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J. Denton · SciRah

Researcher profile · Semantic Scholar

J. Denton

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J. Denton — researcher profile on SciRah

h-index: 31
Works: 179
Citations: 3,192

Most-cited papers

G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons
M. Ghamari-Langroudi, Gregory J. Digby, J. Sebag, G. Millhauser +8 more
2015Nature174 citations Open access
Semantic Scholar
A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel
K. Strange, T. Yamada, J. Denton
2019The Journal of General Physiology92 citations Open access
Semantic Scholar
An insecticide resistance-breaking mosquitocide targeting inward rectifier potassium channels in vectors of Zika virus and malaria
D. R. Swale, Darren W. Engers, S. Bollinger, A. Gross +9 more
2016Scientific Reports69 citations Open access
Semantic Scholar
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992
S. Kharade, H. Kurata, Aaron M. Bender, A. L. Blobaum +12 more
2018Molecular Pharmacology55 citations Open access
Semantic Scholar
Malpighian Tubules as Novel Targets for Mosquito Control
P. Piermarini, C. Esquivel, J. Denton
2017International Journal of Environmental Research and Public Health51 citations Open access
Semantic Scholar
An empirical model of electron and ion fluxes derived from observations at geosynchronous orbit
M. Denton, M. Thomsen, V. Jordanova, M. G. Henderson +4 more
201551 citations Open access
Semantic Scholar
Pharmacological Correction of Trafficking Defects in ATP-sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations*
G. M. Martin, Emily A. Rex, Prasanna K. Devaraneni, J. Denton +4 more
2016Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Localization and role of inward rectifier K(+) channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti.
P. Piermarini, Sonja M. Dunemann, Matthew F Rouhier, T. Calkins +4 more
2015Insect Biochemistry and Molecular Biology38 citations Open access
Semantic Scholar
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function
Maximilian D Lyon, Ping Li, J. Ferreira, R. Lazarenko +15 more
2023Proceedings of the National Academy of Sciences of the United States of America34 citations Open access
Semantic Scholar
Next-generation inward rectifier potassium channel modulators: Discovery and molecular pharmacology.
C. Weaver, J. Denton
2021American Journal of Physiology - Cell Physiology32 citations Open access
Semantic Scholar
VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons.
B. Spitznagel, N. Mishra, Alshaima'a M. Qunies, F. Prael +6 more
2020ACS Chemical Neuroscience31 citations
Semantic Scholar
Abnormal Electroretinogram after Kir7.1 Channel Suppression Suggests Role in Retinal Electrophysiology
Pawan K. Shahi, Xinling Liu, Bryce Aul, Andrea Moyer +4 more
2017Scientific Reports31 citations Open access
Semantic Scholar
ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels
D. R. Swale, H. Kurata, S. Kharade, Jonathan H. Sheehan +8 more
2016ACS Chemical Neuroscience30 citations Open access
Semantic Scholar
High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility
J. Herington, D. R. Swale, Naoko Brown, Elaine L. Shelton +6 more
2015PLoS ONE29 citations Open access
Semantic Scholar
LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology.
T. Yamada, Eric E. Figueroa, J. Denton, K. Strange
2020American Journal of Physiology - Cell Physiology28 citations Open access
Semantic Scholar
The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel
A. Afzal, Eric E. Figueroa, S. Kharade, K. Bittman +3 more
2019Physiological Reports28 citations Open access
Semantic Scholar
The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.
S. Kharade, C. Nichols, J. Denton
2016Future Medicinal Chemistry27 citations Open access
Semantic Scholar
The Molecular Physiology and Toxicology of Inward Rectifier Potassium Channels in Insects.
P. Piermarini, J. Denton, D. R. Swale
2021Annual Review of Entomology25 citations
Semantic Scholar
Targeting renal epithelial channels for the control of insect vectors
K. Beyenbach, Ya-Song Yu, P. Piermarini, J. Denton
2015Tissue Barriers24 citations Open access
Semantic Scholar
Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry
K. Zaborska, P. Dadi, Matthew T. Dickerson, Arya Y. Nakhe +7 more
2020Molecular Metabolism23 citations Open access
Semantic Scholar
Computational and functional analyses of a small-molecule binding site in ROMK.
D. R. Swale, Jonathan H. Sheehan, Sreedatta Banerjee, A. Husni +3 more
2015Biophysical Journal23 citations Open access
Semantic Scholar
Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly
Hirohide Takahashi, Toshiki Yamada, J. Denton, K. Strange +1 more
2023eLife20 citations Open access
Semantic Scholar
Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-gated, Inwardly-rectifying, Potassium (GIRK) Channels
Krystian A. Kozek, Yu Du, Swagat Sharma, Francis J. Prael +5 more
2018ACS Chemical Neuroscience20 citations Open access
Semantic Scholar
Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury
A. Terker, Yahua Zhang, J. Arroyo, Shirong Cao +5 more
2022Cell Reports18 citations Open access
Semantic Scholar
A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC)
Eric E. Figueroa, J. Denton
2022Channels18 citations Open access
Semantic Scholar
G protein–coupled receptors differentially regulate glycosylation and activity of the inwardly rectifying potassium channel Kir7.1
Sheridan J. S. Carrington, C. C. Hernandez, D. R. Swale, Oluwatosin A. Aluko +2 more
2018Journal of Biological Chemistry17 citations Open access
Semantic Scholar
CysLT1 receptor antagonists Pranlukast and Zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
Eric E. Figueroa, Meghan Kramer, K. Strange, J. Denton
2019American Journal of Physiology - Cell Physiology16 citations Open access
Semantic Scholar
Inward rectifier potassium (Kir) channels in the soybean aphid Aphis glycines: functional characterization, pharmacology, and toxicology
P. Piermarini, Edna Alfaro Inocente, N. Acosta, C. Hopkins +2 more
2018Journal of insect physiology16 citations Open access
Semantic Scholar
Dynamic expression of genes encoding subunits of inward rectifier potassium (Kir) channels in the yellow fever mosquito Aedes aegypti.
Zhong-Xia Yang, Beth Statler, T. Calkins, Edna C. Alfaro +4 more
2017Comparative Biochemistry and Physiology Part B Comparative Biochemistry16 citations
Semantic Scholar
Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063
S. Kharade, J. Sánchez-Andrés, Mark G. Fulton, Elaine L. Shelton +8 more
2019Journal of Pharmacology and Experimental Therapeutics15 citations Open access
Semantic Scholar
Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590
S. Kharade, Jonathan H. Sheehan, Eric E. Figueroa, J. Meiler +1 more
2017Molecular Pharmacology14 citations Open access
Semantic Scholar
VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels
Samantha J. McClenahan, Caitlin N. Kent, S. Kharade, Elena Isaeva +15 more
2022Molecular Pharmacology12 citations Open access
Semantic Scholar
Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism.
Eric E. Figueroa, J. Denton
2021American Journal of Physiology - Cell Physiology12 citations Open access
Semantic Scholar
ROMK Inhibitor Actions in the Nephron Probed with Diuretics
S. Kharade, Daniel Flores, C. Lindsley, L. Satlin +1 more
2016AJP - Renal Physiology12 citations Open access
Semantic Scholar
Recent Advances in Structural Characterization of Volume-regulated Anion Channels (VRACs)
Erkan Karakas, K. Strange, J. Denton
2025Journal of Physiology10 citations Open access
Semantic Scholar
Pharmacological Inhibition of Inward Rectifier Potassium Channels Induces Lethality in Larval Aedes aegypti
Renata Rusconi Trigueros, C. Hopkins, J. Denton, P. Piermarini
2018Insects10 citations Open access
Semantic Scholar
Crosstalk between ENaC and basolateral Kir4.1/Kir5.1 channels in the cortical collecting duct
Elena Isaeva, Ruslan Bohovyk, M. Fedoriuk, A. Shalygin +6 more
2021British Journal of Pharmacology8 citations Open access
Semantic Scholar
Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.
Y. Iwaki, Kentaro Yashiro, M. Kokubo, T. Mori +7 more
2019Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound
Kentaro Yashiro, Yuzo Iwaki, Hirohito Urata, Masaya Kokubo +12 more
2025ACS Chemical Neuroscience7 citations Open access
Semantic Scholar
Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B KATP Channels
Kang-Jun Li, Samantha J. McClenahan, Chang-Ho Han, Joseph D. Bungard +7 more
2024Molecular Pharmacology6 citations
Semantic Scholar
Further SAR on the (phenylsulfonyl)piperazine scaffold as inhibitors of the Aedes aegypti Kir1 (AeKir) channel and larvicides
Christopher D. Aretz, S. Kharade, Keagan Chronister, Renata Rusconi Trigueros +4 more
2020ChemMedChem5 citations Open access
Semantic Scholar
Discovery and characterization of 2-nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)-N-(pyridin-4-ylmethyl)anilines as novel inhibitors of the Aedes aegypti Kir1 (AeKir1) channel
Christopher D. Aretz, M. J. Morwitzer, Austin G. Sanford, Alicia M. Hogan +8 more
2019ACS Infectious Diseases5 citations Open access
Semantic Scholar
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors.
M. Sammons, S. Kharade, K. J. Filipski, M. Boehm +11 more
2018ACS Medicinal Chemistry Letters5 citations Open access
Semantic Scholar
A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs
Toshiki Yamada, Paola Bisignano, Erkan Karakas, J. Denton
2025Communications Biology4 citations Open access
Semantic Scholar
Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound
Motoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, K. Mitsui +12 more
2025ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Automated patch clamp analysis of heterologously expressed Kir6.2/SUR1 and Kir6.1/SUR2B KATP currents
Kangjun Li, Vaishali Satpute Janve, J. Denton
2025American Journal of Physiology - Cell Physiology2 citations Open access
Semantic Scholar
Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824
Renn A. Duncan, Daniel H. Haymer, Roman M. Lazarenko, Liangping Li +9 more
2025ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Characterization of four structurally diverse inhibitors of SUR2-containing KATP channels
Kang-Jun Li, Vaishali Satpute Janve, J. Denton
2024Channels2 citations Open access
Semantic Scholar
Editorial: Special section on inward rectifier potassium channels.
J. Denton, E. Delpire
2023American Journal of Physiology - Cell Physiology2 citations Open access
Semantic Scholar
Kir7.1 knockdown and inhibition alter renal electrolyte handling but not the development of hypertension in Dahl salt-sensitive rats.
Adrian Zietara, O. Palygin, V. Levchenko, Lashodya V. Dissanayake +4 more
2023AJP - Renal Physiology2 citations Open access
Semantic Scholar

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