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K. Chappell · SciRah

Researcher profile · Semantic Scholar

K. Chappell

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K. Chappell — researcher profile on SciRah

h-index: 26
Works: 96
Citations: 2,710

Most-cited papers

Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention
M. Magro, V. Mas, K. Chappell, Mónica Vázquez +5 more
2012Proceedings of the National Academy of Sciences of the United States of America274 citations Open access
Semantic Scholar
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Eduardo A. Albornoz, A. Amarilla, N. Modhiran, Sandra Parker +29 more
2022Molecular Psychiatry158 citations Open access
Semantic Scholar
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
K. Selva, C. E. van de Sandt, Melissa M. Lemke, Christina Y. Lee +37 more
2021Nature Communications157 citations Open access
Semantic Scholar
Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation.
Gautier Robin, K. Chappell, M. Stoermer, Shu-Hong Hu +3 more
2009Journal of Molecular Biology145 citations
Semantic Scholar
Viral bacterial co-infection of the respiratory tract during early childhood.
J. Brealey, P. Sly, P. Young, K. Chappell
2015FEMS Microbiology Letters133 citations Open access
Semantic Scholar
Enzymatic Characterization and Homology Model of a Catalytically Active Recombinant West Nile Virus NS3 Protease*
Tessa A Nall, K. Chappell, M. Stoermer, Ning-Xia Fang +3 more
2004Journal of Biological Chemistry115 citations Open access
Semantic Scholar
A broadly protective antibody that targets the flavivirus NS1 protein
N. Modhiran, Hao Song, Li-Dong Liu, C. Bletchly +21 more
2021Science110 citations
Semantic Scholar
The piRNA Response to Retroviral Invasion of the Koala Genome
Tian-Xiong Yu, Birgit S. Koppetsch, S. Pagliarani, Stephen D. Johnston +5 more
2019bioRxiv105 citations Open access
Semantic Scholar
West Nile Virus NS2B/NS3 protease as an antiviral target.
K. Chappell, M. Stoermer, David P. Fairlie, Paul R. Young
2008Current Medicinal Chemistry81 citations
Semantic Scholar
Insights to Substrate Binding and Processing by West Nile Virus NS3 Protease through Combined Modeling, Protease Mutagenesis, and Kinetic Studies*
K. Chappell, M. Stoermer, D. Fairlie, P. Young
2006Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity.
M. Stoermer, K. Chappell, S. Liebscher, C. Jensen +5 more
2008Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial
K. Chappell, F. Mordant, Zheyi Li, D. Wijesundara +31 more
2021Lancet. Infectious Diseases (Print)73 citations Open access
Semantic Scholar
Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity.
K. Chappell, M. Stoermer, D. Fairlie, P. Young
2008Journal of General Virology71 citations Open access
Semantic Scholar
Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children
JC Brealey, K. Chappell, Sally Galbraith, E. Fantino +5 more
2017Respirology (Carlton South. Print)63 citations Open access
Semantic Scholar
An Optimized High-Throughput Immuno-Plaque Assay for SARS-CoV-2
A. Amarilla, N. Modhiran, Y. X. Setoh, Nias Y. G. Peng +9 more
2021Frontiers in Microbiology60 citations Open access
Semantic Scholar
Site-directed Mutagenesis and Kinetic Studies of the West Nile Virus NS3 Protease Identify Key Enzyme-Substrate Interactions*
K. Chappell, Tessa A Nall, M. Stoermer, Ning-Xia Fang +3 more
2005Journal of Biological Chemistry58 citations Open access
Semantic Scholar
Preclinical development of a molecular clamp‐stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
Daniel Watterson, D. Wijesundara, N. Modhiran, F. Mordant +46 more
2021Clinical & Translational Immunology56 citations Open access
Semantic Scholar
Phylogenetic Diversity of Koala Retrovirus within a Wild Koala Population
K. Chappell, J. Brealey, A. Amarilla, Daniel Watterson +6 more
2016Journal of Virology56 citations Open access
Semantic Scholar
Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs
M. Pedrera, F. Macchi, R. McLean, V. Franceschi +14 more
2020Vaccines41 citations Open access
Semantic Scholar
Distinct systems serology features in children, elderly and COVID patients
K. Selva, C. E. van de Sandt, Melissa M. Lemke, Christina Y. Lee +29 more
2020medRxiv36 citations Open access
Semantic Scholar
A generic screening platform for inhibitors of virus induced cell fusion using cellular electrical impedance
Daniel Watterson, J. Robinson, K. Chappell, M. Butler +5 more
2016Scientific Reports36 citations Open access
Semantic Scholar
Retroviral integrations contribute to elevated host cancer rates during germline invasion
Gayle K McEwen, D. E. Alquezar-Planas, A. Dayaram, Amber K. Gillett +9 more
2021Nature Communications33 citations Open access
Semantic Scholar
Pathogenesis, Humoral Immune Responses, and Transmission between Cohoused Animals in a Ferret Model of Human Respiratory Syncytial Virus Infection
Kok-Fei Chan, L. Carolan, J. Druce, K. Chappell +7 more
2017Journal of Virology31 citations Open access
Semantic Scholar
Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion
Nazia Thakur, Carina Conceicao, Ariel Isaacs, Stacey Human +12 more
2020Journal of General Virology30 citations Open access
Semantic Scholar
Structure and antigenicity of divergent Henipavirus fusion glycoproteins
Ariel Isaacs, Y. Low, K. Macauslane, Joy Seitanidou +9 more
2023Nature Communications29 citations Open access
Semantic Scholar
The Next Generation of Influenza Vaccines: Towards a Universal Solution
Christopher L. D. McMillan, P. Young, Daniel Watterson, K. Chappell
2021Vaccines27 citations Open access
Semantic Scholar
Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions
Michaela D. J. Blyton, P. Young, B. Moore, K. Chappell
2021bioRxiv26 citations Open access
Semantic Scholar
Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3.
K. Chappell, M. Stoermer, D. Fairlie, P. Young
2007Protein Expression and Purification24 citations
Semantic Scholar
A platform technology for generating subunit vaccines against diverse viral pathogens
A. Young, Ariel Isaacs, Connor A. P. Scott, N. Modhiran +16 more
2022Frontiers in Immunology22 citations Open access
Semantic Scholar
Chronic SARS-CoV-2, a Cause of Post-acute COVID-19 Sequelae (Long-COVID)?
Jake S. O’Donnell, K. Chappell
2021Frontiers in Microbiology22 citations Open access
Semantic Scholar
Epidemiology of respiratory syncytial virus in a community birth cohort of infants in the first 2 years of life
Mari D. Takashima, K. Grimwood, P. Sly, S. Lambert +3 more
2021European Journal of Pediatrics22 citations Open access
Semantic Scholar
Respiratory Syncytial Virus Infection is Associated with Increased Bacterial Load in the Upper Respiratory Tract in Young Children
K. Chappell, J. Brealey, I. Mackay, C. Bletchly +4 more
201322 citations Open access
Semantic Scholar
Pediatric Pulmonology
J. Brealey, Paul R. Young, T. Sloots, Robert S. Ware +4 more
202021 citations
Semantic Scholar
Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.
A. Shannon, K. Chappell, M. Stoermer, Shiao Y. Chow +3 more
2016Protein Expression and Purification21 citations Open access
Semantic Scholar
Combinatorial F-G Immunogens as Nipah and Respiratory Syncytial Virus Vaccine Candidates
Ariel Isaacs, Stacey T M Cheung, Nazia Thakur, N. Jaberolansar +7 more
2021Viruses20 citations Open access
Semantic Scholar
Rapid Response Subunit Vaccine Design in the Absence of Structural Information
D. Wijesundara, M. Avumegah, J. Lackenby, N. Modhiran +4 more
2020Frontiers in Immunology20 citations Open access
Semantic Scholar
Nucleocapsid Specific Diagnostics for the Detection of Divergent SARS-CoV-2 Variants
Ariel Isaacs, A. Amarilla, Julio Aguado, N. Modhiran +13 more
2022Frontiers in Immunology19 citations Open access
Semantic Scholar
Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas
Michaela D. J. Blyton, M. Pyne, P. Young, K. Chappell
2022PLoS Pathogens18 citations Open access
Semantic Scholar
Koala retrovirus genetic diversity and transmission dynamics within captive koala populations
B. Joyce, Michaela D. J. Blyton, S. Johnston, P. Young +1 more
2021Proceedings of the National Academy of Sciences of the United States of America18 citations Open access
Semantic Scholar
Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine
Jake S. O’Donnell, Ariel Isaacs, Virginie Jakob, Célia Lebas +7 more
2022Frontiers in Immunology17 citations Open access
Semantic Scholar
Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines
Ariel Isaacs, Zheyi Li, Stacey T M Cheung, D. Wijesundara +6 more
2021Vaccines17 citations Open access
Semantic Scholar
The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion
I. Bermingham, K. Chappell, Daniel Watterson, P. Young
2017Journal of Virology17 citations Open access
Semantic Scholar
Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
Christopher L. D. McMillan, Stacey T M Cheung, N. Modhiran, James Barnes +13 more
2021npj Vaccines16 citations Open access
Semantic Scholar
Fighting Ebola: A Window for Vaccine Re-evaluation?
K. Chappell, Daniel Watterson
2017PLoS Pathogens16 citations Open access
Semantic Scholar
A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants
N. Modhiran, S. Lauer, A. Amarilla, P. Hewins +34 more
2023iScience15 citations Open access
Semantic Scholar
Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG
O. Pyankov, Y. X. Setoh, S. A. Bodnev, J. Edmonds +17 more
2017Scientific Reports15 citations Open access
Semantic Scholar
Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages.
N. Vitak, D. Hume, K. Chappell, D. Sester +1 more
2016Developmental and Comparative Immunology15 citations Open access
Semantic Scholar
Product release is rate-limiting for catalytic processing by the Dengue virus protease
A. Shannon, M. Pedroso, K. Chappell, Daniel Watterson +5 more
2016Scientific Reports15 citations Open access
Semantic Scholar
A nanobody-based therapeutic targeting Nipah virus limits viral escape
Ariel Isaacs, Guillermo Valenzuela Nieto, Xing-Hai Zhang, N. Modhiran +29 more
2025Nature Structural & Molecular Biology14 citations
Semantic Scholar
A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases.
Lionel Marcon, D. Kozak, B. Battersby, K. Chappell +3 more
2008Analytical Biochemistry14 citations
Semantic Scholar

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