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Jianzhong Huang · SciRah

Researcher profile · Semantic Scholar

Jianzhong Huang

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Jianzhong Huang — researcher profile on SciRah

h-index: 18
Works: 40
Citations: 2,270

Most-cited papers

Type IIA topoisomerase inhibition by a new class of antibacterial agents
B. Bax, P. Chan, D. Eggleston, A. Fosberry +21 more
2010Nature802 citations
Semantic Scholar
Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance
A. Wohlkonig, P. Chan, A. Fosberry, P. Homes +9 more
2010Nature Structural &Molecular Biology306 citations
Semantic Scholar
Novel Chromosomally Encoded Multidrug Efflux Transporter MdeA in Staphylococcus aureus
Jianzhong Huang, P. O'Toole, W. Shen, H. Amrine-Madsen +7 more
2004Antimicrobial Agents and Chemotherapy156 citations Open access
Semantic Scholar
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
P. Chan, V. Srikannathasan, Jianzhong Huang, Haifeng Cui +15 more
2015Nature Communications145 citations Open access
Semantic Scholar
Comparative Genomics of Klebsiella pneumoniae Strains with Different Antibiotic Resistance Profiles
Vinod Kumar, Peng Sun, J. Vamathevan, Yong Li +4 more
2011Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus
F. Fan, K. Yan, N. Wallis, Shannon L Reed +11 more
2002Antimicrobial Agents and Chemotherapy113 citations Open access
Semantic Scholar
Microbiological Analysis from a Phase 2 Randomized Study in Adults Evaluating Single Oral Doses of Gepotidacin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria gonorrhoeae
N. Scangarella-Oman, Mohammad Hossain, P. Dixon, K. Ingraham +8 more
2018Antimicrobial Agents and Chemotherapy89 citations Open access
Semantic Scholar
Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase
P. Chan, T. Germe, B. Bax, Jianzhong Huang +12 more
2017Proceedings of the National Academy of Sciences of the United States of America74 citations Open access
Semantic Scholar
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
T. Miles, A. Hennessy, B. Bax, G. Brooks +18 more
2013Bioorganic & Medicinal Chemistry Letters61 citations Open access
Semantic Scholar
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Carl A. Machutta, Christopher S. Kollmann, K. Lind, Xiaopeng Bai +61 more
2017Nature Communications60 citations Open access
Semantic Scholar
Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.
T. Miles, Christopher W. Barfoot, G. Brooks, P. Brown +15 more
2011Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.
T. Miles, J. Axten, Christopher W. Barfoot, G. Brooks +19 more
2011Bioorganic & Medicinal Chemistry Letters43 citations Open access
Semantic Scholar
Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual Targeting
Alexandria A. Oviatt, Elizabeth G. Gibson, Jianzhong Huang, Karen Mattern +3 more
2024ACS Infectious Diseases37 citations Open access
Semantic Scholar
Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.
N. Concha, Jianzhong Huang, Xiaopeng Bai, Andrew B. Benowitz +20 more
2016Journal of Medicinal Chemistry32 citations Open access
Semantic Scholar
Relationship between Gepotidacin Exposure and Prevention of On-Therapy Resistance Amplification in a Neisseria gonorrhoeae Hollow-Fiber In Vitro Infection Model
B. VanScoy, N. Scangarella-Oman, Steven Fikes, S. Min +5 more
2020Antimicrobial Agents and Chemotherapy27 citations Open access
Semantic Scholar
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
V. Srikannathasan, A. Wohlkonig, Anthony Shillings, O. Singh +9 more
2015Acta Crystallographica Section F Structural Biology Communications24 citations Open access
Semantic Scholar
Alterations in intestinal microbiota and metabolites in individuals with Down syndrome and their correlation with inflammation and behavior disorders in mice
Shaoli Cai, Jin-Xin Lin, Zhaolong Li, Songnian Liu +5 more
2023Frontiers in Microbiology21 citations Open access
Semantic Scholar
Fragment-based discovery of 6-azaindazoles as inhibitors of bacterial DNA ligase.
S. Howard, N. Amin, Andrew B. Benowitz, E. Chiarparin +15 more
2014ACS Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against Neisseria gonorrhoeae Gyrase and Topoisomerase IV in Cells and In Vitro
Alexandria A. Oviatt, Jessica A Collins, Chelsea A. Mann, Jianzhong Huang +3 more
2025ACS Infectious Diseases18 citations Open access
Semantic Scholar
Recent Developments in Inhibitors of Bacterial Type IIA Topoisomerases
P. Chan, Jianzhong Huang, B. Bax, M. Gwynn
201318 citations Open access
Semantic Scholar
In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections
N. Scangarella-Oman, K. Ingraham, C. Tiffany, Lynn Tomsho +8 more
2019Antimicrobial Agents and Chemotherapy14 citations Open access
Semantic Scholar
Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.
Frédéric Jeannot, Thomas Taillier, P. Despeyroux, Stéphane Renard +14 more
2018Journal of Medicinal Chemistry14 citations Open access
Semantic Scholar
Staphylococcus aureus Formyl-Methionyl Transferase Mutants Demonstrate Reduced Virulence Factor Production and Pathogenicity
Thomas F. Lewandowski, Jianzhong Huang, F. Fan, S. Rogers +5 more
2013Antimicrobial Agents and Chemotherapy13 citations Open access
Semantic Scholar
Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
S. Min, K. Ingraham, Jianzhong Huang, Lynn McCloskey +9 more
2015Antimicrobial Agents and Chemotherapy7 citations Open access
Semantic Scholar
1249. Genetic Evidence That Gepotidacin Shows Well-balanced Dual Targeting against DNA Gyrase And Topoisomerase IV in Neisseria gonorrhoeae
P. Chan, K. Ingraham, S. Min, N. Scangarella-Oman +2 more
2020Open Forum Infectious Diseases4 citations Open access
Semantic Scholar
An Improved Machine Learning Model for Screening and Activity Prediction of Receptor Tyrosine Kinase
Huang-Zhi Xia, Huang-Zhi Xia, Jianzhong Huang
2025Journal of Bionic Engineering3 citations
Semantic Scholar
The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20103 citations
Semantic Scholar
Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai +61 more
2018Nature Communications2 citations Open access
Semantic Scholar
In Vitro Activity and Microbiological Efficacy of Gepotidacin (GSK2140944): A Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients With Acute Bacterial Skin and Skin Structure Infections
N. Scangarella-Oman, K. Ingraham, C. Tiffany, C. Perry +4 more
20161 citations Open access
Semantic Scholar
The 2.1A crystal structure of S. aureus Gyrase complex with GSK299423 and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20101 citations
Semantic Scholar
P-1199. Well-Balanced Dual-Targeting of Gepotidacin against Neisseria gonorrhoeae Gyrase and Topoisomerase IV in Cells and in vitro
Alexandria A. Oviatt, Jessica A Collins, Jianzhong Huang, Karen Mattern +2 more
2026Open Forum Infectious Diseases0 citations
Semantic Scholar
AI-Driven Metabolic Engineering of γ-Aminobutyric Acid: Biosynthetic Advances and Industrial Applications
Si-Ying Wang, Huang-Zhi Xia, Jianzhong Huang
2025INNO-PRESS: Journal of Emerging Applied AI0 citations Open access
Semantic Scholar
1440. The Genetic Basis for a Neisseria gonorrhoeae Clinical Isolate That Contains mtrR-79 Mutation But Is Highly Susceptible to Antibiotics Effluxed by the Mtr Pump System
Jianzhong Huang, K. Ingraham
2020Open Forum Infectious Diseases0 citations Open access
Semantic Scholar
1438. Dissecting the Multifaceted Nature of Antibiotic Resistance in Clinical Isolates of Neisseria gonorrhoeae by Natural Transformation
Jianzhong Huang, K. Ingraham, P. Chan, S. Rittenhouse
2020Open Forum Infectious Diseases0 citations Open access
Semantic Scholar
Discovery of a Tri-substituted Furan Antibacterial That Is More Active against Quinolone-resistant DNA Gyrase Than Wild-type
Jianzhong Huang, Carol Shen, K. Ingraham, Lynn McCloskey +2 more
20160 citations Open access
Semantic Scholar
Inhibitors of the DNA-cleavage gate of bacterial type IIA topoisomerases
B. Bax, A. Fosberry, C. Spitzfaden, Anthony Shillings +3 more
20140 citations Open access
Semantic Scholar
CRYSTAL STRUCTURE OF CATALYTIC CORE OF A. BAUMANNII TOPO IV (PARE- PARC FUSION TRUNCATE)
A. Wohlkonig, P. Chan, A. Fosberry, P. Homes +9 more
20100 citations
Semantic Scholar
The 3.5A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase complexed with GSK299423 and DNA
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20100 citations
Semantic Scholar
The 2.98A crystal structure of the catalytic core (B'A' region) of Staphylococcus aureus DNA Gyrase
B. Bax, P. Chan, D. Eggleston, A. Fosberry +20 more
20100 citations
Semantic Scholar
Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics
B. Bax, M. Hibbs, E. Jones, Andrew J. Theobald +8 more
20090 citations Open access
Semantic Scholar

Frequent co-authors

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P. Chan×17
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P. Chan — researcher profile on SciRah
M. Gwynn×15
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M. Gwynn — researcher profile on SciRah
K. Ingraham×15
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K. Ingraham — researcher profile on SciRah
B. Bax×14
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B. Bax — researcher profile on SciRah

×12

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N. Pearson — researcher profile on SciRah

A. Fosberry×11

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A. Fosberry — researcher profile on SciRah

Anthony Shillings×11

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Anthony Shillings — researcher profile on SciRah

C. Spitzfaden×10

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C. Spitzfaden — researcher profile on SciRah

A. Wohlkonig×9

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A. Wohlkonig — researcher profile on SciRah

Ilaria Giordano×8

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Ilaria Giordano — researcher profile on SciRah

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A. Hennessy — researcher profile on SciRah

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M. Hibbs — researcher profile on SciRah