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L. Petrucelli · SciRah

Researcher profile · Semantic Scholar

L. Petrucelli

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L. Petrucelli — researcher profile on SciRah

h-index: 110
Works: 420
Citations: 41K

Most-cited papers

Temporal order of clinical and biomarker changes in familial frontotemporal dementia
A. Staffaroni, M. Quintana, B. Wendelberger, H. Heuer +100 more
2022Nature Medicine145 citations Open access
Semantic Scholar
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
Maya Maor-Nof, Zohar Shipony, Rodrigo Lopez-Gonzalez, Lisa Nakayama +23 more
2021Cell143 citations Open access
Semantic Scholar
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases
Andrew C. Chang, Xinyu Xiang, Jing Wang, Carolyn Lee +19 more
2022Cell127 citations Open access
Semantic Scholar
Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration
Dylan V. Neel, Himanish Basu, Georgia Gunner, Matthew Bergstresser +19 more
2022bioRxiv122 citations Open access
Semantic Scholar
Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD
Sahba Seddighi, Y. A. Qi, Anna-Leigh Brown, O. Wilkins +47 more
2024Science Translational Medicine98 citations Open access
Semantic Scholar
Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice
Jiyeon Lee, J. Dimitry, Jong-Hee Song, Minsoo Son +7 more
2023Nature Communications81 citations Open access
Semantic Scholar
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD
Sahba Seddighi, Yue A. Qi, Anna-Leigh Brown, O. Wilkins +42 more
2023bioRxiv76 citations Open access
Semantic Scholar
Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
Wei Shao, Tiffany W. Todd, Yan-Wei Wu, Caroline Y Jones +19 more
2022Science73 citations Open access
Semantic Scholar
Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19
M. Prudencio, Y. Erben, C. Marquez, Karen R. Jansen-West +17 more
2021Science Translational Medicine73 citations Open access
Semantic Scholar
TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains
Virginia Estades Ayuso, Sarah R Pickles, Tiffany W. Todd, M. Yue +13 more
2023Molecular Neurodegeneration63 citations Open access
Semantic Scholar
Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders
Tania F. Gendron, M. Heckman, L. White, Austin M. Veire +78 more
2022Cell Reports Medicine62 citations Open access
Semantic Scholar
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
Jessica A. Bush, Haruo Aikawa, R. Fuerst, Yue Li +20 more
2021Science Translational Medicine62 citations Open access
Semantic Scholar
Prognostic clinical and biological markers for amyotrophic lateral sclerosis disease progression: validation and implications for clinical trial design and analysis
Michael Benatar, Eric A. Macklin, A. Malaspina, Mary-Louise Rogers +14 more
2024medRxiv58 citations Open access
Semantic Scholar
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
K. Meijboom, Abbas M. Abdallah, Nicholas P. Fordham, H. Nagase +22 more
2022bioRxiv57 citations Open access
Semantic Scholar
The AD tau core spontaneously self-assembles and recruits full-length tau to filaments
Y. Carlomagno, Sireesha Manne, M. DeTure, M. Prudencio +13 more
2021Cell Reports56 citations Open access
Semantic Scholar
TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A
Yuka Koike, Sarah R Pickles, Virginia Estades Ayuso, Karen R. Jansen-West +10 more
2023PLoS Biology49 citations Open access
Semantic Scholar
Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
Bilal Khalil, D. Chhangani, Melissa C. Wren, C. Smith +24 more
2022Molecular Neurodegeneration45 citations Open access
Semantic Scholar
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD
G. Krishnan, D. Raitcheva, Dan Bartlett, M. Prudencio +13 more
2022Nature Communications44 citations Open access
Semantic Scholar
TAU AND NEUROFILAMENT LIGHT-CHAIN AS FLUID BIOMARKERS IN SPINOCEREBELLAR ATAXIA TYPE 3
H. Garcia-Moreno, M. Prudencio, Gilbert Thomas-Black, Nita Solanky +23 more
2022European Journal of Neurology41 citations Open access
Semantic Scholar
The endo-lysosomal pathway and ALS/FTD
Tiffany W. Todd, Wei Shao, Yong-Jie Zhang, L. Petrucelli
2023Trends in Neurosciences40 citations Open access
Semantic Scholar
TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes
Yi Zeng, Anastasiia Lovchykova, Tetsuya Akiyama, Chang Liu +8 more
2024bioRxiv34 citations Open access
Semantic Scholar
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia
Jordan D. Marks, Virginia Estades Ayuso, Y. Carlomagno, M. Yue +32 more
2024Science Translational Medicine32 citations Open access
Semantic Scholar
Modelling amyotrophic lateral sclerosis in rodents
Tiffany W. Todd, L. Petrucelli
2022Nature Reviews Neuroscience31 citations
Semantic Scholar
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD
Yuzo Fujino, M. Ueyama, T. Ishiguro, Daisaku Ozawa +25 more
2023bioRxiv30 citations Open access
Semantic Scholar
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Anna Calliari, Lillian M. Daughrity, Ellen A Albagli, Paula Castellanos Otero +21 more
2024Molecular Neurodegeneration27 citations Open access
Semantic Scholar
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions
Jinyoung Park, Yan-Wei Wu, Wei Shao, Tania F. Gendron +21 more
2023Cell Reports27 citations Open access
Semantic Scholar
Dorsomedial Prefrontal Hypoexcitability Underlies Lost Empathy in Frontotemporal Dementia
H. Phillips, Huihui Dai, S. Choi, Karen R. Jansen-West +5 more
2023Neuron27 citations Open access
Semantic Scholar
Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis
A. Abdelhak, L. Barba, M. Romoli, P. Benkert +34 more
2023Journal of Neurology26 citations Open access
Semantic Scholar
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins
Jun-Li Gao, Quinlan T Mewborne, A. Girdhar, U. Sheth +24 more
2022Science Translational Medicine23 citations Open access
Semantic Scholar
Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers
Tetsuya Akiyama, Yuka Koike, L. Petrucelli, A. Gitler
2022Clinical and Translational Medicine22 citations Open access
Semantic Scholar
A small molecule exploits hidden structural features within the RNA repeat expansion that causes c9ALS/FTD and rescues pathological hallmarks
Andrei Ursu, Jared T. Baisden, Jessica A. Bush, A. Taghavi +6 more
2021ACS Chemical Neuroscience21 citations Open access
Semantic Scholar
Association of Physical Activity With Neurofilament Light Chain Trajectories in Autosomal Dominant Frontotemporal Lobar Degeneration Variant Carriers.
K. Casaletto, J. Kornack, E. Paolillo, Julio C. Rojas +14 more
2022JAMA Neurology20 citations Open access
Semantic Scholar
A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome
Jessica A. Bush, Samantha M. Meyer, R. Fuerst, Yuquan Tong +12 more
2022Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in amyotrophic lateral sclerosis and frontotemporal dementia
F. J. Arnold, Ya Cui, Sebastian Michels, Michael R. Colwin +20 more
2025Journal of Clinical Investigation19 citations
Semantic Scholar
Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System.
Y. Erben, C. Franco-Mesa, P. Gloviczki, W. Stone +31 more
2021Journal of Vascular Surgery: Venous and Lymphatic Disorders19 citations Open access
Semantic Scholar
Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
Sarah R Pickles, Tania F. Gendron, Y. Koike, M. Yue +15 more
2022Acta Neuropathologica Communications18 citations Open access
Semantic Scholar
TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration
Marina Buciuc, Peter R. Martin, Nirubol Tosakulwong, M. Murray +12 more
2022NeuroImage: Clinical15 citations Open access
Semantic Scholar
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion
E. Udine, N. Finch, M. Dejesus-Hernandez, Jazmyne L. Jackson +9 more
2024Molecular Neurodegeneration14 citations
Semantic Scholar
Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration
R. Saloner, A. Staffaroni, E. Dammer, Erik C. B. Johnson +64 more
2024Research Square14 citations Open access
Semantic Scholar
TDP‐43 Cryptic RNAs in Perry Syndrome: Differences across Brain Regions and TDP‐43 Proteinopathies
Sarah R Pickles, Jesus Gonzalez Bejarano, A. Narayan, Lillian M. Daughrity +19 more
2025Movement Disorders13 citations Open access
Semantic Scholar
Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
A. Murakami, Shunsuke Koga, Hiroaki Sekiya, Björn E. Oskarsson +4 more
2022Brain Pathology13 citations Open access
Semantic Scholar
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing
C. Pottier, F. Küçükali, Matt Baker, A. Batzler +114 more
2024medRxiv12 citations Open access
Semantic Scholar
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue
J. Watzlawik, Xu Hou, Tyrique Richardson, Szymon L Lewicki +14 more
2024Autophagy12 citations Open access
Semantic Scholar
Molecular fragment characteristics and distribution of tangle associated TDP-43 (TATs) and other TDP-43 lesions in Alzheimer's disease.
K. Josephs, Shunsuke Koga, Nirubol Tosakulwong, Stephen D. Weigand +6 more
2023Free neuropathology11 citations
Semantic Scholar
Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo
G. Cabrera, K. Meijboom, Abbas M. Abdallah, Hélène Tran +10 more
2023Gene Therapy11 citations Open access
Semantic Scholar
Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Y. Erben, M. Prudencio, C. Marquez, Karen R. Jansen-West +18 more
2022iScience11 citations Open access
Semantic Scholar
Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model
Karen R. Jansen-West, Tiffany W. Todd, Lillian M. Daughrity, M. Yue +12 more
2022Frontiers in Cell and Developmental Biology10 citations Open access
Semantic Scholar
Abundant transcriptomic alterations in the human cerebellum of patients with a C9orf72 repeat expansion
E. Udine, M. Dejesus-Hernandez, Shu-Lan Tian, S. D. das Neves +16 more
2024Acta Neuropathologica9 citations Open access
Semantic Scholar
Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis
Kyle J. Trageser, Eun-Jeong Yang, Chad Smith, Ruth Iban-Arias +11 more
2023Molecular Neurobiology9 citations Open access
Semantic Scholar
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease
M. Jambeau, Kevin D Meyer, M. Hruska-Plochan, Ricardos Tabet +40 more
2022Proceedings of the National Academy of Sciences of the United States of America9 citations Open access
Semantic Scholar

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