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L. Roman · SciRah

Researcher profile · Semantic Scholar

L. Roman

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L. Roman — researcher profile on SciRah

h-index: 40
Works: 172
Citations: 5,649

Most-cited papers

Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
S. Kashyap, L. Roman, J. Lamont, B. Masters +7 more
2005Journal of Clinical Endocrinology and Metabolism136 citations Open access
Semantic Scholar
Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression
A. Eid, Doug-Yoon Lee, L. Roman, K. Khazim +1 more
2013Molecular and Cellular Biology124 citations Open access
Semantic Scholar
Nox4 NADPH Oxidase Mediates Peroxynitrite-dependent Uncoupling of Endothelial Nitric-oxide Synthase and Fibronectin Expression in Response to Angiotensin II
Doug-Yoon Lee, F. Wauquier, A. Eid, L. Roman +4 more
2013Journal of Biological Chemistry119 citations Open access
Semantic Scholar
Electron Transfer by Neuronal Nitric-oxide Synthase Is Regulated by Concerted Interaction of Calmodulin and Two Intrinsic Regulatory Elements*
L. Roman, B. Masters
2006Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
H. Ji, Benjamin Z. Stanton, J. Igarashi, Hui-Ying Li +4 more
2008Journal of the American Chemical Society90 citations Open access
Semantic Scholar
Discovery of Highly Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase by Fragment Hopping
H. Ji, Hui-Ying Li, P. Martásek, L. Roman +2 more
2009Journal of Medicinal Chemistry84 citations Open access
Semantic Scholar
Selective Neuronal Nitric Oxide Synthase Inhibitors and the Prevention of Cerebral Palsy
H. Ji, Sidhartha Tan, J. Igarashi, Hui-Ying Li +6 more
2009Annals of Neurology70 citations Open access
Semantic Scholar
Deciphering the Binding of Caveolin-1 to Client Protein Endothelial Nitric-oxide Synthase (eNOS)
Andy E. Trane, D. Pavlov, Arpeeta Sharma, Uzma Saqib +5 more
2014Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK)
Rekha Kar, D. Kellogg, L. Roman
2015Biochemical and Biophysical Research Communications - BBRC57 citations Open access
Semantic Scholar
Potent, Highly Selective, and Orally Bioavailable Gem-Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase
F. Xue, Hui-Ying Li, S. Delker, Jian-Guo Fang +4 more
2010Journal of the American Chemical Society55 citations Open access
Semantic Scholar
Role of Endogenous TRPV1 Agonists in a Post-Burn Pain Model of Partial-Thickness Injury
D. Green, S. Ruparel, L. Roman, M. A. Henry +1 more
2013Pain53 citations Open access
Semantic Scholar
Intramolecular Hydrogen Bonding: A Potential Strategy for More Bioavailable Inhibitors of Neuronal Nitric Oxide Synthase
Kristin J Labby, F. Xue, James M. Kraus, H. Ji +6 more
2012Bioorganic & Medicinal Chemistry52 citations Open access
Semantic Scholar
Thermodynamics of Oxidation-Reduction Reactions in Mammalian Nitric-oxide Synthase Isoforms*
Ying T. Gao, Susan M. E. Smith, J. Weinberg, H. J. Montgomery +6 more
2004Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
H. Ji, S. Delker, Hui-Ying Li, P. Martásek +3 more
2010Journal of Medicinal Chemistry47 citations Open access
Semantic Scholar
Neuronal Nitric Oxide Synthase Mediates Insulin- and Oxidative Stress-Induced Glucose Uptake in Skeletal Muscle Myotubes
D. Kellogg, K. Mccammon, Kathryn Hinchee-Rodriguez, M. Adamo +1 more
2017Free Radical Biology & Medicine44 citations Open access
Semantic Scholar
Potent and Selective Double-Headed Thiophene-2-carboximidamide Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma
He Huang, Hui-Ying Li, Sun Yang, G. Chreifi +5 more
2014Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition
Maris A. Cinelli, Hui-Ying Li, G. Chreifi, P. Martásek +3 more
2014Journal of Medicinal Chemistry42 citations Open access
Semantic Scholar
Neuronal nitric oxide synthase is phosphorylated in response to insulin stimulation in skeletal muscle
Kathryn Hinchee-Rodriguez, N. Garg, Priya Venkatakrishnan, Madeline G. Roman +3 more
2013Biochemical and Biophysical Research Communications - BBRC42 citations Open access
Semantic Scholar
Holoenzyme Structures of Endothelial Nitric Oxide Synthase – an Allosteric Role for Calmodulin in Pivoting the FMN Domain for Electron Transfer*
N. Volkmann, P. Martásek, L. Roman, Xiao-Ping Xu +4 more
2014Journal of Structural Biology40 citations Open access
Semantic Scholar
Oxygen Metabolism by Endothelial Nitric-oxide Synthase*
Ying T. Gao, L. Roman, P. Martásek, S. P. Panda +2 more
2007Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy.
Stéphanie A. Eid, W. Abou-Kheir, R. Sabra, G. Daoud +4 more
2012Journal of Biological Regulators and Homeostatic Agents39 citations
Semantic Scholar
Symmetric Double-Headed Aminopyridines, A Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
F. Xue, Jian-Guo Fang, S. Delker, Hui-Ying Li +4 more
2011Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability
Graham R. Lawton, H. Ranaivo, Laura K. Chico, H. Ji +5 more
2009Bioorganic & Medicinal Chemistry38 citations Open access
Semantic Scholar
Recruitment of governing elements for electron transfer in the nitric oxide synthase family.
M. Jachymová, P. Martásek, S. P. Panda, L. Roman +5 more
2005Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Detection of nitrous oxide in the neuronal nitric oxide synthase reaction by gas chromatography-mass spectrometry.
Y. Ishimura, Ying T. Gao, S. P. Panda, L. Roman +2 more
2005Biochemical and Biophysical Research Communications - BBRC36 citations
Semantic Scholar
A comparative study of neuronal and inducible nitric oxide synthases: generation of nitric oxide, superoxide, and hydrogen peroxide.
J. Weaver, S. Porasuphatana, Pei Tsai, S. Pou +2 more
2005Biochimica et Biophysica Acta36 citations
Semantic Scholar
Plasticity of Cytochrome P450 Isozyme Expression in Rat Trigeminal Ganglia Neurons During Inflammation
S. Ruparel, M. A. Henry, A. Akopian, M. P. Patil +3 more
2012Pain32 citations Open access
Semantic Scholar
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Jiwon Seo, J. Igarashi, Hui-Ying Li, P. Martásek +3 more
2007Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase
Maris A. Cinelli, Hui-Ying Li, A. Pensa, Soosung Kang +4 more
2015Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Deletion of the autoregulatory insert modulates intraprotein electron transfer in rat neuronal nitric oxide synthase
Chang-Jian Feng, L. Roman, J. T. Hazzard, Dipak K. Ghosh +2 more
2008FEBS Letters30 citations Open access
Semantic Scholar
Oxygen Metabolism by Neuronal Nitric-oxide Synthase*
Ying T. Gao, S. P. Panda, L. Roman, P. Martásek +2 more
2007Journal of Biological Chemistry30 citations Open access
Semantic Scholar
Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype*
K. Mccammon, S. P. Panda, C. Xia, Jung-Ja P. Kim +9 more
2016Journal of Biological Chemistry28 citations Open access
Semantic Scholar
2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity
Soosung Kang, Hui-Ying Li, Wei Tang, P. Martásek +3 more
2015Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
P. Mukherjee, Hui-Ying Li, I. Sevrioukova, G. Chreifi +4 more
2014Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Structure-guided Design of Selective Inhibitors of Neuronal Nitric Oxide Synthase
He Huang, Hui-Ying Li, P. Martásek, L. Roman +2 more
2013Journal of Medicinal Chemistry25 citations Open access
Semantic Scholar
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Jiwon Seo, P. Martásek, L. Roman, R. Silverman
2007Bioorganic & Medicinal Chemistry24 citations Open access
Semantic Scholar
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-based Scaffold with a Pyridine Linker
Heng-Yen Wang, Yajuan Qin, Hui-Ying Li, L. Roman +3 more
2016Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Nitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity
Soosung Kang, Wei Tang, Hui-Ying Li, G. Chreifi +4 more
2014Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Nitric oxide synthases activation and inhibition by metallacarborane cluster-based isoform-specific affectors
R. Kaplánek, P. Martásek, B. Grüner, S. P. Panda +4 more
2012Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations
He Huang, H. Ji, Hui-Ying Li, Qing Jing +5 more
2012Journal of the American Chemical Society22 citations Open access
Semantic Scholar
L-arginine regulates neuronal nitric oxide synthase production of superoxide and hydrogen peroxide.
Pei Tsai, J. Weaver, G. Cao, S. Pou +3 more
2005Biochemical Pharmacology22 citations
Semantic Scholar
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
J. Gómez-Vidal, P. Martásek, L. Roman, R. Silverman
2004Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors
A. Pensa, Maris A. Cinelli, Hui-Ying Li, G. Chreifi +5 more
2017Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
The Oxidized Linoleic Acid Metabolite-Cytochrome P450 System is Active in Biopsies from Patients with Inflammatory Dental Pain
S. Ruparel, K. Hargreaves, Michael A. Eskander, Spencer Rowan +3 more
2013Pain20 citations Open access
Semantic Scholar
Heme-Coordinating Inhibitors of Neuronal Nitric Oxide Synthase. Iron-Thioether Coordination is Stabilized by Hydrophobic Contacts Without Increased Inhibitor Potency
Jeffrey D. Martell, Hui-Ying Li, T. Doukov, P. Martásek +4 more
2010Journal of the American Chemical Society20 citations Open access
Semantic Scholar
Peripheral but crucial: a hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthase
F. Xue, Hui-Ying Li, Jian-Guo Fang, L. Roman +3 more
2010Bioorganic & Medicinal Chemistry Letters20 citations Open access
Semantic Scholar
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
H. Ji, J. Gómez-Vidal, P. Martásek, L. Roman +1 more
2006Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Differential Calmodulin-Modulatory and Electron Transfer Properties of Neuronal Nitric Oxide Synthase Mu Compared to the Alpha Variant
S. P. Panda, Wen-Bing Li, Priya Venkatakrishnan, Li Chen +4 more
2013FEBS Letters19 citations Open access
Semantic Scholar
The Role of a Conserved Serine Residue within Hydrogen Bonding Distance of FAD in Redox Properties and the Modulation of Catalysis by Ca2+/Calmodulin of Constitutive Nitric-oxide Synthases*
S. P. Panda, Ying T. Gao, L. Roman, P. Martásek +2 more
2006Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Methylated Nω-Hydroxy-L-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Kristin J Labby, Hui-Ying Li, L. Roman, P. Martásek +2 more
2013Biochemistry18 citations Open access
Semantic Scholar

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Ying T. Gao — researcher profile on SciRah

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G. Chreifi — researcher profile on SciRah

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D. Kellogg — researcher profile on SciRah