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F. Hofmann · SciRah

Researcher profile · Semantic Scholar

F. Hofmann

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F. Hofmann — researcher profile on SciRah

h-index: 35
Works: 62
Citations: 4,275

Most-cited papers

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
S. Srinivasan, Fei Wang, Suzana Glavaš, Alexander Ott +4 more
2003Journal of Cell Biology534 citations Open access
Semantic Scholar
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O
I. Walev, S. C. Bhakdi, F. Hofmann, Nabil Djonder +3 more
2001Proceedings of the National Academy of Sciences of the United States of America338 citations Open access
Semantic Scholar
A Common Motif of Eukaryotic Glycosyltransferases Is Essential for the Enzyme Activity of Large Clostridial Cytotoxins*
C. Busch, F. Hofmann, J. Selzer, S. Munro +2 more
1998Journal of Biological Chemistry229 citations Open access
Semantic Scholar
Inactivation of Ras by Clostridium sordellii Lethal Toxin-catalyzed Glucosylation (*)
I. Just, J. Selzer, F. Hofmann, G. A. Green +1 more
1996Journal of Biological Chemistry194 citations Open access
Semantic Scholar
Localization of the Glucosyltransferase Activity of Clostridium difficile Toxin B to the N-terminal Part of the Holotoxin*
F. Hofmann, C. Busch, U. Prepens, I. Just +1 more
1997Journal of Biological Chemistry177 citations Open access
Semantic Scholar
Low pH-induced Formation of Ion Channels by Clostridium difficile Toxin B in Target Cells*
H. Barth, Gunther Pfeifer, F. Hofmann, E. Maier +2 more
2001Journal of Biological Chemistry168 citations Open access
Semantic Scholar
An Inhibitory Role of Rho in the Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells*
E. Klussmann, G. Tamma, D. Lorenz, B. Wiesner +5 more
2001Journal of Biological Chemistry168 citations Open access
Semantic Scholar
Clostridium novyi α-Toxin-catalyzed Incorporation of GlcNAc into Rho Subfamily Proteins*
J. Selzer, F. Hofmann, G. Rex, M. Wilm +3 more
1996Journal of Biological Chemistry138 citations Open access
Semantic Scholar
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
C. Seisenberger, V. Specht, A. Welling, J. Platzer +6 more
2000Journal of Biological Chemistry137 citations
Semantic Scholar
Characterization of the Enzymatic Component of the ADP-Ribosyltransferase Toxin CDTa from Clostridium difficile
Irene Gülke, Gunther Pfeifer, J. Liese, Michaela Fritz +3 more
2001Infection and Immunity134 citations Open access
Semantic Scholar
Sphingosine-1-Phosphate Mediates Migration of Mature Dendritic Cells1
N. Czeloth, G. Bernhardt, F. Hofmann, H. Genth +1 more
2005Journal of Immunology122 citations Open access
Semantic Scholar
Characterization of the Catalytic Site of the ADP-Ribosyltransferase Clostridium botulinum C2 Toxin by Site-directed Mutagenesis*
H. Barth, J. Preiss, F. Hofmann, K. Aktories
1998Journal of Biological Chemistry113 citations Open access
Semantic Scholar
Experimental generation of a tissue-engineered functional and vascularized trachea.
T. Walles, B. Giere, M. Hofmann, J. Schanz +3 more
2004Journal of Thoracic and Cardiovascular Surgery107 citations Open access
Semantic Scholar
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing
M. Höltje, Anja Hoffmann, F. Hofmann, C. Mucke +5 more
2005Journal of Neurochemistry104 citations Open access
Semantic Scholar
C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts
F. Boato, S. Hendrix, Stefanie C. Huelsenbeck, F. Hofmann +7 more
2010Journal of Cell Science97 citations Open access
Semantic Scholar
Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.
S. Conrad, H. Genth, F. Hofmann, I. Just +1 more
2007Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Cellular stability of Rho‐GTPases glucosylated by Clostridium difficile toxin B
H. Genth, J. Huelsenbeck, B. Hartmann, F. Hofmann +2 more
2006FEBS Letters89 citations
Semantic Scholar
Functional Consequences of Monoglucosylation of Ha-Ras at Effector Domain Amino Acid Threonine 35*
C. Herrmann, M. Ahmadian, F. Hofmann, I. Just
1998Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Activation of Rho GTPases by Escherichia coli Cytotoxic Necrotizing Factor 1 Increases Intestinal Permeability in Caco-2 Cells
R. Gerhard, G. Schmidt, F. Hofmann, K. Aktories
1998Infection and Immunity84 citations Open access
Semantic Scholar
Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins
C. Lucius, A. Arner, A. Steusloff, M. Troschka +3 more
1998Journal of Physiology82 citations Open access
Semantic Scholar
Agents That Inhibit Rho, Rac, and Cdc42 Do Not Block Formation of Actin Pedestals in HeLa Cells Infected with Enteropathogenic Escherichia coli
Goni Ben-ami, V. Ozeri, E. Hanski, F. Hofmann +4 more
1998Infection and Immunity77 citations Open access
Semantic Scholar
Neogenin-RGMa Signaling at the Growth Cone Is Bone Morphogenetic Protein-independent and Involves RhoA, ROCK, and PKC*
S. Conrad, H. Genth, F. Hofmann, I. Just +1 more
2007Journal of Biological Chemistry71 citations Open access
Semantic Scholar
Involvement of a Conserved Tryptophan Residue in the UDP-Glucose Binding of Large Clostridial Cytotoxin Glycosyltransferases*
C. Busch, F. Hofmann, R. Gerhard, K. Aktories
2000Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Actin Re-Organization Induced by Chlamydia trachomatis Serovar D - Evidence for a Critical Role of the Effector Protein CT166 Targeting Rac
Jessica Thalmann, K. Janik, Martin May, K. Sommer +4 more
2010PLoS ONE63 citations Open access
Semantic Scholar
Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system.
S. Burger, H. Tatge, F. Hofmann, H. Genth +2 more
2003Biochemical and Biophysical Research Communications - BBRC63 citations
Semantic Scholar
The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis.
Cornelia Frisch, R. Gerhard, K. Aktories, F. Hofmann +1 more
2003Biochemical and Biophysical Research Communications - BBRC63 citations
Semantic Scholar
Regulation of Somatodendritic GABAA Receptor Channels in Rat Hippocampal Neurons: Evidence for a Role of the Small GTPase Rac1
D. K. Meyer, C. Olenik, F. Hofmann, H. Barth +4 more
2000Journal of Neuroscience58 citations Open access
Semantic Scholar
Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition
F. Hofmann, C. Busch, K. Aktories
1998Infection and Immunity58 citations Open access
Semantic Scholar
A 29‐amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation
M. Höltje, Susann Djalali, F. Hofmann, Agnieszka Münster-Wandowski +8 more
2009The FASEB Journal50 citations
Semantic Scholar
Inositol hexakisphosphate increases L‐type Ca2+ channel activity by stimulation of adenylyl cyclase
Shao-Nian Yang, Jia Yu, Georg W. Mayr, F. Hofmann +2 more
2001The FASEB Journal49 citations
Semantic Scholar
Characterization of the Catalytic Domain ofClostridium novyi Alpha-Toxin
C. Busch, K. Schömig, F. Hofmann, K. Aktories
2000Infection and Immunity43 citations Open access
Semantic Scholar
Molecular mode of action of the large clostridial cytotoxins.
I. Just, F. Hofmann, K. Aktories
2000Current Topics in Microbiology and Immunology41 citations
Semantic Scholar
A Role for the Small Molecular Weight GTPases, Rho and Cdc42, in Muscarinic Receptor Signaling to Focal Adhesion Kinase
Daniel A. Linseman, F. Hofmann, Stephen K. Fisher
2000Journal of Neurochemistry41 citations Open access
Semantic Scholar
Glutamate Uptake and Release by Astrocytes Are Enhanced by Clostridium botulinum C3 Protein*
M. Höltje, F. Hofmann, Romy Lux, R. Veh +2 more
2008Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Analysis of the catalytic site of the actin ADP‐ribosylating Clostridium perfringens iota toxin
J. van Damme, M. Jung, F. Hofmann, I. Just +2 more
1996FEBS Letters35 citations Open access
Semantic Scholar
Inhibition of Rho‐dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
Anja Hoffmann, F. Hofmann, I. Just, S. Lehnardt +5 more
2008Glia30 citations
Semantic Scholar
Rundown of somatodendritic N‐methyl‐D‐aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA
W. Nörenberg, F. Hofmann, P. Illés, K. Aktories +1 more
1999British Journal of Pharmacology30 citations Open access
Semantic Scholar
New Method To Generate Enzymatically DeficientClostridium difficile Toxin B as an Antigen for Immunization
H. Genth, J. Selzer, C. Busch, Jürgen Dumbach +3 more
2000Infection and Immunity28 citations Open access
Semantic Scholar
Sequencing and analysis of the gene encoding the α-toxin of Clostridium novyi proves its homology to toxins A and B of Clostridium difficile
F. Hofmann, Andrea Herrmann, E. Habermann, C. von Eichel-Streiber
1995Molecular and General Genetics MGG28 citations
Semantic Scholar
Killing of rat basophilic leukemia cells by lethal toxin from Clostridium sordellii: critical role of phosphatidylinositide 3'-OH kinase/Akt signaling.
Stefanie C. Dreger, F. Schulz, J. Huelsenbeck, R. Gerhard +3 more
2009Biochemistry22 citations
Semantic Scholar
Regulation by Rho family GTPases of IL–1 receptor induced signaling: C3‐like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL‐2 gene expression
U. Dreikhausen, G. Varga, F. Hofmann, H. Barth +3 more
2001European Journal of Immunology20 citations Open access
Semantic Scholar
Molecular Mechanisms of Action of the Large Clostridial Cytotoxins
I. Just, F. Hofmann, K. Aktories
200020 citations
Semantic Scholar
Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis.
M. V. Muetzelburg, F. Hofmann, I. Just, Andreas Pich
2009Journal of chromatography. B, Analytical technologies in the biomedical and life sciences19 citations
Semantic Scholar
Clostridium difficile Toxin B as a Probe for Rho GTPases
I. Just, J. Selzer, F. Hofmann, K. Aktories
200817 citations
Semantic Scholar
Comparison of wild type with recombinant Clostridium difficile toxin A.
R. Gerhard, S. Burger, H. Tatge, H. Genth +2 more
2005Microbial Pathogenesis16 citations
Semantic Scholar
Design of modified botulinum neurotoxin A1 variants with a shorter persistence of paralysis and duration of action
D. Scheps, M. L. de la Paz, M. Jurk, F. Hofmann +1 more
2017Toxicon13 citations
Semantic Scholar
Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin
G. Schmid, A. Schürmann, C. Huppertz, F. Hofmann +2 more
1998Naunyn-Schmiedeberg's Archives of Pharmacology13 citations
Semantic Scholar
Inhibition of amylase secretion from differentiated AR4‐2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity
P. Feick, Sven Gilhaus, Robert Blum, F. Hofmann +2 more
1999FEBS Letters8 citations
Semantic Scholar
Rational design of botulinum neurotoxin A1 mutants with improved oxidative stability
M. López de la Paz, D. Scheps, M. Jurk, F. Hofmann +1 more
2017Toxicon4 citations
Semantic Scholar
Molecular Mechanism of Action of Clostridium difficile Toxins A and B
K. Aktories, J. Selzer, F. Hofmann, I. Just
19972 citations
Semantic Scholar

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