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P. Hamel · SciRah

Researcher profile · Semantic Scholar

P. Hamel

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P. Hamel — researcher profile on SciRah

h-index: 25
Works: 53
Citations: 2,345

Most-cited papers

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
P. Hamel, R. Gill, R. A. Phillips, B. L. Gallie
1992Molecular and Cellular Biology267 citations Open access
Semantic Scholar
Direct transcriptional repression by pRB and its reversal by specific cyclins
R. Bremner, B. Cohen, M. Sopta, P. Hamel +3 more
1995Molecular and Cellular Biology201 citations Open access
Semantic Scholar
Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes.
M. Kiess, R. Gill, P. Hamel
1995Oncogene159 citations
Semantic Scholar
Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland.
Kata Boras-Granic, Hong Chang, R. Grosschedl, P. Hamel
2006Developmental Biology142 citations Open access
Semantic Scholar
The retinoblastoma protein and the cell cycle.
M. Sopta, B. Gallie, R. Gill, P. Hamel +3 more
1992Seminars in Cancer Biology133 citations
Semantic Scholar
Interaction of the pRB-family proteins with factors containing paired-like homeodomains
O. Wiggan, A. Taniguchi-Sidle, P. Hamel
1998Oncogene95 citations
Semantic Scholar
Expression and activity of the retinoblastoma protein (pRB)-family proteins, p107 and p130, during L6 myoblast differentiation.
M. Kiess, R. Gill, P. Hamel
1995Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research94 citations
Semantic Scholar
Regulated expression of the retinoblastoma gene in differentiating embryonal carcinoma cells.
R. Slack, P. Hamel, T. Bladon, R. Gill +1 more
1993Oncogene88 citations
Semantic Scholar
Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse
D. Ung, G. Iacono, H. Meziane, E. Blanchard +22 more
2017Molecular Psychiatry82 citations Open access
Semantic Scholar
Homeless people’s trust and interactions with police and paramedics
T. Zakrison, P. Hamel, Stephen W. Hwang
2004Journal of urban health71 citations Open access
Semantic Scholar
Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR
S. Begum, Nashmil Emani, A. Cheung, O. Wilkins +2 more
2005Oncogene67 citations Open access
Semantic Scholar
Alx‐4, a transcriptional activator whose expression is restricted to sites of epithelial–mesenchymal interactions
Rhea P. Hudson, A. Taniguchi-Sidle, K. Boras, O. Wiggan +1 more
1998Developmental Dynamics66 citations Open access
Semantic Scholar
Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression.
P. Hamel, R. Gill, R. A. Phillips, B. Gallie
1992Oncogene65 citations
Semantic Scholar
Retinoic acid and the cyclin dependent kinase inhibitors synergistically alter proliferation and morphology of U343 astrocytoma cells
P. Dirks, K. Patel, S. Hubbard, C. Ackerley +2 more
1997Oncogene64 citations Open access
Semantic Scholar
Characterization of the human RB1 promoter and of elements involved in transcriptional regulation.
R. Gill, P. Hamel, J. Zhe, E. Zacksenhaus +2 more
1994Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research60 citations
Semantic Scholar
ACTIVATION OF ERK BY SONIC HEDGEHOG INDEPENDENT OF CANONICAL HEDGEHOG SIGNALLING
Hong Chang, Qing Li, Ricardo Moraes, M. Lewis +1 more
2010International Journal of Biochemistry and Cell Biology59 citations Open access
Semantic Scholar
Alx4 Binding to LEF-1 Regulates N-CAM Promoter Activity*
K. Boras, P. Hamel
2002Journal of Biological Chemistry56 citations Open access
Semantic Scholar
The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells
P. Dirks, J. Rutka, S. Hubbard, Soma Mondal +1 more
1998Oncogene54 citations Open access
Semantic Scholar
Pax3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP/non-canonical Wnt-signaling cascade.
O. Wiggan, P. Hamel
2002Journal of Cell Science49 citations
Semantic Scholar
Subcellular Compartmentalization of E2f Family Members Is Required for Maintenance of the Postmitotic State in Terminally Differentiated Muscle
R. Gill, P. Hamel
2000Journal of Cell Biology47 citations Open access
Semantic Scholar
Pax3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion.
O. Wiggan, M. P. Fadel, P. Hamel
2002Journal of Cell Science42 citations
Semantic Scholar
G1 cyclins and control of the cell division cycle in normal and transformed cells.
P. Hamel, J. Hanley-Hyde
1997Cancer Investigation40 citations
Semantic Scholar
Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation
Ricardo Moraes, Hong Chang, N. Harrington, John D. Landua +5 more
2009Development36 citations Open access
Semantic Scholar
Wnt-Signalling in the Embryonic Mammary Gland
Kata Boras-Granic, P. Hamel
2013Journal of mammary gland biology and neoplasia28 citations
Semantic Scholar
Integration of the PRB and P53 Cell Cycle Control Pathways
Craig Stewart, Alejandro Moro Soria, P. Hamel
2001Journal of Neuro-Oncology26 citations
Semantic Scholar
Regulation of calcium binding proteins calreticulin and calsequestrin during differentiation in the myogenic cell line L6
Suzanne Tharin, P. Hamel, E. Conway, M. Michalak +1 more
1996Journal of Cellular Physiology23 citations
Semantic Scholar
Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland
Nadia Okolowsky, P. Furth, P. Hamel
2014Developmental Biology22 citations Open access
Semantic Scholar
Distinct Effects of the mesenchymal dysplasia Gene Variant of Murine Patched-1 Protein on Canonical and Non-canonical Hedgehog Signaling Pathways*
M. Harvey, A. Fleet, Nadia Okolowsky, P. Hamel
2014Journal of Biological Chemistry20 citations Open access
Semantic Scholar
Loss of Alx4, a stromally-restricted homeodomain protein, impairs mammary epithelial morphogenesis.
Purna A. Joshi, Hong Chang, P. Hamel
2006Developmental Biology20 citations Open access
Semantic Scholar
Why don't germline mutations in RB1 predispose to leukemia?
R. A. Phillips, R. Gill, E. Zacksenhaus, R. Bremner +4 more
1992Current Topics in Microbiology and Immunology19 citations
Semantic Scholar
PTCHD1: Identification and Neurodevelopmental Contributions of an Autism Spectrum Disorder and Intellectual Disability Susceptibility Gene
Stephen F. Pastore, Sangyoon Y Ko, P. Frankland, P. Hamel +1 more
2022Genes18 citations Open access
Semantic Scholar
The protein-specific activities of the transmembrane modules of Ptch1 and Ptch2 are determined by their adjacent protein domains
A. Fleet, P. Hamel
2018Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling*
A. Fleet, Jennifer P. Y. Lee, Aaliya Tamachi, Imaan Javeed +1 more
2016Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Genetic interaction between Lef1 and Alx4 is required for early embryonic development.
Kata Boras-Granic, R. Grosschedl, P. Hamel
2006International Journal of Developmental Biology16 citations Open access
Semantic Scholar
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Hong Chang, L. Balenci, Nadia Okolowsky, W. Muller +1 more
2012Developmental Biology13 citations Open access
Semantic Scholar
Alterations of the p53 and pRB pathways in human astrocytoma
J. Rutka, Y. Akiyama, Sang Pyung Lee, Stacey M. Ivanchuk +2 more
2006Brain Tumor Pathology13 citations
Semantic Scholar
How do retinoblastoma tumours form?
B. Gallie, J. Dunn, P. Hamel, M. Muncaster +2 more
1992Eye12 citations
Semantic Scholar
Loss of ALX4 expression in epithelial cells and adjacent stromal cells in breast cancer
H. Chang, N. Mohabir, S. Done, P. Hamel
2009Journal of Clinical Pathology9 citations
Semantic Scholar
Reply: The Prevalence of Psychological Morbidity in West Bank Palestinian Children
P. Hamel, T. Zakrison
20059 citations Open access
Semantic Scholar
Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt N-Glycosylation and Reduce Protein Stability
Connie T. Y. Xie, Stephen F. Pastore, J. Vincent, P. Frankland +1 more
2022bioRxiv8 citations Open access
Semantic Scholar
Distinct epithelial-to-mesenchymal transitions induced by PIK3CAH1047R and PIK3CB
Ersa Gjelaj, P. Hamel
2021Journal of Cell Science5 citations
Semantic Scholar
Lymphoid enhancer factor-1 mediates loading of Pax3 to a promoter harbouring lymphoid enhancer factor-1 binding sites resulting in enhancement of transcription.
T. Christova, Golnessa Mojtahedi, P. Hamel
2010International Journal of Biochemistry and Cell Biology5 citations
Semantic Scholar
Cell type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR
S. Begum, N. Emami, A. Cheung, O. Wilkins +2 more
2008Oncogene3 citations Open access
Semantic Scholar
Molecular cloning, chromosomal mapping, and expression of the mouse p107 gene
Konrad Huppi, D. Siwarski, Beverly A. Mock, J. Dosik +1 more
1996Mammalian Genome2 citations
Semantic Scholar
Summary Pax 3 induces cell aggregation and regulates phenotypic mesenchymal-epithelial interconversion
O. Wiggan, M. P. Fadel, P. Hamel
20011 citations
Semantic Scholar
12 – Retinoblastoma Gene: Mutations, Expression, and Putative Function
R. A. Phillips, J. Dunn, P. Hamel, J. Noble +7 more
19911 citations
Semantic Scholar
Supplementary information Ptchd 1 deficiency induces exciatory synaptic and cognitive dysfunctions in mouse
D. Ung, G. Iacono, H. Meziane, E. Blanchard +22 more
20170 citations
Semantic Scholar
large-T-antigen-binding regions. outside the simian virus 40 gene product is determined by domains Hyperphosphorylation of the retinoblastoma
P. Hamel, B. Cohen, L. Sorce, B. Gallie +1 more
20130 citations
Semantic Scholar
Summary Pax 3 regulates morphogenetic cell behavior in vitro coincident with activation of a PCP / non-canonical Wnt-signaling cascade
O. Wiggan, P. Hamel
20010 citations
Semantic Scholar
Access to Medicines - The Global Debate Over "Free Trade"
T. Zakrison, P. Hamel
20010 citations
Semantic Scholar

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