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O. Barbash · SciRah

Researcher profile · Semantic Scholar

O. Barbash

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O. Barbash — researcher profile on SciRah

h-index: 29
Works: 63
Citations: 5,017

Most-cited papers

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G. Kuplast, C. Majer, P. Boriack-Sjodin +26 more
2015Nature Chemical Biology507 citations
Semantic Scholar
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
P. Mazur, N. Reynoird, P. Khatri, P. Jansen +13 more
2014Nature362 citations Open access
Semantic Scholar
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
Helai P. Mohammad, O. Barbash, C. Creasy
2019Nature Medicine340 citations
Semantic Scholar
Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex
D. Lin, O. Barbash, K. Suresh Kumar, J. Weber +5 more
2006332 citations Open access
Semantic Scholar
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
A. Fedoriw, Satyajit R. Rajapurkar, S. O'Brien, Sarah V. Gerhart +43 more
2019Cancer Cell290 citations Open access
Semantic Scholar
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
Jia-Yi Fong, L. Pignata, Pierre-Alexis Goy, K. Kawabata +31 more
2019Cancer Cell248 citations Open access
Semantic Scholar
Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.
D. Lin, O. Barbash, K. Suresh Kumar, J. Weber +5 more
2006Molecules and Cells220 citations
Semantic Scholar
Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.
A. Chaidos, Valentina S Caputo, Katerina Gouvedenou, Binbin Liu +21 more
2014Blood199 citations
Semantic Scholar
BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
Anastasia Wyce, G. Ganji, Kimberly N. Smitheman, C. Chung +15 more
2013PLoS ONE189 citations Open access
Semantic Scholar
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression
Kelly Chiang, A. Zielinska, A. Shaaban, María Pilar Sánchez-Bailón +11 more
2017Cell Reports186 citations Open access
Semantic Scholar
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
S. Piha-Paul, C. Hann, C. French, S. Cousin +21 more
2019JNCI Cancer Spectrum172 citations Open access
Semantic Scholar
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer
Anastasia Wyce, Y. Degenhardt, Yuchen Bai, Baochau Le +7 more
2013OncoTarget170 citations Open access
Semantic Scholar
Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
Charles C. Bell, K. A. Fennell, Yih-Chih Chan, F. Rambow +32 more
2019Nature Communications167 citations Open access
Semantic Scholar
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation
G. V. Van Aller, N. Reynoird, O. Barbash, Michael J. Huddleston +12 more
2012Epigenetics166 citations Open access
Semantic Scholar
Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
Sarah V. Gerhart, Wendy A. Kellner, Christine Thompson, M. Pappalardi +12 more
2018Scientific Reports165 citations Open access
Semantic Scholar
Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1
S. Benzeno, Fengmin Lu, M. Guo, O. Barbash +5 more
2006Oncogene152 citations Open access
Semantic Scholar
Mutations in Fbx4 inhibit phosphorylation-dependent dimerization of the SCFFbx4 ligase and contribute to cyclin D1 overexpression in human cancer
O. Barbash, Petia Zamfirova, D. Lin, Xiang-Mei Chen +5 more
2008Cancer Cell147 citations Open access
Semantic Scholar
The Oxidative Stressor Arsenite Activates Vascular Endothelial Growth Factor mRNA Transcription by an ATF4-dependent Mechanism*
C. Roybal, L. A. Hunsaker, O. Barbash, D. L. Vander Jagt +1 more
2005Journal of Biological Chemistry143 citations Open access
Semantic Scholar
Expression of Angiogenic Factors Vascular Endothelial Growth Factor and Interleukin-8/CXCL8 Is Highly Responsive to Ambient Glutamine Availability
Ekaterina V. Bobrovnikova-Marjon, P. Marjon, O. Barbash, D. L. Vander Jagt +1 more
2004Cancer Research109 citations Open access
Semantic Scholar
Genotoxic Stress-Induced Cyclin D1 Phosphorylation and Proteolysis Are Required for Genomic Stability
Laura L. Pontano, Priya Aggarwal, O. Barbash, E. Brown +2 more
2008Molecular and Cellular Biology76 citations Open access
Semantic Scholar
Targeting Histone Methylation in Cancer.
M. McCabe, Helai P. Mohammad, O. Barbash, Ryan G. Kruger
2017Cancer Journal61 citations
Semantic Scholar
‘Z4’ Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism
H. Shiota, Janine E. Elya, A. A. Alekseyenko, P. Chou +7 more
2018Molecular Cancer Research57 citations Open access
Semantic Scholar
The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation
L. P. Vaites, E. Lee, Z. Lian, O. Barbash +5 more
2011Molecular and Cellular Biology49 citations Open access
Semantic Scholar
Homologous Recombination Deficiency: Concepts, Definitions, and Assays
M. Stewart, Diana Merino Vega, R. Arend, J. Baden +21 more
2022The Oncologist45 citations Open access
Semantic Scholar
A Phase I/II Study to Investigate the Safety and Clinical Activity of the Protein Arginine Methyltransferase 5 Inhibitor GSK3326595 in Subjects with Myelodysplastic Syndrome and Acute Myeloid Leukemia
J. Watts, T. Bradley, A. Thomassen, A. Brunner +8 more
2019Blood37 citations Open access
Semantic Scholar
SCFFbx4/αB-crystallin E3 ligase: When one is not enough
O. Barbash, J. Diehl
200837 citations Open access
Semantic Scholar
The FBXO4 Tumor Suppressor Functions as a Barrier to BrafV600E-Dependent Metastatic Melanoma
E. Lee, Zhao Lian, K. D'Andrea, Richard Letrero +11 more
2013Molecular and Cellular Biology36 citations Open access
Semantic Scholar
to Cyclin D1 Overexpression in Human Cancer
O. Barbash, Petia Zamfirova, D. Lin, Xiang-Mei Chen +5 more
200832 citations
Semantic Scholar
MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers
Anastasia Wyce, Jeanne J. Matteo, Shawn W. Foley, D. Felitsky +14 more
2018Oncogenesis31 citations Open access
Semantic Scholar
Inhibiting Type I arginine methyltransferase activity promotes T cell-mediated antitumor immune responses
A. Fedoriw, Leilei Shi, S. O'Brien, Kimberly N. Smitheman +16 more
2022Cancer immunology research29 citations Open access
Semantic Scholar
Phosphorylation-dependent regulation of SCFFbx4 dimerization and activity involves a novel component, 14-3-3ε
O. Barbash, E. Lee, J. Diehl
2011Oncogene29 citations Open access
Semantic Scholar
SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy
O. Barbash, D. Lin, J. Diehl
2007Cell Division28 citations Open access
Semantic Scholar
Abstract CT014: GSK525762, a selective bromodomain (BRD) and extra terminal protein (BET) inhibitor: results from part 1 of a phase I/II open-label single-agent study in patients with NUT midline carcinoma (NMC) and other cancers
P. O'Dwyer, S. Piha-Paul, C. French, Sara Harward +12 more
201626 citations
Semantic Scholar
TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma
T. Erazo, Chiara M. Evans, D. Zakheim, Eren L. Chu +19 more
2022Nature Communications25 citations Open access
Semantic Scholar
A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies
M. Dawson, G. Borthakur, Brian J. P. Huntly, A. Karadimitris +27 more
2022Clinical Cancer Research25 citations Open access
Semantic Scholar
SCF(Fbx4/alphaB-crystallin) E3 ligase: when one is not enough.
O. Barbash, J. Diehl
2008Cell Cycle24 citations
Semantic Scholar
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
Viral Shah, G. Giotopoulos, H. Osaki, Markus Meyerhöfer +25 more
2024Blood19 citations Open access
Semantic Scholar
Limited Anti-Tumor Activity of Combined BET and MEK Inhibition in Neuroblastoma
J. Healy, Lori S. Hart, Alexander L Shazad, M. Gagliardi +12 more
2020Pediatric Blood & Cancer18 citations Open access
Semantic Scholar
A Phase I/II Study of GSK525762 Combined with Fulvestrant in Patients with Hormone Receptor–positive/HER2-negative Advanced or Metastatic Breast Cancer
D. Cescon, J. Hilton, Serafín Morales Murilo, R. Layman +16 more
2023Clinical Cancer Research13 citations Open access
Semantic Scholar
11 – Regulation of the Cell Cycle
Yan Li, O. Barbash, J. Diehl
200812 citations
Semantic Scholar
A Chemical Acetylation-Based Mass Spectrometry Platform for Histone Methylation Profiling
F. Zappacosta, C. Wagner, Anthony Della Pietra, Sarah V. Gerhart +6 more
2021Molecular & Cellular Proteomics10 citations Open access
Semantic Scholar
456MO METEOR-1: A phase I study of the safety and efficacy of the protein arginine methyltransferase 5 (PRMT5) inhibitor GSK3326595 in advanced solid tumors
S. Postel-Vinay, A. Italiano, P. Romano, P. Cassier +16 more
2022Annals of Oncology9 citations Open access
Semantic Scholar
Abstract CT038: A phase I, open-label, dose-escalation study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of GSK3326595 in subjects with solid tumors and non-Hodgkin's lymphoma
D. Rasco, A. Tolcher, L. Siu, K. Heinhuis +7 more
20178 citations
Semantic Scholar
A phase Ib open-label, dose escalation and expansion study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK525762 in combination with abiraterone or enzalutamide in metastatic castrate-resistant prostate cancer.
U. Vaishampayan, V. Narayan, D. Wise, J. Lang +14 more
20187 citations
Semantic Scholar
Identification of a First-in-Class PRMT5 Inhibitor with Potent in Vitro and in Vivo Activity in Preclinical Models of Mantle Cell Lymphoma
Elayne Penebre, Kristy G. Kuplast, C. Majer, L. Johnston +21 more
20146 citations
Semantic Scholar
A phase I/II dose escalation and expansion study to investigate the safety, pharmacokinetics, pharmacodynamics and clinical activity of GSK525762 in combination with fulvestrant in subjects with ER+ breast cancer.
J. Sparano, D. Cescon, M. Oliveira, D. Stover +9 more
20175 citations
Semantic Scholar
B and Activating Protein-1 κ Nuclear Factor-Responsive to Ambient Glutamine Availability : Role of Growth Factor and Interleukin-8 / CXCL 8 Is Highly Expression of Angiogenic Factors Vascular Endothelial
Ekaterina V. Bobrovnikova-Marjon, P. Marjon, O. Barbash, D. L. Vander Jagt +1 more
20045 citations
Semantic Scholar
Chapter 13 – Regulation of the Cell Cycle
O. Barbash, J. Diehl
20083 citations
Semantic Scholar
Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials
Hailei Zhang, Ania Rutkowska, A. González-Martín, M. Mirza +8 more
2024Cancer Research Communications2 citations Open access
Semantic Scholar
Abstract 4693: Mechanism-based combination strategies for BET inhibitors in NUT midline carcinoma
Anastasia Wyce, P. Soden, D. Felitsky, Jeanne J. Matteo +8 more
20162 citations
Semantic Scholar

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