Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

Brian J. P. Huntly · SciRah

Researcher profile · Semantic Scholar

Brian J. P. Huntly

Share profile

Brian J. P. Huntly — researcher profile on SciRah

h-index: 53
Works: 202
Citations: 20K

Most-cited papers

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
K. Tzelepis, Hiroko Koike-Yusa, E. De Braekeleer, Yi-Long Li +23 more
2016Cell Reports630 citations Open access
Semantic Scholar
BET inhibitor resistance emerges from leukaemia stem cells
C. Fong, O. Gilan, E. Lam, Alan F. Rubin +22 more
2015Nature519 citations Open access
Semantic Scholar
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy
D. Forte, M. García-Fernández, Abel Sánchez-Aguilera, V. Stavropoulou +20 more
2020Cell Metabolism188 citations Open access
Semantic Scholar
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
M. Gozdecka, Eshwar Meduri, M. Mazan, K. Tzelepis +23 more
2018Nature Genetics145 citations Open access
Semantic Scholar
Functional interdependence of BRD4 and DOT1L in MLL leukemia
O. Gilan, E. Lam, Isabelle Becher, Dave Lugo +27 more
2016Nature Structural &Molecular Biology105 citations Open access
Semantic Scholar
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A. Krupka, Jie Gao, N. Grigoropoulos +33 more
2020Molecules and Cells83 citations Open access
Semantic Scholar
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms
B. Wyspianska, Andrew J. Bannister, I. Barbieri, J. Nangalia +13 more
2014Leukemia71 citations Open access
Semantic Scholar
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors
S. Horton, G. Giotopoulos, Hai-Yang Yun, S. Vohra +27 more
2017Nature Cell Biology65 citations Open access
Semantic Scholar
Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.
Thomas McKerrell, T. Moreno, H. Ponstingl, N. Bolli +28 more
2016Blood59 citations Open access
Semantic Scholar
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia
P. Gallipoli, G. Giotopoulos, Brian J. P. Huntly
2015Therapeutic Advances in Hematology56 citations Open access
Semantic Scholar
Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Christopher A. G. Booth, Nikolaos Barkas, Wen Hao Neo, Hanane Boukarabila +16 more
2018Cancer Cell55 citations Open access
Semantic Scholar
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development
Neil A. Barrett, C. Malouf, C. Kapeni, Wendi A. Bacon +4 more
2016Cell Reports46 citations Open access
Semantic Scholar
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
A. F. Domingues, R. Kulkarni, G. Giotopoulos, Shikha Gupta +11 more
2020eLife43 citations Open access
Semantic Scholar
BET bromodomain inhibitors in leukemia.
Faisal Basheer, Brian J. P. Huntly
2015Experimental Hematology40 citations Open access
Semantic Scholar
Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications
L. Marando, Brian J. P. Huntly
2020Current Oncology Reports38 citations Open access
Semantic Scholar
A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression
G. Giotopoulos, L. van der Weyden, H. Osaki, A. Rust +12 more
2015Journal of Experimental Medicine38 citations Open access
Semantic Scholar
Real‐world tyrosine kinase inhibitor treatment pathways, monitoring patterns and responses in patients with chronic myeloid leukaemia in the United Kingdom: the UK TARGET CML study
D. Milojkovic, N. Cross, Sahra Ali, J. Byrne +18 more
2020British Journal of Haematology31 citations Open access
Semantic Scholar
A Phase I Study of GSK525762, a Selective Bromodomain (BRD) and Extra Terminal Protein (BET) Inhibitor: Results from Part 1 of Phase I/II Open Label Single Agent Study in Patients with Acute Myeloid Leukemia (AML)
M. Dawson, E. Stein, Brian J. P. Huntly, A. Karadimitris +17 more
201731 citations
Semantic Scholar
Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5+/− leukemia
L. van der Weyden, G. Giotopoulos, K. Wong, A. Rust +4 more
2015BMC Cancer27 citations Open access
Semantic Scholar
Novel epigenetic therapies in hematological malignancies: Current status and beyond.
P. Gallipoli, Brian J. P. Huntly
2017Seminars in Cancer Biology26 citations Open access
Semantic Scholar
A Phase I/II Open-Label Study of Molibresib for the Treatment of Relapsed/Refractory Hematologic Malignancies
M. Dawson, G. Borthakur, Brian J. P. Huntly, A. Karadimitris +27 more
2022Clinical Cancer Research25 citations Open access
Semantic Scholar
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
Liliana Arede, Elena Foerner, S. Wind, R. Kulkarni +15 more
2021Blood Advances22 citations Open access
Semantic Scholar
Novel and Rare Fusion Transcripts Involving Transcription Factors and Tumor Suppressor Genes in Acute Myeloid Leukemia
A. Padella, G. Simonetti, Giulia Paciello, G. Giotopoulos +23 more
2019Cancers22 citations Open access
Semantic Scholar
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
Viral Shah, G. Giotopoulos, H. Osaki, Markus Meyerhöfer +25 more
2024Blood19 citations Open access
Semantic Scholar
Histone modifiers are oxygen sensors
P. Gallipoli, Brian J. P. Huntly
2019Science19 citations Open access
Semantic Scholar
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes
Tomoya Isobe, I. Kucinski, Melania Barile, Xiaonan Wang +20 more
2023Cell Genomics14 citations Open access
Semantic Scholar
A Phase I Study of Molibresib (GSK525762), a Selective Bromodomain (BRD) and Extra Terminal Protein (BET) Inhibitor: Results from Part 1 of a Phase I/II Open Label Single Agent Study in Subjects with Non-Hodgkin's Lymphoma (NHL)
M. Dickinson, M. Kamdar, Brian J. P. Huntly, Carlos Fernández de Larrea +19 more
2018Blood12 citations
Semantic Scholar
The RNA editing landscape in acute myeloid leukemia reveals associations with disease mutations and clinical outcome
Eshwar Meduri, C. Breeze, L. Marando, Simon E. Richardson +1 more
2022iScience11 citations Open access
Semantic Scholar
A Phase I/II Open-Label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK525762 in Subjects with Relapsed, Refractory Hematologic Malignancies
G. Borthakur, M. Dawson, E. Stein, A. Karadimitris +8 more
201611 citations
Semantic Scholar
Machine Learning Provides Individualized Prediction of Outcomes after First Complete Remission in Adult AML Patients - Results from the Harmony Platform
A. Hernández Sánchez, Javier Martínez Elicegui, M. Sobas, E. Sträng +37 more
2023Blood9 citations
Semantic Scholar
Sialic acid‐binding immunoglobulin‐like lectin (Sigelac)‐15 is a rapidly internalised cell‐surface antigen expressed by acute myeloid leukaemia cells
Huan Cao, Andreas Neerincx, B. Bono, U. Lakner +8 more
2021British Journal of Haematology8 citations Open access
Semantic Scholar
Independence of epigenetic and genetic diversity in AML
D. Sasca, Brian J. P. Huntly
2016Nature Medicine8 citations Open access
Semantic Scholar
Influence of Bone Marrow Blast Enumeration and Co-Occurring Myelodysplasia Related Gene Mutations in NPM1-Mutated Myeloid Malignancies
C. Lachowiez, Georgios Asimomitis, E. Bernard, Ivory Tang +10 more
2023Blood6 citations
Semantic Scholar
Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting
Katharina M. Lang, K. Harrison, P. Williamson, Brian J. P. Huntly +8 more
2019Trials6 citations Open access
Semantic Scholar
Harmony Alliance Provides a Machine Learning Researching Tool to Predict the Risk of Relapse after First Remission in AML Patients Treated without Allogeneic Haematopoietic Stem Cell Transplantation
M. Sobas, Javier Martínez Elicegui, Ángela Villaverde Ramiro, T. González +40 more
2021Blood4 citations Open access
Semantic Scholar
Outcomes of Relapsed/Refractory Patients with IDH1/2 Mutated AML Treated with Non-Targeted Therapy: Results from the NCRI AML Trials
R. Hills, R. Gale, D. Linch, Brian J. P. Huntly +4 more
2018Blood4 citations Open access
Semantic Scholar
Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia
R. Mecklenbrauck, Ángela Villaverde Ramiro, E. Sträng, R. Gabdoulline +26 more
2026Leukemia3 citations Open access
Semantic Scholar
Interim Analysis of Promise, a Clinical Study Combining the BET Inhibitor OPN-2853 with Ruxolitinib in Patients with Advanced Myelofibrosis Experiencing an Inadequate Response to Ruxolitinib
A. Mead, Brian J. P. Huntly, B. Psaila, C. Harrison +5 more
2024Blood3 citations
Semantic Scholar
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation
V. Shah, G. Giotopoulos, H. Osaki, Markus Meyerhöfer +16 more
2022bioRxiv3 citations Open access
Semantic Scholar
Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion
Shannon Burke, Jue-Xuan Wang, Xiong-Feng Chen, Mariaestela Ortiz +8 more
20153 citations
Semantic Scholar
Acoustic chip for rapid label-free early-stage detection of rare leukemic cells
Bruno F.E. Matarèse, Andrew J. Flewitt, Brian J. P. Huntly
2024bioRxiv2 citations Open access
Semantic Scholar
Integrated functional genomic screening to bypass TKI resistance in chronic myeloid leukemia
Tumas Beinortas, Brian J. P. Huntly
2024Cell Reports Medicine2 citations Open access
Semantic Scholar
Targeting Chromatin Regulation in Acute Myeloid Leukemia
Simon E. Richardson, Brian J. P. Huntly
2021HemaSphere2 citations Open access
Semantic Scholar
Genetic Vulnerabilities of DNMT3AR882H in Myeloid Malignancies
M. Gozdecka, Monika Dudek, K. Tzelepis, Aristi Damaskou +8 more
2019Blood2 citations Open access
Semantic Scholar
Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML.
G. Giotopoulos, Brian J. P. Huntly
2018Cancer Cell2 citations Open access
Semantic Scholar
Prognostic models turn the Heat(IT)up on FLT3ITD-mutated AML
P. Gallipoli, Brian J. P. Huntly
2018Clinical Cancer Research2 citations Open access
Semantic Scholar
Faculty Opinions recommendation of The landscape of accessible chromatin in mammalian preimplantation embryos.
Brian J. P. Huntly
20162 citations
Semantic Scholar
Functional and Molecular Consequences of the Dnmt3aR882H Mutation in Acute Myeloid Leukaemia
M. Gozdecka, M. Mazan, V. Iyer, Anna Farne +6 more
20152 citations
Semantic Scholar
Diffner E, Beck D, Gudgin E, et al. Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia. Blood. 2013;121(12):2289-2300.
Eva Diffner, D. Beck, E. Gudgin, J. Thoms +18 more
2014Blood2 citations Open access
Semantic Scholar
Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia
Bac Viet Le, Umeshkumar M. Vekariya, Monika M. Toma, M. Nieborowska-Skorska +24 more
2026Cell Reports Medicine1 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

G. Giotopoulos×15
Invite
G. Giotopoulos — researcher profile on SciRah
P. Gallipoli×11
Invite
P. Gallipoli — researcher profile on SciRah
G. Vassiliou×9
Invite
G. Vassiliou — researcher profile on SciRah
M. Dawson×7
Invite
M. Dawson — researcher profile on SciRah

×7

Invite

Eshwar Meduri — researcher profile on SciRah

Invite

M. Gozdecka — researcher profile on SciRah

Invite

R. Prinjha — researcher profile on SciRah

Faisal Basheer×6

Invite

Faisal Basheer — researcher profile on SciRah

Invite

L. Marando — researcher profile on SciRah

Invite

H. Osaki — researcher profile on SciRah

Invite

M. Mazan — researcher profile on SciRah

Invite

P. Yeh — researcher profile on SciRah