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M. Hoekstra · SciRah

Researcher profile · Semantic Scholar

M. Hoekstra

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M. Hoekstra — researcher profile on SciRah

h-index: 37
Works: 189
Citations: 6,028

Most-cited papers

Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing.
Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan, K. Charissé +21 more
2014Journal of the American Chemical Society1,054 citations
Semantic Scholar
A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.
R. van den Berg, S. Kooijman, R. Noordam, A. Ramkisoensing +24 more
2018Cell Reports77 citations Open access
Semantic Scholar
Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells
Ya-Nan Wang, S. V. D. van der Tuin, N. Tjeerdema, A. V. van Dam +17 more
2015Hepatology73 citations Open access
Semantic Scholar
SR-BI as target in atherosclerosis and cardiovascular disease - A comprehensive appraisal of the cellular functions of SR-BI in physiology and disease.
M. Hoekstra
2017Atherosclerosis60 citations Open access
Semantic Scholar
High density lipoprotein as a source of cholesterol for adrenal steroidogenesis: a study in individuals with low plasma HDL-C
A. Bochem, A. Holleboom, J. Romijn, M. Hoekstra +5 more
2013Journal of Lipid Research58 citations Open access
Semantic Scholar
Adrenal-Specific Scavenger Receptor BI Deficiency Induces Glucocorticoid Insufficiency and Lowers Plasma Very-Low-Density and Low-Density Lipoprotein Levels in Mice
M. Hoekstra, R. J. van der Sluis, M. Van Eck, T. V. Van Berkel
2013Arteriosclerosis, Thrombosis and Vascular Biology43 citations Open access
Semantic Scholar
High-density lipoproteins and non-alcoholic fatty liver disease
M. Hoekstra, M. Van Eck
2023Atherosclerosis Plus34 citations Open access
Semantic Scholar
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Laura M. de Jong, Soukayna Boussallami, E. Sánchez-López, M. Giera +6 more
2023Frontiers in Pharmacology30 citations Open access
Semantic Scholar
Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells.
Zhaosha Li, J. Kruijt, R. J. van der Sluis, T. V. Van Berkel +1 more
2013Physiological Genomics29 citations
Semantic Scholar
LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
M. Hoekstra, S. Korporaal, R. J. van der Sluis, V. Hirsch-Reinshagen +5 more
2013Journal of Lipid Research26 citations Open access
Semantic Scholar
Gene Editing for the Treatment of Hypercholesterolemia
M. Hoekstra, M. Van Eck
2024Current Atherosclerosis Reports24 citations Open access
Semantic Scholar
Glucocorticoids are active players and therapeutic targets in atherosclerotic cardiovascular disease.
R. J. van der Sluis, M. Hoekstra
2020Molecular and Cellular Endocrinology24 citations Open access
Semantic Scholar
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo
J. E. Nahon, C. Groeneveldt, J. Geerling, M. Van Eck +1 more
2018British Journal of Pharmacology24 citations Open access
Semantic Scholar
Rediscovering SR-BI: Surprising New Roles for The HDL Receptor
M. Hoekstra, M. Sorci-Thomas
2017Current Opinion in Lipidology24 citations Open access
Semantic Scholar
The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity
L. Koorneef, Jan Kroon, E. Viho, Lucas F Wahl +6 more
2020Journal of Endocrinology22 citations Open access
Semantic Scholar
Mouse models of disturbed HDL metabolism.
M. Hoekstra, M. Van Eck
2015Handbook of Experimental Pharmacology22 citations Open access
Semantic Scholar
Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice.
J. E. Nahon, M. Hoekstra, V. van Harmelen, P. Rensen +3 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease21 citations Open access
Semantic Scholar
Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model.
J. E. Nahon, M. Hoekstra, S. Havik, P. V. van Santbrink +4 more
2018Atherosclerosis20 citations
Semantic Scholar
Time to run: Late rather than early exercise training in mice remodels the gut microbiome and reduces atherosclerosis development
Milena Schönke, Z. Ying, A. Kovynev, Wietse In Het Panhuis +7 more
2022bioRxiv19 citations Open access
Semantic Scholar
Adrenocortical LDL receptor function negatively influences glucocorticoid output.
R. J. van der Sluis, M. Van Eck, M. Hoekstra
2015Journal of Endocrinology17 citations Open access
Semantic Scholar
Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development.
Marco van der Stoep, Zhaosha Li, L. Calpe-Berdiel, R. J. van der Sluis +7 more
2013Biochemical Pharmacology17 citations
Semantic Scholar
Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish.
R. Verwilligen, Lindsay Mulder, Frans J. Rodenburg, A. Van Dijke +3 more
2022Atherosclerosis15 citations Open access
Semantic Scholar
Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice.
R. van der Geest, Amber B. Ouweneel, R. J. van der Sluis, A. Groen +2 more
2016Toxicology and Applied Pharmacology15 citations
Semantic Scholar
PRMT5 inhibition induces pro‐inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice
Yiheng Zhang, R. Verwilligen, M. Van Eck, M. Hoekstra
2023Journal of Cellular and Molecular Medicine14 citations Open access
Semantic Scholar
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice.
M. Hoekstra, J. E. Nahon, Laura M. de Jong, Mara J. Kröner +2 more
2019Biochimica et Biophysica Acta - Molecular Basis of Disease14 citations Open access
Semantic Scholar
Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice.
Amber B. Ouweneel, M. Hoekstra, Ezra van der Wel, F. Schaftenaar +4 more
2019Atherosclerosis14 citations Open access
Semantic Scholar
Leukocytosis and Enhanced Susceptibility to Endotoxemia but Not Atherosclerosis in Adrenalectomized APOE Knockout Mice
M. Hoekstra, V. Frodermann, Tim van den Aardweg, R. J. van der Sluis +1 more
2013PLoS ONE14 citations Open access
Semantic Scholar
SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice.
M. Hoekstra, Amber B. Ouweneel, J. Price, R. van der Geest +4 more
2020Journal of Nutritional Biochemistry13 citations Open access
Semantic Scholar
Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal Absorption of Cholesterol in Adult Mice.
Lidiya G. Dimova, J. D. de Boer, J. Plantinga, T. Plösch +3 more
2017Gastroenterology13 citations
Semantic Scholar
High-Density Lipoprotein: An Ambiguous Therapeutic Target in Atherosclerosis and Cardiovascular Disease
M. Hoekstra, T. V. Van Berkel
201613 citations
Semantic Scholar
HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile
M. Hoekstra, M. Van Eck
2016Journal of Lipid Research13 citations Open access
Semantic Scholar
CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation
Laura M. de Jong, Chandan Harpal, D. van den Berg, M. Hoekstra +4 more
2024Drug Metabolism And Disposition12 citations Open access
Semantic Scholar
PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice
Laura M. de Jong, Zheng-Zheng Zhang, Yvette den Hartog, T. Sijsenaar +7 more
2022Scientific Reports12 citations Open access
Semantic Scholar
Simvastatin treatment aggravates the glucocorticoid insufficiency associated with hypocholesterolemia in mice.
Amber B. Ouweneel, R. J. van der Sluis, J. E. Nahon, M. Van Eck +1 more
2017Atherosclerosis12 citations Open access
Semantic Scholar
PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice.
Yiheng Zhang, R. Verwilligen, M. de Boer, T. Sijsenaar +2 more
2021Atherosclerosis11 citations Open access
Semantic Scholar
Hematopoietic Stabilin-1 deficiency does not influence atherosclerosis susceptibility in LDL receptor knockout mice.
J. E. Nahon, M. Hoekstra, Silvia van Hulst, C. Manta +4 more
2019Atherosclerosis11 citations
Semantic Scholar
UvA-DARE ( Digital Academic Repository ) HDL cholesterol : atherosclerosis and beyond
A. Bochem, A. Holleboom, J. Romijn, M. Hoekstra +5 more
201311 citations
Semantic Scholar
Zebrafish as outgroup model to study evolution of scavenger receptor class B type I functions.
R. Verwilligen, Lindsay Mulder, P. Araújo, M. Carneiro +3 more
2023Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids10 citations Open access
Semantic Scholar
High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins
Josefien W. Hommes, Rachel M. Kratofil, S. Wahlen, C. D. de Haas +7 more
2021Scientific Reports10 citations Open access
Semantic Scholar
PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo.
Yiheng Zhang, M. de Boer, Ezra van der Wel, M. Van Eck +1 more
2021Biochimica et Biophysica Acta - Molecular Basis of Disease10 citations Open access
Semantic Scholar
LR11/SorLA links triglyceride-rich lipoproteins to risk of developing cardiovascular disease in FH patients.
R. Vongpromek, H. Bujo, M. Hoekstra, W. Schneider +9 more
2015Atherosclerosis10 citations
Semantic Scholar
Prolactin receptor antagonism uncouples lipids from atherosclerosis susceptibility.
R. J. van der Sluis, Tim van den Aardweg, A. Reuwer, M. Twickler +4 more
2014Journal of Endocrinology10 citations Open access
Semantic Scholar
Gene Editing Therapy in Cardiovascular Disease: 2026 ACC Scientific Statement: A Report of the American College of Cardiology.
A. Ambardekar, A. Bhatt, M. Hoekstra, M. Kelly +2 more
2026Journal of the American College of Cardiology9 citations
Semantic Scholar
Apolipoprotein A1 deficiency in mice primes bone marrow stem cells for T cell lymphopoiesis
Amber B. Ouweneel, Myrthe E. Reiche, Olga S C Snip, R. Wever +6 more
2021Journal of Cell Science9 citations Open access
Semantic Scholar
ANGPTL3 (Angiopoietin‐Like 3) Preferentially Resides on High‐Density Lipoprotein in the Human Circulation, Affecting Its Activity
J. Kraaijenhof, T. Tromp, N. Nurmohamed, L. Reeskamp +8 more
2023Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease8 citations Open access
Semantic Scholar
Epidermal 1-O-acylceramides appear with the establishment of the water permeability barrier in mice and are produced by maturating keratinocytes.
M. Rabionet, Pauline Bernard, M. Pichery, Christian Marsching +16 more
2022Lipids8 citations Open access
Semantic Scholar
MicroRNA-499-5p: a therapeutic target in the context of cardiovascular disease.
M. Hoekstra
2016Annals of Translational Medicine8 citations Open access
Semantic Scholar
Protein Arginine Methyltransferase 1: A Multi-Purpose Player in the Development of Cancer and Metabolic Disease
D. D. de Korte, M. Hoekstra
2025Biomolecules7 citations
Semantic Scholar
2-Hydroxypropyl-beta-cyclodextrin Treatment Does Not Induce Atherosclerotic Lesion Regression in Western-Type Diet-Fed Apolipoprotein E Knockout Mice
Olga S C Snip, M. Hoekstra, Yiheng Zhang, J. Geerling +1 more
2022Biomolecules7 citations Open access
Semantic Scholar
Hypercholesterolemia in young adult APOE-/- mice alters epidermal lipid composition and impairs barrier function.
Renata Martins Cardoso, Eline Creemers, Samira Absalah, G. Gooris +3 more
2019Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids7 citations Open access
Semantic Scholar

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