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I. Lahortiga · SciRah

Researcher profile · Semantic Scholar

I. Lahortiga

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I. Lahortiga — researcher profile on SciRah

h-index: 26
Works: 71
Citations: 2,832

Most-cited papers

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
K. De Keersmaecker, Z. Atak, Ning Li, C. Vicente +26 more
2012Nature Genetics414 citations Open access
Semantic Scholar
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
I. Lahortiga, K. De Keersmaecker, P. Van Vlierberghe, C. Graux +14 more
2007Nature Genetics282 citations
Semantic Scholar
CD74-NRG1 fusions in lung adenocarcinoma.
L. Fernandez-Cuesta, D. Plenker, H. Osada, R. Sun +47 more
2014Cancer Discovery268 citations
Semantic Scholar
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
M. Kleppe, I. Lahortiga, Tiama El-Chaar, K. De Keersmaecker +12 more
2009Nature Genetics195 citations Open access
Semantic Scholar
Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia
C. Vicente, C. Schwab, M. Broux, E. Geerdens +15 more
2015Haematologica150 citations Open access
Semantic Scholar
JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma.
K. Van Roosbroeck, Luk Cox, T. Tousseyn, I. Lahortiga +9 more
2009Blood112 citations Open access
Semantic Scholar
The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors.
E. Lierman, I. Lahortiga, H. van Miegroet, N. Mentens +2 more
2007Haematologica108 citations Open access
Semantic Scholar
Novel translocations that disrupt the platelet‐derived growth factor receptor β (PDGFRB) gene in BCR–ABL‐negative chronic myeloproliferative disorders
E. J. Baxter, S. Kulkarni, J. Vizmanos, R. Jaju +12 more
2003British Journal of Haematology98 citations Open access
Semantic Scholar
Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia
X. Agirre, J. Román-Gómez, I. Vázquez, A. Jiménez-Velasco +10 more
2006International Journal of Cancer97 citations Open access
Semantic Scholar
Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities
C. Vicente, I. Vázquez, A. Conchillo, M. García-Sánchez +6 more
2012Leukemia79 citations
Semantic Scholar
Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotyping
M. Odero, K. Carlson, Maria J. José Calasanz, I. Lahortiga +2 more
2001Genes, Chromosomes and Cancer75 citations Open access
Semantic Scholar
Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice.
D. Shing, M. Trubia, F. Marchesi, E. Radaelli +12 more
2007Journal of Clinical Investigation74 citations Open access
Semantic Scholar
TP53 is frequently altered by methylation, mutation, and/or deletion in acute lymphoblastic leukaemia
X. Agirre, F. Novo, Maria J. José Calasanz, M. Larráyoz +4 more
2003Molecular Carcinogenesis73 citations
Semantic Scholar
High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes
Zeynep Kalender Atak, K. De Keersmaecker, V. Gianfelici, E. Geerdens +13 more
2012PLoS ONE72 citations Open access
Semantic Scholar
NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder.
J. Vizmanos, F. Novo, J. Román, E. J. Baxter +6 more
2004Cancer Research71 citations Open access
Semantic Scholar
Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia
C. Graux, Marian Stevens-Kroef, M. Lafage, N. Dastugue +21 more
2009Leukemia70 citations Open access
Semantic Scholar
In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
K. De Keersmaecker, I. Lahortiga, N. Mentens, Cedric Folens +6 more
2008Haematologica67 citations Open access
Semantic Scholar
Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia
I. Vázquez, M. Maicas, J. Cervera, X. Agirre +16 more
2011Haematologica55 citations Open access
Semantic Scholar
Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements
I. Lahortiga, I. Vázquez, X. Agirre, M. Larráyoz +4 more
2004Genes, Chromosomes and Cancer51 citations Open access
Semantic Scholar
Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion
I. Lahortiga, C. Akin, J. Cools, T. Wilson +10 more
2008Haematologica45 citations Open access
Semantic Scholar
NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15).
I. Lahortiga, J. Vizmanos, X. Agirre, I. Vázquez +7 more
2003Cancer Research44 citations
Semantic Scholar
Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells
I. Lahortiga, X. Agirre, E. Belloni, I. Vázquez +6 more
2004Oncogene38 citations Open access
Semantic Scholar
Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia
Antonis Dagklis, D. Pauwels, I. Lahortiga, E. Geerdens +8 more
2015Haematologica35 citations Open access
Semantic Scholar
t(10;16)(q22;p13) and MORF‐CREBBP fusion is a recurrent event in acute myeloid leukemia
J. Vizmanos, M. Larráyoz, I. Lahortiga, F. Floristán +4 more
2003Genes, Chromosomes and Cancer34 citations Open access
Semantic Scholar
A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome
M. Odero, J. Vizmanos, J. Román, I. Lahortiga +5 more
2002Genes, Chromosomes and Cancer33 citations Open access
Semantic Scholar
JAK2-V617F activating mutation in acute myeloid leukemia: prognostic impact and association with other molecular markers
Carmen Vicente, I. Vázquez, N. Marcotegui, A. Conchillo +7 more
2007Leukemia30 citations
Semantic Scholar
A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia
E. Belloni, M. Trubia, M. Mancini, Valentina Derme +7 more
2004Genes, Chromosomes and Cancer20 citations
Semantic Scholar
Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling
S. Wandinger, I. Lahortiga, K. Jacobs, M. Klammer +8 more
2016PLoS ONE15 citations Open access
Semantic Scholar
Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia
K. De Keersmaecker, I. Lahortiga, C. Graux, P. Marynen +3 more
2006Leukemia14 citations Open access
Semantic Scholar
Coexistence of different clonal populations harboring the b3a2 (p210) and e1a2 (p190) BCR-ABL1 fusion transcripts in chronic myelogenous leukemia resistant to imatinib.
X. Agirre, J. Román-Gómez, I. Vázquez, A. Jiménez-Velasco +8 more
2005Cancer Genetics and Cytogenetics12 citations
Semantic Scholar
Chromosomal aberrations and fusion genes in myeloid malignancies
V. Gianfelici, I. Lahortiga, J. Cools
2012Expert Review of Hematology11 citations
Semantic Scholar
Short communication Molecular cytogenetic characterization of breakpoints in 19 patients with hematologic malignancies and 12p unbalanced translocations
M. Odero, K. Carlson, I. Lahortiga, Maria J. José Calasanz +1 more
200311 citations
Semantic Scholar
FISH analysis of hematological neoplasias with 1p36 rearrangements allows the definition of a cluster of 2.5 Mb included in the minimal region deleted in 1p36 deletion syndrome
I. Lahortiga, I. Vázquez, E. Belloni, J. Román +7 more
2005Human Genetics10 citations Open access
Semantic Scholar
NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2.
I. Lahortiga, E. Belloni, I. Vázquez, X. Agirre +9 more
2005Cancer Genetics and Cytogenetics9 citations Open access
Semantic Scholar
Identification of novel FLT3 kinase inhibitors.
D. Pauwels, H. Klaassen, I. Lahortiga, A. Kilonda +6 more
2013European journal of medicinal chemistry8 citations
Semantic Scholar
NUP 98 Is Fused to Adducin 3 in a Patient with T-Cell Acute Lymphoblastic Leukemia and Myeloid Markers , with a New Translocation t ( 10 ; 11 ) ( q 25 ; p 15 ) 1
I. Lahortiga, J. Vizmanos, X. Agirre, I. Vázquez +7 more
20037 citations
Semantic Scholar
JAK 2 rearrangements , including the novel SEC 31 AJAK 2 fusion , are recurrent in classical Hodgkin lymphoma *
K. Van Roosbroeck, Luk Cox, T. Tousseyn, I. Lahortiga +9 more
20116 citations
Semantic Scholar
MYB Overexpression Is Directly Involved in Acute Myeloid Leukemia Pathogenesis and Could Constitute a New Therapeutic Target for Patients with Aberrant Expression of This Gene.
C. Vicente, A. Conchillo, D. Pauwels, I. Vázquez +5 more
20096 citations
Semantic Scholar
A novel t(4;9)(q21;p24) fuses SEC31A to JAK2 in nodular-sclerosis Hodgkin lymphoma
K. Van Roosbroeck, I. Lahortiga, J. Cools, P. Vandenberghe +3 more
20083 citations
Semantic Scholar
A novel t(2;3)(p11;q27) in a case of follicular lymphoma.
Cinzia Tapinassi, C. Micucci, I. Lahortiga, Omar Malazzi +4 more
2007Cancer Genetics and Cytogenetics3 citations
Semantic Scholar
Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes.
B. Saez, J. Martín-Subero, I. Lahortiga, C. Largo +6 more
2007Cancer Genetics and Cytogenetics3 citations
Semantic Scholar
Exome sequencing identifies mutation of the ribosome in T-ALL
K. De Keersmaecker, Z. Atak, Ning Li, C. Vicente +25 more
20132 citations
Semantic Scholar
New opportunities and new problems for acute myeloid leukemia treatment
I. Lahortiga, J. Cools
2012Haematologica2 citations Open access
Semantic Scholar
Spectral karyotyping (SKY)
E. Belloni, E. Bonnomi, I. Lahortiga, M. Odero +2 more
2010ecancermedicalscience2 citations Open access
Semantic Scholar
In vitro validation of gamma-secretase inhibitors for the treatment of T-cell acute lymphoblastic leukemia
K. De Keersmaecker, I. Lahortiga, N. Mentens, Cedric Folens +2 more
20072 citations
Semantic Scholar
New 9p24 abnormalities in hematological malignancies
K. Van Roosbroeck, I. Lahortiga, P. Vandenberghe, C. Peeters +4 more
20072 citations
Semantic Scholar
Cryptic chromosomal aberrations waiting to be discovered
I. Lahortiga, J. Cools
2006Leukemia2 citations
Semantic Scholar
Role of HH pathway in T cell acute lymphoblastic leukaemia (T-ALL)
Antonis Dagklis, D. Pauwels, I. Lahortiga, Z. Atak +8 more
20131 citations
Semantic Scholar
Exome sequencing identifies mutation of the ribosome in T-cell acute lymphoblastic leukemia
K. De Keersmaecker, Z. Atak, Ning Li, Stephanie Patchett +16 more
20121 citations
Semantic Scholar
Downregulation of EVI 1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia
I. Vázquez, M. Maicas, J. Cervera, X. Agirre +16 more
20111 citations
Semantic Scholar

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