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Mei-Chu Lo · SciRah

Researcher profile · Semantic Scholar

Mei-Chu Lo

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Mei-Chu Lo — researcher profile on SciRah

h-index: 20
Works: 35
Citations: 2,215

Most-cited papers

Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery.
Mei-Chu Lo, A. Aulabaugh, G. Jin, R. Cowling +3 more
2004Analytical Biochemistry680 citations
Semantic Scholar
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.
Da-Qing Sun, Zhi-Hong Li, Y. Rew, Michael W. Gribble +46 more
2014Journal of Medicinal Chemistry261 citations Open access
Semantic Scholar
A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation.
Ryan P. Wurz, Ken Dellamaggiore, Hannah Dou, Noelle Javier +6 more
2017Journal of Medicinal Chemistry161 citations
Semantic Scholar
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
Y. Rew, Da-Qing Sun, Felix Gonzalez-Lopez De Turiso, M. Bartberger +31 more
2012Journal of Medicinal Chemistry159 citations Open access
Semantic Scholar
Better substrates for bacterial transglycosylases.
Xiang-Yang Ye, Mei-Chu Lo, L. Brunner, D. Walker +2 more
2001Journal of the American Chemical Society136 citations
Semantic Scholar
The Kinetic Characterization of Escherichia coli MurG Using Synthetic Substrate Analogues
Ha Sha, E. Chang, Mei-Chu Lo, Hong-Bin Men +3 more
199980 citations
Semantic Scholar
Rational design and binding mode duality of MDM2-p53 inhibitors.
Felix Gonzalez-Lopez de Turiso, Da-Qing Sun, Y. Rew, M. Bartberger +26 more
2013Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.
Ana Z. González, J. Eksterowicz, M. Bartberger, Hilary P. Beck +32 more
2014Journal of Medicinal Chemistry77 citations Open access
Semantic Scholar
A New Mechanism of Action Proposed for Ramoplanin
Mei-Chu Lo, Hong-Bin Men, A. Branstrom, Jeremiah S. Helm +3 more
200075 citations
Semantic Scholar
Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xiang-Hong Wang, J. Eksterowicz, Michael W. Gribble +47 more
2014Journal of Medicinal Chemistry67 citations Open access
Semantic Scholar
Identification, Characterization, and Crystal Structure ofBacillus subtilis Nicotinic Acid Mononucleotide Adenylyltransferase*
A. Olland, Kathryn W. Underwood, R. Czerwinski, Mei-Chu Lo +6 more
2002Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.
Ana Z. González, Zhi-Hong Li, Hilary P. Beck, J. Canon +30 more
2014Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.
Y. Rew, Da-Qing Sun, Xuelei Yan, Hilary P. Beck +31 more
2014Journal of Medicinal Chemistry40 citations Open access
Semantic Scholar
Preclinical Evaluation of AMG 925, a FLT3/CDK4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen S. Keegan, Cong Li, Zhi-Hong Li, Ji Ma +22 more
2014Molecular Cancer Therapeutics34 citations Open access
Semantic Scholar
A new structure for the substrate-binding antibiotic ramoplanin.
Mei-Chu Lo, Jeremiah S. Helm, Gopal Sarngadharan, István Pelczer +1 more
2001Journal of the American Chemical Society31 citations
Semantic Scholar
Structures and mechanism of human glycosyltransferase β1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important player in immune homeostasis
Y. Hao, A. Créquer-Grandhomme, Noelle Javier, Aman Singh +4 more
2020Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.
Ming Yu, Yingcai Wang, Jiang Zhu, M. Bartberger +25 more
2014ACS Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
P. Nowak, D. Cole, A. Aulabaugh, J. Bard +20 more
2010Bioorganic & Medicinal Chemistry Letters24 citations Open access
Semantic Scholar
Biophysical characterization of the interactions of HTI-286 with tubulin heterodimer and microtubules.
G. Krishnamurthy, Wendy Cheng, Mei-Chu Lo, A. Aulabaugh +5 more
2003Biochemistry23 citations
Semantic Scholar
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.
G. Rescourio, Ana Z. González, Salman Y. Jabri, B. Belmontes +27 more
2019Journal of Medicinal Chemistry21 citations
Semantic Scholar
Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease
Justin K. Murray, J. Long, Lei Liu, Shivani Singh +14 more
2021Nucleic Acid Therapeutics16 citations Open access
Semantic Scholar
The solution structure of the DNA-binding domain of Skn-1.
Mei-Chu Lo, Ha Sha, István Pelczer, Santona Pal +1 more
1998Proceedings of the National Academy of Sciences of the United States of America16 citations Open access
Semantic Scholar
Optimization beyond AMG 232: discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein-protein interaction.
Yingcai Wang, Jiang Zhu, J. Liu, Xiao-Qi Chen +16 more
2014Bioorganic & Medicinal Chemistry Letters14 citations Open access
Semantic Scholar
Probing the interaction of HTI-286 with tubulin using a stilbene analogue.
Mei-Chu Lo, A. Aulabaugh, G. Krishnamurthy, Joshua A. Kaplan +3 more
2004Journal of the American Chemical Society13 citations
Semantic Scholar
Structure-Based Design of Novel Inhibitors of the MDM 2 − p 53 Interaction
Y. Rew, Da-Qing Sun, Felix Gonzalez-Lopez De Turiso, M. Bartberger +32 more
201210 citations
Semantic Scholar
Skn-1: evidence for a bipartite recognition helix in DNA binding.
Santona Pal, Mei-Chu Lo, Darby Schmidt, István Pelczer +2 more
1997Proceedings of the National Academy of Sciences of the United States of America10 citations Open access
Semantic Scholar
Development of a nucleotide sugar purification method using a mixed mode column & mass spectrometry detection.
Heather Eastwood, Fang Xia, Mei-Chu Lo, Jing Zhou +4 more
2015Journal of Pharmaceutical and Biomedical Analysis8 citations
Semantic Scholar
Development of a time-resolved fluorescence resonance energy transfer assay for cyclin-dependent kinase 4 and identification of its ATP-noncompetitive inhibitors.
Mei-Chu Lo, R. Ngo, K. Dai, Cong Li +7 more
2012Analytical Biochemistry8 citations
Semantic Scholar
Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase.
C. Meleza, Bobbie M. Thomasson, C. Ramachandran, J. C. O'Neill +2 more
2016Analytical Biochemistry5 citations
Semantic Scholar
A highly sensitive high-throughput luminescence assay for malonyl-CoA decarboxylase.
Mei-Chu Lo, Ming-Han Wang, Ki Won Kim, James Busby +5 more
2008Analytical Biochemistry5 citations
Semantic Scholar
An Automated High-Throughput Fluorescence In Situ Hybridization (FISH) Assay Platform for Use in the Identification and Optimization of siRNA-Based Therapeutics
H. Dou, Rommel Mallari, Andrew Pipathsouk, Amrita Das +1 more
2020SLAS discovery : advancing life sciences R & D4 citations Open access
Semantic Scholar
Abstract 3663: Discovery of sulfonamide-piperidinones as potent inhibitors of the MDM2-p53 protein-protein interaction
Zhi-Hong Li, Jiasheng Fu, Y. Rew, Michael W. Gribble +19 more
20151 citations
Semantic Scholar
Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase
A. Olland, Kathryn W. Underwood, R. Czerwinski, Mei-Chu Lo +6 more
20021 citations
Semantic Scholar
Small Molecule Therapeutics Preclinical Evaluation of AMG 925 , a FLT 3 / CDK 4 Dual Kinase Inhibitor for Treating Acute Myeloid Leukemia
Kathleen S. Keegan, Cong Li, Zhi-Hong Li, Ji Ma +22 more
20140 citations
Semantic Scholar
Abstract A279: Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor.
K. Dai, Kathleen S. Keegan, Zhi-Hong Li, M. Ji +19 more
20130 citations
Semantic Scholar

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