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K. England · SciRah

Researcher profile · Semantic Scholar

K. England

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K. England — researcher profile on SciRah

h-index: 12
Works: 18
Citations: 906

Most-cited papers

Targeting histone lysine demethylases — Progress, challenges, and the future
C. Thinnes, K. England, A. Kawamura, R. Chowdhury +2 more
2014Biochimica et Biophysica Acta182 citations Open access
Semantic Scholar
Recent Progress in Histone Demethylase Inhibitors.
T. McAllister, K. England, R. Hopkinson, P. Brennan +2 more
2016Journal of Medicinal Chemistry161 citations Open access
Semantic Scholar
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
Emma V. Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adán Pinto-Fernández +25 more
2020Life Science Alliance117 citations Open access
Semantic Scholar
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells
A. Tumber, A. Nuzzi, E. Hookway, S. Hatch +24 more
2017Cell Chemical Biology114 citations Open access
Semantic Scholar
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
V. Bavetsias, R. Lanigan, G. F. Ruda, B. Atrash +39 more
2016Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
Peter G. Jones, R. I. Storer, Y. Sabnis, Florian M Wakenhut +13 more
2017Journal of Medicinal Chemistry54 citations Open access
Semantic Scholar
Subtle overlapping deletions in the terminal region of chromosome 6q24.2-q26: three cases studied using FISH.
S. Sukumar, Sheng-Biao Wang, K. Hoang, C. Vanchiere +4 more
1999American journal of medical genetics48 citations
Semantic Scholar
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor
K. England, A. Tumber, T. Krojer, G. Scozzafava +9 more
2014MedChemComm31 citations Open access
Semantic Scholar
Acidic triazoles as soluble guanylate cyclase stimulators.
Lee R. Roberts, P. Bradley, Mark E. Bunnage, K. England +10 more
2011Bioorganic & Medicinal Chemistry Letters29 citations
Semantic Scholar
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
D. O’Brien, Hannah B. L. Jones, F. Guenther, E. Murphy +8 more
2023Molecular & Cellular Proteomics26 citations Open access
Semantic Scholar
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
D. O'Brien, Hannah B. L. Jones, F. Guenther, E. Murphy +7 more
2022bioRxiv18 citations Open access
Semantic Scholar
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
Y. Le Bihan, Rachel M. Lanigan, B. Atrash, Mark G. McLaughlin +25 more
2019European journal of medicinal chemistry14 citations Open access
Semantic Scholar
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Darragh P. O'Brien, Hannah B. L. Jones, Yu-Qi Shi, F. Guenther +11 more
2024bioRxiv12 citations Open access
Semantic Scholar
An improved synthesis of a novel α1A partial agonist including a new two-step synthesis of 4-fluoropyrazole
K. England, H. Mason, Rachel Osborne, Lee R. Roberts
20108 citations
Semantic Scholar
A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation
Emma V. Rusilowicz-Jones, Jane Jardine, Andreas Kallinos, Adán Pinto-Fernández +25 more
2020bioRxiv7 citations Open access
Semantic Scholar
USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms
M. Williamson, Rachel Heon‐Roberts, Sarah N J Franks, Elliot D. Mock +24 more
2026bioRxiv1 citations Open access
Semantic Scholar
A potent and selective inhibitor of a histone demethylase
K. England
20151 citations
Semantic Scholar
Crystal Structure of human JMJD2A complexed with KDOOA011340
T. Krojer, M. Vollmar, L. Crawley, A. Szykowska +11 more
20150 citations
Semantic Scholar

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