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J. Falck · SciRah

Researcher profile · Semantic Scholar

J. Falck

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J. Falck — researcher profile on SciRah

h-index: 78
Works: 712
Citations: 23K

Most-cited papers

Dirhodium Catalyzed C-H Arene Amination using Hydroxylamines
Mahesh P Paudyal, A. Adebesin, Scott R. Burt, D. Ess +3 more
2016Science222 citations Open access
Semantic Scholar
PGC-1 alpha Regulates HO-1 Expression, Mitochondrial Dynamics and Biogenesis: Role of Epoxyeicosatrienoic Acid
S. Singh, J. Schragenheim, Jian Cao, J. Falck +2 more
2016Prostaglandins & other lipid mediators114 citations Open access
Semantic Scholar
Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa
L. Yonker, H. Mou, Kengyeh K. Chu, Michael A. Pazos +11 more
2017Scientific Reports69 citations Open access
Semantic Scholar
EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice.
Jian Cao, S. Singh, J. Mcclung, Gregory Joseph +7 more
2017American Journal of Physiology. Heart and Circulatory Physiology67 citations Open access
Semantic Scholar
GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells
Sang-Kyu Park, A. Herrnreiter, S. L. Pfister, Kathryn M. Gauthier +3 more
2018Journal of Biological Chemistry62 citations Open access
Semantic Scholar
20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding
V. Garcia, B. Shkolnik, Laura Milhau, J. Falck +1 more
2016Journal of Pharmacology and Experimental Therapeutics53 citations Open access
Semantic Scholar
Uncovering the signalling, structure and function of the 20-HETE-GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75
Jonathan V. Pascale, E. Park, A. Adebesin, J. Falck +2 more
2021British Journal of Pharmacology50 citations Open access
Semantic Scholar
High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.
Ankit Gilani, Varunkumar G. Pandey, V. Garcia, Kevin Agostinucci +8 more
2018American Journal of Physiology. Regulatory Integrative and Comparative Physiology49 citations Open access
Semantic Scholar
Catalyst-Controlled Diastereoselective Synthesis of Cyclic Amines via C-H Functionalization.
Sailu Munnuri, A. Adebesin, Mahesh P Paudyal, M. Yousufuddin +2 more
2017Journal of the American Chemical Society47 citations
Semantic Scholar
Picolinate Directed Arene meta-C-H Amination via FeCl3 Catalysis.
Raghunath Reddy Anugu, Sailu Munnuri, J. Falck
2020Journal of the American Chemical Society45 citations
Semantic Scholar
Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling.
Marco Raffaele, L. Bellner, S. Singh, G. Favero +5 more
2019Experimental Cell Research44 citations
Semantic Scholar
Epoxyeicosatrienoic Acid Activation of the Wnt1 Canonical Pathway Mediated by an Increase in Heme Oxygenase 1, Reduces Infarct Size and Cardiac Dysfunction
Jian Cao, P. Tsenovoy, Ellen Thompson, J. Falck +5 more
2015Prostaglandins & other lipid mediators44 citations Open access
Semantic Scholar
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis
Xiao-Ning Han, Xiao-Chun Zhao, Xi Lan, Qian Li +10 more
2019Journal of Cerebral Blood Flow and Metabolism42 citations Open access
Semantic Scholar
20-HETE Interferes with Insulin Signaling and Contributes to Obesity-Driven Insulin Resistance
Ankit Gilani, Kevin Agostinucci, Sakib Hossain, Jonathan V. Pascale +4 more
2020Prostaglandins & other lipid mediators38 citations Open access
Semantic Scholar
Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction.
Gregory Joseph, Amanda Soler, Rebecca L. Hutcheson, Ian Hunter +8 more
2017American Journal of Physiology. Heart and Circulatory Physiology37 citations Open access
Semantic Scholar
Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice
S. Singh, L. Bellner, L. Vanella, Jian Cao +3 more
2016Journal of Nutrition and Metabolism37 citations Open access
Semantic Scholar
Drugs in the Pipeline Series
W. Campbell, J. Imig, J. Schmitz, J. Falck
2017Journal of Cardiovascular Pharmacology36 citations Open access
Semantic Scholar
Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.
V. Garcia, Gregory Joseph, B. Shkolnik, Yan Ding +7 more
2015American Journal of Physiology. Regulatory Integrative and Comparative Physiology33 citations Open access
Semantic Scholar
Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
M. Skibba, M. A. Hye Khan, Lauren L. Kolb, Michael M. Yeboah +3 more
2017Frontiers in Pharmacology32 citations Open access
Semantic Scholar
Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination.
Sailu Munnuri, Raghunath Reddy Anugu, J. Falck
2019Organic Letters31 citations
Semantic Scholar
EPOXYEICOSATRIENOIC ACID ANALOG MITIGATES KIDNEY INJURY IN A RAT MODEL OF RADIATION NEPHROPATHY
Abdul Hye Khan, B. Fish, G. Wahl, Amit Sharma +5 more
2016Clinical science31 citations Open access
Semantic Scholar
Novel Roles of Epoxyeicosanoids in Regulating Cardiac Mitochondria
H. El-Sikhry, Nasser B. Alsaleh, R. Dakarapu, J. Falck +1 more
2016PLoS ONE30 citations Open access
Semantic Scholar
20-HETE Contributes to Ischemia-induced Angiogenesis
Li Chen, Gregory Joseph, F. Zhang, H. Nguyen +6 more
2016Vascular pharmacology29 citations Open access
Semantic Scholar
Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1α via downregulation of prolyl hydroxylase 3.
J. Neckář, Anna K. Hsu, M. A. Hye Khan, G. Gross +9 more
2018American Journal of Physiology. Heart and Circulatory Physiology28 citations Open access
Semantic Scholar
Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury.
Y. Muroya, Fan Fan, K. Regner, J. Falck +3 more
2015Journal of the American Society of Nephrology28 citations Open access
Semantic Scholar
20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond
Jonathan V. Pascale, Alexandra Wolf, Yonaton Kadish, Danielle Diegisser +11 more
2023Advances in Pharmacology27 citations Open access
Semantic Scholar
Eicosanoids derived from cytochrome P450 pathway of arachidonic acid and inflammatory shock.
B. Tunçtan, Sefika Pınar Şenol, Meryem Temiz-Resitoglu, D. Guden +3 more
2019Prostaglandins & other lipid mediators27 citations
Semantic Scholar
ANDROGEN-INDUCED HYPERTENSION IN ANGIOTENSINOGEN DEFICIENT MICE: ROLE OF 20-HETE AND EETS
V. Garcia, Jennifer Cheng, A. Weidenhammer, Yan Ding +5 more
2014Prostaglandins & other lipid mediators27 citations Open access
Semantic Scholar
Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension
L. C̆ervenka, Z. Husková, L. Kopkan, S. Kikerlová +11 more
2018Journal of Hypertension26 citations Open access
Semantic Scholar
Elevated 20-HETE in Metabolic Syndrome Regulates Arterial Stiffness and Systolic Hypertension via MMP12 Activation
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca L. Hutcheson +12 more
2018Journal of Molecular and Cellular Cardiology24 citations Open access
Semantic Scholar
Hyperbaric oxygenation modulates vascular reactivity to angiotensin-(1-7) in diabetic rats: Potential role of epoxyeicosatrienoic acids
Aleksandar Kibel, S. Novak, A. Cosic, Z. Mihaljević +2 more
2015Diabetes & vascular disease research24 citations
Semantic Scholar
CYP4A/20-HETE regulates ischemia-induced neovascularization via its actions on endothelial progenitor and preexisting endothelial cells.
Li Chen, Samantha Tang, F. Zhang, V. Garcia +4 more
2019American Journal of Physiology. Heart and Circulatory Physiology23 citations Open access
Semantic Scholar
Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
P. Kala, M. Miklovič, Šárka Jíchová, P. Škaroupková +13 more
2021Biomedicines22 citations Open access
Semantic Scholar
11,12 ‐Epoxyeicosatrienoic acid (11,12 EET) reduces excitability and excitatory transmission in the hippocampus
Nandkishor K. Mule, A. O. Leon, J. Falck, M. Arand +1 more
2017Neuropharmacology22 citations Open access
Semantic Scholar
Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats
J. Neckář, M. A. Khan, G. Gross, Michaela Cyprová +11 more
2019Clinical science21 citations Open access
Semantic Scholar
Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogs as Potential Clinical Antiarrhythmic Agents.
A. Adebesin, Tim Wesser, Jonnalagadda Vijaykumar, Anne Konkel +8 more
2019Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats.
Michael M. Yeboah, M. A. Hye Khan, Marla A. Chesnik, Amit Sharma +3 more
2016AJP - Renal Physiology21 citations Open access
Semantic Scholar
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats
Šárka Jíchová, L. Kopkan, Z. Husková, Š. Doleželová +10 more
2016Journal of Hypertension21 citations Open access
Semantic Scholar
Regio- and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis-Epoxides
J. Jat, S. R. De, G. Kumar, A. Adebesin +2 more
2015Organic Letters21 citations Open access
Semantic Scholar
Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity
J. Imig, M. A. Hye Khan, Anna Burkhan, Guan Chen +2 more
2021International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats
J. Hrdlička, J. Neckář, F. Papoušek, Z. Husková +11 more
2019Frontiers in Pharmacology18 citations Open access
Semantic Scholar
20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats
L. Sedláková, S. Kikerlová, Z. Husková, L. Červenková +9 more
2018Bioscience Reports17 citations Open access
Semantic Scholar
Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock
Sefika Pınar Şenol, Meryem Temiz, D. Guden, Pelin Cecen +6 more
2016Inflammation Research17 citations
Semantic Scholar
Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.
I. Kizub, Anand Lakhkar, V. Dhagia, S. Joshi +8 more
2016American Journal of Physiology - Lung cellular and Molecular Physiology17 citations Open access
Semantic Scholar
MACROPHAGE 12(S)-HETE ENHANCES ANGIOTENSIN II-INDUCED CONTRACTION BY A BLT2 AND TP RECEPTOR-MEDIATED MECHANISM IN MURINE ARTERIES
T. Kriska, A. Herrnreiter, S. L. Pfister, A. Adebesin +2 more
2021HYPERTENSION16 citations Open access
Semantic Scholar
Epoxyeicosatrienoic Acid Analog EET-A Blunts Development of Lupus Nephritis in Mice
M. A. Hye Khan, A. Stavniichuk, M. Sattar, J. Falck +1 more
2019Frontiers in Pharmacology16 citations Open access
Semantic Scholar
Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids.
Yuka Sato, W. Sato, S. Maruyama, C. Wilcox +10 more
2015Journal of the American Society of Nephrology16 citations Open access
Semantic Scholar
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
P. Alánová, Z. Husková, L. Kopkan, A. Sporková +15 more
2015Vascular pharmacology16 citations
Semantic Scholar
Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock
B. Tunçtan, Sefika Pınar Şenol, Meryem Temiz-Resitoglu, Dilsah Ezgi Yilmaz +8 more
2022Journal of Cardiovascular Pharmacology15 citations
Semantic Scholar
A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway
Ahmed M. Darwesh, Wesam Bassiouni, A. Adebesin, A. S. Mohammad +2 more
2020International Journal of Molecular Sciences15 citations Open access
Semantic Scholar

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