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M. Gwynn · SciRah

Researcher profile · Semantic Scholar

M. Gwynn

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M. Gwynn — researcher profile on SciRah

h-index: 23
Works: 43
Citations: 5,509

Most-cited papers

Drugs for bad bugs: confronting the challenges of antibacterial discovery
D. Payne, M. Gwynn, D. Holmes, D. Pompliano
2007Nature reviews. Drug discovery2,418 citations
Semantic Scholar
Type IIA topoisomerase inhibition by a new class of antibacterial agents
B. Bax, P. Chan, D. Eggleston, A. Fosberry +21 more
2010Nature802 citations
Semantic Scholar
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
A. Wohlkonig, P. Chan, A. Fosberry, P. Homes +9 more
2010Nature Structural &Molecular Biology306 citations
Semantic Scholar
Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci
E. I. Wilding, James R. Brown, A. Bryant, A. F. Chalker +6 more
2000Journal of Bacteriology273 citations Open access
Semantic Scholar
Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics
D. Beauregard, D. Williams, M. Gwynn, D. Knowles
1995Antimicrobial Agents and Chemotherapy226 citations Open access
Semantic Scholar
Nat. Rev. Drug Disc.
D. Payne, M. Gwynn, D. Holmes, D. Pompliano
2007207 citations
Semantic Scholar
Challenges of antibacterial discovery revisited
M. Gwynn, A. Portnoy, S. Rittenhouse, D. Payne
2010Annals of the New York Academy of Sciences192 citations
Semantic Scholar
Novel Chromosomally Encoded Multidrug Efflux Transporter MdeA in Staphylococcus aureus
Jianzhong Huang, P. O'Toole, W. Shen, H. Amrine-Madsen +7 more
2004Antimicrobial Agents and Chemotherapy156 citations Open access
Semantic Scholar
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
P. Chan, V. Srikannathasan, Jianzhong Huang, Haifeng Cui +15 more
2015Nature Communications145 citations Open access
Semantic Scholar
Essentiality, Expression, and Characterization of the Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase ofStaphylococcus aureus
E. I. Wilding, Dong-Yul Kim, A. Bryant, M. Gwynn +7 more
2000Journal of Bacteriology83 citations Open access
Semantic Scholar
Enterococcus faecalis Acetoacetyl-Coenzyme A Thiolase/3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase, a Dual-Function Protein of Isopentenyl Diphosphate Biosynthesis
M. Hedl, Autumn L. Sutherlin, E. Wilding, M. Mazzulla +7 more
2002Journal of Bacteriology70 citations Open access
Semantic Scholar
Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus
D. Gentry, Lynn McCloskey, M. Gwynn, S. Rittenhouse +3 more
2008Antimicrobial Agents and Chemotherapy67 citations Open access
Semantic Scholar
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
T. Miles, A. Hennessy, B. Bax, G. Brooks +18 more
2013Bioorganic & Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Staphylococcus aureus 3-Hydroxy-3-methylglutaryl-CoA Synthase
N. Campobasso, Mehul Patel, I. Wilding, H. Kallender +2 more
2004Journal of Biological Chemistry60 citations Open access
Semantic Scholar
Efflux and target mutations as quinolone resistance mechanisms in clinical isolates of Streptococcus pneumoniae.
J. Broskey, K. Coleman, M. Gwynn, Lynn McCloskey +3 more
2000Journal of Antimicrobial Chemotherapy56 citations
Semantic Scholar
Genomic approaches to antibacterial discovery.
D. Payne, M. Gwynn, D. Holmes, M. Rosenberg
2004Methods in molecular biology51 citations
Semantic Scholar
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.
T. Miles, Christopher W. Barfoot, G. Brooks, P. Brown +15 more
2011Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
T. Miles, A. Hennessy, B. Bax, G. Brooks +16 more
2016Bioorganic & Medicinal Chemistry Letters46 citations Open access
Semantic Scholar
Regrowth of Pseudomonas aeruginosa and other bacteria after the bactericidal action of carbenicillin and other beta-lactam antibiotics.
M. Gwynn, T. L. Webb, G. Rolinson
1981Journal of Infectious Diseases45 citations
Semantic Scholar
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.
T. Miles, J. Axten, Christopher W. Barfoot, G. Brooks +19 more
2011Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential.
D. Gentry, I. Wilding, John Johnson, Dong-Zhao Chen +6 more
2010Journal of Microbiological Methods34 citations
Semantic Scholar
Molecular Evolution Perspectives on Intraspecific Lateral DNA Transfer of Topoisomerase and Gyrase Loci in Streptococcus pneumoniae, with Implications for Fluoroquinolone Resistance Development and Spread
M. Stanhope, Stacey L. Walsh, J. A. Becker, Michael J. Italia +7 more
2005Antimicrobial Agents and Chemotherapy26 citations Open access
Semantic Scholar
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
V. Srikannathasan, A. Wohlkonig, Anthony Shillings, O. Singh +9 more
2015Acta Crystallographica Section F Structural Biology Communications24 citations Open access
Semantic Scholar
Recent Developments in Inhibitors of Bacterial Type IIA Topoisomerases
P. Chan, Jianzhong Huang, B. Bax, M. Gwynn
201318 citations Open access
Semantic Scholar
Staphylococcus aureus Gyrase-Quinolone-DNA Ternary Complexes Fail to Arrest Replication Fork Progression in Vitro
H. Hiasa, Margaret E. Shea, C. Richardson, M. Gwynn
2003Journal of Biological Chemistry14 citations Open access
Semantic Scholar
Selection of variants of Gram-negative bacteria with elevated production of type 1 beta-lactamase.
M. Gwynn, G. N. Rolinsun
1983Journal of Antimicrobial Chemotherapy12 citations
Semantic Scholar
Comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo.
M. Basker, M. Gwynn, A. R. White
1979Chemotherapy12 citations
Semantic Scholar
Susceptibility of Pseudomonas aeruginosa to catechol-substituted cephalosporin is unrelated to the pyochelin–Fe transporter FptA
Françoise Hoegy, M. Gwynn, I. Schalk
2010Amino Acids5 citations
Semantic Scholar
Selection of variants of pseudomonas aeruginosa resistant to beta-lactam antibiotics
M. Gwynn, G. Rolinson
2005Infection4 citations
Semantic Scholar
Bactericidal action of amoxycillin alone and in combination with gentamicin and rifampicin against Brucella melitensis.
M. Gwynn, G. Rolinson
1980Journal of Infection4 citations
Semantic Scholar
The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20103 citations
Semantic Scholar
Emerging resistance of antibiotics among various bacterial infections
S. Ali, M. Taj, S. Ali, Safa Farooqi +496 more
2022International Journal of Biosciences2 citations Open access
Semantic Scholar
The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20101 citations
Semantic Scholar
EFFICIENT, MICROWAVE ASSISTED SYNTHESIS OF 4-(substituted fluoro-phenyl)-substituted-6H-1-thia-5, 7, 8, 9a -tetraaza-cyclopenta[e]azulenes And Their MICROBIAL ACTIVITY
Vikas K. Bhosale, V. Kapase, Kulbhushan A. Sasane, L. Patil +157 more
2021International Journal of Biology Pharmacy and Allied Sciences0 citations Open access
Semantic Scholar
New Developments in Mold and Core Binder Technology for Aluminum Casting
M. Zamani, S. Seifeddine, D. Neff, M. Gwynn +11 more
20150 citations
Semantic Scholar
CRYSTAL STRUCTURE OF CATALYTIC CORE OF A. BAUMANNII TOPO IV (PARE- PARC FUSION TRUNCATE)
A. Wohlkonig, P. Chan, A. Fosberry, P. Homes +9 more
20100 citations
Semantic Scholar
The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20100 citations
Semantic Scholar
The 2.98A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20100 citations
Semantic Scholar
CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE)
A. Wohlkonig, P. Chan, A. P. Fosberry, P. Homes +9 more
20100 citations
Semantic Scholar
Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics
B. Bax, M. Hibbs, E. Jones, Andrew J. Theobald +8 more
20090 citations Open access
Semantic Scholar
Crystal structure of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from Staphylococcus aureus
N. Campobasso, M. Patel, I. Wilding, H. Kallender +2 more
20040 citations
Semantic Scholar
A Global Quantitative Analysis of Operon/Gene Transcription in Bacillus Anthracis During Experimental Infection
M. Gwynn, D. McDevitt
20030 citations
Semantic Scholar
Genes de voie du mevalonate
J. R. Brown, M. Gwynn, Thomas B. Mathie, Joseph E. Myers +3 more
20000 citations
Semantic Scholar

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Jianzhong Huang×15
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B. Bax×14
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N. Pearson×13
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P. Chan×11
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Anthony Shillings×10

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A. Wohlkonig×10

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Ilaria Giordano×9

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C. Spitzfaden×9

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M. Hibbs — researcher profile on SciRah

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D. Gentry — researcher profile on SciRah