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Jean-François Hernandez · SciRah

Researcher profile · Semantic Scholar

Jean-François Hernandez

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Jean-François Hernandez — researcher profile on SciRah

h-index: 23
Works: 97
Citations: 1,838

Most-cited papers

Solution structure of the squash trypsin inhibitor MCoTI-II. A new family for cyclic knottins.
A. Heitz, Jean-François Hernandez, J. Gagnon, Thai Trinh Hong +4 more
2001Biochemistry168 citations
Semantic Scholar
Squash inhibitors: from structural motifs to macrocyclic knottins.
L. Chiche, A. Heitz, Jean-Christophe Gelly, J. Gracy +4 more
2004Current protein and peptide science167 citations
Semantic Scholar
Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.
L. Nauton, R. Kahn, G. Garau, Jean-François Hernandez +1 more
2008Journal of Molecular Biology88 citations
Semantic Scholar
Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17
M. Shukla, Htut Htut Htoo, Phitchayapak Wintachai, Jean-François Hernandez +7 more
2015Journal of Pineal Research85 citations
Semantic Scholar
Structural biology of C1: dissection of a complex molecular machinery
G. Arlaud, C. Gaboriaud, N. Thielens, V. Rossi +3 more
2001Immunological Reviews83 citations
Semantic Scholar
Knottin cyclization: impact on structure and dynamics
A. Heitz, O. Avrutina, D. le-Nguyen, U. Diederichsen +4 more
2008BMC Structural Biology74 citations Open access
Semantic Scholar
BACE1- and BACE2-expressing Human Cells
D. Andrau, C. Dumanchin-Njock, E. Ayral, J. Vizzavona +7 more
2003Journal of Biological Chemistry66 citations Open access
Semantic Scholar
The N-terminal CUB-Epidermal Growth Factor Module Pair of Human Complement Protease C1r Binds Ca2+ with High Affinity and Mediates Ca2+-dependent Interaction with C1s*
N. Thielens, Karine Enrie, M. Lacroix, M. Jaquinod +3 more
1999Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Functional cooperation of the mitochondrial processing peptidase subunits.
P. Luciano, Séverine Geoffroy, A. Brandt, Jean-François Hernandez +1 more
1997Journal of Molecular Biology62 citations
Semantic Scholar
1,2,4‐Triazole‐3‐thione Compounds as Inhibitors of Dizinc Metallo‐β‐lactamases
Laurent Sevaille, Laurent Gavara, C. Bebrone, F. De Luca +19 more
2017ChemMedChem55 citations Open access
Semantic Scholar
Amyloid Fibril Formation from Sequences of a Natural β-Structured Fibrous Protein, the Adenovirus Fiber*
K. Papanikolopoulou, G. Schoehn, V. Forge, V. Forsyth +4 more
2005Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Solid-phase synthesis of isocoumarins: a traceless halocyclization approach.
Marine Peuchmaur, V. Lisowski, Céline Gandreuil, L. Maillard +2 more
2009Journal of Organic Chemistry50 citations
Semantic Scholar
Synthesis of Various 3-Substituted 1,2,4-Oxadiazole-Containing Chiral β3- and α-Amino Acids from Fmoc-Protected Aspartic Acid
Abdallah Hamze, Jean-François Hernandez, P. Fulcrand, J. Martinez
200347 citations
Semantic Scholar
The crystal structure of the Epstein-Barr virus protease shows rearrangement of the processed C terminus.
M. Buisson, Jean-François Hernandez, D. Lascoux, G. Schoehn +5 more
2002Journal of Molecular Biology45 citations
Semantic Scholar
Activation of α-secretase by curcumin-aminoacid conjugates.
Ramesh B. Narasingapa, Manjunatha R. Jargaval, Srinivas Pullabhatla, Htut Htut Htoo +4 more
2012Biochemical and Biophysical Research Communications - BBRC38 citations
Semantic Scholar
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors.
Laurent Gavara, Laurent Sevaille, F. De Luca, P. Mercuri +23 more
2020European journal of medicinal chemistry36 citations Open access
Semantic Scholar
N-Acyl Benzotriazole Derivatives for the Synthesis of Dipeptides and Tripeptides and Peptide Biotinylation by Mechanochemistry
Lori Gonnet, Thibault Tintillier, Natacha Venturini, Laure Konnert +5 more
201735 citations Open access
Semantic Scholar
P105 Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity
O. Burgy, G. Wettstein, P. Bellaye, N. Décologne +9 more
201633 citations
Semantic Scholar
Sox2 functionally interacts with βAPP, the βAPP intracellular domain and ADAM10 at a transcriptional level in human cells.
G. Sarlak, H. H. Htoo, Jean-François Hernandez, H. Iizasa +4 more
2016Neuroscience29 citations
Semantic Scholar
Multiscale surface self-assembly of an amyloid-like peptide.
Mathilde Lepère, C. Chevallard, Jean-François Hernandez, A. Mitraki +1 more
2007Langmuir27 citations
Semantic Scholar
Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: a potential target for cancer therapy.
M. Maynadier, Lubomir L. Vezenkov, M. Amblard, Vincent Martin +7 more
2013Journal of Controlled Release25 citations
Semantic Scholar
Design and characterization of a new cell‐permeant inhibitor of the β‐secretase BACE1
S. Lefranc-Jullien, V. Lisowski, Jean-François Hernandez, J. Martinez +1 more
2005British Journal of Pharmacology25 citations Open access
Semantic Scholar
A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase
D. Giganti, Anthony Bouillon, L. Tawk, F. Robert +10 more
2014Nature Communications24 citations Open access
Semantic Scholar
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity.
Alice Legru, F. Verdirosa, Jean-François Hernandez, G. Tassone +12 more
2021European journal of medicinal chemistry23 citations Open access
Semantic Scholar
Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of α-secretase
M. Cissé, Céline Gandreuil, Jean-François Hernandez, J. Martinez +2 more
200622 citations
Semantic Scholar
Pharmacological evidences for DFK167‐sensitive presenilin‐independent γ‐secretase‐like activity
Jean Sévalle, E. Ayral, Jean-François Hernandez, J. Martinez +1 more
2009Journal of Neurochemistry21 citations
Semantic Scholar
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
Alice Legru, F. Verdirosa, Yen Vo-Hoang, G. Tassone +22 more
2022Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
BACE1- and BACE2-expressing Human Cells CHARACTERIZATION OF (cid:1) -AMYLOID PRECURSOR PROTEIN-DERIVED CATABOLITES, DESIGN OF A NOVEL FLUORIMETRIC ASSAY, AND IDENTIFICATION OF NEW IN VITRO INHIBITORS*
D. Andrau, C. Dumanchin-Njock, E. Ayral, J. Vizzavona +7 more
200320 citations
Semantic Scholar
Unraveling the Speciation of β-Amyloid Peptides during the Aggregation Process by Taylor Dispersion Analysis.
Mihai Deleanu, Jean-François Hernandez, L. Cipelletti, J. Biron +4 more
2021Analytical Chemistry19 citations Open access
Semantic Scholar
Cyclic Enkephalins with a Diversely Substituted Guanidine Bridge or a Thiourea Bridge: Synthesis, Biological and Structural Evaluations
Youness Touati-Jallabe, Engin Bojnik, Baptiste Legrand, Elodie Mauchauffée +6 more
2013Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
Mapping of the interaction between the immunodominant loop of the ectodomain of HIV-1 gp41 and human complement protein C1q.
Isabelle Quinkal, Jean-François Hernandez, S. Chevallier, G. Arlaud +1 more
1999European Journal of Biochemistry18 citations
Semantic Scholar
Presenilin‐directed inhibitors of γ‐secretase trigger caspase 3 activation in presenilin‐expressing and presenilin‐deficient cells
C. Alves da Costa, E. Ayral, Jean-François Hernandez, P. S. St George-Hyslop +1 more
2004Journal of Neurochemistry17 citations Open access
Semantic Scholar
4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition
Laurent Gavara, F. Verdirosa, Alice Legru, P. Mercuri +12 more
2020Biomolecules16 citations Open access
Semantic Scholar
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-β-lactamase inhibitors.
Laurent Gavara, Alice Legru, F. Verdirosa, Laurent Sevaille +13 more
2021Bioorganic chemistry (Print)14 citations Open access
Semantic Scholar
Methamphetamine regulates βAPP processing in human neuroblastoma cells.
M. Shukla, S. Maitra, Jean-François Hernandez, P. Govitrapong +1 more
2019Neuroscience Letters14 citations Open access
Semantic Scholar
Solid-phase synthesis of arginine-containing peptides and fluorogenic substrates using a side-chain anchoring approach.
Abdallah Hamze, J. Martinez, Jean-François Hernandez
2004Journal of Organic Chemistry14 citations
Semantic Scholar
1,2,4‐Triazole‐3‐Thione Analogues with a 2‐Ethylbenzoic Acid at Position 4 as VIM‐type Metallo‐β‐Lactamase Inhibitors
F. Verdirosa, Laurent Gavara, Laurent Sevaille, G. Tassone +18 more
2022ChemMedChem13 citations Open access
Semantic Scholar
Critical residue combinations dictate peptide presentation by MHC class II molecules.
Jean-François Hernandez, F. Cretin, S. Lombard-Platet, Jean-Paul Salvi +4 more
1994Peptides13 citations
Semantic Scholar
MPN miniaturized procedure for the enumeration of faecal enterococci in fresh and marine waters: the MUST procedure
Jean-François Hernandez, A. Pourcher, J. Delattre, C. Oger +1 more
1993Oceanographic Literature Review13 citations
Semantic Scholar
Calibration of 1,2,4-Triazole-3-Thione, an Original Zn-Binding Group of Metallo-β-Lactamase Inhibitors. Validation of a Polarizable MM/MD Potential by Quantum Chemistry.
Karolina Kwapien, Mirna Damergi, S. Nader, L. El Khoury +7 more
2017Journal of Physical Chemistry B12 citations
Semantic Scholar
Noncationic dipeptide mimic oligomers as cell penetrating nonpeptides (CPNP).
Lubomir L. Vezenkov, M. Maynadier, Jean-François Hernandez, Marie-Christine Averlant-Petit +5 more
2010Bioconjugate chemistry12 citations
Semantic Scholar
Taylor Dispersion Analysis and Atomic Force Microscopy Provide a Quantitative Insight into the Aggregation Kinetics of Aβ (1-40)/Aβ (1-42) Amyloid Peptide Mixtures.
Mihai Deleanu, O. Deschaume, L. Cipelletti, Jean-François Hernandez +3 more
2022ACS Chemical Neuroscience11 citations Open access
Semantic Scholar
The bacterial-like HslVU protease complex subunits are involved in the control of different cell cycle events in trypanosomatids.
Diane-Ethna Mbang-Benet, Y. Sterkers, C. Morelle, N. Kebe +7 more
2014Acta Tropica11 citations
Semantic Scholar
Structure–Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA‐Based Vector
Lubomir L. Vezenkov, Clément Sanchez, V. Bellet, Vincent Martin +7 more
2016ChemMedChem10 citations
Semantic Scholar
Synthesis of (R) and (S) enantiomers of Fmoc-protected 1,2,4-oxadiazole-containing β3-amino acids from Fmoc-(R)-β-HAsp(OtBu)-OH
Abdallah Hamze, Jean-François Hernandez, J. Martinez
200310 citations
Semantic Scholar
The HslV Protease from Leishmania major and Its Activation by C-terminal HslU Peptides
N. Kebe, K. Samanta, Priyanka Singh, Josephine Lai-Kee-Him +12 more
2019International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins.
Mathieu Verbeken, E. Wynendaele, Elodie Mauchauffée, N. Bracke +9 more
2015Peptides9 citations
Semantic Scholar
Cyclic peptides with a diversely substituted guanidine bridge: solid-phase synthesis and structural analysis.
Youness Touati-Jallabe, L. Chiche, Abdallah Hamze, A. Aumelas +4 more
2011Chemistry9 citations
Semantic Scholar
Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor.
E. Ayral, P. Gloanec, G. Bergé, G. de Nanteuil +6 more
2009Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Taylor dispersion analysis discloses the impairment of Aβ peptide aggregation by the presence of a fluorescent tag
Mihai Deleanu, Jean-François Hernandez, H. Cottet, Joseph Chamieh
2022Electrophoresis7 citations Open access
Semantic Scholar

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J. Martinez×13
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J. Martinez — researcher profile on SciRah
F. Checler×8
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F. Checler — researcher profile on SciRah
Laurent Gavara×8
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Laurent Gavara — researcher profile on SciRah
J. Docquier×7
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×6

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Alice Legru — researcher profile on SciRah

F. Verdirosa×6

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B. Vincent — researcher profile on SciRah

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E. Ayral — researcher profile on SciRah

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Laurent Sevaille — researcher profile on SciRah

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P. Mercuri — researcher profile on SciRah