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Edward J. Kelly · SciRah

Researcher profile · Semantic Scholar

Edward J. Kelly

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Edward J. Kelly — researcher profile on SciRah

h-index: 37
Works: 90
Citations: 5,056

Most-cited papers

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.
Brian A. Masters, Edward J. Kelly, C. Quaife, R. Brinster +1 more
1994Proceedings of the National Academy of Sciences of the United States of America630 citations Open access
Semantic Scholar
Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia.
C. Quaife, S. Findley, J. C. Erickson, G. Froelick +3 more
1994Biochemistry571 citations
Semantic Scholar
Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles
Brian A. Masters, Carol J. Quaife, J. C. Erickson, Edward J. Kelly +4 more
1994Journal of Neuroscience332 citations Open access
Semantic Scholar
Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
Lawrence A. Vernetti, Albert Gough, N. Baetz, S. Blutt +18 more
2017Scientific Reports252 citations Open access
Semantic Scholar
Development of a microphysiological model of human kidney proximal tubule function
Elijah J. Weber, A. Chapron, Brian D. Chapron, J. Voellinger +11 more
2016Kidney International239 citations Open access
Semantic Scholar
Pharmacokinetics of Metformin during Pregnancy
S. Eyal, T. Easterling, D. Carr, J. Umans +8 more
2010Drug Metabolism And Disposition209 citations Open access
Semantic Scholar
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity.
Shih‐Yu Chang, Elijah J. Weber, Viktoriya S. Sidorenko, A. Chapron +12 more
2017JCI Insight155 citations Open access
Semantic Scholar
Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics
B. Prasad, Katherine Johnson, S. Billington, C. Lee +5 more
2016Drug Metabolism And Disposition148 citations Open access
Semantic Scholar
A murine model of Menkes disease reveals a physiological function of metallothionein
Edward J. Kelly, R. Palmiter
1996Nature Genetics131 citations
Semantic Scholar
A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.
M. Adler, S. Ramm, M. Hafner, J. Muhlich +9 more
2016Journal of the American Society of Nephrology120 citations Open access
Semantic Scholar
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics
Li Wang, C. Collins, Edward J. Kelly, X. Chu +12 more
2016Drug Metabolism And Disposition113 citations Open access
Semantic Scholar
CYP4V2 in Bietti's Crystalline Dystrophy: Ocular Localization, Metabolism of ω-3-Polyunsaturated Fatty Acids, and Functional Deficit of the p.H331P Variant
M. Nakano, Edward J. Kelly, C. Wiek, H. Hanenberg +1 more
2012Molecular Pharmacology110 citations Open access
Semantic Scholar
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
R. P. Tonge, Edward J. Kelly, S. Bruschi, Tom Kalhorn +3 more
1998Toxicology and Applied Pharmacology104 citations
Semantic Scholar
Expression and Characterization of CYP4V2 as a Fatty Acid ω-Hydroxylase
M. Nakano, Edward J. Kelly, A. Rettie
2009Drug Metabolism And Disposition101 citations Open access
Semantic Scholar
Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip
Courtney Sakolish, Elijah J. Weber, Edward J. Kelly, J. Himmelfarb +7 more
2018Scientific Reports87 citations Open access
Semantic Scholar
Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.
Elijah J. Weber, Kevin A Lidberg, Lu Wang, T. Bammler +15 more
2018JCI Insight82 citations Open access
Semantic Scholar
CHARACTERIZATION OF DIFFERENTIAL TISSUE ABUNDANCE OF MAJOR NON-CYP ENZYMES IN HUMAN.
A. Basit, Naveen K. Neradugomma, C. Wolford, Peter W. Fan +8 more
2020Molecular Pharmaceutics78 citations
Semantic Scholar
Effect of Gestational Age on mRNA and Protein Expression of Polyspecific Organic Cation Transporters during Pregnancy
Nora Lee, M. Hebert, B. Prasad, T. Easterling +3 more
2013Drug Metabolism And Disposition68 citations Open access
Semantic Scholar
Characterization of the human MDR1 gene.
M. Bodor, Edward J. Kelly, R. Ho
2005AAPS Journal64 citations
Semantic Scholar
Translational Assessment of Drug‐Induced Proximal Tubule Injury Using a Kidney Microphysiological System
C. Maass, Nathan Sorensen, J. Himmelfarb, Edward J. Kelly +2 more
2019CPT: Pharmacometrics & Systems Pharmacology60 citations Open access
Semantic Scholar
Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.
Edward J. Kelly, M. Nakano, Priyanka Rohatgi, Vladimir Yarov-Yarovoy +1 more
2011Molecular Interventions55 citations Open access
Semantic Scholar
Identification of Amino Acid Determinants in CYP4B1 for Optimal Catalytic Processing of 4-Ipomeanol
C. Wiek, E. Schmidt, K. Roellecke, M. Freund +7 more
2015Biochemical Journal53 citations Open access
Semantic Scholar
Reconstructing the Human Renal Vascular-Tubular Unit in Vitro
S. G. Rayner, Kiet T. Phong, Jun Xue, D. Lih +4 more
2018Advanced Healthcare Materials52 citations Open access
Semantic Scholar
Special Section – New Models in Drug Metabolism and Transport — Minireview Emerging Kidney Models to Investigate Metabolism , Transport , and Toxicity of Drugs and Xenobiotics
P. Bajaj, S. Chowdhury, R. Yucha, Edward J. Kelly +1 more
201850 citations
Semantic Scholar
Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition
M. Nakano, Catherine M. Lockhart, Edward J. Kelly, A. Rettie
2014Drug metabolism reviews (Softcover ed.)50 citations Open access
Semantic Scholar
Expression of human metallothionein-III in transgenic mice.
J. C. Erickson, Brian A. Masters, Edward J. Kelly, R. Brinster +1 more
1995Neurochemistry International50 citations Open access
Semantic Scholar
A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
T. Nieskens, M. Persson, Edward J. Kelly, A. Sjögren
2020Drug Metabolism And Disposition47 citations Open access
Semantic Scholar
Predicting Tubular Reabsorption with a Human Kidney Proximal Tubule Tissue-on-a-Chip and Physiologically-Based Modeling
Courtney Sakolish, Zunwei Chen, Chimeddulam Dalaijamts, K. Mitra +6 more
2019Toxicology in Vitro46 citations Open access
Semantic Scholar
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.
Shih‐Yu Chang, J. Voellinger, K. V. Van Ness, Brian D. Chapron +6 more
2017Toxicology in Vitro46 citations
Semantic Scholar
Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice.
Carol J. Quaife, Edward J. Kelly, Brian A. Masters, R. Brinster +1 more
1998Toxicology and Applied Pharmacology46 citations Open access
Semantic Scholar
Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification.
Edward J. Kelly, Kristin E Erickson, C. Sengstag, D. Eaton
2002Toxicological Sciences44 citations Open access
Semantic Scholar
Generation and characterization of a murine model of Bietti crystalline dystrophy.
Catherine M. Lockhart, M. Nakano, A. Rettie, Edward J. Kelly
2014Investigative Ophthalmology and Visual Science43 citations Open access
Semantic Scholar
PHARMACOGENETICS OF INTRAVENOUS AND ORAL BUSULFAN IN HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS
N. Abbasi, B. Vadnais, Jennifer A. Knutson, D. Blough +6 more
2010Journal of clinical pharmacology43 citations Open access
Semantic Scholar
Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing
Wei‐Yang Chen, Eric A. Evangelista, Jade Yang, Edward J. Kelly +1 more
2021Frontiers in Pharmacology38 citations Open access
Semantic Scholar
The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice.
N. Salama, Edward J. Kelly, T. Bui, R. Ho
2005Journal of Pharmacy and Science38 citations
Semantic Scholar
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics
P. Bajaj, S. Chowdhury, Robert Yucha, Edward J. Kelly +1 more
2018Drug Metabolism And Disposition37 citations Open access
Semantic Scholar
Identification of CYP3A7 for Glyburide Metabolism in Human Fetal Livers
Diana L. Shuster, Linda J. Risler, B. Prasad, J. Calamia +7 more
2014Biochemical Pharmacology37 citations Open access
Semantic Scholar
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system
Edward J. Kelly, Zhican Wang, J. Voellinger, Catherine K. Yeung +13 more
2013Stem cell research & therapeutics35 citations Open access
Semantic Scholar
Mu-class GSTs are responsible for aflatoxin B(1)-8, 9-epoxide-conjugating activity in the nonhuman primate macaca fascicularis liver.
Charles Wang, T. Bammler, Yingying Guo, Edward J. Kelly +1 more
2000Toxicological Sciences34 citations
Semantic Scholar
Microphysiological System Modeling of Ochratoxin A-Associated Nephrotoxicity
T. Imaoka, Jade Yang, Lu Wang, M. McDonald +7 more
2020Toxicology33 citations Open access
Semantic Scholar
Tissue Chips in Space—Challenges and Opportunities
Catherine K. Yeung, P. Koenig, Stefanie Countryman, K. Thummel +2 more
2019Clinical and Translational Science33 citations Open access
Semantic Scholar
Purification and characterization of hexahistidine-tagged cyclohexanone monooxygenase expressed in Saccharomyces cerevisiae and Escherichia coli.
M. Cheesman, M. Kneller, Edward J. Kelly, Stella J. Thompson +3 more
2001Protein Expression and Purification33 citations
Semantic Scholar
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences
K. V. Van Ness, Francine Cesar, Catherine K. Yeung, J. Himmelfarb +1 more
2021Clinical and Translational Science30 citations Open access
Semantic Scholar
An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion.
A. Chapron, Brian D. Chapron, Dale W. Hailey, Shih‐Yu Chang +6 more
2020ACS Pharmacology & Translational Science30 citations Open access
Semantic Scholar
Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system
T. Imaoka, Wei-Ze Huang, Sara Shum, Dale W. Hailey +6 more
2020Scientific Reports29 citations Open access
Semantic Scholar
Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2
Catherine M. Lockhart, Travis B. Smith, Paul Yang, M. Naidu +4 more
2017British Journal of Ophthalmology28 citations Open access
Semantic Scholar
Mechanisms of CYP3A induction during pregnancy: studies in HepaRG cells
M. Sachar, Edward J. Kelly, J. Unadkat
2019AAPS Journal25 citations Open access
Semantic Scholar
Reevaluating the Role of Megalin in Renal Vitamin D Homeostasis Using a Human Cell-Derived Microphysiological System
Brian D. Chapron, A. Chapron, Brian R. Phillips, Miracle C Okoli +4 more
2018ALTEX25 citations Open access
Semantic Scholar
RETRACTION: CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids
M. Farooq, Edward J. Kelly, J. Unadkat
2016Drug Metabolism And Disposition25 citations Open access
Semantic Scholar
Concise Review: Current and Emerging Biomarkers of Nephrotoxicity.
Elijah J. Weber, J. Himmelfarb, Edward J. Kelly
2017Current Opinion in Toxicology24 citations Open access
Semantic Scholar

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