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G. Kukolj · SciRah

Researcher profile · Semantic Scholar

G. Kukolj

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G. Kukolj — researcher profile on SciRah

h-index: 37
Works: 116
Citations: 4,974

Most-cited papers

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
D. Lamarre, P. Anderson, M. Bailey, P. Beaulieu +24 more
2003Nature892 citations Open access
Semantic Scholar
Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile
M. Tsiang, Gregg S. Jones, J. Goldsmith, Andrew Mulato +14 more
2016Antimicrobial Agents and Chemotherapy248 citations Open access
Semantic Scholar
Restoration of HCV-specific CD8+ T cell function by interferon-free therapy.
B. Martin, Nadine Hennecke, V. Lohmann, Antonin Kayser +4 more
2014Journal of Hepatology239 citations
Semantic Scholar
Faldaprevir and deleobuvir for HCV genotype 1 infection.
S. Zeuzem, V. Soriano, T. Asselah, J. Bronowicki +13 more
2013New England Journal of Medicine234 citations Open access
Semantic Scholar
Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection.
Y. Tsantrizos, G. Bolger, P. Bonneau, D. R. Cameron +6 more
2003Angewandte Chemie166 citations
Semantic Scholar
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication.
F. Vaillancourt, L. Pilote, M. Cartier, J. Lippens +4 more
2009Virology162 citations Open access
Semantic Scholar
Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
A. Tsai, A. Irrinki, J. Kaur, T. Cihlář +3 more
2017Journal of Virology138 citations Open access
Semantic Scholar
Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase*
G. Kukolj, G. McGibbon, G. McKercher, M. Marquis +6 more
2005Journal of Biological Chemistry129 citations Open access
Semantic Scholar
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.
S. Zeuzem, T. Asselah, P. Angus, J. Zarski +16 more
2011Gastroenterology127 citations Open access
Semantic Scholar
Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection.
M. Manns, M. Bourlière, Y. Benhamou, S. Pol +12 more
2011Journal of Hepatology123 citations
Semantic Scholar
Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease
Peter W. White, M. Llinàs-Brunet, M. Amad, R. Bethell +7 more
2010Antimicrobial Agents and Chemotherapy116 citations Open access
Semantic Scholar
Faldaprevir combined with pegylated interferon alfa‐2a and ribavirin in treatment‐naïve patients with chronic genotype1 HCV: SILEN‐C1 trial
M. Sulkowski, T. Asselah, J. Lalezari, P. Ferenci +12 more
2013Hepatology114 citations Open access
Semantic Scholar
An NS 3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
D. Lamarre, P. Anderson, M. Bailey, P. Beaulieu +24 more
2003106 citations
Semantic Scholar
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.
P. Beaulieu, M. Bös, Y. Bousquet, G. Fazal +10 more
2004Bioorganic & Medicinal Chemistry Letters100 citations Open access
Semantic Scholar
An NS3 Serine Protease Inhibitor Abrogates Replication of Subgenomic Hepatitis C Virus RNA*
A. Pause, G. Kukolj, M. Bailey, M. Brault +10 more
2003Journal of Biological Chemistry97 citations Open access
Semantic Scholar
Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.
P. Beaulieu, M. Bös, Y. Bousquet, Patrick DeRoy +8 more
2004Bioorganic & Medicinal Chemistry Letters86 citations Open access
Semantic Scholar
Hepatitis C Virus Subgenomic Replicons in the Human Embryonic Kidney 293 Cell Line
S. Ali, Charles Pellerin, D. Lamarre, G. Kukolj
2004Journal of Virology80 citations Open access
Semantic Scholar
Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.
P. Beaulieu, Y. Bousquet, J. Gauthier, James R. Gillard +5 more
2004Journal of Medicinal Chemistry79 citations
Semantic Scholar
Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
P. Beaulieu, James R. Gillard, D. Bykowski, Christian Brochu +13 more
2006Bioorganic & Medicinal Chemistry Letters78 citations Open access
Semantic Scholar
Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
G. McKercher, P. Beaulieu, D. Lamarre, S. LaPlante +4 more
2004Nucleic Acids Research76 citations Open access
Semantic Scholar
Faldaprevir combined with peginterferon alfa‐2a and ribavirin in chronic hepatitis C virus genotype‐1 patients with prior nonresponse: SILEN‐C2 trial
Mark S. Sulkowski, M. Bourlière, J. Bronowicki, T. Asselah +12 more
2013Hepatology75 citations Open access
Semantic Scholar
Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment
A. Erhardt, K. Deterding, Y. Benhamou, M. Reiser +16 more
2009Antiviral Therapy71 citations
Semantic Scholar
101 SVR4 AND SVR12 WITH AN INTERFERON-FREE REGIMEN OF BI201335 AND BI207127, +/- RIBAVIRIN, IN TREATMENT-NAIVE PATIENTS WITH CHRONIC GENOTYPE-1 HCV INFECTION: INTERIM RESULTS OF SOUND-C2
S. Zeuzem, V. Soriano, T. Asselah, J. Bronowicki +12 more
201266 citations
Semantic Scholar
Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target
F. Vaillancourt, M. Brault, L. Pilote, N. Uyttersprot +15 more
2012Journal of Virology59 citations Open access
Semantic Scholar
Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control
Christopher W. Pohlmeyer, Veronica D. Gonzalez, A. Irrinki, Ricardo Ramírez +11 more
2019Journal of Virology55 citations Open access
Semantic Scholar
An advanced BLT-humanized mouse model for extended HIV-1 cure studies
Kerry J. Lavender, C. Pace, K. Sutter, Ronald J. Messer +12 more
2018AIDS (London)55 citations Open access
Semantic Scholar
In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335
L. Lagacé, Peter W. White, C. Bousquet, N. Dansereau +10 more
2011Antimicrobial Agents and Chemotherapy51 citations Open access
Semantic Scholar
Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
S. LaPlante, James R. Gillard, A. Jakalian, N. Aubry +6 more
2010Journal of the American Chemical Society46 citations
Semantic Scholar
Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.
S. LaPlante, A. Jakalian, N. Aubry, Y. Bousquet +7 more
2004Angewandte Chemie46 citations
Semantic Scholar
Rapid and strong antiviral activity of the non-nucleosidic NS5B polymerase inhibitor BI 207127 in combination with peginterferon alfa 2a and ribavirin.
D. Larrey, A. Lohse, V. de Lédinghen, C. Trépo +22 more
2012Journal of Hepatology42 citations
Semantic Scholar
Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV).
P. Beaulieu, M. Bös, M. Cordingley, C. Chabot +11 more
2012Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.
S. LaPlante, P. Forgione, C. Boucher, R. Coulombe +10 more
2014Journal of Medicinal Chemistry37 citations
Semantic Scholar
Baseline Hepatitis C Virus (HCV) NS3 Polymorphisms and Their Impact on Treatment Response in Clinical Studies of the HCV NS3 Protease Inhibitor Faldaprevir
K. L. Berger, I. Triki, M. Cartier, M. Marquis +7 more
2013Antimicrobial Agents and Chemotherapy37 citations Open access
Semantic Scholar
Sequence and phenotypic analysis for resistance monitoring in hepatitis C virus drug development: recommendations from the HCV DRAG.
A. Kwong, I. Nájera, J. Bechtel, S. Bowden +25 more
2011Gastroenterology37 citations Open access
Semantic Scholar
Faldaprevir (Bi 201335), Deleobuvir (Bi 207127) and Ribavirin Oral Therapy for Treatment-Naive HCV Genotype 1: Sound-C1 Final Results
S. Zeuzem, T. Asselah, P. Angus, J. Zarski +16 more
2013Antiviral Therapy35 citations
Semantic Scholar
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
S. LaPlante, M. Bös, Christian Brochu, C. Chabot +10 more
2014Journal of Medicinal Chemistry32 citations
Semantic Scholar
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.
A. Draffan, Barbara Frey, Brett R. Pool, Carlie T. Gannon +25 more
2014ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
O. Hucke, R. Coulombe, P. Bonneau, Mégan Bertrand-Laperle +14 more
2014Journal of Medicinal Chemistry28 citations
Semantic Scholar
CD160 isoforms and regulation of CD4 and CD8 T-cell responses
M. El-Far, Charles Pellerin, L. Pilote, J. Fortin +7 more
2014Journal of Translational Medicine25 citations Open access
Semantic Scholar
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
P. Beaulieu, R. Coulombe, J. Duan, G. Fazal +12 more
2013Bioorganic & Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Viral Resistance in Hepatitis C Virus Genotype 1-Infected Patients Receiving the NS3 Protease Inhibitor Faldaprevir (BI 201335) in a Phase 1b Multiple-Rising-Dose Study
K. L. Berger, L. Lagacé, I. Triki, M. Cartier +5 more
2013Antimicrobial Agents and Chemotherapy24 citations Open access
Semantic Scholar
Antiviral Effect, Safety, and Pharmacokinetics of Five-Day Oral Administration of Deleobuvir (BI 207127), an Investigational Hepatitis C Virus RNA Polymerase Inhibitor, in Patients with Chronic Hepatitis C
D. Larrey, A. Lohse, C. Trépo, J. Bronowicki +10 more
2013Antimicrobial Agents and Chemotherapy23 citations Open access
Semantic Scholar
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons.
P. Beaulieu, James R. Gillard, Eric Jolicoeur, J. Duan +3 more
2011Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Timothy A. Stammers, R. Coulombe, J. Rancourt, B. Thavonekham +11 more
2013Bioorganic & Medicinal Chemistry Letters21 citations Open access
Semantic Scholar
954 BI 201335, A POTENT HCV NS3 PROTEASE INHIBITOR, IN TREATMENT-NAIVE AND -EXPERIENCED CHRONIC HCV GENOTYPE-1 INFECTION: GENOTYPIC AND PHENOTYPIC ANALYSIS OF THE NS3 PROTEASE DOMAIN
G. Kukolj, Y. Benhamou, M. Manns, M. Bourlière +7 more
200921 citations Open access
Semantic Scholar
The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans
J. Duan, G. Bolger, Michel Garneau, M. Amad +10 more
2012Antimicrobial Agents and Chemotherapy20 citations Open access
Semantic Scholar
Development and Validation of a High-Throughput Screening Assay for the Hepatitis C Virus p7 Viroporin
C. Gervais, F. Dô, Ariane Cantin, G. Kukolj +3 more
2011Journal of biomolecular screening20 citations Open access
Semantic Scholar
STARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection.
P. Ferenci, T. Asselah, G. Foster, S. Zeuzem +21 more
2015Journal of Hepatology19 citations Open access
Semantic Scholar
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Timothy A. Stammers, R. Coulombe, M. du Plessis, G. Fazal +10 more
2013Bioorganic & Medicinal Chemistry Letters19 citations
Semantic Scholar
Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance
Jeff A. O'Meara, C. Lemke, Cédrickx Godbout, G. Kukolj +5 more
2012Journal of Biological Chemistry19 citations Open access
Semantic Scholar

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P. Beaulieu×19
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P. Beaulieu — researcher profile on SciRah
J. Stern×13
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J. Stern — researcher profile on SciRah
S. LaPlante×12
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S. LaPlante — researcher profile on SciRah
G. McKercher×11
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G. McKercher — researcher profile on SciRah

James R. Gillard

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James R. Gillard — researcher profile on SciRah

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L. Lagacé — researcher profile on SciRah

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M. Cordingley×8

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M. Cordingley — researcher profile on SciRah

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M. Poupart — researcher profile on SciRah

Y. Tsantrizos×8

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Y. Tsantrizos — researcher profile on SciRah

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