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R. Corbau · SciRah

Researcher profile · Semantic Scholar

R. Corbau

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R. Corbau — researcher profile on SciRah

h-index: 20
Works: 50
Citations: 1,175

Most-cited papers

Characterization of Fusion Determinants Points to the Involvement of Three Discrete Regions of Both E1 and E2 Glycoproteins in the Membrane Fusion Process of Hepatitis C Virus
Dimitri Lavillette, E. Pécheur, P. Donot, J. Fresquet +5 more
2007Journal of Virology201 citations Open access
Semantic Scholar
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
C. Mowbray, Catherine Burt, R. Corbau, Simon Gayton +9 more
2009Bioorganic & Medicinal Chemistry Letters81 citations Open access
Semantic Scholar
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
N. Draoui, O. Schicke, Antony E. Fernandes, Xavier Drozak +11 more
2013Bioorganic & Medicinal Chemistry65 citations Open access
Semantic Scholar
Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model
D. Suhy, Shih-Chu Kao, Tin Mao, L. Whiteley +17 more
2012Molecular Therapy61 citations Open access
Semantic Scholar
Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1
R. Corbau, Julie Mori, Chris Phillips, Lesley Fishburn +11 more
2010Antimicrobial Agents and Chemotherapy61 citations Open access
Semantic Scholar
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
L. Jones, G. Allan, Oscar Barba, Catherine Burt +12 more
2009Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
Biochemical Activities of Minute Virus of Mice Nonstructural Protein NS1 Are Modulated In Vitro by the Phosphorylation State of the Polypeptide
J. Nüesch, R. Corbau, P. Tattersall, J. Rommelaere
1998Journal of Virology56 citations Open access
Semantic Scholar
RNAi prevents and reverses phenotypes induced by mutant human ataxin‐1
Megan S. Keiser, A. M. Monteys, R. Corbau, P. Gonzalez-Alegre +1 more
2016Annals of Neurology52 citations Open access
Semantic Scholar
Regulation of MVM NS1 by protein kinase C: impact of mutagenesis at consensus phosphorylation sites on replicative functions and cytopathic effects.
R. Corbau, Valérie Duverger, J. Rommelaere, J. Nüesch
2000Virology50 citations Open access
Semantic Scholar
Replicative Functions of Minute Virus of Mice NS1 Protein Are Regulated In Vitro by Phosphorylation through Protein Kinase C
J. Nüesch, S. Dettwiler, R. Corbau, J. Rommelaere
1998Journal of Virology45 citations Open access
Semantic Scholar
Development and Automation of a 384-Well Cell Fusion Assay to Identify Inhibitors of CCR5/CD4-Mediated HIV Virus Entry
J. Bradley, Jasween Gill, F. Bertelli, S. Letafat +9 more
2004Journal of biomolecular screening41 citations Open access
Semantic Scholar
Regulation of Minute Virus of Mice NS1 Replicative Functions by Atypical PKCλ In Vivo
J. Nüesch, S. Lachmann, R. Corbau, J. Rommelaere
2003Journal of Virology39 citations Open access
Semantic Scholar
Phosphorylation of the viral nonstructural protein NS1 during MVMp infection of A9 cells.
R. Corbau, N. Salomé, J. Rommelaere, J. Nüesch
1999Virology39 citations Open access
Semantic Scholar
Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
C. Mowbray, Catherine Burt, R. Corbau, M. Perros +4 more
2009Bioorganic & Medicinal Chemistry Letters32 citations
Semantic Scholar
Preclinical evaluation of FLT190, a liver-directed AAV gene therapy for Fabry disease
Jey M. Jeyakumar, Azadeh Kia, Lawrence C S Tam, J. McIntosh +17 more
2023Gene Therapy31 citations Open access
Semantic Scholar
HCV-NS3 inhibitors: determination of their kinetic parameters and mechanism.
M. Flores, J. Strawbridge, G. Ciaramella, R. Corbau
2009Biochimica et Biophysica Acta28 citations
Semantic Scholar
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
C. Mowbray, R. Corbau, Michael Hawes, L. Jones +6 more
2009Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision
H. Denise, S. Moschos, B. Sidders, Frances Burden +10 more
2014Molecular Therapy: Nucleic Acids25 citations Open access
Semantic Scholar
Comparison of the Non‐Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers
L. Jones, G. Allan, R. Corbau, D. Middleton +5 more
2011Chemical Biology and Drug Design23 citations
Semantic Scholar
Regulation of minute virus of mice NS1 replicative functions by atypical PKClambda in vivo.
J. Nüesch, S. Lachmann, R. Corbau, J. Rommelaere
2003Journal of Virology23 citations
Semantic Scholar
Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa
V. Liebens, Valerie Defraine, Wouter Knapen, Toon Swings +6 more
2017Antimicrobial Agents and Chemotherapy18 citations Open access
Semantic Scholar
Differences in wild-type– and R338L-tenase complex formation are at the root of R338L-factor IX assay discrepancies
J. Foley, Erald Shehu, A. Riddell, E. Gray +9 more
2022Blood Advances15 citations Open access
Semantic Scholar
In Vitro Characterization of the Activity of PF-05095808, a Novel Biological Agent for Hepatitis C Virus Therapy
H. Lavender, K. Brady, Frances Burden, O. Delpuech-Adams +10 more
2011Antimicrobial Agents and Chemotherapy15 citations Open access
Semantic Scholar
1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage
Valerie Defraine, V. Liebens, E. Loos, Toon Swings +10 more
2018Frontiers in Microbiology13 citations Open access
Semantic Scholar
Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models
Valerie Defraine, L. Verstraete, F. Van Bambeke, Ahalieyah Anantharajah +7 more
2017Frontiers in Microbiology11 citations Open access
Semantic Scholar
Optimization of 5‐Aryloxyimidazole Non‐Nucleoside Reverse Transcriptase Inhibitors
L. Jones, G. Allan, R. Corbau, D. Hay +9 more
2008ChemMedChem11 citations
Semantic Scholar
First-in-human study of a liver-directed AAV gene therapy (FLT190) in Fabry disease
D. Hughes, Niten Patel, R. Kinch, L. Dronfield +6 more
20209 citations
Semantic Scholar
Liver-directed gene therapy corrects Fabry disease in mice
Jey M. Jeyakumar, Azadeh Kia, J. McIntosh, D. Verhoef +5 more
2019Molecular Genetics and Metabolism9 citations
Semantic Scholar
Identification of novel FLT3 kinase inhibitors.
D. Pauwels, H. Klaassen, I. Lahortiga, A. Kilonda +6 more
2013European journal of medicinal chemistry8 citations
Semantic Scholar
FLT201, a novel liver-directed AAV gene therapy candidate for Gaucher disease type 1
F. Comper, C. Miranda, B. Liou, Tihomir S. Dodev +20 more
2025Molecular Therapy6 citations Open access
Semantic Scholar
Preclinical Evaluation of an Engineered AAV Capsid in Non-Human Primates for the Treatment of Haemophilia B
Allison P. Dane, J. McIntosh, Doyoung Lee, R. Sheridan +4 more
2018Blood6 citations Open access
Semantic Scholar
Liver-Directed AAV Gene Therapy for Gaucher Disease
Carlos J. Miranda, M. Canavese, E. Chisari, Jalpa Pandya +10 more
2019Blood5 citations Open access
Semantic Scholar
Efficacy Evaluation of Liver-Directed Gene Therapy in Fabry Mice
Azadeh Kia, J. McIntosh, Cecilia Rosales, Paniz Hosseini +5 more
2018Blood4 citations
Semantic Scholar
FLT201: An AAV-mediated gene therapy for type 1 Gaucher disease designed to target difficult to reach tissues
R. Corbau, Carlos J. Miranda, F. Comper, Petya Kalcheva +13 more
20213 citations
Semantic Scholar
Generation of β-Glucocerebrosidase variants with increased half-life in human plasma for liver directed AAV gene therapy aimed at the treatment of Gaucher disease type 1
F. Comper, I-Mei Yu, Petya Kalcheva, Carlos J. Miranda +10 more
20212 citations
Semantic Scholar
Liver directed AAV gene therapy to treat Gaucher disease
Carlos J. Miranda, J. McIntosh, Azadeh Kia, M. Canavese +7 more
2019Molecular Genetics and Metabolism1 citations
Semantic Scholar
A Novel Lysine to Arginine Substitution at Position 301 Enhances Activity of Factor IX
D. Verhoef, J. Foley, Andrew Goodale, Emma Macrae +5 more
2018Blood1 citations
Semantic Scholar
185. Safety Study by Validated Immunoassays in a Phase III Study of Subjects with Inherited Retinal Dystrophy Due to Mutations in the Gene Encoding Human Retinal Pigment Epithelium-Specific Protein 65 (RPE65) Injected with Adeno-Associated Viral Vectors
Daniel J. Hui, Yi-Feng Chen, Thomas Antrilli, Yun Liu +5 more
20161 citations Open access
Semantic Scholar
Development of a GLA nAb assay with a fully-human, neutralizing IgG4 positive control to characterize antibody response in Fabry disease patients
Sujata Ravi, Erald Shehu, J. Foley, O. Allen +4 more
20210 citations
Semantic Scholar
One-off liver directed AAV gene therapy achieves long term uptake of acid beta-glucocerebrosidase by macrophages of affected tissues in Gaucher disease
Carlos J. Miranda, E. Chisari, Natalie Northcott, Jalpa Pandya +11 more
20200 citations
Semantic Scholar
Design and Characterization of FLT210, a Potent Next Generation AAV-hFVIII Vector Candidate
Azadeh Kia, F. Comper, Samantha Correia, C. Casari +20 more
2019Blood0 citations Open access
Semantic Scholar
A small molecule candidate for antibiotic co-therapy in the fight against persistence
Valerie Defraine, V. Liebens, Toon Swings, R. Corbau +6 more
20160 citations
Semantic Scholar
A novel antimicrobial in the fight against the nosocomial pathogen Pseudomonas aeruginosa
Evelien Gerits, V. Liebens, Wouter Knapen, Toon Swings +10 more
20140 citations
Semantic Scholar
HIV Virus Entry Development and Automation of a 384-Well Cell Fusion Assay to Identify Inhibitors of CCR5/CD4-Mediated
J. Bradley, F. Bertelli, S. Letafat, R. Corbau +3 more
20130 citations
Semantic Scholar
Novel molecules targeting Pseudomonas aeruginosa persisters cells
V. Liebens, Wouter Knapen, Toon Swings, Valerie Defraine +5 more
20130 citations
Semantic Scholar
Identification of small molecules targeting Pseudomonas aeruginosa persisters
V. Liebens, Wouter Knapen, Toon Swings, Valerie Defraine +5 more
20130 citations
Semantic Scholar
Identification of small molecules targeting P. aeruginosa persister cells
V. Liebens, Wouter Knapen, Toon Swings, Valerie Defraine +5 more
20130 citations
Semantic Scholar
Hepatitis C Virus Therapy PF-05095808, a Novel Biological Agent for Characterization of the Activity of In Vitro
R. Corbau, P. Troke, J. F. Wright, B. Savic +6 more
20120 citations
Semantic Scholar
Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays
L. Jones, G. Allan, Oscar Barba, Catherine Burt +8 more
20090 citations
Semantic Scholar
Derives de pyrazole
R. Corbau, C. Mowbray, M. Perros, Paul A. Stupple +1 more
20010 citations
Semantic Scholar

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