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N. Kanu · SciRah

Researcher profile · Semantic Scholar

N. Kanu

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N. Kanu — researcher profile on SciRah

h-index: 32
Works: 98
Citations: 6,050

Most-cited papers

Replication stress links structural and numerical cancer chromosomal instability
R. Burrell, S. McClelland, D. Endesfelder, P. Groth +17 more
2013Nature850 citations
Semantic Scholar
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
S. Turajlic, K. Litchfield, Hang Xu, R. Rosenthal +16 more
2017The Lancet Oncology800 citations Open access
Semantic Scholar
Lung adenocarcinoma promotion by air pollutants
William Hill, Emilia L. Lim, C. Weeden, Claudia Lee +322 more
2023Nature710 citations Open access
Semantic Scholar
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
C. Abbosh, A. Frankell, T. Harrison, Judit Kisistók +302 more
2023Nature355 citations Open access
Semantic Scholar
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
Catherine Houlihan, N. Vora, T. Byrne, D. Lewer +318 more
2020The Lancet222 citations Open access
Semantic Scholar
The evolution of non-small cell lung cancer metastases in TRACERx
Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis +282 more
2023Nature217 citations Open access
Semantic Scholar
RETRACTED ARTICLE: Antibodies against endogenous retroviruses promote lung cancer immunotherapy
K. Ng, J. Boumelha, K. Enfield, J. Almagro +327 more
2023Nature202 citations Open access
Semantic Scholar
Genomic–transcriptomic evolution in lung cancer and metastasis
Carlos Martínez-Ruiz, J. Black, C. Puttick, M. Hill +42 more
2023Nature190 citations Open access
Semantic Scholar
Origins and impact of extrachromosomal DNA
Chris Bailey, O. Pich, K. Thol, T. Watkins +86 more
2024Nature168 citations Open access
Semantic Scholar
A comprehensive survey of the mutagenic impact of common cancer cytotoxics
B. Szikriszt, Á. Póti, O. Pipek, M. Krzystanek +9 more
2016Genome Biology160 citations Open access
Semantic Scholar
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
N. Kanu, M. Cerone, Gerald Goh, L. Zalmas +13 more
2016Genome Biology155 citations Open access
Semantic Scholar
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
S. Venkatesan, R. Rosenthal, N. Kanu, N. Mcgranahan +5 more
2018Annals of Oncology143 citations Open access
Semantic Scholar
Individualized tumor-informed circulating tumor DNA analysis for postoperative monitoring of non-small cell lung cancer.
Ke-Zhong Chen, Fan Yang, Hai-Feng Shen, Chenyang Wang +12 more
2023Cancer Cell128 citations Open access
Semantic Scholar
The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program “CASCADE”
P. Savas, Z. Teo, C. Lefèvre, C. Flensburg +16 more
2016PLoS Medicine122 citations Open access
Semantic Scholar
Induction of AP0BEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
S. Venkatesan, M. Angelova, C. Puttick, Hao-Ran Zhai +42 more
2021Cancer Discovery106 citations Open access
Semantic Scholar
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
J. Black, G. Bartha, C. Abbott, S. Boyle +276 more
2025Nature Medicine102 citations Open access
Semantic Scholar
Evolutionary characterisation of lung adenocarcinoma morphology in TRACERx
T. Karasaki, D. Moore, S. Veeriah, C. Naceur-Lombardelli +48 more
2023Nature Medicine102 citations Open access
Semantic Scholar
ATMIN defines an NBS1‐independent pathway of ATM signalling
N. Kanu, A. Behrens
2007EMBO Journal89 citations Open access
Semantic Scholar
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress
N. Kanu, Tian-Yi Zhang, R. Burrell, A. Chakraborty +10 more
2015Oncogene85 citations Open access
Semantic Scholar
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
D. Caswell, Philippe Gui, M. Mayekar, Emily K Law +81 more
2023Nature Genetics81 citations Open access
Semantic Scholar
Chromosomal instability selects gene copy number variants encoding core regulators of proliferation in ER+ breast cancer
D. Endesfelder, R. Burrell, N. Kanu, N. Mcgranahan +5 more
2014Cancer Research77 citations Open access
Semantic Scholar
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
K. Litchfield, S. Stanislaw, L. Spain, L. Gallegos +176 more
2020Cell Reports70 citations Open access
Semantic Scholar
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Inma M. Berenjeno, R. Piñeiro, Sandra D. Castillo, Wayne Pearce +19 more
2017Nature Communications70 citations Open access
Semantic Scholar
UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function
Tian-Yi Zhang, J. Cronshaw, N. Kanu, A. Snijders +1 more
2014Proceedings of the National Academy of Sciences of the United States of America63 citations Open access
Semantic Scholar
Using DNA sequencing data to quantify T cell fraction and therapy response
R. Bentham, K. Litchfield, T. Watkins, Emilia L. Lim +288 more
2021Nature62 citations Open access
Semantic Scholar
The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain*
N. Kanu, K. Penicud, M. Hristova, B. Wong +4 more
2010Journal of Biological Chemistry59 citations Open access
Semantic Scholar
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
S. Hobor, Maise Al Bakir, C. Hiley, M. Skrzypski +291 more
2024Nature Communications49 citations Open access
Semantic Scholar
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution
C. Puttick, Thomas P. Jones, Michelle M. Leung, Felipe Gálvez-Cancino +18 more
2024Nature Genetics44 citations Open access
Semantic Scholar
Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
Tian-Yi Zhang, K. Penicud, Christopher Bruhn, Joanna I. Loizou +3 more
2012Cell Reports44 citations Open access
Semantic Scholar
Multi-omics integrated circulating cell-free DNA genomic signatures enhanced the diagnostic performance of early-stage lung cancer and postoperative minimal residual disease.
Yun Li, Guan-Chao Jiang, Wendy Wu, Hao-Xia Yang +14 more
2023EBioMedicine42 citations Open access
Semantic Scholar
ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma
Joanna I. Loizou, Rocío Sancho, N. Kanu, D. Bolland +4 more
2011Cancer Cell36 citations Open access
Semantic Scholar
Unintended on-target chromosomal instability following CRISPR/Cas9 single gene targeting
J. Przewrocka, A. Rowan, R. Rosenthal, N. Kanu +1 more
2020Annals of Oncology32 citations Open access
Semantic Scholar
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma
I. Noorani, M. Haughey, J. Luebeck, A. Rowan +26 more
2024bioRxiv30 citations Open access
Semantic Scholar
A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms
B. Szikriszt, Á. Póti, E. Németh, N. Kanu +2 more
2021Mutagenesis28 citations Open access
Semantic Scholar
ATMINistrating ATM signaling
N. Kanu, A. Behrens
200828 citations Open access
Semantic Scholar
Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer
Ke-Zhong Chen, Guannan Kang, Zhihong Zhang, A. Lizaso +12 more
2023BMC Medicine27 citations Open access
Semantic Scholar
The Genome of the Chicken DT40 Bursal Lymphoma Cell Line
J. Molnár, Á. Póti, O. Pipek, M. Krzystanek +6 more
2014G3: Genes, Genomes, Genetics27 citations Open access
Semantic Scholar
Scalable and robust SARS-CoV-2 testing in an academic center
J. Aitken, Karen Ambrose, S. Barrell, R. Beale +282 more
2020Nature Biotechnology26 citations Open access
Semantic Scholar
Corrigendum: Replication stress links structural and numerical cancer chromosomal instability
R. Burrell, S. McClelland, D. Endesfelder, P. Groth +17 more
2013Nature26 citations Open access
Semantic Scholar
ATMINistrating ATM signalling: regulation of ATM by ATMIN.
N. Kanu, A. Behrens
2008Cell Cycle26 citations
Semantic Scholar
Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER
O. Lucas, S. Ward, Rija Zaidi, A. Bunkum +20 more
2024Nature Genetics23 citations Open access
Semantic Scholar
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation
Sophia M. Blake, Stefan H. Stricker, Hanna Halavach, A. Poetsch +7 more
2016eLife19 citations Open access
Semantic Scholar
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
D. Biswas, Yun-Hsin Liu, J. Herrero, Yin Wu +32 more
2025Nature Cancer17 citations Open access
Semantic Scholar
Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance
M. Mayekar, D. Caswell, N. Vokes, Emily K Law +44 more
2020bioRxiv17 citations Open access
Semantic Scholar
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution
F. Gimeno-Valiente, Carla Castignani, Elizabeth Larose Cadieux, N. Mensah +264 more
2025Nature Genetics15 citations Open access
Semantic Scholar
Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution
M. Dietzen, Hao-Ran Zhai, O. Lucas, O. Pich +9 more
2024Nature Communications15 citations Open access
Semantic Scholar
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
N. Kanu, E. Grönroos, P. Martinez, R. Burrell +25 more
2015Oncogene15 citations Open access
Semantic Scholar
Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers.
Ke-Zhong Chen, Ai-Rong Yang, D. Carbone, N. Kanu +14 more
2022Cell Reports14 citations Open access
Semantic Scholar
Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data
I. Lönnstedt, F. Caramia, Jason Li, D. Fumagalli +13 more
2014Genome Biology14 citations Open access
Semantic Scholar
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling
Wei-Ting Lu, L. Zalmas, Chris Bailey, J. Black +34 more
2024Nature Cell Biology12 citations Open access
Semantic Scholar

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N. Mcgranahan×25
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C. Swanton×21
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M. Jamal-Hanjani×19
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Maise Al Bakir×16

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