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Guan Chen · SciRah

Researcher profile · Semantic Scholar

Guan Chen

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Guan Chen — researcher profile on SciRah

h-index: 21
Works: 38
Citations: 1,346

Most-cited papers

p38 Isoforms Have Opposite Effects on AP-1-dependent Transcription through Regulation of c-Jun
R. Pramanik, Xiaomei Qi, S. Borowicz, D. Choubey +3 more
2003Journal of Biological Chemistry164 citations Open access
Semantic Scholar
The p38 MAPK stress pathway as a tumor suppressor or more?
Mathew Loesch, Guan Chen
2008Frontiers in Bioscience109 citations Open access
Semantic Scholar
The p38 and JNK Pathways Cooperate to trans-Activate Vitamin D Receptor via c-Jun/AP-1 and Sensitize Human Breast Cancer Cells to Vitamin D3-induced Growth Inhibition*
Xiaomei Qi, R. Pramanik, Jintang Wang, R. Schultz +4 more
2002Journal of Biological Chemistry102 citations Open access
Semantic Scholar
PTPH1 dephosphorylates and cooperates with p38γ MAPK to increase Ras oncogenesis through PDZ-mediated interaction
Songwang Hou, Huiying Zhi, Nicole M. Pohl, Mathew Loesch +4 more
2010Cancer Research80 citations Open access
Semantic Scholar
p38γ MAPK Cooperates with c-Jun in trans-Activating Matrix Metalloproteinase 9*
Mathew Loesch, Huiying Zhi, Songwang Hou, Xiaomei Qi +5 more
2010Journal of Biological Chemistry78 citations Open access
Semantic Scholar
p38γ MAPK is essential for aerobic glycolysis and pancreatic tumorigenesis
Fang Wang, Xiaomei Qi, Ryan Wertz, Matthew Mortensen +13 more
2020Cancer Research67 citations Open access
Semantic Scholar
p38 MAPK Activation Selectively Induces Cell Death in K-ras-mutated Human Colon Cancer Cells through Regulation of Vitamin D Receptor*
Xiaomei Qi, Jun Tang, R. Pramanik, R. Schultz +4 more
2004Journal of Biological Chemistry64 citations Open access
Semantic Scholar
p38α Antagonizes p38γ Activity through c-Jun-dependent Ubiquitin-proteasome Pathways in Regulating Ras Transformation and Stress Response*
Xiaomei Qi, Nicole M. Pohl, Mathew Loesch, Songwang Hou +4 more
2007Journal of Biological Chemistry52 citations Open access
Semantic Scholar
p 38 ; Mitogen-Activated Protein Kinase Integrates Signaling Crosstalk between Ras and Estrogen Receptor to Increase Breast Cancer Invasion
Xiaomei Qi, Jun Tang, Mathew Loesch, Nicole M. Pohl +2 more
200652 citations
Semantic Scholar
Essential Role of p38γ in K-Ras Transformation Independent of Phosphorylation*
Jun Tang, Xiaomei Qi, D. Mercola, Jia-Huai Han +1 more
2005Journal of Biological Chemistry52 citations Open access
Semantic Scholar
PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization
Huiying Zhi, Songwang Hou, Rong-shan Li, Z. Basir +3 more
2010Oncogene46 citations Open access
Semantic Scholar
p38γ MAPK is required for inflammation-associated colon tumorigenesis
N. Yin, Xiaomei Qi, Susan Tsai, Yan Lu +6 more
2016Oncogene44 citations
Semantic Scholar
p38γ MAPK is a therapeutic target for triple-negative breast cancer by stimulation of cancer stem-like cell expansion
Xiaomei Qi, N. Yin, Shao Ma, Adrienne Lepp +6 more
2015Stem Cells44 citations Open access
Semantic Scholar
Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity*
Qing-ping Li, Xiaomei Qi, R. Pramanik, Nicole M. Pohl +2 more
2007Journal of Biological Chemistry35 citations Open access
Semantic Scholar
Estrogen Receptor Inhibits c-Jun-dependent Stress-induced Cell Death by Binding and Modifying c-Jun Activity in Human Breast Cancer Cells*
Xiaomei Qi, S. Borowicz, R. Pramanik, R. Schultz +2 more
2004Journal of Biological Chemistry35 citations Open access
Semantic Scholar
p38γ Mitogen-activated Protein Kinase (MAPK) Confers Breast Cancer Hormone Sensitivity by Switching Estrogen Receptor (ER) Signaling from Classical to Nonclassical Pathway via Stimulating ER Phosphorylation and c-Jun Transcription*
Xiaomei Qi, Huiying Zhi, Adrienne Lepp, Phillip Wang +5 more
2012Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Phosphorylation and Stabilization of Topoisomerase IIα Protein by p38γ Mitogen-activated Protein Kinase Sensitize Breast Cancer Cells to Its Poisons*
Xiaomei Qi, Songwang Hou, Adrienne Lepp, Rongshan Li +3 more
2011Journal of Biological Chemistry31 citations Open access
Semantic Scholar
p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
Xiaomei Qi, Nicole M. Pohl, Mathew Loesch, Songwang Hou +4 more
2007Journal of Biological Chemistry30 citations
Semantic Scholar
Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
Jun Tang, Xiaomei Qi, D. Mercola, Jia-Huai Han +1 more
2005Journal of Biological Chemistry29 citations
Semantic Scholar
Protein-Tyrosine Phosphatase H1 Increases Breast Cancer Sensitivity to Antiestrogens by Dephosphorylating Estrogen Receptor at Tyr537
P. Suresh, Shao Ma, A. Migliaccio, Guan Chen
2013Molecular Cancer Therapeutics27 citations
Semantic Scholar
p38γ Mitogen-activated Protein Kinase Signals through Phosphorylating Its Phosphatase PTPH1 in Regulating Ras Protein Oncogenesis and Stress Response*
Songwang Hou, P. Suresh, Xiaomei Qi, Adrienne Lepp +2 more
2012Journal of Biological Chemistry22 citations Open access
Semantic Scholar
p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease
Xiaomei Qi, Guan Chen
2023Cells21 citations Open access
Semantic Scholar
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer
Xiaomei Qi, C. Xie, Songwang Hou, Gang Li +10 more
2014OncoTarget21 citations Open access
Semantic Scholar
Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy
Xiaomei Qi, Fang Wang, Matthew Mortensen, Ryan Wertz +1 more
2018Acta Pharmaceutica Sinica B20 citations Open access
Semantic Scholar
Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER)
Shao Ma, N. Yin, Xiaomei Qi, S. L. Pfister +3 more
2015OncoTarget19 citations Open access
Semantic Scholar
Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity
J. Imig, M. A. Hye Khan, Anna Burkhan, Guan Chen +2 more
2021International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
MK2 Regulates Ras Oncogenesis through Stimulating ROS Production.
Yusuke Kobayashi, Xiaomei Qi, Guan Chen
2012Genes & cancer14 citations Open access
Semantic Scholar
Isoform-specific and cell/tissue-dependent effects of p38 MAPKs in regulating inflammation and inflammation-associated oncogenesis.
Jian-Zhong Qin, H. Xin, Xiaomei Qi, Guan Chen
2022Frontiers in Bioscience13 citations Open access
Semantic Scholar
The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation
N. Yin, Adrienne Lepp, Yongsheng Ji, Matthew Mortensen +4 more
2017Journal of Biological Chemistry13 citations Open access
Semantic Scholar
p38 gamma MAP kinase
Songwang Hou, Adrienne Lepp, Guan Chen
201011 citations
Semantic Scholar
p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion.
Xiaomei Qi, Jundong Tang, Mathew Loesch, Nicole M. Pohl +2 more
2006Cancer Research3 citations
Semantic Scholar
Correction: p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis.
Fang Wang, Xiaoqin Qi, Ryan Wertz, Matthew Mortensen +13 more
2025Cancer Research2 citations
Semantic Scholar
Editorial Preface for Targeted Cancer Therapy
Guan Chen, Wei Li
2018Acta Pharmaceutica Sinica B2 citations Open access
Semantic Scholar
Protein tyrosine phosphatase PTPH1 potentiates receptor tyrosine kinase HER2 oncogenesis via a PDZ-coupled and phosphorylation-driven scaffold.
Xiaomei Qi, Fang Wang, Linda B. Thomas, Shao Ma +6 more
2024American Journal of Cancer Research1 citations
Semantic Scholar
P38γ Promotes Tumorigenesis Through Activating Immune Evasion
N. Chandrashekar, Xiaomei Qi, Guan Chen
2026Cells0 citations Open access
Semantic Scholar
Abstract 2152: p38α MAPK regulates signal transduction between estrogen receptor (ER) and its antagonist by switching ER signaling from the classical to the non-classical pathway
Guan Chen, Huiying Zhi, Songwang Hou, Phillip Wang +4 more
20120 citations
Semantic Scholar
Abstract 317: p38γ MAPK regulates topoisomerase IIα activity by phosphorylation
Xiaomei Qi, Songwang Hou, Zhenkun Lou, Guan Chen
20100 citations
Semantic Scholar
Abstract 1061A: Role of protein tyrosine phosphatase PTPH1 in breast cancer
Huiying Zhi, Songwang Hou, Rongshan Li, Z. Basir +2 more
20100 citations
Semantic Scholar

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