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S. Bruschi · SciRah

Researcher profile · Semantic Scholar

S. Bruschi

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S. Bruschi — researcher profile on SciRah

h-index: 14
Works: 26
Citations: 798

Most-cited papers

Cysteine S-conjugate β-lyases: Important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents
Arthur J. L. Cooper, B. Krasnikov, Z. Niatsetskaya, J. Pinto +4 more
2010Amino Acids104 citations Open access
Semantic Scholar
Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice.
R. P. Tonge, Edward J. Kelly, S. Bruschi, Tom Kalhorn +3 more
1998Toxicology and Applied Pharmacology104 citations
Semantic Scholar
Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.
M. L. Adams, R. H. Pierce, Mary E. Vail, Collin C. White +5 more
2001Molecular Pharmacology98 citations
Semantic Scholar
Cell culture model for acetaminophen-induced hepatocyte death in vivo.
R. Pierce, C. C. Franklin, J. Campbell, R. Tonge +4 more
2002Biochemical Pharmacology59 citations
Semantic Scholar
Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity.
S. Bruschi, K. West, J. W. Crabb, Radhey S. Gupta +1 more
1993Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.
Arthur J. L. Cooper, S. Bruschi, M. W. Anders
2002Biochemical Pharmacology55 citations
Semantic Scholar
Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity.
H. Ho, Collin C. White, C. Fernández, N. Fausto +3 more
2005Toxicological Sciences50 citations Open access
Semantic Scholar
Mitochondrial aspartate aminotransferase catalyses cysteine S-conjugate beta-lyase reactions.
Arthur J. L. Cooper, S. Bruschi, A. Iriarte, M. Martinez-Carrión
2002Biochemical Journal44 citations Open access
Semantic Scholar
Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death.
S. Bruschi, J. Lindsay, J. Crabb
1998Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine.
E. A. James, S. Gygi, M. Adams, R. Pierce +4 more
2002Biochemistry31 citations
Semantic Scholar
Human mitochondrial and cytosolic branched-chain aminotransferases are cysteine S-conjugate beta-lyases, but turnover leads to inactivation.
Arthur J. L. Cooper, S. Bruschi, M. Conway, S. Hutson
2003Biochemical Pharmacology28 citations
Semantic Scholar
Co-purification of mitochondrial HSP70 and mature protein disulfide isomerase with a functional rat kidney high-M(r) cysteine S-conjugate beta-lyase.
Arthur J. L. Cooper, Jian-Ping Wang, C. Gartner, S. Bruschi
2001Biochemical Pharmacology28 citations
Semantic Scholar
Mechanisms of Acetaminophen-Induced Liver Disease
S. Nelson, S. Bruschi
200217 citations
Semantic Scholar
In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation
S. Bruschi, Richard J. Bull
199315 citations
Semantic Scholar
Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine.
H. Ho, Yankai Jia, K. Coe, Qiuxia Gao +7 more
2006Biochemical Pharmacology13 citations
Semantic Scholar
Cysteine S-conjugate β-lyases
Arthur J. L. Cooper, B. Krasnikov, J. Pinto, S. Bruschi
2010Current Protocols in Toxicology11 citations Open access
Semantic Scholar
BCL-xL overexpression effectively protects against tetrafluoroethylcysteine-induced intramitochondrial damage and cell death.
H. Ho, Zhong-Hua Hu, S. Tzung, D. Hockenbery +3 more
2005Biochemical Pharmacology11 citations
Semantic Scholar
Implication of alterations in intracellular calcium ion homoeostasis in the advent of paracetamol-induced cytotoxicity in primary mouse hepatocyte monolayer cultures.
S. Bruschi, B. Priestly
1990Toxicology in Vitro11 citations
Semantic Scholar
Formation, characterization, and immunoreactivity of lysine thioamide adducts from fluorinated nephrotoxic cysteine conjugates in vitro and in vivo.
Michael B. Fisher, Patrick J. Hayden, S. Bruschi, Deanne M. Dulik +3 more
1993Chemical Research in Toxicology9 citations
Semantic Scholar
Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen
S. Bruschi
20055 citations
Semantic Scholar
In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation.
S. Bruschi, Richard J. Bull
1993Fundamental and Applied Toxicology5 citations
Semantic Scholar
Mitochondrial stress protein actions during chemically induced renal proximal tubule cell death.
S. Bruschi, J. Lindsay
1994Biochemistry and cell biology = Biochimie et biologie cellulaire4 citations
Semantic Scholar
Vertebrate histone gene transcription occurs from both DNA strands.
S. Bruschi, J. R. E. Wells
1981Nucleic Acids Research3 citations Open access
Semantic Scholar
Tetrafluoroethylcysteine-induced alterations to mitochondrial complex III activities in vitro
M. Adams, S. Nelson, S. Bruschi
20020 citations
Semantic Scholar
Effect of dichloroacetate and trichloroacetate on the incorporation of 3 H-thymidine in primary rat hepatocyte cultures
A. Vanderpol, S. Bruschi, R. Bull
19910 citations
Semantic Scholar
Investigations into mechanisms of paracetamol-induced toxicity using in vitro' systems / by Sam A. Bruschi
S. Bruschi
19870 citations
Semantic Scholar

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