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P. Holt · SciRah

Researcher profile · Semantic Scholar

P. Holt

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P. Holt — researcher profile on SciRah

h-index: 83
Works: 477
Citations: 27K

Most-cited papers

After asthma: redefining airways diseases.
I. Pavord, R. Beasley, A. Agustí, G. Anderson +19 more
2017The Lancet903 citations Open access
Semantic Scholar
The infant airway microbiome in health and disease impacts later asthma development
S. Teo, Danny Mok, K. Pham, M. Kusel +14 more
2015Cell Host and Microbe861 citations Open access
Semantic Scholar
Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.
A. Tarique, J. Logan, Emma Thomas, P. Holt +2 more
2015American Journal of Respiratory Cell and Molecular Biology509 citations Open access
Semantic Scholar
Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks
F. Demenais, P. Margaritte-Jeannin, K. Barnes, W. Cookson +171 more
2017Nature Genetics505 citations Open access
Semantic Scholar
An exposome perspective: Early‐life events and immune development in a changing world
H. Renz, P. Holt, M. Inouye, A. Logan +2 more
2017Journal of Allergy and Clinical Immunology196 citations Open access
Semantic Scholar
Dynamics of airway microbiota identify a critical window for interplay of pathogenic bacteria and allergic sensitization in childhood respiratory disease
S. Teo, H. Tang, Danny Mok, L. Judd +15 more
2018Cell Host and Microbe192 citations Open access
Semantic Scholar
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
S. Vogelezang, J. Bradfield, T. Ahluwalia, J. Curtin +141 more
2020PLoS Genetics177 citations Open access
Semantic Scholar
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Johannes Waage, M. Standl, J. Curtin, L. Jessen +84 more
2018Nature Genetics146 citations Open access
Semantic Scholar
Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children
X. Hong, K. Hao, C. Ladd-Acosta, K. Hansen +28 more
2015140 citations
Semantic Scholar
Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis
Steven M. Brunwasser, B. Snyder, A. Driscoll, D. Fell +12 more
2020The Lancet Respiratory Medicine90 citations Open access
Semantic Scholar
Developmental patterns in the nasopharyngeal microbiome during infancy are associated with asthma risk
H. Tang, A. Lång, S. Teo, L. Judd +10 more
2020Journal of Allergy and Clinical Immunology79 citations Open access
Semantic Scholar
Distinguishing benign from pathologic TH2 immunity in atopic children.
P. Holt, D. Strickland, A. Bosco, D. Belgrave +8 more
2016Journal of Allergy and Clinical Immunology64 citations Open access
Semantic Scholar
Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children
JC Brealey, K. Chappell, Sally Galbraith, E. Fantino +5 more
2017Respirology (Carlton South. Print)63 citations Open access
Semantic Scholar
CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis.
A. Tarique, P. Sly, P. Holt, A. Bosco +5 more
2017Journal of Cystic Fibrosis62 citations Open access
Semantic Scholar
Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass.
K. Zhu, W. Oddy, P. Holt, W. C. S. Ping-Delfos +5 more
2017American Journal of Clinical Nutrition46 citations Open access
Semantic Scholar
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
C. Middeldorp, A. Mahajan, M. Horikoshi, N. Robertson +218 more
2019European Journal of Epidemiology45 citations Open access
Semantic Scholar
The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage.
P. Holt
2015Journal of Allergy and Clinical Immunology44 citations Open access
Semantic Scholar
Primary prevention of severe lower respiratory illnesses in at-risk infants using the immunomodulator OM85.
P. Sly, Sally Galbraith, Zahir Islam, B. Holt +2 more
2019Journal of Allergy and Clinical Immunology43 citations Open access
Semantic Scholar
Developmental regulation of type 1 and type 3 interferon production and risk for infant infections and asthma development
P. Holt, Danny Mok, Debasis Panda, Lynnsey A. Renn +8 more
2019Journal of Allergy and Clinical Immunology39 citations Open access
Semantic Scholar
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges.
H. Tang, S. Teo, P. Sly, P. Holt +1 more
2021Journal of Allergy and Clinical Immunology38 citations Open access
Semantic Scholar
Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses
N. Troy, E. Hollams, P. Holt, A. Bosco
2016BMC Medical Genomics38 citations Open access
Semantic Scholar
Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection.
T. Choi, Mark K. Devries, L. Bacharier, W. Busse +38 more
2020American Journal of Respiratory and Critical Care Medicine35 citations Open access
Semantic Scholar
Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis.
A. Jones, D. Anderson, Sally Galbraith, E. Fantino +8 more
2019American Journal of Respiratory and Critical Care Medicine33 citations Open access
Semantic Scholar
Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
Qin-Qin Huang, H. Tang, S. Teo, Danny Mok +11 more
2020Nature Communications31 citations Open access
Semantic Scholar
Systems biology and big data in asthma and allergy: recent discoveries and emerging challenges
H. Tang, P. Sly, P. Holt, K. Holt +1 more
2019European Respiratory Journal31 citations Open access
Semantic Scholar
Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation
K. T. Mincham, N. Scott, J. Lauzon-Joset, J. Leffler +6 more
2018Journal of Clinical Investigation30 citations Open access
Semantic Scholar
Targeting maternal immune function during pregnancy for asthma prevention in offspring: harnessing the "farm effect"?
P. Holt, D. Strickland, A. Custovic
2020Journal of Allergy and Clinical Immunology29 citations Open access
Semantic Scholar
Oestrogen amplifies pre‐existing atopy‐associated Th2 bias in an experimental asthma model
J. Lauzon-Joset, K. T. Mincham, Ana P. Abad, B. Short +3 more
2019Clinical and Experimental Allergy29 citations
Semantic Scholar
Immune function during early adolescence positively predicts adult facial sexual dimorphism in both men and women
Y. Foo, L. W. Simmons, D. Perrett, P. Holt +2 more
2020Evolution and human behavior28 citations Open access
Semantic Scholar
Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age
N. Kiraly, J. Koplin, N. Crawford, S. Bannister +9 more
2016Allergy. European Journal of Allergy and Clinical Immunology28 citations Open access
Semantic Scholar
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy
H. Tang, S. Teo, D. Belgrave, M. D. Evans +12 more
2018eLife24 citations Open access
Semantic Scholar
Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies.
N. Troy, Deborah Strickland, M. Serralha, Emma de Jong +10 more
2022Journal of Allergy and Clinical Immunology22 citations Open access
Semantic Scholar
Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults
L. Black, S. Burrows, R. Lucas, C. Marshall +7 more
2016British Journal of Nutrition22 citations Open access
Semantic Scholar
Transplacental Innate Immune Training via Maternal Microbial Exposure: Role of XBP1-ERN1 Axis in Dendritic Cell Precursor Programming
K. T. Mincham, A. Jones, M. Bodinier, N. Scott +5 more
2020Frontiers in Immunology21 citations Open access
Semantic Scholar
Environmental Microbial Exposure and Protection against Asthma.
P. Holt, P. Sly
2015New England Journal of Medicine21 citations
Semantic Scholar
Whole cell pertussis vaccination and decreased risk of IgE-mediated food allergy: a nested case-control study.
M. Estcourt, D. Campbell, M. Gold, P. Richmond +11 more
2019Journal of Allergy and Clinical Immunology: In Practice20 citations
Semantic Scholar
Time spent outdoors through childhood and adolescence – assessed by 25‐hydroxyvitamin D concentration – and risk of myopia at 20 years
G. Lingham, D. Mackey, K. Zhu, R. Lucas +7 more
2021Acta ophthalmologica19 citations Open access
Semantic Scholar
Pregnancy Induces a Steady-State Shift in Alveolar Macrophage M1/M2 Phenotype That Is Associated With a Heightened Severity of Influenza Virus Infection: Mechanistic Insight Using Mouse Models
J. Lauzon-Joset, N. Scott, K. T. Mincham, P. Stumbles +2 more
2019Journal of Infectious Diseases18 citations
Semantic Scholar
Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics
A. Jones, N. Troy, Elisha White, E. Hollams +8 more
2018Scientific Reports18 citations Open access
Semantic Scholar
Basophil counts in PBMC populations during childhood acute wheeze/asthma are associated with future exacerbations.
J. Leffler, A. Jones, E. Hollams, Franciska Prastanti +5 more
2018Journal of Allergy and Clinical Immunology18 citations Open access
Semantic Scholar
Progressive increase of FcεRI expression across several PBMC subsets is associated with atopy and atopic asthma within school‐aged children
J. Leffler, James F. Read, A. Jones, Danny Mok +9 more
2019Pediatric Allergy and Immunology17 citations Open access
Semantic Scholar
Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study
Jing Guo, Wen-Jing Zhu, Huimin Wang, P. Holt +2 more
2019Allergy, Asthma & Clinical Immunology15 citations Open access
Semantic Scholar
Transiently increased IgE responses in infants and pre-schoolers receiving only acellular Diphtheria-Pertussis-Tetanus (DTaP) vaccines compared to those initially receiving at least one dose of cellular vaccine (DTwP) - Immunological curiosity or canary in the mine?
P. Holt, T. Snelling, O. White, P. Sly +6 more
2016Vaccine15 citations Open access
Semantic Scholar
Rewiring of gene networks underlying mite allergen‐induced CD4 + Th‐cell responses during immunotherapy
A. Jones, D. Anderson, N. Troy, Dominic Mallon +5 more
2020Allergy. European Journal of Allergy and Clinical Immunology12 citations
Semantic Scholar
Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM‐85
J. Lauzon-Joset, K. T. Mincham, N. Scott, Yasmine Khandan +3 more
2021bioRxiv9 citations Open access
Semantic Scholar
Atopy-Dependent and Independent Immune Responses in the Heightened Severity of Atopics to Respiratory Viral Infections: Rat Model Studies
J. Lauzon-Joset, A. Jones, K. T. Mincham, Jenny Thomas +4 more
2018Frontiers in Immunology9 citations Open access
Semantic Scholar
A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment
Aarti Saiganesh, B. Hales, Yu-Chun Li, P. Holt +2 more
2018Allergy. European Journal of Allergy and Clinical Immunology9 citations
Semantic Scholar
IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming
Emma de Jong, J. Lauzon-Joset, J. Leffler, M. Serralha +5 more
2021Frontiers in Immunology8 citations Open access
Semantic Scholar
OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
Gladymar Perez Chacon, M. Estcourt, J. Totterdell, D. Campbell +8 more
2020BMJ Open8 citations Open access
Semantic Scholar
Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis
J. Thyssen, T. Ahluwalia, L. Paternoster, N. Ballardini +32 more
2019Allergy. European Journal of Allergy and Clinical Immunology8 citations Open access
Semantic Scholar

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