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S. Leight · SciRah

Researcher profile · Semantic Scholar

S. Leight

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S. Leight — researcher profile on SciRah

h-index: 27
Works: 39
Citations: 5,565

Most-cited papers

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis
D. Praticò, K. Uryu, S. Leight, John Q. Trojanoswki +1 more
2001Journal of Neuroscience804 citations Open access
Semantic Scholar
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
Pang-Hsien Tu, James E. Galvin, M. Baba, Benoit I. Giasson +6 more
1998Annals of Neurology684 citations
Semantic Scholar
Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
D. Cook, M. Forman, Jane C. Sung, S. Leight +4 more
1997Nature Medicine461 citations
Semantic Scholar
Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration
Hui-Ming Gao, P. T. Kotzbauer, K. Uryu, S. Leight +2 more
2008Journal of Neuroscience421 citations Open access
Semantic Scholar
Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
C. Clark, Sharon X. Xie, J. Chittams, D. Ewbank +15 more
2003Archives of Neurology394 citations
Semantic Scholar
Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis
K. Uryu, H. Laurer, T. McIntosh, D. Praticò +4 more
2002Journal of Neuroscience374 citations Open access
Semantic Scholar
Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease
M. Grossman, J. Farmer, S. Leight, Melissa Work +9 more
2005Annals of Neurology240 citations
Semantic Scholar
CSF biomarkers in frontotemporal lobar degeneration with known pathology
H. Bian, J. V. van Swieten, S. Leight, Lauren Massimo +9 more
2008Neurology239 citations Open access
Semantic Scholar
Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells.
Brian R. Sperbera, S. Leight, M. Goedert, V. Lee
1995Neuroscience Letters222 citations Open access
Semantic Scholar
A panel of epitope‐specific antibodies detects protein domains distributed throughout human α‐synuclein in lewy bodies of Parkinson's disease
Benoit I. Giasson, R. Jakes, M. Goedert, John E. Duda +3 more
2000Journal of Neuroscience Research220 citations
Semantic Scholar
Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites.
Ralf Hoffmann, Virginia M.-Y. Lee, S. Leight, István Varga +1 more
1997Biochemistry160 citations
Semantic Scholar
Pesticide Exposure Exacerbates α-Synucleinopathy in an A53T Transgenic Mouse Model
E. Norris, K. Uryu, S. Leight, B. Giasson +2 more
2007123 citations Open access
Semantic Scholar
Accelerated Aβ Deposition in APPswe/PS1ΔE9 Mice with Hemizygous Deletions of TTR (Transthyretin)
Se-Hoon Choi, S. Leight, V. Lee, Tong Li +4 more
2007Journal of Neuroscience117 citations Open access
Semantic Scholar
Intraneuronal APP, Not Free Aβ Peptides In 3xTg-AD Mice: Implications For Tau Versus Aβ Mediated Alzheimer Neurodegeneration
M. J. Winton, Edward B. Lee, Eveline Sun, Margaret M. Wong +4 more
2011Journal of Neuroscience109 citations Open access
Semantic Scholar
Expression of trk receptors in the developing and adult human central and peripheral nervous system
Y. Muragaki, N. Timothy, S. Leight, Barbara L. Hempstead +3 more
1995The Journal of comparative neurology107 citations
Semantic Scholar
Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia
William T. Hu, C. McMillan, D. Libon, S. Leight +4 more
2010Neurology105 citations Open access
Semantic Scholar
Biomarkers for Early Detection of Alzheimer Pathology
C. Clark, C. Davatzikos, A. Borthakur, A. Newberg +3 more
2007Neurosignals101 citations Open access
Semantic Scholar
Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons.
Bin Zhang, S. Veasey, M. Wood, Lewis Z. Leng +5 more
2005American Journal of Pathology92 citations Open access
Semantic Scholar
Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
Se Hoon Choi, S. Leight, V. Lee, Tong Li +4 more
2007Journal of Neuroscience89 citations
Semantic Scholar
Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies
Garrett S. Gibbons, R. Banks, Bumjin Kim, Lakshmi Changolkar +5 more
2018Journal of Neuropathology and Experimental Neurology83 citations Open access
Semantic Scholar
Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model.
E. Norris, K. Uryu, S. Leight, B. Giasson +2 more
2007American Journal of Pathology74 citations
Semantic Scholar
Comparison of xMAP and ELISA assays for detecting CSF biomarkers of Alzheimer's Disease
Li-San Wang, Yuk-Yee Leung, Shu-Kai Chang, S. Leight +6 more
2012Journal of Alzheimer's Disease63 citations Open access
Semantic Scholar
Cortical biochemistry in MCI and Alzheimer disease
M. Forman, E. Mufson, S. Leurgans, D. Praticó +4 more
2007Neurology60 citations
Semantic Scholar
Differential Effects of the Swedish Mutant Amyloid Precursor Protein on β-Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells*
M. Forman, D. Cook, S. Leight, R. Doms +1 more
1997Journal of Biological Chemistry51 citations Open access
Semantic Scholar
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
Garrett S. Gibbons, R. Banks, Bumjin Kim, Hong Xu +9 more
2017Journal of Neuroscience42 citations Open access
Semantic Scholar
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle +9 more
2020Molecular Neurodegeneration36 citations Open access
Semantic Scholar
Thromboxane Receptor Activation Mediates Isoprostane-Induced Increases in Amyloid Pathology in Tg2576 Mice
D. Shineman, Bin Zhang, S. Leight, D. Praticò +1 more
2008Journal of Neuroscience30 citations Open access
Semantic Scholar
Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils
Bin Zhang, Victoria M. Kehm, Ronald J. Gathagan, S. Leight +3 more
2019Methods in molecular biology27 citations Open access
Semantic Scholar
Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells.
M. Forman, D. Cook, S. Leight, R. Doms +1 more
1998Journal of Biological Chemistry20 citations
Semantic Scholar
Commentary on “Optimal design of clinical trials for drugs designed to slow the course of Alzheimer℉s disease.” Biochemical biomarkers of late‐life dementia
Christopher M. Clark, D. Praticò, L. Shaw, S. Leight +4 more
2006Alzheimer's & Dementia12 citations Open access
Semantic Scholar
Cellular localization of Nicastrin affects amyloid β species production
V. Morais, S. Leight, Donald S. Pijak, V. Lee +1 more
2008FEBS Letters9 citations
Semantic Scholar
Retraction: Winton et al., Intraneuronal APP, Not Free Aβ Peptides in 3xTg-AD Mice: Implications for Tau Versus Aβ-Mediated Alzheimer Neurodegeneration
M. J. Winton, Edward B. Lee, Eveline Sun, Margaret M. Wong +3 more
2015Journal of Neuroscience1 citations Open access
Semantic Scholar
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle +9 more
2020Molecular Neurodegeneration0 citations Open access
Semantic Scholar
P2‐098: Comparison of diagnostics values of cerebrospinal fluid tau and structural magnetic resonance imaging in classifying patients with Alzheimer's disease versus normal subjects
Sharon X. Xie, C. Davatzikos, J. Chittams, Xiao-Ying Wu +4 more
20080 citations
Semantic Scholar
P4–002: Bimolecular fluorescence complementation studies of APP homodimerization and heterodimerization
Bin Zhang, A. Stieber, S. Leight, Lewis Z. Leng +2 more
20060 citations
Semantic Scholar
P2–207: Cortical biochemical markers of mild cognitive impairment
M. Forman, S. Leurgans, Domenico Praticò, Sonali Joyce +4 more
20060 citations
Semantic Scholar
Reply
M. Grossman, V. Lee, J. Farmer, S. Leight +1 more
20050 citations
Semantic Scholar
P2-205 SUBTYPES OF MILD COGNITIVE IMPAIRMENT AND THEIR CONVERSION TO ALZHEIMER DEMENTIA IN THE VITA STUDY
Elena, Mariani, Sara, Ercolani +12 more
20030 citations
Semantic Scholar
Multiphosphorylated synthetic peptides as antigens and immunogens in Alzheimer’s disease paired helical filaments
L. Otvos, V. Lee, S. Leight, P. Davies +1 more
20020 citations
Semantic Scholar

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