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S. Schoenwaelder · SciRah

Researcher profile · Semantic Scholar

S. Schoenwaelder

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S. Schoenwaelder — researcher profile on SciRah

h-index: 45
Works: 100
Citations: 7,925

Most-cited papers

Bidirectional signaling between the cytoskeleton and integrins.
S. Schoenwaelder, K. Burridge
1999Current Opinion in Cell Biology807 citations Open access
Semantic Scholar
Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms.
S. Jackson, Roxane Darbousset, S. Schoenwaelder
2019Blood557 citations Open access
Semantic Scholar
PI 3-kinase p110β: a new target for antithrombotic therapy
S. Jackson, S. Schoenwaelder, Isaac Goncalves, W. Nesbitt +22 more
2005Nature Medicine545 citations
Semantic Scholar
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.
S. Schoenwaelder, K. Jarman, E. Gardiner, M. Hua +13 more
2011Blood347 citations
Semantic Scholar
Rap1b is required for normal platelet function and hemostasis in mice.
M. Chrzanowska-Wodnicka, S. Smyth, S. Schoenwaelder, T. Fischer +1 more
2005Journal of Clinical Investigation343 citations Open access
Semantic Scholar
Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.
S. Schoenwaelder, Yu-Ping Yuan, E. Josefsson, Michael J. White +12 more
2009Blood327 citations
Semantic Scholar
PI 3-kinase p110beta: a new target for antithrombotic therapy.
S. Jackson, S. Schoenwaelder, Isaac Goncalves, W. Nesbitt +22 more
2005Nature Medicine285 citations
Semantic Scholar
Antiplatelet therapy: in search of the 'magic bullet'
S. Jackson, S. Schoenwaelder
2003Nature reviews. Drug discovery203 citations
Semantic Scholar
The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function
J. K. Mountford, C. Petitjean, Harun Wijanarko Kusuma Putra, J. McCafferty +12 more
2015Nature Communications195 citations Open access
Semantic Scholar
Reconstituted High-Density Lipoprotein Attenuates Platelet Function in Individuals With Type 2 Diabetes Mellitus by Promoting Cholesterol Efflux
A. Calkin, B. Drew, A. Ono, S. Duffy +6 more
2009Circulation195 citations Open access
Semantic Scholar
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.
I. Lawrenson, Sabine H. Wimmer-Kleikamp, P. Lock, S. Schoenwaelder +4 more
2002Journal of Cell Science180 citations
Semantic Scholar
Procoagulant platelets: are they necrotic?
S. Jackson, S. Schoenwaelder
2010Blood174 citations
Semantic Scholar
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain.
Prasad D. Cooray, Yu-Ping Yuan, S. Schoenwaelder, C. A. Mitchell +2 more
1996Biochemical Journal173 citations Open access
Semantic Scholar
Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Clots*
S. Schoenwaelder, Yu-Ping Yuan, P. Cooray, H. Salem +1 more
1997Journal of Biological Chemistry157 citations Open access
Semantic Scholar
The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.
Mehran Ghasemzadeh, Z. Kaplan, I. Alwis, S. Schoenwaelder +10 more
2013Blood156 citations Open access
Semantic Scholar
The protein tyrosine phosphatase Shp-2 regulates RhoA activity.
S. Schoenwaelder, L. Petch, D. Williamson, R. Shen +2 more
2000Current Biology152 citations Open access
Semantic Scholar
Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency.
P. Mangin, Cindy L. Yap, C. Nonne, S. Sturgeon +6 more
2006Blood151 citations
Semantic Scholar
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.
A. Ono, E. Westein, S. Hsiao, W. Nesbitt +3 more
2008Blood143 citations
Semantic Scholar
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
Lin Luo, A. Wall, J. Yeo, N. Condon +10 more
2014Nature Communications135 citations Open access
Semantic Scholar
Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation*
K. Gilio, I. Munnix, P. Mangin, J. Cosemans +10 more
2009Journal of Biological Chemistry132 citations Open access
Semantic Scholar
Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.
S. Jackson, S. Schoenwaelder, Yu-Ping Yuan, I. Rabinowitz +2 more
1994Journal of Biological Chemistry121 citations Open access
Semantic Scholar
Evidence for a Calpeptin-sensitive Protein-tyrosine Phosphatase Upstream of the Small GTPase Rho
S. Schoenwaelder, K. Burridge
1999Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
S. Schoenwaelder, Roxane Darbousset, S. Cranmer, H. Ramshaw +17 more
2017Nature Communications110 citations Open access
Semantic Scholar
Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways.
Analia E. Garcia, Soochong Kim, Kamala Bhavaraju, S. Schoenwaelder +1 more
2010Biochemical Journal93 citations
Semantic Scholar
New insights into the haemostatic function of platelets
A. Wei, S. Schoenwaelder, R. Andrews, S. Jackson
2009British Journal of Haematology93 citations
Semantic Scholar
Identification of a Unique Co-operative Phosphoinositide 3-Kinase Signaling Mechanism Regulating Integrin αIIbβ3 Adhesive Function in Platelets*
S. Schoenwaelder, A. Ono, S. Sturgeon, S. M. Chan +11 more
2007Journal of Biological Chemistry88 citations Open access
Semantic Scholar
The Bioactive Phospholipid, Lysophosphatidylcholine, Induces Cellular Effects via G-Protein-dependent Activation of Adenylyl Cyclase*
Yu-Ping Yuan, S. Schoenwaelder, H. Salem, S. Jackson
1996Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2.
Isaac Goncalves, S. Hughan, S. Schoenwaelder, Cindy L. Yap +2 more
2003Journal of Biological Chemistry84 citations Open access
Semantic Scholar
Targeting the PI3K p110α Isoform Inhibits Medulloblastoma Proliferation, Chemoresistance, and Migration
A. Guerreiro, S. Fattet, B. Fischer, T. Shalaby +5 more
2008Clinical Cancer Research82 citations Open access
Semantic Scholar
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.
Peter J. Wen, Shona L. Osborne, M. P. Zanin, Pei Ching Low +7 more
2011Nature Communications77 citations Open access
Semantic Scholar
Phosphoinositide 3-Kinase p110β Regulates Integrin αIIbβ3 Avidity and the Cellular Transmission of Contractile Forces*
S. Schoenwaelder, A. Ono, W. Nesbitt, J. Lim +2 more
2009Journal of Biological Chemistry76 citations Open access
Semantic Scholar
Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4
Z. Kaplan, Alessandro Zarpellon, I. Alwis, Yu-Ping Yuan +5 more
2015Nature Communications75 citations Open access
Semantic Scholar
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.
Michael J. White, S. Schoenwaelder, E. Josefsson, K. Jarman +6 more
2012Blood73 citations
Semantic Scholar
Phosphatidylinositol 3,4,5‐trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5‐phosphatase and a novel 5‐phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3‐kinase.
S. Jackson, S. Schoenwaelder, M. Matzaris, Susan Brown +1 more
1995EMBO Journal70 citations Open access
Semantic Scholar
Endogenous fibrinolysis facilitates clot retraction in vivo.
A. Samson, I. Alwis, Jessica A. A. Maclean, Pramith Priyananda +3 more
2017Blood69 citations Open access
Semantic Scholar
RhoA Sustains Integrin αIIbβ3Adhesion Contacts under High Shear*
S. Schoenwaelder, S. Hughan, Karen Boniface, Sujanie Fernando +4 more
2002Journal of Biological Chemistry68 citations Open access
Semantic Scholar
Distinct Substrate Specificities and Functional Roles for the 78- and 76-kDa Forms of μ-Calpain in Human Platelets*
S. Schoenwaelder, S. Kulkarni, H. Salem, S. Imajoh‐ohmi +3 more
1997Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia
Yu-Ping Yuan, I. Alwis, M. Wu, Z. Kaplan +8 more
2017Science Translational Medicine66 citations
Semantic Scholar
MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents
A. Samson, Lining Ju, Hyun Ah Kim, Shen-Peng R. Zhang +5 more
2015Scientific Reports65 citations Open access
Semantic Scholar
14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function
S. Schoenwaelder, Roxane Darbousset, S. Cranmer, H. Ramshaw +17 more
2016Nature Communications61 citations Open access
Semantic Scholar
Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
L. Ju, J. Mcfadyen, S. Al-Daher, I. Alwis +12 more
2018Nature Communications58 citations Open access
Semantic Scholar
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis.
M. McCormack, Mark A. Hall, S. Schoenwaelder, Quan Zhao +8 more
2006Blood50 citations Open access
Semantic Scholar
A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110γ Isoform in Medulloblastoma Cell Proliferation and Chemoresistance
A. Guerreiro, S. Fattet, D. Kulesza, A. Atamer +7 more
2011Molecular Cancer Research49 citations Open access
Semantic Scholar
Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.
A. Arcaro, Kathrin T. Doepfner, D. Boller, A. Guerreiro +6 more
2007Biochemical Journal48 citations Open access
Semantic Scholar
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
R. Heller, Q. Chang, Gunter Ehrlich, Sherry N. Hsieh +5 more
2008Cardiovascular Research46 citations
Semantic Scholar
Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets.
S. Schoenwaelder, A. Ono, S. Sturgeon, S. M. Chan +11 more
2007Journal of Biological Chemistry43 citations
Semantic Scholar
Dual P2Y12 receptor signaling in thrombin‐stimulated platelets – involvement of phosphoinositide 3‐kinase β but not γ isoform in Ca2+ mobilization and procoagulant activity
P. V. D. van der Meijden, S. Schoenwaelder, M. Feijge, J. Cosemans +5 more
200842 citations Open access
Semantic Scholar
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.
S. Schoenwaelder, S. Hughan, Karen Boniface, Sujanie Fernando +4 more
2002Journal of Biological Chemistry42 citations
Semantic Scholar
Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function.
S. Schoenwaelder, S. Jackson
2012Blood36 citations
Semantic Scholar
Type I phosphoinositide 3-kinases: potential antithrombotic targets?
Shaun P. Jackson, S. Schoenwaelder
2006Cellular and Molecular Life Sciences (CMLS)33 citations Open access
Semantic Scholar

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