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Kole T. Roybal · SciRah

Researcher profile · Semantic Scholar

Kole T. Roybal

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Kole T. Roybal — researcher profile on SciRah

h-index: 30
Works: 83
Citations: 7,680

Most-cited papers

Precision Tumor Recognition by T Cells With Combinatorial Antigen Sensing Circuits
Kole T. Roybal, Levi J. Rupp, Leonardo Morsut, Whitney J. Walker +3 more
2016Cell953 citations Open access
Semantic Scholar
Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
Leonardo Morsut, Kole T. Roybal, X. Xiong, R. Gordley +3 more
2016Cell936 citations Open access
Semantic Scholar
Mania-like behavior induced by disruption of CLOCK
Kole T. Roybal, D. Theobold, Ami Graham, Jennifer A Dinieri +12 more
2007Proceedings of the National Academy of Sciences of the United States of America815 citations Open access
Semantic Scholar
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
Kole T. Roybal, Jasper Z. Williams, Leonardo Morsut, Levi J. Rupp +5 more
2016Cell698 citations Open access
Semantic Scholar
Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
Chia-yung Wu, Kole T. Roybal, E. Puchner, J. Onuffer +1 more
2015Science675 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
Levi J. Rupp, Kathrin Schumann, Kole T. Roybal, Rachel E. Gate +3 more
2016Scientific Reports664 citations Open access
Semantic Scholar
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
Joseph H. Choe, P. Watchmaker, M. Simic, Ryan D. Gilbert +17 more
2021Science Translational Medicine475 citations Open access
Semantic Scholar
SynNotch CAR Circuits Enhance Solid Tumor Recognition and Promote Persistent Anti-tumor Activity in Mouse Models
Axel Hyrenius-Wittsten, Yang Su, Minhee Park, Julie M. Garcia +5 more
2021Science Translational Medicine228 citations Open access
Semantic Scholar
Synthetic cytokine circuits that drive T cell infiltration into immune-excluded tumors
G. Allen, Nicholas W. Frankel, N. Reddy, Hersh K. Bhargava +12 more
2022Science181 citations Open access
Semantic Scholar
Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies
I. Zhu, Raymond Liu, Julie M. Garcia, Axel Hyrenius-Wittsten +6 more
2022Cell181 citations Open access
Semantic Scholar
Multidimensional control of therapeutic human cell function with synthetic gene circuits
Hui-Shan Li, Divya V. Israni, Keith A. Gagnon, K. Gan +6 more
2022Science151 citations Open access
Semantic Scholar
Precise T cell recognition programs designed by transcriptionally linking multiple receptors
Jasper Z. Williams, G. Allen, Devan H. Shah, Igal S. Sterin +9 more
2020Science145 citations Open access
Semantic Scholar
Designed endocytosis-inducing proteins degrade targets and amplify signals
Bu-Wei Huang, Mohamad H. Abedi, Green Ahn, B. Coventry +41 more
2024Nature133 citations Open access
Semantic Scholar
Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade
C. Pai, J. Huang, Xiao-Qing Lu, D. M. Simons +23 more
2019Immunity124 citations Open access
Semantic Scholar
Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities
Kole T. Roybal, W. Lim
2017Annual Review of Immunology115 citations Open access
Semantic Scholar
DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation
Xiao Huang, Jasper Z. Williams, Ryan Chang, Zhong-Bo Li +9 more
2020Nature Nanotechnology107 citations Open access
Semantic Scholar
Spatiotemporal Patterning During T Cell Activation Is Highly Diverse
K. Singleton, Kole T. Roybal, Yi Sun, Guo Fu +3 more
2009Science Signaling99 citations Open access
Semantic Scholar
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
Daniel B. Goodman, C. Azimi, Kendall Kearns, Alexis Talbot +13 more
2022Science Translational Medicine91 citations Open access
Semantic Scholar
Naturally occurring T cell mutations enhance engineered T cell therapies
Julie M. Garcia, Jay Daniels, Yujin Lee, I. Zhu +11 more
2024Nature84 citations Open access
Semantic Scholar
The CD3 ζ subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR/CD3 complex at the immunological synapse
Laura M. DeFord-Watts, David S. Dougall, S. Belkaya, Blake A. Johnson +6 more
2011Journal of Immunology83 citations Open access
Semantic Scholar
Engineered receptors for soluble cellular communication and disease sensing
Dan I. Piraner, Mohamad H. Abedi, Maria J. Duran Gonzalez, Adam M. Chazin-Gray +11 more
2024Nature70 citations Open access
Semantic Scholar
Differential Regulation of the Period Genes in Striatal Regions following Cocaine Exposure
Edgardo Falcón, A. Ozburn, S. Mukherjee, Kole T. Roybal +1 more
2013PLoS ONE63 citations Open access
Semantic Scholar
CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
Poornima Ramkumar, Anthony B. Abarientos, Rui-Lin Tian, M. Seyler +13 more
2020Blood Advances55 citations Open access
Semantic Scholar
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting
K. Landgraf, Steven R. Williams, D. Steiger, D. Gebhart +4 more
2019Communications Biology50 citations Open access
Semantic Scholar
CD4+ CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy
Guy Ledergor, Zenghua Fan, Kai Wu, Elizabeth McCarthy +15 more
2024Blood Advances49 citations Open access
Semantic Scholar
Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion
A. Shemesh, H. Pickering, Kole T. Roybal, L. Lanier
2022Journal of Experimental Medicine41 citations Open access
Semantic Scholar
In vivo site-specific engineering to reprogram T cells
William A Nyberg, Pierre-Louis Bernard, Wayne Ngo, Charlotte H. Wang +35 more
2026Nature40 citations Open access
Semantic Scholar
Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression
A. Shemesh, Ya-Peng Su, D. Calabrese, Daniel Chen +5 more
2022Journal of Experimental Medicine38 citations Open access
Semantic Scholar
Synthetic Biology Approaches to Engineer T cells
Chia-yung Wu, Levi J. Rupp, Kole T. Roybal, W. Lim
2015Current Opinion in Immunology37 citations Open access
Semantic Scholar
IFN-α suppresses GATA3 transcription from a distal exon and promotes H3K27 tri-methylation of the CNS-1 enhancer in human Th2 cells
J. Huber, Sarah R. Gonzales-van Horn, Kole T. Roybal, Michelle A. Gill +1 more
2014Journal of Immunology34 citations Open access
Semantic Scholar
Paving New Roads for CARs.
Axel Hyrenius-Wittsten, Kole T. Roybal
2019Trends in Cancer28 citations
Semantic Scholar
Computational spatiotemporal analysis identifies WAVE2 and Cofilin as joint regulators of costimulation-mediated T cell actin dynamics
Kole T. Roybal, T. E. Buck, Xiongtao Ruan, Baek Hwan Cho +7 more
2016Science Signaling28 citations Open access
Semantic Scholar
The actin‐driven spatiotemporal organization of T‐cell signaling at the system scale
Kole T. Roybal, Parisa Sinai, P. Verkade, R. Murphy +1 more
2013Immunological Reviews26 citations Open access
Semantic Scholar
Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network
Kole T. Roybal, E. Mace, J. Mantell, P. Verkade +2 more
2015PLoS ONE25 citations Open access
Semantic Scholar
Clinically-driven design of synthetic gene regulatory programs in human cells
Divya V. Israni, Hui-Shan Li, Keith A. Gagnon, J. Sander +4 more
2021bioRxiv19 citations Open access
Semantic Scholar
Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function
Kole T. Roybal, C. Wülfing
2010Science Signaling19 citations
Semantic Scholar
Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors
Casey Beppler, John Eichorst, Kyle Marchuk, En Cai +4 more
2022Journal of Cell Biology16 citations Open access
Semantic Scholar
NextGen cell-based immunotherapies in cancer and other immune disorders.
C. Azimi, Q. Tang, Kole T. Roybal, J. Bluestone
2019Current Opinion in Immunology16 citations
Semantic Scholar
Mycobacterial Shuttle Vectors Designed for High-Level Protein Expression in Infected Macrophages
Jennifer L. Eitson, Jennifer J. Medeiros, Ashley R. Hoover, Shashikant Srivastava +5 more
2012Applied and Environmental Microbiology12 citations Open access
Semantic Scholar
Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells
I. Zhu, Raymond Liu, Axel Hyrenius-Wittsten, Dan I. Piraner +4 more
2021bioRxiv11 citations Open access
Semantic Scholar
Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma
Jaehoon Shin, Matthew F. L. Parker, I. Zhu, Aryn A Alanizi +13 more
2022Journal of Nuclear Medicine10 citations Open access
Semantic Scholar
Synthetic biology: at the crossroads of genetic engineering and human therapeutics—a Keystone Symposia report
J. Cable, J. Leonard, Timothy K. Lu, Zhen Xie +22 more
2021Annals of the New York Academy of Sciences8 citations
Semantic Scholar
Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling
Kole T. Roybal, E. Mace, Danielle J. Clark, Alan D. Leard +4 more
2015PLoS ONE8 citations Open access
Semantic Scholar
Toward the clinical development of synthetic immunity to cancer
Julie M. Garcia, Cassandra E. Burnett, Kole T. Roybal
2023Immunological Reviews7 citations Open access
Semantic Scholar
Refining cell therapy
Kole T. Roybal
2018Science6 citations
Semantic Scholar
Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors
Scott N. Furlan, R. Mandraju, Travis Brewer, Kole T. Roybal +5 more
2014mAbs6 citations Open access
Semantic Scholar
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation
Bu-Wei Huang, Mohamad H. Abedi, Green Ahn, B. Coventry +39 more
2023bioRxiv5 citations Open access
Semantic Scholar
Multi-antigen recognition circuits overcome challenges of specificity, heterogeneity, and durability in T cell therapy for glioblastoma
Joseph H. Choe, P. Watchmaker, M. Simic, Ryan D. Gilbert +14 more
2021bioRxiv5 citations Open access
Semantic Scholar
Synthesizing a Smarter CAR T cell: Advanced Engineering of T-cell Immunotherapies
I. Zhu, Dan I. Piraner, Kole T. Roybal
2023Cancer immunology research4 citations Open access
Semantic Scholar
Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapies
Daniel B. Goodman, C. Azimi, Kendall Kearns, Kiavash Garakani +9 more
2021bioRxiv4 citations Open access
Semantic Scholar

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