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M. Perros · SciRah

Researcher profile · Semantic Scholar

M. Perros

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M. Perros — researcher profile on SciRah

h-index: 22
Works: 42
Citations: 3,319

Most-cited papers

Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
P. Dorr, M. Westby, Susan Dobbs, P. Griffin +12 more
2005Antimicrobial Agents and Chemotherapy1,178 citations Open access
Semantic Scholar
Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry
M. Westby, C. Smith-Burchnell, Julie Mori, Marilyn Lewis +5 more
2006Journal of Virology388 citations Open access
Semantic Scholar
Emergence of CXCR4-Using Human Immunodeficiency Virus Type 1 (HIV-1) Variants in a Minority of HIV-1-Infected Patients following Treatment with the CCR5 Antagonist Maraviroc Is from a Pretreatment CXCR4-Using Virus Reservoir
M. Westby, Marilyn Lewis, J. Whitcomb, M. Youle +5 more
2006Journal of Virology363 citations
Semantic Scholar
HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention
W. Blair, C. Pickford, S. Irving, D. Brown +15 more
2010PLoS Pathogens295 citations Open access
Semantic Scholar
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
G. Basarab, Gunther H. Kern, J. McNulty, J. Mueller +19 more
2015Scientific Reports99 citations Open access
Semantic Scholar
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
C. Mowbray, Catherine Burt, R. Corbau, Simon Gayton +9 more
2009Bioorganic & Medicinal Chemistry Letters81 citations Open access
Semantic Scholar
Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
Isabel M. Vincent, D. Ehmann, S. Mills, M. Perros +1 more
2016Antimicrobial Agents and Chemotherapy79 citations Open access
Semantic Scholar
Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc.
David A. Price, D. Armour, M. D. de Groot, D. Leishman +4 more
2006Bioorganic & Medicinal Chemistry Letters69 citations Open access
Semantic Scholar
The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF‐4878691)
M. Fidock, B. Souberbielle, C. Laxton, J. Rawal +14 more
2011Clinical pharmacology and therapy62 citations
Semantic Scholar
Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1
R. Corbau, Julie Mori, Chris Phillips, Lesley Fishburn +11 more
2010Antimicrobial Agents and Chemotherapy61 citations Open access
Semantic Scholar
New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation
W. Blair, Joan Cao, J. Fok-Seang, P. Griffin +9 more
2009Antimicrobial Agents and Chemotherapy61 citations Open access
Semantic Scholar
Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.
L. Jones, G. Allan, Oscar Barba, Catherine Burt +12 more
2009Journal of Medicinal Chemistry57 citations Open access
Semantic Scholar
A sustainable model for antibiotics
M. Perros
2015Science47 citations
Semantic Scholar
Development and Automation of a 384-Well Cell Fusion Assay to Identify Inhibitors of CCR5/CD4-Mediated HIV Virus Entry
J. Bradley, Jasween Gill, F. Bertelli, S. Letafat +9 more
2004Journal of biomolecular screening41 citations Open access
Semantic Scholar
An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Paul A. Stupple, David V. Batchelor, Martin Corless, P. Dorr +16 more
2011Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
C. Mowbray, Catherine Burt, R. Corbau, M. Perros +4 more
2009Bioorganic & Medicinal Chemistry Letters32 citations
Semantic Scholar
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
C. Mowbray, R. Corbau, Michael Hawes, L. Jones +6 more
2009Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: effects of viral diversity, target cell and receptor density.
S. Willey, Paul Peters, W. M. Sullivan, P. Dorr +2 more
2005Antiviral Research27 citations
Semantic Scholar
Challenges and opportunities in the discovery, development, and commercialization of pathogen-targeted antibiotics.
D. Altarac, Michael J. Gutch, J. Mueller, Matthew D. Ronsheim +2 more
2021Drug Discovery Today25 citations Open access
Semantic Scholar
A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41
E. Murray, D. Leaman, N. Pawa, Hannah Perkins +4 more
2010Journal of Virology25 citations Open access
Semantic Scholar
The Discovery of CCR5 Receptor Antagonists for the Treatment of HIV Infection: Hit‐to‐Lead Studies
D. Armour, M. D. de Groot, M. Edwards, M. Perros +3 more
2006ChemMedChem24 citations
Semantic Scholar
Baseline CD4+ T-cell counts and weighted background susceptibility scores strongly predict response to maraviroc regimens in treatment-experienced patients
J. Schapiro, C. Boucher, D. Kuritzkes, D. A. van de Vijver +10 more
2011Antiviral Therapy23 citations
Semantic Scholar
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones
G. Basarab, S. Ghorpade, Liezl Gibhard, R. Mueller +13 more
2022Antimicrobial Agents and Chemotherapy22 citations Open access
Semantic Scholar
CCR5 inhibitors in HIV-1 therapy
P. Dorr, M. Perros
2008Expert Opinion on Drug Discovery21 citations
Semantic Scholar
Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV.
David A. Price, D. Armour, M. D. de Groot, D. Leishman +4 more
2008Current Topics in Medicinal Chemistry21 citations
Semantic Scholar
The Discovery of Tropane‐derived CCR5 Receptor Antagonists
D. Armour, M. D. de Groot, David A. Price, B. Stammen +3 more
2006Chemical Biology and Drug Design21 citations Open access
Semantic Scholar
Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy
S. Butler, H. Valdez, M. Westby, M. Perros +7 more
2011Journal of Acquired Immune Deficiency Syndromes20 citations Open access
Semantic Scholar
Antifungal activity of selective serotonin reuptake inhibitors attributed to non-specific cytotoxicity.
T. Young, G. Oliver, David C. Pryde, M. Perros +1 more
2003Journal of Antimicrobial Chemotherapy20 citations Open access
Semantic Scholar
CCR5 pharmacology methodologies and associated applications.
R. Mansfield, S. Able, P. Griffin, B. Irvine +12 more
2009Methods in Enzymology18 citations
Semantic Scholar
CCR5 antagonists for the treatment of HIV infection and AIDS
M. Perros
200716 citations
Semantic Scholar
968 GENOTYPIC CHARACTERISATION OF HCV NS5B FOLLOWING 8-DAY MONOTHERAPY WITH THE POLYMERASE INHIBITOR PF-00868554 IN HCV-INFECTED SUBJECTS
P. Troke, Marilyn Lewis, P. Simpson, E. van der Ryst +4 more
200914 citations
Semantic Scholar
Optimization of 5‐Aryloxyimidazole Non‐Nucleoside Reverse Transcriptase Inhibitors
L. Jones, G. Allan, R. Corbau, D. Hay +9 more
2008ChemMedChem11 citations
Semantic Scholar
Design and optimisation of potent gp120-CD4 inhibitors.
T. Tran, F. Adam, F. Calo, D. R. Fenwick +13 more
2009Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
G. Basarab, Gunther H. Kern, J. McNulty, J. Mueller +19 more
2015Scientific Reports8 citations Open access
Semantic Scholar
Discovery of a small molecule inhibitor through interference with the gp120-CD4 interaction.
David H Williams, F. Adam, D. R. Fenwick, J. Fok-Seang +14 more
2009Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.
T. Parkinson, M. Howett, P. Welsh, S. D. Patrick +6 more
2007Antiviral Research3 citations
Semantic Scholar
5th Antiviral Drug Discovery & Development Summit
W. Blair, M. Perros
20042 citations
Semantic Scholar
A Low-Molecular-Weight Entry Inhibitor of both CCR 5-and CXCR 4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp 41
E. Murray, D. Leaman, N. Pawa, Hannah Perkins +4 more
20101 citations
Semantic Scholar
Characterization of a Novel Series of gp120 Inhibitors
T. Parkinson, P. T. Stephenson, C. Pickford, T. Tran +7 more
20081 citations
Semantic Scholar
5th Antiviral Drug Discovery and Development Summit.
W. Blair, M. Perros
2004Expert Opinion on Investigational Drugs1 citations
Semantic Scholar
CCR 5 Signaling Assays and Application to Quantify and Characterize Ligand-Dependent Agonism , Antagonism , and Inverse Agonism
R. Mansfield, S. Able, P. Griffin, B. Irvine +12 more
20090 citations
Semantic Scholar
Maraviroc Discovery and Resistance: Current Understanding and Future Considerations
M. Westby, M. Perros
20080 citations
Semantic Scholar

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