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R. Faggioni · SciRah

Researcher profile · Semantic Scholar

R. Faggioni

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R. Faggioni — researcher profile on SciRah

h-index: 33
Works: 61
Citations: 8,047

Most-cited papers

Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.
M. Romano, M. Sironi, C. Toniatti, N. Polentarutti +10 more
1997Immunity1,177 citations Open access
Semantic Scholar
Leptin in the regulation of immunity, inflammation, and hematopoiesis
G. Fantuzzi, R. Faggioni
2000Journal of Leukocyte Biology1,026 citations
Semantic Scholar
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers.
X. Yao, Jia-Qi Huang, H. Zhong, N. Shen +3 more
2014Pharmacology and Therapeutics653 citations
Semantic Scholar
Defective inflammatory response in interleukin 6-deficient mice
E. Fattori, M. Cappelletti, P. Costa, C. Sellitto +6 more
1994Journal of Experimental Medicine581 citations Open access
Semantic Scholar
Leptin regulation of the immune response and the immunodeficiency of malnutrition 1
R. Faggioni, K. Feingold, C. Grunfeld
2001The FASEB Journal521 citations
Semantic Scholar
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection.
Hiroki Yoshida, S. Hamano, G. Senaldi, T. Covey +8 more
2001Immunity464 citations Open access
Semantic Scholar
A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
E. Piper, C. Brightling, R. Niven, C. Oh +7 more
2012European Respiratory Journal363 citations Open access
Semantic Scholar
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.
R. Faggioni, J. Jones-Carson, D. A. Reed, C. Dinarello +3 more
2000Proceedings of the National Academy of Sciences of the United States of America351 citations Open access
Semantic Scholar
IL-1β mediates leptin induction during inflammation.
R. Faggioni, G. Fantuzzi, J. Fuller, C. Dinarello +2 more
1998American Journal of Physiology. Regulatory Integrative and Comparative Physiology290 citations
Semantic Scholar
Leptin deficiency enhances sensitivity to endotoxin-induced lethality.
R. Faggioni, G. Fantuzzi, C. Gabay, A. Moser +3 more
1999American Journal of Physiology. Regulatory Integrative and Comparative Physiology280 citations
Semantic Scholar
Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn's Disease: A Phase 2a Study.
B. Sands, Jingjing Chen, B. Feagan, M. Penney +13 more
2017Gastroenterology245 citations Open access
Semantic Scholar
N-acetylcysteine and glutathione as inhibitors of tumor necrosis factor production.
Platon Peristeris, B. D. Clark, S. Gatti, R. Faggioni +5 more
1992Cellular Immunology235 citations
Semantic Scholar
Effect of endotoxin in IL-1 beta-deficient mice.
G. Fantuzzi, Hui Zheng, R. Faggioni, F. Benigni +4 more
1996Journal of Immunology195 citations
Semantic Scholar
Molecular mapping and detoxification of the lipid A binding site by synthetic peptides.
A. Rustici, M. Velucchi, R. Faggioni, M. Sironi +4 more
1993Science146 citations
Semantic Scholar
LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.
R. Faggioni, J. Fuller, A. Moser, K. Feingold +1 more
1997American Journal of Physiology133 citations
Semantic Scholar
IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice
R. Faggioni, R. Cattley, Jane Guo, S. Flores +15 more
2001Journal of Immunology127 citations Open access
Semantic Scholar
Leptin deficiency, not obesity, protects mice from Con A‐induced hepatitis
B. Siegmund, Kelly C. Lear-Kaul, R. Faggioni, G. Fantuzzi
2002European Journal of Immunology102 citations Open access
Semantic Scholar
Cytokine release assays: current practices and future directions.
D. Finco, C. Grimaldi, M. Fort, M. Walker +11 more
2014Cytokine84 citations
Semantic Scholar
Role of tumour necrosis factor and reactive oxygen intermediates in lipopolysaccharide‐induced pulmonary oedema and lethality
S. Gatti, R. Faggioni, B. Echtenacher, P. Ghezzi
1993Clinical and Experimental Immunology81 citations Open access
Semantic Scholar
Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor
M. Romano, R. Faggioni, M. Sironi, S. Sacco +4 more
1997Mediators of Inflammation79 citations Open access
Semantic Scholar
A phase 1 study evaluating the pharmacokinetics, safety and tolerability of repeat dosing with a human IL-13 antibody (CAT-354) in subjects with asthma
Dave Singh, B. Kane, N. Molfino, R. Faggioni +2 more
2010BMC Pulmonary Medicine78 citations Open access
Semantic Scholar
Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema.
R. Faggioni, S. Gatti, M. T. Demitri, R. Delgado +4 more
1994Journal of Laboratory and Clinical Medicine72 citations
Semantic Scholar
Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice.
M. Mengozzi, G. Fantuzzi, R. Faggioni, Arnaud Marchant +6 more
1994Immunology71 citations
Semantic Scholar
Molecular Mechanism of HER2 Rapid Internalization and Redirected Trafficking Induced by Anti-HER2 Biparatopic Antibody
Jackie Cheng, M. Liang, M. F. Carvalho, N. Tigue +3 more
2020Antibodies66 citations Open access
Semantic Scholar
An open-label, single-dose bioavailability study of the pharmacokinetics of CAT-354 after subcutaneous and intravenous administration in healthy males.
C. Oh, R. Faggioni, Feng Jin, L. Roskos +4 more
2010British Journal of Clinical Pharmacology57 citations Open access
Semantic Scholar
Regulatory Effects of Novel Neurotrophin-1/B Cell-Stimulating Factor-3 (Cardiotrophin-Like Cytokine) on B Cell Function
G. Senaldi, M. Stolina, Jane Guo, R. Faggioni +9 more
2002Journal of Immunology53 citations Open access
Semantic Scholar
Leptin deficiency enhances sensitivity to endotoxin-induced lethality.
R. Faggioni, G. Fantuzzi, C. Gabay, A. Moser +3 more
1999American Journal of Physiology51 citations
Semantic Scholar
PK-PD modeling of protein drugs: implications in assay development.
L. Roskos, A. Schneider, I. Vainshtein, M. Schwickart +4 more
2011Bioanalysis49 citations
Semantic Scholar
TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.
Fabio Benigni, R. Faggioni, M. Sironi, G. Fantuzzi +6 more
1996Journal of Immunology49 citations Open access
Semantic Scholar
Independent down-regulation of central and peripheral tumor necrosis factor production as a result of lipopolysaccharide tolerance in mice
R. Faggioni, G. Fantuzzi, Pia Villa, W. Buurman +2 more
1995Infection and Immunity49 citations Open access
Semantic Scholar
Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.
D. Finch, M. Sleeman, J. Moisan, Franco Ferraro +20 more
2011Journal of Molecular Biology48 citations
Semantic Scholar
Regulatory effects of osteoprotegerin on cellular and humoral immune responses.
M. Stolina, Jane Guo, R. Faggioni, H. Brown +1 more
2003Clinical Immunology46 citations
Semantic Scholar
Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections.
R. Faggioni, Fabio Benigni, P. Ghezzi
1995Neuroimmunomodulation46 citations
Semantic Scholar
Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha.
R. Memon, Gökhan S. Hotamışlıgil, Sarah M. Wiesbrock, K. Uysal +4 more
2000Biochimica et Biophysica Acta32 citations
Semantic Scholar
830 Initial Evaluation of MEDI2070 (Specific Anti-IL-23 Antibody) in Patients With Active Crohn's Disease Who Have Failed Anti-TNF Antibody Therapy: A Randomized, Double-Blind Placebo-Controlled Phase 2A Induction Study
B. Sands, Jingjing Chen, M. Penney, P. Newbold +7 more
201521 citations
Semantic Scholar
Recently identified peptides involved in the regulation of body weight.
D. Bessesen, R. Faggioni
1998Seminars in Oncology19 citations
Semantic Scholar
A randomized, placebo-controlled, single ascending-dose study to assess the safety, tolerability, pharmacokinetics, and immunogenicity of subcutaneous tralokinumab in Japanese healthy volunteers.
P. Baverel, Dewei She, E. Piper, S. Ueda +3 more
2017Drug Metabolism and Pharmacokinetics16 citations Open access
Semantic Scholar
Correction to: 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018)
S. Berry, Nicolas A. Giraldo, Peter Nguyen, B. Green +87 more
2019Journal of Immunotherapy for Cancer14 citations Open access
Semantic Scholar
Cabozantinib exposure–response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma
B. Tran, Jing Li, Neang S. Ly, R. Faggioni +1 more
2023Cancer Chemotherapy and Pharmacology13 citations Open access
Semantic Scholar
Effects of ICOS+ T cell depletion via afucosylated monoclonal antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring.
S. M. Nicholson, Gianluca Carlesso, Lily I. Cheng, Halie Cook +12 more
2017Reproductive Toxicology11 citations
Semantic Scholar
Pretreatment with granulocyte-colony stimulating factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18.
C. L. Shaklee, Jane Guo, R. Faggioni, G. Fantuzzi +1 more
2004Cytokine11 citations
Semantic Scholar
Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia
D. Kuruvilla, Y. Chia, K. Balic, Nai-Shun Yao +8 more
2020British Journal of Clinical Pharmacology10 citations Open access
Semantic Scholar
Mechanisms of Interleukin‐2-Induced Hydrothoraxy in Mice: Protective Effect of Endotoxin Tolerance and Dexamethasone and Possible Role of Reactive Oxygen Intermediates
R. Faggioni, P. Allavena, L. Cantoni, M. Carelli +9 more
1994Journal of Immunotherapy with Emphasis on Tumor Immunology8 citations
Semantic Scholar
Mast cells do not contribute to the rapid appearance of TNF in the serum of LPS-treated mice: a study with mast cell-deficient mice.
S. Gatti, R. Faggioni, M. Sironi, Annalaura Erroi +1 more
1993International Journal of Immunopharmacology7 citations
Semantic Scholar
Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer
Neang S. Ly, Jun Yu Li, R. Faggioni, L. Roskos +1 more
2023Clinical Pharmacokinetics5 citations Open access
Semantic Scholar
Phase 2 randomized, double-blind, placebo-controlled study of tralokinumab, an anti-IL-13 monoclonal antibody, in moderate to severe asthma
E. Piper, C. Brightling, R. Niven, C. Oh +7 more
2011European Respiratory Journal5 citations
Semantic Scholar
Efficacy and safety of moxetumomab pasudotox (moxe) in adult patients (pts) with relapsed/refractory hairy cell leukemia (HCL) in relation to drug exposure, baseline disease burden, and immunogenicity.
D. Kuruvilla, Y. Chia, L. Santiago, K. Balic +8 more
20184 citations
Semantic Scholar
Pharmacokinetics of Human Therapeutics Characterized in Nonhuman Primates
C. Tseng, R. Faggioni, L. Roskos
20154 citations
Semantic Scholar
Pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of moxetumomab pasudotox (Moxe), an immunotoxin targeting CD22, in adult patients (Pts) with relapsed or refractory hairy cell leukemia (HCL).
K. Balic, N. Standifer, L. Santiago, D. Kuruvilla +9 more
20182 citations
Semantic Scholar
SAT0249 Safety, pharmacokinetics, pharmacodynamics and inhibition of T-cell dependent antibody response (TDAR) with MEDI4920, a novel, engineered CD40 ligand (CD40L) antagonist: results of a first-time-in-human study
M. Albulescu, M. Gunsior, J. Li, J. Bush +6 more
20172 citations Open access
Semantic Scholar

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