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C. Yuan · SciRah

Researcher profile · Semantic Scholar

C. Yuan

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C. Yuan — researcher profile on SciRah

h-index: 11
Works: 22
Citations: 367

Most-cited papers

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)
Jia-Wang Liu, Shi-Long Zheng, V. Akerstrom, C. Yuan +12 more
2016Journal of Medicinal Chemistry73 citations Open access
Semantic Scholar
Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.
Daniel B. Horne, Kaustav Biswas, James Brown, M. Bartberger +18 more
2018Journal of Medicinal Chemistry51 citations Open access
Semantic Scholar
2-(S)-phenethylaminothiazolones as potent, orally efficacious inhibitors of 11beta-hydroxysteriod dehydrogenase type 1.
D. S. St Jean, C. Yuan, E. A. Bercot, R. Cupples +9 more
2007Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
C. Yuan, D. S. St Jean, Qingyian Liu, Lynn Cai +19 more
2007Bioorganic & Medicinal Chemistry Letters39 citations Open access
Semantic Scholar
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease.
J. Chen, Qingyian Liu, C. Yuan, V. Gore +33 more
2015Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
C. Fotsch, M. Bartberger, E. A. Bercot, Michelle M. Chen +22 more
2008Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.
Kaustav Biswas, A. Li, J. Chen, D. D'Amico +29 more
2007Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.
A. Li, C. Yuan, D. Chow, Michelle M. Chen +9 more
2011ACS Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr.
C. Dominguez, Leon M. Smith, Qi Huang, C. Yuan +19 more
2007Bioorganic & Medicinal Chemistry Letters19 citations Open access
Semantic Scholar
Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Q. Zeng, J. Allen, Matthew P. Bourbeau, Xiang-Hong Wang +19 more
2010Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease.
J. Chen, Wenyuan Qian, Kaustav Biswas, C. Yuan +31 more
2013Bioorganic & Medicinal Chemistry Letters13 citations Open access
Semantic Scholar
Aryl sulfonamides containing tetralin allylic amines as potent and selective bradykinin B1 receptor antagonists.
Qingyian Liu, Wenyuan Qian, A. Li, Kaustav Biswas +12 more
2010Bioorganic & Medicinal Chemistry Letters6 citations Open access
Semantic Scholar
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase.
Mei-Chu Lo, Ming-Han Wang, Ki Won Kim, James Busby +5 more
2008Analytical Biochemistry5 citations
Semantic Scholar
Discovery of HBW-3-10: A potent, orally active, reversible Bruton’s tyrosine kinase (BTK) inhibitor with antitumor activity in mice.
N. Lee, Ying-Fu Li, C. Yuan, Guan-Feng Liu +1 more
2021Journal of Clinical Oncology2 citations
Semantic Scholar
Discovery of HBW-3-20, the first potent reversible inhibitor of Bruton’s tyrosine kinase (BTK) with high brain exposure.
N. Lee, Ying-Fu Li, C. Yuan, Guan-Feng Liu +1 more
20210 citations
Semantic Scholar
Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors: Reducing pregnane X receptor (PXR) activity and exploring activity in a monkey pharmacodynamic model
F. Christopher, M. Bartberger, E. A. Bercot, Michelle M. Chen +22 more
20080 citations
Semantic Scholar
arylamine substituted and use methods
C. Yuan, Kevin Yang, S. van der Plas, B. Riahi +7 more
20050 citations
Semantic Scholar
Piperazine derivatives and application procedures
B. Askew, Kaustav Biswas, Jennifer N. Chau, Jian Chen +15 more
20040 citations
Semantic Scholar
Substituted amine derivatives and their use for the treatment of angiogenesis-related disorders
B. Askew, S. C. Booker, Guo-Qing Chen, Lucian Dipietro +11 more
20030 citations
Semantic Scholar
N- (3, -Dimethylindolin-6-yl) AE2 ä (4-pyridylmethyl) aminoü (3-pyridyl) ücarbonsäureamid and pharmaceutical compositions containing this.
Guo-Qing Chen, Jeffrey A. Adams, J. Bemis, S. Booker +20 more
20020 citations
Semantic Scholar
N- (3,3-dimethylindolin-6-yl) (2 - ((4-pyridylmethyl) amino) (3-pyridyl)) carboxamide and their pharmaceutical compositions.
Jeffrey A. Adams, J. Bemis, S. Booker, Guo-Qiang Cai +20 more
20020 citations
Semantic Scholar
N- (3,3-dimethylindolin-6-yl) {2- [4-pyridylmethyl) amino] (3-pyridyl)} carboxamide, as well as compositions thereof farmacaceutiske
Guo-Qing Chen, Jeffrey A. Adams, J. Bemis, S. Booker +20 more
20020 citations
Semantic Scholar

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