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Aaron M. Bender · SciRah

Researcher profile · Semantic Scholar

Aaron M. Bender

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Aaron M. Bender — researcher profile on SciRah

h-index: 16
Works: 51
Citations: 770

Most-cited papers

Whole-body Sleeping Beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality
Lara S. Collier, D. Adams, Christopher S. Hackett, Laura E. Bendzick +14 more
2009Cancer Research78 citations Open access
Semantic Scholar
Sleeping Beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high grade astrocytomas
Aaron M. Bender, Lara S. Collier, F. Rodriguez, Christina Tieu +8 more
2010Cancer Research68 citations Open access
Semantic Scholar
Classics in Chemical Neuroscience: Memantine.
Shahrina Alam, Kaelyn S. Lingenfelter, Aaron M. Bender, C. Lindsley
2017ACS Chemical Neuroscience63 citations
Semantic Scholar
Classics in Chemical Neuroscience: Xanomeline.
Aaron M. Bender, Carrie K. Jones, C. Lindsley
2017ACS Chemical Neuroscience59 citations
Semantic Scholar
Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992
S. Kharade, H. Kurata, Aaron M. Bender, A. L. Blobaum +12 more
2018Molecular Pharmacology55 citations Open access
Semantic Scholar
Opioid Peptidomimetics: Leads for the Design of Bioavailable Mixed Efficacy Mu Opioid Receptor (MOR) Agonist/Delta Opioid Receptor (DOR) Antagonist Ligands
H. Mosberg, Larisa Yeomans, Aubrie A. Harland, Aaron M. Bender +5 more
2013Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands
Aubrie A. Harland, Aaron M. Bender, Nicholas W. Griggs, Chao Gao +5 more
2016Journal of Medicinal Chemistry34 citations Open access
Semantic Scholar
Asymmetric Synthesis and In Vitro and In Vivo Activity of Tetrahydroquinolines Featuring a Diverse Set of Polar Substitutions at the 6 Position as Mixed Efficacy μ Opioid Receptor/δ Opioid Receptor Ligands
Aaron M. Bender, Nicholas W. Griggs, Jessica P. Anand, J. Traynor +2 more
2015ACS Chemical Neuroscience28 citations Open access
Semantic Scholar
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation.
Aaron M. Bender, Aaron T. Garrison, C. Lindsley
2018ACS Chemical Neuroscience27 citations
Semantic Scholar
DARK Classics in Chemical Neuroscience: Carfentanil.
Anna E Ringuette, Matthew Spock, C. Lindsley, Aaron M. Bender
2020ACS Chemical Neuroscience26 citations
Semantic Scholar
Preparation of Unsymmetrical 1,2,4,5-Tetrazines via a Mild Suzuki Cross-Coupling Reaction.
Aaron M. Bender, T. Chopko, T. M. Bridges, C. Lindsley
2017Organic Letters26 citations
Semantic Scholar
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy.
M. Moehle, Aaron M. Bender, Jonathan W. Dickerson, Daniel J. Foster +18 more
2021ACS Pharmacology & Translational Science23 citations Open access
Semantic Scholar
Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity µ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands
Aaron M. Bender, M. Clark, Michael P. Agius, J. Traynor +1 more
2013Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
DARK Classics in Chemical Neuroscience: Methaqualone.
Joseph A Inger, Elias R Mihan, Jhansi Kolli, C. Lindsley +1 more
2023ACS Chemical Neuroscience18 citations
Semantic Scholar
2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery
Aaron M. Bender, Lauren C Parr, William B Livingston, C. Lindsley +1 more
2023Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Rapid Synthesis of Boc-2',6'-dimethyl-l-tyrosine and Derivatives and Incorporation into Opioid Peptidomimetics.
Aaron M. Bender, Nicholas W. Griggs, Chao Gao, Tyler J Trask +2 more
2015ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity
S. Moran, Zixiu Xiang, C. Doyle, James Maksymetz +8 more
2019Science Signaling15 citations Open access
Semantic Scholar
Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold
Aaron M. Bender, Hyekyung P. Cho, Kellie D. Nance, Kaelyn S. Lingenfelter +16 more
2018ACS Chemical Neuroscience12 citations Open access
Semantic Scholar
Structure-Activity Relationships of Pan-Gαq/11 Coupled Muscarinic Acetylcholine Receptor Positive Allosteric Modulators
Alice E. Berizzi, Aaron M. Bender, C. Lindsley, P. J. Conn +3 more
2018ACS Chemical Neuroscience12 citations Open access
Semantic Scholar
Classics in Chemical Neuroscience: Tianeptine
Yu Nishio, C. Lindsley, Aaron M. Bender
2024ACS Chemical Neuroscience11 citations Open access
Semantic Scholar
Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design
Anthony F. Nastase, Jessica P. Anand, Aaron M. Bender, D. Montgomery +5 more
2019Journal of Medicinal Chemistry11 citations Open access
Semantic Scholar
Development of a Peripherally Restricted 5-HT2B Partial Agonist for Treatment of Pulmonary Arterial Hypertension
M. Valentine, Aaron M. Bender, Sheila Shay, K. Paffenroth +13 more
2023JACC: Basic to Translational Science9 citations Open access
Semantic Scholar
Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a High-Throughput Screen
Aaron M. Bender, M. Valentine, J. Bauer, Emily L. Days +2 more
2023Assay and drug development technologies9 citations Open access
Semantic Scholar
The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate.
Joseph D. Panarese, Darren W. Engers, Yong-Jin Wu, J. Guernon +19 more
2019Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist.
Matthew Spock, Trever R. Carter, Katrina A. Bollinger, Changho Han +16 more
2021ACS Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists
Aaron M. Bender, Rebecca L. Weiner, Vincent B. Luscombe, S. Ajmera +9 more
2017Bioorganic & Medicinal Chemistry Letters7 citations Open access
Semantic Scholar
Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
Wessel A. C. Burger, J. Mobbs, Bhavika Rana, Jinan Wang +10 more
2025Nature Communications6 citations Open access
Semantic Scholar
Discovery of VU6007496: Challenges in the Development of an M1 Positive Allosteric Modulator Backup Candidate
Julie L. Engers, Katrina A. Bollinger, Rory A. Capstick, Madeline F. Long +15 more
2024ACS Chemical Neuroscience6 citations Open access
Semantic Scholar
Synthesis of Substituted 6,7-Dihydro-5H-pyrrolo[2,3-c]pyridazines/pyrazines via Catalyst-Free, Tandem Hydroamination-Aromatic Substitution.
Jeremy A Turkett, Anna E Ringuette, C. Lindsley, Aaron M. Bender
2020Journal of Organic Chemistry6 citations
Semantic Scholar
Development of a Selective and High Affinity Radioligand, [3H]VU6013720, for the M4 Muscarinic Receptor
Aidong Qi, Haley E Kling, Natasha B. Billard, Alice L. Rodriguez +8 more
2023Molecular Pharmacology5 citations Open access
Semantic Scholar
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists
N. Jayakodiarachchi, Mallory A. Maurer, Daniel C Schultz, C. J. Dodd +6 more
2024ACS Medicinal Chemistry Letters4 citations Open access
Semantic Scholar
Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M1 Positive Allosteric Modulators
Julie L. Engers, Aaron M. Bender, Jacob J. Kalbfleisch, Hyekyung P. Cho +11 more
2018ACS Chemical Neuroscience4 citations Open access
Semantic Scholar
Discovery of Thieno[3,2‑b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Katherine E Crocker, S. H. Henderson, Rory A. Capstick, David Whomble +19 more
2025ACS Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Brain-Penetrant Macrocycles: Design Considerations, Future Prospects, and Call for Papers.
Cori A Malinky, Aaron M. Bender
2024Journal of Medicinal Chemistry3 citations
Semantic Scholar
Synthesis of the Dimeric Diarylheptanoids Alpinidinoid C and Officinine B Enabled by Blue-Light-Mediated Triple-Minisci-Type Alkylation
Daniel C Schultz, Upendra Rathnayake, Renn A. Duncan, Alexa E Richardson +1 more
2024Organic Letters3 citations Open access
Semantic Scholar
Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5
Elizabeth S. Childress, Rory A. Capstick, Katherine E Crocker, Miranda L. Ledyard +17 more
2024ACS Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Discovery of a Novel Class of Heteroaryl-Pyrrolidinones as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M1
P. Spearing, Hyekyung P. Cho, Vincent B. Luscombe, A. L. Blobaum +7 more
2021Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Synthesis and Characterization of Chiral 6-Azaspiro[2.5]Octanes as Potent and Selective Antagonists of the M4 Muscarinic Acetylcholine Receptor.
Aaron M. Bender, Trever R. Carter, Matthew Spock, Alice L. Rodriguez +11 more
2021Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
Cryo-EM reveals a new allosteric binding site at the M5 mAChR
Wessel A. C. Burger, J. Mobbs, Bhavika Rana, Jinan Wang +10 more
2025bioRxiv2 citations Open access
Semantic Scholar
Characterization of Next-Generation Inhibitors for the Inward-Rectifier Potassium Channel Kir2.1: Discovery of VU6080824
Renn A. Duncan, Daniel H. Haymer, Roman M. Lazarenko, Liangping Li +9 more
2025ACS Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Total Synthesis and Pharmacological Evaluation of Phochrodines A–C
Jacob L Bouchard, Si-Chen Chang, Srinivasan Krishnan, C. Presley +6 more
2025Journal of Natural Products2 citations Open access
Semantic Scholar
Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy
M. Moehle, Aaron M. Bender, Jonathan W. Dickerson, Daniel J. Foster +15 more
20202 citations Open access
Semantic Scholar
Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype
Aaron M. Bender, Rebecca L. Weiner, Vincent B. Luscombe, Hyekyung P. Cho +5 more
2017Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2
Daniel H. Haymer, Renn A. Duncan, Alice L. Rodriguez, Allie Han +12 more
2026Journal of Medicinal Chemistry1 citations Open access
Semantic Scholar
Characterization of Novel and Known Activators of Cannabinoid Receptor Subtype 2 Reveals Mixed Pharmacology That Differentiates Mycophenolate Mofetil and GW-842,166X from MDA7
Alice L. Rodriguez, Aidong Qi, Allie Han, Haley E Kling +6 more
2025International Journal of Molecular Sciences1 citations Open access
Semantic Scholar
Alkylation of NH-sulfoximines under Mitsunobu-type conditions.
C. J. Dodd, Daniel C. Schultz, Jinming Li, C. Lindsley +1 more
2023Organic and biomolecular chemistry1 citations Open access
Semantic Scholar
Development of Novel M4 Muscarinic Acetylcholine Receptor Antagonists for the Treatment of Movement Disorders
Jerri L. Rook, Aaron M. Bender, Jonathan W. Dickerson, Daniel J Foster +5 more
2022The FASEB Journal1 citations
Semantic Scholar
Experimental gliomas in mice using the Sleeping Beauty (SB) transposon system: neuropathologic aspects
F. Rodriguez, Lara S. Collier, Laura E. Green, Aaron M. Bender +3 more
20081 citations
Semantic Scholar
Peptidomimetics Exhibiting Mu Opioid Receptor (MOPr) Agonist/Delta Opioid Receptor (DOPr) Antagonist Activity as Novel Pain Therapeutics
Nicholas W. Griggs, Aaron M. Bender, Chao Gao, Jessica P. Anand +2 more
2016The FASEB Journal0 citations Open access
Semantic Scholar
Synthesis and Evaluation of Mixed Efficacy Mu Opioid Receptor (MOR), Delta Opioid Receptor (DOR) Peptidomimetic Ligands.
Aaron M. Bender
20160 citations
Semantic Scholar

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C. Lindsley×37
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C. Niswender×18
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Alice L. Rodriguez×14
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J. Rook×11
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Hyekyung P. Cho

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Si-Chen Chang×9

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T. M. Bridges×8

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Julie L. Engers×8

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