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E. Sausville · SciRah

Researcher profile · Semantic Scholar

E. Sausville

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E. Sausville — researcher profile on SciRah

h-index: 88
Works: 404
Citations: 33K

Most-cited papers

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors
E. Sausville, P. LoRusso, M. Carducci, J. Carter +10 more
2014Cancer Chemotherapy and Pharmacology176 citations Open access
Semantic Scholar
Autophagy modulation: a target for cancer treatment development
A. Duffy, Jackson Le, E. Sausville, A. Emadi
2015Cancer Chemotherapy and Pharmacology140 citations
Semantic Scholar
Phase I safety, pharmacokinetic and pharmacodynamic study of the poly (ADP-ribose) polymerase (PARP) inhibitor veliparib (ABT-888) in combination with irinotecan in patients with advanced solid tumors
P. LoRusso, Jing Li, A. Burger, L. Heilbrun +21 more
2016Clinical Cancer Research100 citations Open access
Semantic Scholar
Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice
A. Heredia, Nhut M. Le, R. Gartenhaus, E. Sausville +5 more
2015Proceedings of the National Academy of Sciences of the United States of America97 citations Open access
Semantic Scholar
Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
P. LoRusso, M. Edelman, S. Bever, Karen M. Forman +9 more
2012Journal of Clinical Oncology89 citations Open access
Semantic Scholar
Clinical and laboratory studies of the novel cyclin-dependent kinase inhibitor dinaciclib (SCH 727965) in acute leukemias
I. Gojo, M. Sadowska, Alison R. Walker, E. Feldman +10 more
2013Cancer Chemotherapy and Pharmacology85 citations Open access
Semantic Scholar
A phase I/II study of carfilzomib 2–10-min infusion in patients with advanced solid tumors
K. Papadopoulos, Howard A. Iii Burris, M. Gordon, Peter P. Lee +8 more
2013Cancer Chemotherapy and Pharmacology76 citations Open access
Semantic Scholar
Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias
Ken Shiozawa, T. Nakanishi, M. Tan, Hong-Bin Fang +6 more
2009Clinical Cancer Research68 citations Open access
Semantic Scholar
SAFETY, EFFICACY, PHARMACOKINETICS AND PHARMACODYNAMICS OF THE COMBINATION OF SORAFENIB AND TANESPIMYCIN
U. Vaishampayan, A. Burger, E. Sausville, L. Heilbrun +6 more
2010Clinical Cancer Research62 citations Open access
Semantic Scholar
Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate
R. Duncan, Yee-Nee Sat-Klopsch, A. Burger, M. Bibby +2 more
2013Cancer Chemotherapy and Pharmacology60 citations Open access
Semantic Scholar
Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas.
M. Nathenson, A. Conley, E. Sausville
2018The Oncologist57 citations Open access
Semantic Scholar
Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome
I. Gojo, A. Perl, S. Luger, M. Baer +6 more
2013Investigational new drugs56 citations Open access
Semantic Scholar
A Phase II Study of Temozolomide in Patients with Advanced Aerodigestive Tract and Colorectal Cancers and Methylation of the O6-Methylguanine-DNA Methyltransferase Promoter
D. Hochhauser, R. Glynne-Jones, V. Potter, C. Grávalos +5 more
2013Molecular Cancer Therapeutics53 citations
Semantic Scholar
Disparities in black and white patients with multiple myeloma referred for autologous hematopoietic transplantation: A single center study
V. Bhatnagar, Yin Wu, O. Goloubeva, K. Ruehle +7 more
2015Cancer50 citations Open access
Semantic Scholar
Reducing Undesirable Hepatic Clearance of a Tumor-Targeted Vinca Alkaloid via Novel Saccharopeptidic Modifications
C. Leamon, J. Reddy, P. Klein, I. Vlahov +12 more
2011Journal of Pharmacology and Experimental Therapeutics49 citations
Semantic Scholar
Targetable HPMA Copolymer–Aminohexylgeldanamycin Conjugates for Prostate Cancer Therapy
Mark P. Borgman, Abhijit Ray, Rohit Kolhatkar, E. Sausville +2 more
2009Pharmaceutical Research46 citations Open access
Semantic Scholar
Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia
A. Emadi, Jennie Y. Law, E. Strovel, R. Lapidus +17 more
2017Cancer Chemotherapy and Pharmacology45 citations
Semantic Scholar
First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors
P. LoRusso, P. Goncalves, L. Casetta, J. Carter +7 more
2015Investigational new drugs45 citations
Semantic Scholar
Asparaginase in the treatment of non-ALL hematologic malignancies
A. Emadi, Hania Zokaee, E. Sausville
2014Cancer Chemotherapy and Pharmacology43 citations
Semantic Scholar
Ten-day decitabine as initial therapy for newly diagnosed patients with acute myeloid leukemia unfit for intensive chemotherapy
Bhavana Bhatnagar, V. Duong, T. Gourdin, Michael L. Tidwell +5 more
2014Leukemia and Lymphoma43 citations
Semantic Scholar
Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management
N. Bade, Crystal Lu, Ciera L. Patzke, M. Baer +8 more
2020Journal of Oncology Pharmacy Practice33 citations
Semantic Scholar
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma
M. Nathenson, C. Barysauskas, Robert A. Nathenson, W. Regine +2 more
2018World Journal of Surgical Oncology27 citations Open access
Semantic Scholar
A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone
L. Pidugu, J. C. Emmanuel Mbimba, Muqeet Ahmad, E. Pozharski +3 more
2016BMC Structural Biology26 citations Open access
Semantic Scholar
Subdural hematomas in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia receiving imatinib mesylate in conjunction with systemic and intrathecal chemotherapy
Shiven B. Patel, I. Gojo, Michael L. Tidwell, E. Sausville +1 more
2011Leukemia and Lymphoma26 citations
Semantic Scholar
Treatment of CD19‐positive mixed phenotype acute leukemia with blinatumomab
F. El Chaer, O. Ali, E. Sausville, Jennie Y. Law +9 more
2018American journal of hematology/oncology24 citations Open access
Semantic Scholar
Relapsed Philadelphia Chromosome-Positive Pre-B-ALL after CD19-Directed CAR-T Cell Therapy Successfully Treated with Combination of Blinatumomab and Ponatinib
F. El Chaer, N. Holtzman, E. Sausville, Jennie Y. Law +7 more
2019Acta Haematologica19 citations
Semantic Scholar
Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice
S. Medina-Moreno, Thomas C. Dowling, J. Zapata, Nhut M. Le +4 more
2017PLoS ONE18 citations Open access
Semantic Scholar
Preclinical and first‐in‐human phase I studies of KW‐2450, an oral tyrosine kinase inhibitor with insulin‐like growth factor receptor‐1/insulin receptor selectivity
G. Schwartz, M. Dickson, P. LoRusso, E. Sausville +5 more
2016Cancer Science18 citations Open access
Semantic Scholar
Looking for answers: the current status of neoadjuvant treatment in localized soft tissue sarcomas
M. Nathenson, E. Sausville
2016Cancer Chemotherapy and Pharmacology17 citations Open access
Semantic Scholar
Perturbation of cellular oxidative state induced by dichloroacetate and arsenic trioxide for treatment of acute myeloid leukemia
A. Emadi, M. Sadowska, Brandon A. Carter-Cooper, V. Bhatnagar +4 more
2015Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis17 citations Open access
Semantic Scholar
A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms
W. Figg, M. Monga, D. Headlee, Avni A. Shah +12 more
2014Cancer Chemotherapy and Pharmacology17 citations Open access
Semantic Scholar
Treatment of catheter-related deep vein thrombosis in patients with acute leukemia with anticoagulation
N. Oliver, B. Short, M. Thein, V. Duong +5 more
2015Leukemia and Lymphoma16 citations
Semantic Scholar
Phase I study of XMT-1001 given IV every 3 weeks to patients with advanced solid tumors.
E. Sausville, L. Garbo, G. Weiss, D. Shkolny +4 more
201015 citations
Semantic Scholar
Indoximod Combined with Standard Induction Chemotherapy Is Well Tolerated and Induces a High Rate of Complete Remission with MRD-Negativity in Patients with Newly Diagnosed AML: Results from a Phase 1 Trial
A. Emadi, V. Duong, J. Pantin, Mohammad Imran +12 more
2018Blood13 citations Open access
Semantic Scholar
Synthesis, Characterization and Evaluation of Isoniazid Analogues as Potent Anticancer Agents
H. Kumar, D. Malhotra, Rajiv K. Sharma, E. Sausville +1 more
201113 citations
Semantic Scholar
Cytotoxic drugs: past, present and future
H. Newell, E. Sausville
2015Cancer Chemotherapy and Pharmacology11 citations Open access
Semantic Scholar
A phase I study of EC0225 administered weeks 1 and 2 of a 4-week cycle.
Sunil Sharma, E. Sausville, P. LoRusso, N. Vogelzang +5 more
201010 citations
Semantic Scholar
Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2
R. Lapidus, Brandon A. Carter-Cooper, M. Sadowska, E. Choi +11 more
2016Pharmaceuticals9 citations Open access
Semantic Scholar
Unbalanced 11;18 translocation in an acute erythroid leukemia after radioactive iodine therapy.
Nikolaos A. Trikalinos, Qing Chen, Y. Ning, E. Sausville +1 more
2013Cancer Genetics9 citations
Semantic Scholar
Promises from trametinib in RAF active tumors.
E. Sausville
2012New England Journal of Medicine9 citations
Semantic Scholar
Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - a novel class of compounds with potent activity against acute myeloid leukemia cells
Brandon A. Carter-Cooper, S. Fletcher, D. Ferraris, E. Choi +6 more
2016Bioorganic & Medicinal Chemistry Letters8 citations Open access
Semantic Scholar
Phase 1b Evaluation of the Safety and Efficacy of a 30-Minute IV Infusion of Carfilzomib In Patients with Relapsed and/or Refractory Multiple Myeloma
K. Papadopoulos, D. Siegel, S. Singhal, J. Infante +8 more
20108 citations
Semantic Scholar
Peripheral blood blast rate of clearance is an independent predictor of clinical response and outcomes in acute myeloid leukaemia
N. Holtzman, F. El Chaer, M. Baer, O. Ali +8 more
2019British Journal of Haematology7 citations Open access
Semantic Scholar
Comparative Analysis of Methods for Detecting Isocitrate Dehydrogenase 1 and 2 Mutations and Their Metabolic Consequence, 2-Hydroxyglutarate, in Different Neoplasms
S. Babakoohi, R. Lapidus, R. Faramand, E. Sausville +1 more
2017Applied immunohistochemistry & molecular morphology (Print)7 citations
Semantic Scholar
Socioeconomic status and survival in glioblastoma
Nikolaos A. Trikalinos, Y. Kwok, O. Goloubeva, M. Mehta +1 more
20166 citations
Semantic Scholar
PRECEDENT: A randomized phase II trial comparing EC145 and pegylated liposomal doxorubicin (PLD) in combination, versus PLD alone, in subjects with platinum-resistant ovarian cancer.
R. Naumann, R. Coleman, R. Burger, T. Herzog +16 more
2011Journal of Clinical Oncology6 citations
Semantic Scholar
Perspectives on the History and Evolution of Tumor Models
S. Decker, E. Sausville
20116 citations
Semantic Scholar
A phase I study of the folate-targeted conjugate EC0489 in patients with refractory or advanced metastatic cancer.
W. Harb, B. Conley, P. LoRusso, E. Sausville +6 more
20106 citations
Semantic Scholar
Disparate Effects of Cytotoxic Chemotherapy on the Antiviral Activity of Antiretroviral Therapy: Implications for Treatments of HIV-Infected Cancer Patients
S. Medina-Moreno, J. Zapata, M. Cottrell, Nhut M. Le +7 more
2019Antiviral Therapy5 citations Open access
Semantic Scholar
Schistocytes, echinocytes, iron deficiency anemia, and thrombocytopenia - hematologic manifestations of splenic angiosarcoma.
P. Rosenblatt, R. Koka, Qing Chen, J. Papadimitriou +2 more
2013Archives of Iranian medicine5 citations
Semantic Scholar

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