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Haruo Aikawa · SciRah

Researcher profile · Semantic Scholar

Haruo Aikawa

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Haruo Aikawa — researcher profile on SciRah

h-index: 16
Works: 38
Citations: 1,102

Most-cited papers

AuBr(3)-catalyzed [4 + 2] benzannulation between an enynal unit and enol.
N. Asao, Haruo Aikawa, Yoshinori Yamamoto
2004Journal of the American Chemical Society214 citations
Semantic Scholar
Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
Matthew G. Costales, Haruo Aikawa, Yue Li, Jessica L. Childs-Disney +10 more
2020Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Lewis acid-catalyzed [4 + 2] benzannulation between enynal units and enols or enol ethers: novel synthetic tools for polysubstituted aromatic compounds including indole and benzofuran derivatives.
N. Asao, Haruo Aikawa
2006Journal of Organic Chemistry110 citations
Semantic Scholar
Small molecule recognition of disease-relevant RNA structures
Samantha M. Meyer, C. Williams, Yoshihiro Akahori, Toru Tanaka +4 more
2020Chemical Society Reviews94 citations Open access
Semantic Scholar
Targeted Degradation of the Oncogenic MicroRNA 17–92 Cluster by Structure-Targeting Ligands
Xiao-Hui Liu, Hafeez S Haniff, Jessica L. Childs-Disney, A. Shuster +3 more
2020Journal of the American Chemical Society70 citations Open access
Semantic Scholar
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models
Jessica A. Bush, Haruo Aikawa, R. Fuerst, Yue Li +20 more
2021Science Translational Medicine62 citations Open access
Semantic Scholar
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing
Jonathan L. Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa +15 more
2020Journal of the American Chemical Society54 citations Open access
Semantic Scholar
Gold-catalyzed etherification and Friedel-Crafts alkylation using ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent.
N. Asao, Haruo Aikawa, Sakie Tago, K. Umetsu
2007Organic Letters54 citations
Semantic Scholar
Cell-Permeable Stapled Peptides Based on HIV-1 Integrase Inhibitors Derived from HIV-1 Gene Products
Wataru Nomura, Haruo Aikawa, Nami Ohashi, E. Urano +13 more
2013ACS Chemical Biology47 citations Open access
Semantic Scholar
Gold-catalyzed substitution reaction with ortho-alkynylbenzoic acid alkyl ester as an efficient alkylating agent
Haruo Aikawa, Sakie Tago, K. Umetsu, Naomichi Haginiwa +1 more
200944 citations
Semantic Scholar
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype
Hafeez S Haniff, Xiao-Hui Liu, Yuquan Tong, Samantha M. Meyer +6 more
2021Cell Chemical Biology30 citations Open access
Semantic Scholar
Study of an RNA-Focused DNA-Encoded Library Informs Design of a Degrader of a r(CUG) Repeat Expansion
Quentin M. R. Gibaut, Yoshihiro Akahori, Jessica A. Bush, A. Taghavi +5 more
2022Journal of the American Chemical Society28 citations Open access
Semantic Scholar
Exploratory Study on the RNA-Binding Structural Motifs by Library Screening Targeting pre-miRNA-29 a.
T. Fukuzumi, A. Murata, Haruo Aikawa, Yasue Harada +1 more
2015Chemistry28 citations
Semantic Scholar
Synthesis of 1,8-di(1-adamantyl)naphthalenes as single enantiomers stable at ambient temperatures.
Haruo Aikawa, Y. Takahira, M. Yamaguchi
2011Chemical Communications23 citations
Semantic Scholar
A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome
Jessica A. Bush, Samantha M. Meyer, R. Fuerst, Yuquan Tong +12 more
2022Proceedings of the National Academy of Sciences of the United States of America20 citations Open access
Semantic Scholar
Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation.
T. Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike +1 more
2012Organic Letters16 citations
Semantic Scholar
Formation of double helix self-assembled monolayers of ethynylhelicene oligomer disulfides on gold surfaces
Koji Yamamoto, Hiroki Sugiura, Ryo Amemiya, Haruo Aikawa +4 more
201115 citations
Semantic Scholar
Pharmacophore-based small molecule CXCR4 ligands.
T. Narumi, Tomohiro Tanaka, C. Hashimoto, Wataru Nomura +7 more
2012Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Evaluation of a synthetic C34 trimer of HIV-1 gp41 as AIDS vaccines.
C. Hashimoto, Wataru Nomura, Aki Ohya, E. Urano +6 more
2012Bioorganic & Medicinal Chemistry10 citations
Semantic Scholar
Gold-catalyzed alkylation of silyl enol ethers with ortho-alkynylbenzoic acid esters
Haruo Aikawa, T. Kaneko, N. Asao, Yoshinori Yamamoto
2011Beilstein Journal of Organic Chemistry8 citations Open access
Semantic Scholar
Low‐Molecular‐Weight CXCR4 Ligands with Variable Spacers
T. Narumi, Haruo Aikawa, Tomohiro Tanaka, C. Hashimoto +8 more
2013ChemMedChem7 citations
Semantic Scholar
Exploration of labeling by near infrared dyes of the polyproline linker for bivalent-type CXCR4 ligands.
Wataru Nomura, Haruo Aikawa, Shohei Taketomi, Miho Tanabe +2 more
2015Bioorganic & Medicinal Chemistry5 citations Open access
Semantic Scholar
Design of an orally bioavailable small molecule that modulates the microtubule-associated protein tau’s pre-mRNA splicing
Peiyuan Zhang, A. Taghavi, Masahito Abe, Haruo Aikawa +7 more
2025bioRxiv2 citations
Semantic Scholar
Expanding chemical space of DNA-binding molecules with three base-binding units.
Yukihiro Yagi, Haruo Aikawa, Takeshi Yamada, K. Nakatani
2018Bioorganic & Medicinal Chemistry Letters2 citations
Semantic Scholar
A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH.
Haruo Aikawa, A. Yano, Kazuhiko Nakatani
2017Organic and biomolecular chemistry2 citations
Semantic Scholar
Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization
Tomofumi Nakamura, Joseph R. Campbell, A. R. Moore, Sachiko Otsu +3 more
2016Journal of Virological Methods2 citations Open access
Semantic Scholar
Synthesis of 8-Substituted Adenine and Adenosine Libraries and the Binding to pre-miR-29a
T. Fukuzumi, Haruo Aikawa, Yasue Harada, Ayako Sugai +2 more
20142 citations
Semantic Scholar
Evaluation of a synthetic C 34 trimer of HIV-1 gp 41 as AIDS vaccines
C. Hashimoto, Wataru Nomura, Aki Ohya, E. Urano +6 more
20121 citations
Semantic Scholar
AuBr3‐Catalyzed [4 + 2] Benzannulation Between an Enynal Unit and Enol.
N. Asao, Haruo Aikawa, Yoshinori Yamamoto
20041 citations
Semantic Scholar
Correction to Supporting Information for Costales et al., Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer
Matthew G. Costales, Haruo Aikawa, Yue Li, Jessica L. Childs-Disney +10 more
2022Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
RNA-seq data for a small molecule alleviating C9orf72 ALS pathology by interfacing G4C2 RNA repeats with endogenous decay pathways
Jessica A. Bush, Yuquan Tong, Samantha M. Meyer, Haruo Aikawa +2 more
20210 citations
Semantic Scholar
弱酸性pHでのみシトシンバルジDNAに選択的に結合する2,7‐ジアミノ‐1,4,8‐トリアザナフタレン誘導体
Haruo Aikawa, A. Yano, K. Nakatani
20170 citations
Semantic Scholar
Development of Cell-Penetrating ZIP Tag-Probe Systems for Fluorescent Imaging of Protein Dynamics in Cells
Wataru Nomura, T. Narumi, Haruo Aikawa, H. Tamamura
20130 citations
Semantic Scholar
Development of Designed Bivalent Ligands for CXCR4 and Their Function on Receptor Binding
Wataru Nomura, Tomohiro Tanaka, T. Aoki, A. Sohma +3 more
20120 citations
Semantic Scholar
Designed Antigens Based on the Dynamic Structural Changes of gp41 for Development of Effective HIV -1 Vaccines
Wataru Nomura, C. Hashimoto, Toru Nakahara, Aki Ohya +7 more
20120 citations
Semantic Scholar
Intense Blue Fluorescence of Tag-Probe Systems Based on a Leucine Zipper Assembly
Wataru Nomura, H. Tsutsumi, Seiichiro Abe, Atsumi Mori +3 more
20110 citations
Semantic Scholar
Gold‐Catalyzed Substitution Reaction with ortho‐Alkynylbenzoic Acid Alkyl Ester as an Efficient Alkylating Agent.
Haruo Aikawa, Sakie Tago, K. Umetsu, Naomichi Haginiwa +1 more
20090 citations
Semantic Scholar
Gold-Catalyzed Etherification and Friedel—Crafts Alkylation Using ortho-Alkynylbenzoic Acid Alkyl Ester as an Efficient Alkylating Agent.
N. Asao, Haruo Aikawa, Sakie Tago, K. Umetsu
20080 citations
Semantic Scholar

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