma44 citations Open access
Semantic Scholar
Integrin alphaMbeta2 orchestrates and accelerates plasminogen activation and fibrinolysis by neutrophils.
E. Pluskota, D. Soloviev, Khalil H. Bdeir, D. Cines +1 more
2004Journal of Biological Chemistry44 citations
Semantic Scholar
Inhibition of pathologic retinal neovascularization by alpha-defensins.
M. Economopoulou, Khalil H. Bdeir, D. Cines, F. Fogt +6 more
2005Blood42 citations
Semantic Scholar
Proteomic identification of lynchpin urokinase plasminogen activator receptor protein interactions associated with epithelial cancer malignancy.
R. Saldanha, M. Molloy, Khalil H. Bdeir, D. Cines +5 more
2007Journal of Proteome Research41 citations
Semantic Scholar
α-Defensin: Link between inflammation and atherosclerosis
H. Nassar, E. Lavi, S. Akkawi, Khalil H. Bdeir +4 more
200738 citations
Semantic Scholar
Involvement of the Urokinase Kringle Domain in Lipopolysaccharide-Induced Acute Lung Injury1
Xue-qing Wang, Khalil H. Bdeir, S. Yarovoi, D. Cines +2 more
2006Journal of Immunology38 citations Open access
Semantic Scholar
Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling.
T. Tarui, N. Andronicos, R. Czekay, A. Mazar +6 more
2003Journal of Biological Chemistry37 citations
Semantic Scholar
Induction of Plasminogen Activator Inhibitor-1 by Urokinase in Lung Epithelial Cells*
S. Shetty, Khalil H. Bdeir, D. Cines, S. Idell
2003Journal of Biological Chemistry37 citations Open access
Semantic Scholar
The DEL-1-β3 integrin axis promotes regulatory T cell responses during inflammation resolution.
Xiaofei Li, Alessandra Colamatteo, Lydia Kalafati, T. Kajikawa +12 more
2020Journal of Clinical Investigation33 citations Open access
Semantic Scholar
Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury.
Y. Bhandary, T. Velusamy, Praveenkumar Shetty, R. Shetty +7 more
2009American Journal of Respiratory and Critical Care Medicine32 citations Open access
Semantic Scholar
RBC-coupled tPA Prevents Impairment of Cerebral Vasodilatory Responses and Tissue Injury In Pediatric Cerebral Hypoxia/Ischemia Through Inhibition of ERK MAPK Activation
W. Armstead, K. Ganguly, J. Kiessling, Xiao-Han Chen +6 more
2009Journal of Cerebral Blood Flow and Metabolism32 citations Open access
Semantic Scholar
Fibrin Affinity of Erythrocyte-Coupled Tissue-Type Plasminogen Activators Endures Hemodynamic Forces and Enhances Fibrinolysis in Vivo
K. Ganguly, Mukul S. Goel, T. Krasik, Khalil H. Bdeir +4 more
2006Journal of Pharmacology and Experimental Therapeutics31 citations
Semantic Scholar
Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activation.
T. Tarui, N. Akakura, M. Majumdar, N. Andronicos +7 more
2006Thrombosis and Haemostasis30 citations
Semantic Scholar
Lipoprotein receptor-related protein 1 regulates collagen 1 expression, proteolysis, and migration in human pleural mesothelial cells.
T. Tucker, Laterrica C. Williams, K. Koenig, H. Kothari +7 more
2012American Journal of Respiratory Cell and Molecular Biology29 citations Open access
Semantic Scholar
Induction of tissue factor by urokinase in lung epithelial cells and in the lungs.
S. Shetty, Y. Bhandary, Shwetha K. Shetty, T. Velusamy +10 more
2010American Journal of Respiratory and Critical Care Medicine28 citations Open access
Semantic Scholar
uPA Impairs Cerebrovasodilation After Hypoxia/Ischemia Through LRP and ERK MAPK
W. Armstead, D. Cines, Khalil H. Bdeir, I. Kulikovskaya +2 more
2008Brain Research28 citations Open access
Semantic Scholar
The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins.
S. Kwak, Sanchayita Mitra, Khalil H. Bdeir, D. Strassheim +5 more
2005Journal of Leukocyte Biology27 citations
Semantic Scholar
INTRAPLEURAL LOW-MOLECULAR-WEIGHT UROKINASE OR TISSUE PLASMINOGEN ACTIVATOR VERSUS SINGLE-CHAIN UROKINASE IN TETRACYCLINE-INDUCED PLEURAL LOCULATION IN RABBITS
S. Idell, A. Azghani, Shan-Chiung Chen, K. Koenig +6 more
2007Experimental Lung Research25 citations
Semantic Scholar
ADAMTS13 Autoantibodies Cloned from Patients with Acquired Thrombotic Thrombocytopenic Purpura: 2. Pathogenicity in an animal model
E. Ostertag, Khalil H. Bdeir, Stephen Kacir, Michelle Thiboutot +8 more
2016Transfusion24 citations Open access
Semantic Scholar
alpha-Defensin: link between inflammation and atherosclerosis.
H. Nassar, E. Lavi, S. Akkawi, Khalil H. Bdeir +4 more
2007Atherosclerosis24 citations
Semantic Scholar
tPA regulates pulmonary vascular activity through NMDA receptors.
T. Nassar, Khalil H. Bdeir, S. Yarovoi, R. A. Fanne +5 more
2011American Journal of Physiology - Lung cellular and Molecular Physiology23 citations Open access
Semantic Scholar
uPA modulates the age-dependent effect of brain injury on cerebral hemodynamics through LRP and ERK MAPK
W. Armstead, D. Cines, Khalil H. Bdeir, Yasmina Bdeir +2 more
2008Journal of Cerebral Blood Flow and Metabolism23 citations Open access
Semantic Scholar
Alpha‐defensins: risk factor for thrombosis in COVID‐19 infection
Suhair Abdeen, Khalil H. Bdeir, Rami Abu-Fanne, E. Maraga +9 more
2021British Journal of Haematology21 citations Open access
Semantic Scholar
Urokinase-type Plasminogen Activator (uPA) Induces Pulmonary Microvascular Endothelial Permeability through Low Density Lipoprotein Receptor-related Protein (LRP)-dependent Activation of Endothelial Nitric-oxide Synthase*
Anastasia M. Makarova, T. Lebedeva, T. Nassar, A. Higazi +5 more
2011Journal of Biological Chemistry21 citations Open access
Semantic Scholar
Urokinase induces activation of STAT3 in lung epithelial cells.
S. Shetty, G. Rao, D. Cines, Khalil H. Bdeir
2006American Journal of Physiology - Lung cellular and Molecular Physiology21 citations
Semantic Scholar
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils.
Yan-Ping Yang, A. Friggeri, Sami Banerjee, Khalil H. Bdeir +3 more
2010American Journal of Respiratory and Critical Care Medicine18 citations Open access
Semantic Scholar

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D. Cines×38
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D. Cines — researcher profile on SciRah
A. Higazi×11
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S. Idell×10
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T. Chavakis×7
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A. Mazar — researcher profile on SciRah

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V. Muzykantov — researcher profile on SciRah

V. Stepanova×5

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V. Stepanova — researcher profile on SciRah

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S. Yarovoi — researcher profile on SciRah

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S. Zaitsev — researcher profile on SciRah

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W. Armstead — researcher profile on SciRah