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Lakshmi Changolkar · SciRah

Researcher profile · Semantic Scholar

Lakshmi Changolkar

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Lakshmi Changolkar — researcher profile on SciRah

h-index: 21
Works: 36
Citations: 2,621

Most-cited papers

Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
Zhuohao He, Jing L. Guo, Jennifer D. McBride, Sneha Narasimhan +13 more
2017Nature Medicine598 citations Open access
Semantic Scholar
Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
Jing L. Guo, Sneha Narasimhan, Lakshmi Changolkar, Zhuohao He +7 more
2016Journal of Experimental Medicine414 citations Open access
Semantic Scholar
Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain
Sneha Narasimhan, Jing L. Guo, Lakshmi Changolkar, A. Stieber +7 more
2017Journal of Neuroscience333 citations Open access
Semantic Scholar
Transmission of tauopathy strains is independent of their isoform composition
Zhuohao He, Jennifer D. McBride, Hong Xu, Lakshmi Changolkar +9 more
2020Nature Communications147 citations Open access
Semantic Scholar
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Nabil F. Darwich, Jessica M. Phan, Boram Kim, Eunran Suh +18 more
2020Science127 citations Open access
Semantic Scholar
Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
Sneha Narasimhan, Lakshmi Changolkar, Dawn M. Riddle, A. Kats +7 more
2019Journal of Experimental Medicine99 citations Open access
Semantic Scholar
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples
S. Prokop, Kelly R. Miller, Sergio R. Labra, Rose M. Pitkin +6 more
2019Acta Neuropathologica88 citations Open access
Semantic Scholar
Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies
Garrett S. Gibbons, R. Banks, Bumjin Kim, Lakshmi Changolkar +5 more
2018Journal of Neuropathology and Experimental Neurology83 citations Open access
Semantic Scholar
A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis
E. Bernstein, Tara L. Muratore-Schroeder, Robert L. Diaz, Jennifer C. Chow +6 more
2008Proceedings of the National Academy of Sciences of the United States of America72 citations Open access
Semantic Scholar
macroH2A1 Histone Variants Are Depleted on Active Genes but Concentrated on the Inactive X Chromosome
Lakshmi Changolkar, J. Pehrson
2006Molecular and Cellular Biology68 citations
Semantic Scholar
Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
A. Dregni, Pu Duan, Hong Xu, Lakshmi Changolkar +3 more
2022Nature Communications64 citations Open access
Semantic Scholar
Mice without MacroH2A Histone Variants
J. Pehrson, Lakshmi Changolkar, C. Costanzi, N. Leu
2014Molecular and Cellular Biology63 citations Open access
Semantic Scholar
Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin
Lakshmi Changolkar, Geetika Singh, Kai-Rong Cui, Joel B. Berletch +3 more
2010Molecular and Cellular Biology63 citations Open access
Semantic Scholar
Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor
E. Cornblath, Howard L. Li, Lakshmi Changolkar, Bin Zhang +7 more
2021Science Advances60 citations Open access
Semantic Scholar
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Hong Xu, Mia O’Reilly, Garrett S. Gibbons, Lakshmi Changolkar +11 more
2021Acta Neuropathologica47 citations Open access
Semantic Scholar
macroH2A1-Dependent Silencing of Endogenous Murine Leukemia Viruses
Lakshmi Changolkar, Geetika Singh, J. Pehrson
2008Molecular and Cellular Biology45 citations Open access
Semantic Scholar
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
Garrett S. Gibbons, R. Banks, Bumjin Kim, Hong Xu +9 more
2017Journal of Neuroscience42 citations Open access
Semantic Scholar
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle +9 more
2020Molecular Neurodegeneration36 citations Open access
Semantic Scholar
Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)
Garrett S. Gibbons, Soo-Jung Kim, J. Robinson, Lakshmi Changolkar +4 more
2019Acta Neuropathologica Communications35 citations Open access
Semantic Scholar
Reconstitution of nucleosomes with histone macroH2A1.2.
Lakshmi Changolkar, J. Pehrson
2002Biochemistry35 citations
Semantic Scholar
Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle +2 more
2022Acta Neuropathologica Communications27 citations Open access
Semantic Scholar
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression
Noah Lubben, J. Brynildsen, Connor M. Webb, Howard L. Li +11 more
2024Translational Neurodegeneration21 citations Open access
Semantic Scholar
Alzheimer’s disease seeded tau forms paired helical filaments yet lacks seeding potential
Pu Duan, A. Dregni, Hong Xu, Lakshmi Changolkar +3 more
2024Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo.
Sarah A. Weitzman, Sneha Narasimhan, Zhuohao He, Lakshmi Changolkar +5 more
2020Journal of Neuropathology and Experimental Neurology12 citations Open access
Semantic Scholar
LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons
Michael X. Henderson, Lakshmi Changolkar, J. Trojanowski, V. Lee
2021Journal of Parkinson's Disease7 citations Open access
Semantic Scholar
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Hong Xu, Q. Qiu, Peng Hu, Kevt'her Hoxha +15 more
2024Acta Neuropathologica6 citations Open access
Semantic Scholar
The Sgp3 Locus Derived from the 129 Strain is Responsible for Enhanced Endogenous Retroviral Expression in macroH2A1-deficient Mice
L. Baudino, Lakshmi Changolkar, J. Pehrson, S. Izui
2010Journal of Autoimmunity6 citations Open access
Semantic Scholar
Repositioning of polyubiquitin alters the pathologic tau filament structure
Ryohei Watanabe, B. Creekmore, Nabil F. Darwich, Hong Xu +8 more
2025bioRxiv2 citations
Semantic Scholar
Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation
Michael X. Henderson, E. Cornblath, Howard L. Li, Lakshmi Changolkar +7 more
2020bioRxiv2 citations Open access
Semantic Scholar
Repositioning of polyubiquitin alters the pathologic tau filament structure
Ryohei Watanabe, B. Creekmore, Nabil F. Darwich, Courtney L. Smith +11 more
2026Nature Structural & Molecular Biology1 citations Open access
Semantic Scholar
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread
Elliot Jang, Kevt'her Hoxha, Damian Mozier, A. Insana +12 more
2024Journal of Neuroscience1 citations Open access
Semantic Scholar
Histone macroH2A purification and nucleosome reconstitution.
Lakshmi Changolkar, J. Pehrson
2004Methods in Enzymology1 citations
Semantic Scholar
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
Noah Lubben, J. Brynildsen, Connor M. Webb, Howard L. Li +11 more
2023bioRxiv0 citations Open access
Semantic Scholar
Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization
Courtney A. Marshall, Jennifer D. McBride, Lakshmi Changolkar, Dawn M. Riddle +2 more
2022Acta Neuropathologica Communications0 citations Open access
Semantic Scholar
Computational modeling of tau pathology spread reveals genetic correlates of regional vulnerability and the impact of a LRRK2 mutation (P9-3.005)
E. Cornblath, Howard L. Li, Lakshmi Changolkar, Bin Zhang +7 more
2022Neurology0 citations
Semantic Scholar
Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle +9 more
2020Molecular Neurodegeneration0 citations Open access
Semantic Scholar

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