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Wayne Pearce · SciRah

Researcher profile · Semantic Scholar

Wayne Pearce

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Wayne Pearce — researcher profile on SciRah

h-index: 28
Works: 49
Citations: 5,181

Most-cited papers

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
K. Okkenhaug, A. Bilancio, Géraldine Farjot, H. Priddle +8 more
2002Science1,039 citations
Semantic Scholar
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
M. Graupera, J. Guillermet-Guibert, L. Foukas, Li-Kun Phng +11 more
2008Nature530 citations
Semantic Scholar
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
L. Foukas, M. Claret, Wayne Pearce, K. Okkenhaug +6 more
2006Nature459 citations
Semantic Scholar
Inactivation of the PI3K p110δ breaks regulatory T cell-mediated immune tolerance to cancer
K. Ali, Dalya R. Soond, R. Piñeiro, T. Hagemann +10 more
2014Nature427 citations Open access
Semantic Scholar
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
K. Ali, A. Bilancio, Matthew J. Thomas, Wayne Pearce +13 more
2004Nature382 citations
Semantic Scholar
Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells1
D. Patton, O. Garden, Wayne Pearce, Louise E. Clough +7 more
2006Journal of Immunology328 citations Open access
Semantic Scholar
Somatic Activating Mutations in Pik3ca Cause Sporadic Venous Malformations in Mice and Humans
Sandra D. Castillo, Elena Tzouanacou, M. Zaw-Thin, Inma M. Berenjeno +24 more
2016Science Translational Medicine198 citations Open access
Semantic Scholar
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
E. Aksoy, S. Taboubi, D. Torres, S. Delbauve +9 more
2012Nature Immunology186 citations Open access
Semantic Scholar
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.
K. Ali, A. Bilancio, Matthew J. Thomas, Wayne Pearce +13 more
2004Nature185 citations
Semantic Scholar
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase
B. Eickholt, A. Ahmed, M. Davies, E. Papakonstanti +10 more
2007PLoS ONE126 citations Open access
Semantic Scholar
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
H. Ji, F. Rintelen, C. Waltzinger, Dominique Bertschy-Meier +9 more
2007Blood121 citations Open access
Semantic Scholar
Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo
K. Ali, M. Camps, Wayne Pearce, H. Ji +6 more
2008Journal of Immunology109 citations Open access
Semantic Scholar
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism
L. Foukas, B. Bilanges, L. Bettedi, Wayne Pearce +4 more
2013EMBO Molecular Medicine99 citations Open access
Semantic Scholar
Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
K. Ali, Dalya R. Soond, R. Piñeiro, T. Hagemann +10 more
2016Nature96 citations Open access
Semantic Scholar
Macrophages Transfected with Adenovirus to Express IL-4 Reduce Inflammation in Experimental Glomerulonephritis1
D. Kluth, Clare V. Ainslie, Wayne Pearce, S. Finlay +3 more
2001Journal of Immunology96 citations Open access
Semantic Scholar
Differential Effects of Necrotic or Apoptotic Cell Uptake on Antigen Presentation by Macrophages
R. Barker, L. Erwig, Wayne Pearce, Anne Devine +1 more
2000Pathobiology (Basel)77 citations
Semantic Scholar
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
Samira Alliouachene, B. Bilanges, G. Chicanne, Karen E. Anderson +13 more
2015Cell Reports75 citations Open access
Semantic Scholar
Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases
Matthew J. Thomas, Alexandra Smith, Denis Head, Laura Milne +9 more
2005European Journal of Immunology75 citations Open access
Semantic Scholar
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
B. Bilanges, Samira Alliouachene, Wayne Pearce, D. Morelli +24 more
2017Nature Communications74 citations Open access
Semantic Scholar
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
Inma M. Berenjeno, J. Guillermet-Guibert, Wayne Pearce, A. Gray +2 more
2011Biochemical Journal73 citations Open access
Semantic Scholar
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Inma M. Berenjeno, R. Piñeiro, Sandra D. Castillo, Wayne Pearce +19 more
2017Nature Communications70 citations Open access
Semantic Scholar
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner
R. Madsen, R. Knox, Wayne Pearce, Saioa López +4 more
2018Proceedings of the National Academy of Sciences of the United States of America56 citations Open access
Semantic Scholar
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
M. Lechner, V. Schartinger, C. Steele, W. Nei +68 more
2021Nature Communications49 citations Open access
Semantic Scholar
Role of the p110δ PI 3-kinase in integrin and ITAM receptor signalling in platelets
Y. Senis, B. Atkinson, A. Pearce, P. Wonerow +7 more
2005Platelets49 citations Open access
Semantic Scholar
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
J. Guillermet-Guibert, L. Smith, G. Halet, M. Whitehead +14 more
2015PLoS Genetics43 citations Open access
Semantic Scholar
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.
P. Cutillas, A. Khwaja, M. Graupera, Wayne Pearce +3 more
2006Proceedings of the National Academy of Sciences of the United States of America41 citations Open access
Semantic Scholar
Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice
Samira Alliouachene, B. Bilanges, C. Chaussade, Wayne Pearce +4 more
2016Diabetologia30 citations Open access
Semantic Scholar
Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.
V. Rajeeve, Wayne Pearce, M. Cascante, B. Vanhaesebroeck +1 more
2013Biochemical Journal29 citations
Semantic Scholar
Inactivation of PI(3)K p110 delta breaks regulatory T-cell-mediated immune tolerance to cancer (vol 510, pg 407, 2014)
K. Ali, Soond, R. Piñeiro, T. Hagemann +10 more
201626 citations
Semantic Scholar
Long‐term treatment of cancer‐prone germline PTEN mutant mice with low‐dose rapamycin extends lifespan and delays tumour development
Priyanka Tibarewal, V. Rathbone, Georgia Constantinou, Wayne Pearce +9 more
2022Journal of Pathology17 citations Open access
Semantic Scholar
A class I PI3K signalling network regulates primary cilia disassembly in normal physiology and disease
S. Conduit, Wayne Pearce, Amandeep Bhamra, B. Bilanges +13 more
2024Nature Communications11 citations Open access
Semantic Scholar
The p110 delta isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (vol 13, pg 1045, 2012)
E. Aksoy, S. Taboubi, D. Torres, S. Delbauve +9 more
20137 citations
Semantic Scholar
Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome
Priyanka Tibarewal, V. Rathbone, S. Conduit, G. Classen +28 more
2025Disease Models & Mechanisms3 citations Open access
Semantic Scholar
Inactivation of PI3K (cid:1) and PI3K (cid:2) distorts T-cell development and causes multiple organ inﬂammation
H. Ji, F. Rintelen, C. Waltzinger, D. Meier +9 more
20073 citations
Semantic Scholar
Novel role for PI3Kβ in placental function through regulation of system A amino acid transporter expression, associated with embryonic lethality
S. Conduit, Cindy X. W. Zhang, Wayne Pearce, J. Guillermet-Guibert +2 more
2025Cellular and Molecular Life Sciences2 citations Open access
Semantic Scholar
Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock
York Posor, S. Conduit, Wayne Pearce, D. Morelli +7 more
2025Proceedings of the National Academy of Sciences of the United States of America2 citations
Semantic Scholar
Abstract 4738: Pharmacological activation of PI3Kα triggers cancer cell death under metabolic stress
B. Bilanges, R. Madsen, D. Morelli, Thomas P. Jones +11 more
2026Cancer Research0 citations
Semantic Scholar
Abstract 5750: Solid tumor cell-intrinsic function of PI3Kδ
S. Conduit, Elena Lopez-Guadamillas, D. Morelli, Harriet Howard +3 more
2026Cancer Research0 citations
Semantic Scholar
A mouse model of PTEN Hamartoma Tumour Syndrome reveals that loss of the nuclear function of PTEN drives macrocephaly, lymphoid overgrowth, and late-onset cancer
Priyanka Tibarewal, V. Rathbone, S. Conduit, G. Classen +28 more
2025bioRxiv0 citations Open access
Semantic Scholar
Abstract B22: Investigation of PTEN genotype-phenotype correlations in the PTEN hamartoma tumor syndrome (PHTS) using in vitro and in vivo approaches
Wayne Pearce, N. Kessaris, Nicholas R. Leslie, B. Vanhaesebroeck +6 more
20200 citations
Semantic Scholar
Title : Somatic Activating Mutations in Pik 3 ca Cause Sporadic Venous Malformations in Mice and Humans
Sandra D. Castillo, Elena Tzouanacou, M. Zaw-Thin, Inma M. Berenjeno +27 more
20160 citations
Semantic Scholar
CD4+CD25+Foxp3+ Regulatory T Cells Is Critical for the Function of δ p110Edge: The Phosphoinositide 3-Kinase
K. Okkenhaug, S. Sancho, L. Walker, B. Vanhaesebroeck +7 more
20130 citations
Semantic Scholar
Abstract A86: Inactivation of p110delta PI3K releases potent antitumor immunity.
K. Ali, Dalya R. Soond, R. Pinero, Wayne Pearce +5 more
20130 citations
Semantic Scholar
Phosphoinositide 3-Kinases : p 110 Isoform-Specific Functions of Vanhaesebroeck
M. Camps, Wayne Pearce, H. Ji, T. Rückle +5 more
20080 citations
Semantic Scholar
Reduced Akt and increased RhoA/PTEN signaling in DRG neurons with inactive p110δ.
B. Eickholt, A. Ahmed, M. Davies, E. Papakonstanti +10 more
20070 citations Open access
Semantic Scholar
The role of the p110 delta PI3-kinase isoform in inflammatory bowel disease
K. Kok, Wayne Pearce, M. Peppelenbosch, B. Vanhaesebroeck +1 more
20070 citations
Semantic Scholar
This information is current as Experimental Glomerulonephritis Express IL-4 Reduce Inflammation in Macrophages Transfected with Adenovirus to
D. Kluth, Clare V. Ainslie, Wayne Pearce, S. Finlay +3 more
20010 citations
Semantic Scholar
Subject Index Vol. 67, 1999
S. Goerdt, C. Orfanos, C. Sorg, O. Politz +108 more
2000Pathobiology (Basel)0 citations Open access
Semantic Scholar
1–14 Prélude: Macrophages in Inflammation / 15–35 Macrophages in Anti-Inflammation: Molecular Mechanisms / 36–46 Macrophages in Anti-Inflammation: Apoptosis / 47–56 Macrophages in Anti-Inflammation: Induction of Tolerance
S. Goerdt, C. Orfanos, C. Sorg, O. Politz +108 more
2000Pathobiology (Basel)0 citations
Semantic Scholar

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A. Bilancio — researcher profile on SciRah

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