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W. V. van Spil · SciRah

Researcher profile · Semantic Scholar

W. V. van Spil

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W. V. van Spil — researcher profile on SciRah

h-index: 23
Works: 74
Citations: 2,249

Most-cited papers

Serum adipokines in osteoarthritis; comparison with controls and relationship with local parameters of synovial inflammation and cartilage damage.
T. N. de Boer, W. V. van Spil, A. Huisman, A. Polak +3 more
2012Osteoarthritis and Cartilage251 citations
Semantic Scholar
Recent advances in understanding the phenotypes of osteoarthritis
A. Mobasheri, S. Saarakkala, M. Finnilä, M. Karsdal +2 more
2019F1000Research197 citations Open access
Semantic Scholar
Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria.
W. V. van Spil, J. DeGroot, W. Lems, J. Oostveen +1 more
2010Osteoarthritis and Cartilage196 citations Open access
Semantic Scholar
Osteoarthritis phenotypes and novel therapeutic targets.
W. V. van Spil, O. Kubassova, M. Boesen, A. Bay-Jensen +1 more
2019Biochemical Pharmacology194 citations Open access
Semantic Scholar
Osteoarthritis Year in Review 2016: biomarkers (biochemical markers).
A. Mobasheri, A. Bay-Jensen, W. V. van Spil, J. Larkin +1 more
2017Osteoarthritis and Cartilage165 citations Open access
Semantic Scholar
An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid.
M. Beekhuizen, L. Gierman, W. V. van Spil, G. V. van Osch +4 more
2013Osteoarthritis and Cartilage133 citations Open access
Semantic Scholar
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes
A. Mobasheri, W. V. van Spil, E. Budd, I. Uzielienė +6 more
2019Current Opinion in Rheumatology111 citations Open access
Semantic Scholar
Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis
W. V. van Spil, J. Bijlsma, S. Mastbergen, F. Lafeber
2012Annals of the Rheumatic Diseases81 citations Open access
Semantic Scholar
Osteoarthritis year 2013 in review: biomarkers; reflecting before moving forward, one step at a time.
F. Lafeber, W. V. van Spil
2013Osteoarthritis and Cartilage74 citations Open access
Semantic Scholar
Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers
E. V. van Helvoort, W. V. van Spil, M. Jansen, P. Welsing +16 more
2020BMJ Open72 citations Open access
Semantic Scholar
Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from CHECK, a large cohort of individuals with very early symptomatic osteoarthritis.
W. V. van Spil, N. Jansen, J. Bijlsma, M. Reijman +3 more
2012Osteoarthritis and Cartilage62 citations Open access
Semantic Scholar
Osteoarthritis year in review 2019: biomarkers (biochemical markers).
W. V. van Spil, I. Szilagyi
2019Osteoarthritis and Cartilage61 citations Open access
Semantic Scholar
Cross-sectional and predictive associations between plasma adipokines and radiographic signs of early-stage knee osteoarthritis: data from CHECK.
W. V. van Spil, P. Welsing, M. Kloppenburg, S. Bierma-Zeinstra +3 more
2012Osteoarthritis and Cartilage61 citations Open access
Semantic Scholar
A consensus-based framework for conducting and reporting osteoarthritis phenotype research
W. V. van Spil, S. Bierma-Zeinstra, L. Deveza, N. Arden +21 more
2020Arthritis Research & Therapy56 citations Open access
Semantic Scholar
The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK.
W. V. van Spil, P. Welsing, S. Bierma-Zeinstra, J. Bijlsma +3 more
2015Osteoarthritis and Cartilage52 citations Open access
Semantic Scholar
Lack of evidence of a beneficial effect of azathioprine in dogs treated with prednisolone for idiopathic immune-mediated hemolytic anemia: a retrospective cohort study
C. Piek, W. V. van Spil, G. Junius, A. Dekker
2011BMC Veterinary Research47 citations Open access
Semantic Scholar
Bone Texture Analysis for Prediction of Incident Radio-graphic Hip Osteoarthritis Using Machine Learning: Data from the Cohort Hip and Cohort Knee (CHECK) study
J. Hirvasniemi, W. Gielis, Saeed Arbabi, R. Agricola +3 more
2019Osteoarthritis and Cartilage42 citations Open access
Semantic Scholar
The clinical and radiographic course of early knee and hip osteoarthritis over 10 years in CHECK (Cohort Hip and Cohort Knee).
D. Schiphof, J. Runhaar, J. Waarsing, W. V. van Spil +2 more
2019Osteoarthritis and Cartilage42 citations Open access
Semantic Scholar
Too much opioid, too much harm.
L. Deveza, David J. Hunter, W. V. van Spil
2017Osteoarthritis and Cartilage38 citations Open access
Semantic Scholar
Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects.
W. V. van Spil, S. Nair, M. B. Kinds, P. Emans +3 more
2013Osteoarthritis and Cartilage35 citations Open access
Semantic Scholar
Six weeks of continuous joint distraction appears sufficient for clinical benefit and cartilaginous tissue repair in the treatment of knee osteoarthritis.
J. V. D. van der Woude, R. V. van Heerwaarden, S. Spruijt, F. Eckstein +6 more
2016Knee (Oxford)31 citations Open access
Semantic Scholar
Bone phenotypes in rheumatology – there is more to bone than just bone
C. Thudium, S. Nielsen, S. Sardar, A. Mobasheri +5 more
2020BMC Musculoskeletal Disorders29 citations Open access
Semantic Scholar
Trajectories of femorotibial cartilage thickness among persons with or at risk of knee osteoarthritis: development of a prediction model to identify progressors.
L. Deveza, A. Downie, Jose Gerardo Tamez-Peña, F. Eckstein +2 more
2019Osteoarthritis and Cartilage27 citations Open access
Semantic Scholar
An automated workflow based on hip shape improves personalized risk prediction for hip osteoarthritis in the CHECK study.
W. Gielis, H. Weinans, P. Welsing, W. V. van Spil +4 more
2020Osteoarthritis and Cartilage23 citations Open access
Semantic Scholar
Alterations in the chondrocyte surfaceome in response to pro-inflammatory cytokines
B. Jeremiasse, Csaba Matta, Christopher R. Fellows, D. Boocock +5 more
2019BMC Molecular and Cell Biology22 citations Open access
Semantic Scholar
Synovial Macrophages: Potential Key Modulators of Cartilage Damage, Osteophyte Formation and Pain in Knee Osteoarthritis
M. Berkelaar, N. Korthagen, Gerrit Jansen, W. V. van Spil
201822 citations Open access
Semantic Scholar
Efficacy of bisphosphonates in specific knee osteoarthritis subpopulations: protocol for an OA Trial Bank systematic review and individual patient data meta-analysis
L. Deveza, S. Bierma-Zeinstra, W. V. van Spil, Win Min Oo +4 more
2018BMJ Open19 citations Open access
Semantic Scholar
Diagnosis of early stage knee osteoarthritis based on early clinical course: data from the CHECK cohort
Qiuke Wang, J. Runhaar, M. Kloppenburg, M. Boers +58 more
2021Arthritis Research & Therapy18 citations Open access
Semantic Scholar
A sex-specific association between incident radiographic osteoarthritis of hip or knee and incident peripheral arterial calcifications: 8-year prospective data from Cohort Hip and Cohort Knee (CHECK).
W. Gielis, P. Welsing, W. V. van Spil, J. Runhaar +2 more
2017Osteoarthritis and Cartilage14 citations Open access
Semantic Scholar
Disease burden of knee osteoarthritis patients with a joint replacement compared to matched controls: a population-based analysis of a Dutch medical claims database.
J. Nielen, A. Boonen, P. Dagnelie, B. V. D. van den Bemt +5 more
2017Osteoarthritis and Cartilage11 citations Open access
Semantic Scholar
Population-based user-perceived experience of Rheumatic?: a novel digital symptom-checker in rheumatology
Karin Lundberg, Ling Qin, C. Aulin, W. V. van Spil +2 more
2023RMD Open8 citations Open access
Semantic Scholar
Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA
C. Thudium, A. Engstrøm, A. Bay-Jensen, P. Frederiksen +8 more
2023Arthritis Research & Therapy8 citations Open access
Semantic Scholar
Novel optical spectral transmission (OST)-guided versus conventionally disease activity-guided treatment: study protocol of a randomized clinical trial on guidance of a treat-to-target strategy for early rheumatoid arthritis
N. Besselink, A. Westgeest, R. Klaasen, M. Gamala +8 more
2019Trials8 citations Open access
Semantic Scholar
Associations of CTX-II with biochemical markers of bone turnover raise questions about its tissue origin: new insights from CHECK
B. de Klerk, F. Lafeber, W. V. van Spil
2014Annals of the Rheumatic Diseases8 citations
Semantic Scholar
Can optical spectral transmission assess ultrasound-detected synovitis in hand osteoarthritis?
N. Besselink, J. Jacobs, A. Westgeest, P. Van Der Meijde +4 more
2019PLoS ONE7 citations Open access
Semantic Scholar
Associations of markers of matrix metabolism, inflammation markers, and adipokines with superior cam deformity of the hip and their relation with future hip osteoarthritis.
W. V. van Spil, R. Agricola, K. Drossaers-Bakker, H. Weinans +1 more
2015Osteoarthritis and Cartilage6 citations Open access
Semantic Scholar
C1M, C2M, C3M, PRO-C2, and CRPM in serum reflect different potential pathogenetic domains of osteoarthritis, data from check
A. Bay-Jensen, M. Karsdal, H. LadelChristoph, W. V. van Spil
20184 citations Open access
Semantic Scholar
SAT0536 Axial alignment of the knee – importance in cartilage repair? high tibial osteotomy vs. distraction
N. Besselink, R. V. van Heerwaarden, J. V. D. van der Woude, K. Wiegant +4 more
20173 citations Open access
Semantic Scholar
SAT0499 Identification of biochemical phenotypes in knee osteoarthritis: longitudinal data from the fnih oa biomarker consortium
Bernadette Jeremiasse, P. Welsing, Christopher R. Fellows, F. Lafeber +1 more
20173 citations Open access
Semantic Scholar
The approach consortium: a 2-year, European, cohort study to describe, validate, and predict phenotypes of knee osteoarthritis by use of clinical, imaging, and biochemical markers
E. V. van Helvoort, W. V. van Spil, A. Marijnissen, P. Welsing +12 more
20182 citations Open access
Semantic Scholar
The performance of urinary collagen type ii c-telopeptide (UCTX-II) in knee osteoarthritis: A meta-analysis
B. Jeremiasse, W. V. van Spil, F. Lafeber
20172 citations Open access
Semantic Scholar
CTX-II levels are associated with peripheral bone density, suggesting CTX-II epitope release from bone: data from Cohort Hip and Cohort Knee (CHECK)
W. V. van Spil, K. Vincken, W. Lems, F. Lafeber
20132 citations Open access
Semantic Scholar
Intersite comparison and test-retest reliability of cartilage thickness and compostional analysis in the approach study – a 2-year multicenter European exploratory study for phenotype characterizaton of knee osteoarthritis
F. Eckstein, S. Maschek, A. Bay-Jensen, J. Boere +21 more
2019Osteoarthritis and Cartilage1 citations Open access
Semantic Scholar
Gait kinematics for patients with early stage knee osteoarthritis in the approach project
D. Hodgins, A. Bay-Jensen, J. Boere, L. Hussaarts +15 more
2019Osteoarthritis and Cartilage1 citations Open access
Semantic Scholar
FRI0535 The clinical and radiographic early course of knee and hip osteoarthritis over 10 years in check (COHORT HIP AND COHORT KNEE)
D. Schiphof, Jos Runhaar, J. Waarsing, W. V. van Spil +2 more
2018Osteoarthritis1 citations Open access
Semantic Scholar
Associations among a spectrum of knee osteoarthritis features on MRI inform about potential pathogenic mechanisms, data from the OAI/FNIH biomarkers consortium
W. V. van Spil, L. Deveza, D. Hunter
20181 citations Open access
Semantic Scholar
ASSOCIATIONS BETWEEN BIOMARKERS AND SYMPTOMS IN PATIENTS WITH COMPLAINTS SUSPECTED TO BE EARLY HIP OSTEOARTHRITIS. A CHECK STUDY
A. C. Berkel van, D. Schiphof, W. V. van Spil, J. Runhaar +3 more
2022Osteoarthritis and Cartilage0 citations Open access
Semantic Scholar
Changes in inflammation and musculoskeletal tissue-derived biomarker serum levels in response to high- and low-intensity resistance training in individuals with knee osteoarthritis
N. Jansen, A. Engstrøm, C. Thudium, A. Bay-Jensen +9 more
20200 citations Open access
Semantic Scholar
A year in review: biomarkers
W. V. van Spil
2019Osteoarthritis and Cartilage0 citations Open access
Semantic Scholar
The zodiak trial: protocol of a double-blind, placebo-controled, two-year clinical trial of zoledronic acid as a disease-modifying drug in knee osteoarthritis with bone marrow lesions
W. V. van Spil, W. Gielis, H. H. Weijnans, R. Custers +3 more
2019Osteoarthritis and Cartilage0 citations Open access
Semantic Scholar

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