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Frederick J. Sheedy · SciRah

Researcher profile · Semantic Scholar

Frederick J. Sheedy

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Frederick J. Sheedy — researcher profile on SciRah

h-index: 29
Works: 49
Citations: 11K

Most-cited papers

Macrophages in atherosclerosis: a dynamic balance
K. Moore, Frederick J. Sheedy, E. Fisher
2013Nature reviews. Immunology2,511 citations Open access
Semantic Scholar
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
Frederick J. Sheedy, E. Pålsson-McDermott, E. J. Hennessy, C. Martin +5 more
2010Nature Immunology1,066 citations
Semantic Scholar
Pyruvate Kinase M2 regulates Hif-1α activity and IL-1β induction, and is a critical determinant of the Warburg Effect in LPS-activated macrophages
E. Pålsson-McDermott, Anne M. Curtis, G. Goel, M. Lauterbach +14 more
2015Cell Metabolism999 citations Open access
Semantic Scholar
MicroRNAs: the fine-tuners of Toll-like receptor signalling
L. O'Neill, Frederick J. Sheedy, C. McCoy
2011Nature reviews. Immunology903 citations
Semantic Scholar
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.
Katey J. Rayner, Frederick J. Sheedy, Christine Esau, F. Hussain +9 more
2011Journal of Clinical Investigation733 citations Open access
Semantic Scholar
CD36 coordinates NLRP3 inflammasome activation by facilitating the intracellular nucleation from soluble to particulate ligands in sterile inflammation
Frederick J. Sheedy, A. Grebe, Katey J. Rayner, Parisa Kalantari +10 more
2013Nature Immunology636 citations Open access
Semantic Scholar
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
E. Pålsson-McDermott, Anne M. Curtis, G. Goel, M. Lauterbach +14 more
2015Cell Metabolism622 citations Open access
Semantic Scholar
Turning 21: Induction of miR-21 as a Key Switch in the Inflammatory Response
Frederick J. Sheedy
2015Frontiers in Immunology479 citations Open access
Semantic Scholar
Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides
Katey J. Rayner, Christine Esau, F. Hussain, Allison L. Mcdaniel +13 more
2011Nature449 citations Open access
Semantic Scholar
Inhibition of miR-33 a / b in non-human primates raises plasma HDL and reduces VLDL triglycerides
Katey J. Rayner, Christine Esau, F. Hussain, Allison L. Mcdaniel +19 more
2011397 citations
Semantic Scholar
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
M. Ouimet, Stefanie Köster, Erik T. Sakowski, Bhama Ramkhelawon +12 more
2016Nature Immunology329 citations Open access
Semantic Scholar
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication
Laura E. Gleeson, Frederick J. Sheedy, E. Pålsson-McDermott, Denise Triglia +4 more
2016Journal of Immunology313 citations
Semantic Scholar
IL-10 Inhibits miR-155 Induction by Toll-like Receptors*
C. McCoy, Frederick J. Sheedy, Joseph E. Qualls, Sarah L. Doyle +3 more
2010Journal of Biological Chemistry275 citations Open access
Semantic Scholar
Adding fuel to fire: microRNAs as a new class of mediators of inflammation
Frederick J. Sheedy, L. O'Neill
2008Annals of the Rheumatic Diseases255 citations
Semantic Scholar
Netrin-1 promotes adipose tissue macrophage accumulation and insulin resistance in obesity
Bhama Ramkhelawon, E. J. Hennessy, M. Ménager, T. D. Ray +10 more
2014Nature Medicine158 citations Open access
Semantic Scholar
Mycobacterium tuberculosis limits host glycolysis and IL-1β by restriction of PFK-m via microRNA-21
Emer E. Hackett, Hugo Charles-Messance, S. O'Leary, Laura E. Gleeson +13 more
2020Cell Reports152 citations Open access
Semantic Scholar
Regulating metabolic inflammation by nutritional modulation.
Hugo Charles-Messance, K. Mitchelson, E. de Marco Castro, Frederick J. Sheedy +1 more
2020Journal of Allergy and Clinical Immunology92 citations Open access
Semantic Scholar
IL-1 signaling in atherosclerosis: sibling rivalry
Frederick J. Sheedy, K. Moore
2013Nature Immunology78 citations Open access
Semantic Scholar
Metabolic reprogramming & inflammation: Fuelling the host response to pathogens.
Laura E. Gleeson, Frederick J. Sheedy
2016Seminars in Immunology73 citations
Semantic Scholar
Toll-like Receptor-4 (TLR4) Down-regulates MicroRNA-107, Increasing Macrophage Adhesion via Cyclin-dependent Kinase 6*
E. J. Hennessy, Frederick J. Sheedy, David Santamaría, M. Barbacid +1 more
2011Journal of Biological Chemistry67 citations Open access
Semantic Scholar
Recognition of yeast β-glucan particles triggers immunometabolic signaling required for trained immunity
Cian J. H. Horneck Johnston, Anna E. Ledwith, M. Lundahl, Hugo Charles-Messance +12 more
2024iScience62 citations Open access
Semantic Scholar
Cigarette Smoking Impairs the Bioenergetic Immune Response to Mycobacterium tuberculosis Infection
Laura E. Gleeson, S. O'Leary, Daniel Ryan, A. McLaughlin +2 more
2018American Journal of Respiratory Cell and Molecular Biology56 citations
Semantic Scholar
Targeting immunometabolism in host defence against Mycobacterium tuberculosis
Frederick J. Sheedy, M. Divangahi
2020Immunology48 citations Open access
Semantic Scholar
von Willebrand factor links primary hemostasis to innate immunity
C. Drakeford, S. Águila, F. Roche, K. Hokamp +19 more
2022Nature Communications46 citations Open access
Semantic Scholar
The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis
Frederick J. Sheedy, I. Marinou, Luke A. J. O'Neill, A. G. Wilson
2007Annals of the Rheumatic Diseases43 citations
Semantic Scholar
Respiratory Tract Infections in Diabetes – Lessons From Tuberculosis and Influenza to Guide Understanding of COVID-19 Severity
Amnah Al-Sayyar, Katina D Hulme, Ronan Thibaut, J. Bayry +3 more
2022Frontiers in Endocrinology42 citations Open access
Semantic Scholar
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling
Clíona Ní Cheallaigh, Frederick J. Sheedy, J. Harris, Natalia Muñoz‐Wolf +23 more
2016Immunity36 citations Open access
Semantic Scholar
TIRAP Ser180Leu polymorphism is associated with Behcet's disease.
O. Durrani, K. Banahan, Frederick J. Sheedy, Laura McBride +10 more
2011Rheumatology36 citations
Semantic Scholar
β-glucans from Agaricus bisporus mushroom products drive Trained Immunity
Sarah Case, Tara O'Brien, Anna E. Ledwith, Shilong Chen +10 more
2024Frontiers in Nutrition32 citations Open access
Semantic Scholar
Obesity, COVID-19 and innate immunometabolism
Laura E. Gleeson, H. Roche, Frederick J. Sheedy
2020British Journal of Nutrition26 citations Open access
Semantic Scholar
Train to Lose: Innate Immune Memory in Metaflammation.
Hugo Charles-Messance, Frederick J. Sheedy
2020Molecular Nutrition & Food Research17 citations
Semantic Scholar
Trained immunity causes myeloid cell hypercoagulability
A. Rehill, Seán McCluskey, Anna E. Ledwith, T. Ryan +14 more
2024bioRxiv10 citations Open access
Semantic Scholar
An Army Marches on Its Stomach: Metabolic Intermediates as Antimicrobial Mediators in Mycobacterium tuberculosis Infection
Emer E. Hackett, Frederick J. Sheedy
2020Frontiers in Cellular and Infection Microbiology10 citations Open access
Semantic Scholar
Phagocyte metabolism: neutrophils have their cake but don't eat it.
J. Phelan, Frederick J. Sheedy
2021Trends in immunology6 citations
Semantic Scholar
miR-21 alters circulating Treg function in vascular disease-hope for restoring immunoregulatory responses in atherosclerosis?
Emer E. Hackett, Frederick J. Sheedy
2017Annals of Translational Medicine5 citations Open access
Semantic Scholar
"Negative regulation of innate immune signalling by components of the button mushroom Agaricus bisporus".
Michele O'Sullivan, Elaine Dempsey, Sarah Case, Emer E. Hackett +9 more
2023Molecular Nutrition & Food Research4 citations Open access
Semantic Scholar
Biodegradable microparticles promote anti-inflammatory innate immune memory though a size- and mTOR dependent process.
Roisin I. Lynch, Aoife L Gorman, Seán McCluskey, Cian J H Horneck-Johnston +4 more
2026Journal of Leukocyte Biology2 citations Open access
Semantic Scholar
Protective Properties of the White Button Mushroom, Agaricus bisporus, in a Mouse Model of Colitis
Elaine Dempsey, Aaron M. Walsh, Supriya Yadav, Jude Wilson +2 more
2025Molecular Nutrition & Food Research2 citations Open access
Semantic Scholar
Pyruvate KinaseM 2 Regul ates Hif-1 a Activity and IL-1 b Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages Graphical Abstract Highlights
E. Pålsson-McDermott, Anne M. Curtis, G. Goel, M. Lauterbach +14 more
20151 citations
Semantic Scholar
Abstract 624: MiR-33 Antagonism Prevents the Progression of Atherosclerosis by Promoting an M2 Macrophage Phenotype
H. Ediriweera, M. Ouimet, Frederick J. Sheedy, Katey J. Rayner +6 more
2014Arteriosclerosis, Thrombosis and Vascular Biology1 citations
Semantic Scholar
Diet, Metabolism and Innate Immune Training in individuals With MAFLD
Helen M. Roche, K. Mitchelson, Sinéad M. Mullin, Meabh Ní Chathail +4 more
2025Current Developments in Nutrition0 citations Open access
Semantic Scholar
Decision letter: De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis
H. Boshoff, Frederick J. Sheedy
20210 citations Open access
Semantic Scholar
Novel role for caspase-11 in host defence against Mycobacterium tuberculosis.
E. Creagh, C. Nulty, Frederick J. Sheedy
20210 citations
Semantic Scholar
Shields Up-Systemic Protection Provided by microRNA-21 During Sepsis?
Clíona Ní Cheallaigh, Frederick J. Sheedy
2017Critical Care Medicine0 citations
Semantic Scholar
This information is current as ReplicationControl of Intracellular Bacillary Alveolar Macrophages That Is Required for Induces Aerobic Glycolysis in Human Mycobacterium tuberculosis Cutting Edge :
M. O'Sullivan, L. O'Neill, J. Keane, Palsson-McDermott +4 more
20160 citations
Semantic Scholar
Abstract 610: Netrin-1 Promotes Macrophage Accumulation and Insulin Resistance in Obesity
Bhama Ramkhelawon, E. J. Hennessy, M. Ménager, T. D. Ray +8 more
2014Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
Abstract 369: Cd36 Sensing of Metabolic Danger Signals is a Common Mechanism of Nlrp3 Inflammasome Activation
Frederick J. Sheedy, K. Moore
2013Arteriosclerosis, Thrombosis and Vascular Biology0 citations
Semantic Scholar
Abstract 45: Antiatherosclerotic Effects of miR-33 Inhibition: Increased Reverse Cholesterol Transport and Alternative-Activation (M2) of Macrophages
Katey J. Rayner, Frederick J. Sheedy, Christine Esau, F. Hussain +9 more
20120 citations
Semantic Scholar
Modulation of microRNA by toll-like receptors
Frederick J. Sheedy
20090 citations
Semantic Scholar

Frequent co-authors

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K. Moore×13
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K. Moore — researcher profile on SciRah
L. O'Neill×11
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L. O'Neill — researcher profile on SciRah
Laura E. Gleeson×10
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Laura E. Gleeson — researcher profile on SciRah
J. Keane×9
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J. Keane — researcher profile on SciRah

Katey J. Rayner

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Katey J. Rayner — researcher profile on SciRah

Emer E. Hackett×7

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Emer E. Hackett — researcher profile on SciRah

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E. Fisher — researcher profile on SciRah

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S. Corr — researcher profile on SciRah

E. Pålsson-McDermott×5

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E. Pålsson-McDermott — researcher profile on SciRah

Christine Esau×5

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Christine Esau — researcher profile on SciRah

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T. D. Ray — researcher profile on SciRah

E. J. Hennessy×4

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E. J. Hennessy — researcher profile on SciRah